This gene encodes a member of the rhodopsin subfamily of G-protein-coupled receptors that is expressed in the pancreas and gastrointestinal tract. The encoded protein is activated by lipid amides including lysophosphatidylcholine and oleoylethanolamide and may be involved in glucose homeostasis. This protein is a potential drug target in the treatment of type 2 diabetes.[provid... See more...

Aliases for GPR119 Gene

Aliases for GPR119 Gene

  • G Protein-Coupled Receptor 119 2 3 5
  • Glucose-Dependent Insulinotropic Receptor 3 4
  • GPCR2 2 3
  • G-Protein Coupled Receptor 119 4
  • G-Protein Coupled Receptor 2 3
  • GPR119 5
  • HGPCR2 2

External Ids for GPR119 Gene

Previous GeneCards Identifiers for GPR119 Gene

  • GC0XM128224
  • GC0XM129243
  • GC0XM129346
  • GC0XM129518
  • GC0XM118912

Summaries for GPR119 Gene

Entrez Gene Summary for GPR119 Gene

  • This gene encodes a member of the rhodopsin subfamily of G-protein-coupled receptors that is expressed in the pancreas and gastrointestinal tract. The encoded protein is activated by lipid amides including lysophosphatidylcholine and oleoylethanolamide and may be involved in glucose homeostasis. This protein is a potential drug target in the treatment of type 2 diabetes.[provided by RefSeq, Jan 2010]

GeneCards Summary for GPR119 Gene

GPR119 (G Protein-Coupled Receptor 119) is a Protein Coding gene. Diseases associated with GPR119 include Type 2 Diabetes Mellitus. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Akt Signaling. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and phosphatidylcholine binding. An important paralog of this gene is MC5R.

UniProtKB/Swiss-Prot Summary for GPR119 Gene

  • Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.

Tocris Summary for GPR119 Gene

  • GPR119 receptors, also referred to as SNORF25, RUP3, GPCR2 and OSGPR116, are Galphas-protein-coupled receptors with a degree of homology to cannabinoid receptors. They are predominantly expressed in the pancreas and gastrointestinal tract in humans and rodents.

Gene Wiki entry for GPR119 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR119 Gene

Genomics for GPR119 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GPR119 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ130339 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 0.3 +45.7 45673 2.4 ZNF592 ZNF10 POLR2A YY1 SMAD5 SIN3A ELK1 MBD2 TBP NR2C1 HSALNG0140121 SLC25A14 HSALNG0140123 GPR119
GH0XJ130342 Enhancer 0.2 Ensembl 0.3 +42.3 42273 0.4 SLC25A14 HSALNG0140121 HSALNG0140123 GPR119
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR119 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR119

Top Transcription factor binding sites by QIAGEN in the GPR119 gene promoter:
  • aMEF-2
  • AML1a
  • FOXD1
  • GR
  • GR-alpha
  • Lhx3a
  • LHX3b
  • MEF-2A
  • Meis-1a
  • MRF-2

Genomic Locations for GPR119 Gene

Latest Assembly
chrX:130,379,449-130,385,674
(GRCh38/hg38)
Size:
6,226 bases
Orientation:
Minus strand

Previous Assembly
chrX:129,513,423-129,519,648
(GRCh37/hg19 by Entrez Gene)
Size:
6,226 bases
Orientation:
Minus strand

chrX:129,518,319-129,519,511
(GRCh37/hg19 by Ensembl)
Size:
1,193 bases
Orientation:
Minus strand

Genomic View for GPR119 Gene

Genes around GPR119 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR119 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR119 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR119 Gene

Proteins for GPR119 Gene

  • Protein details for GPR119 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDV5-GP119_HUMAN
    Recommended name:
    Glucose-dependent insulinotropic receptor
    Protein Accession:
    Q8TDV5
    Secondary Accessions:
    • Q495H7
    • Q4VBN3

    Protein attributes for GPR119 Gene

    Size:
    335 amino acids
    Molecular mass:
    36889 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR119 Gene

Post-translational modifications for GPR119 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPR119 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR119 Gene

Domains & Families for GPR119 Gene

Gene Families for GPR119 Gene

Protein Domains for GPR119 Gene

InterPro:
Blocks:
  • Beta and gamma crystallin

Suggested Antigen Peptide Sequences for GPR119 Gene

GenScript: Design optimal peptide antigens:
  • G-protein coupled receptor 119 (GP119_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TDV5

UniProtKB/Swiss-Prot:

GP119_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR119: view

Function for GPR119 Gene

Molecular function for GPR119 Gene

UniProtKB/Swiss-Prot Function:
Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.

Gene Ontology (GO) - Molecular Function for GPR119 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IBA 21873635
GO:0005515 protein binding IPI 32296183
GO:0008289 lipid binding IEA --
GO:0031210 phosphatidylcholine binding IEA,IBA 21873635
genes like me logo Genes that share ontologies with GPR119: view
genes like me logo Genes that share phenotypes with GPR119: view

Animal Models for GPR119 Gene

MGI Knock Outs for GPR119:

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR119

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GPR119 Gene

Localization for GPR119 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR119 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR119 gene
Compartment Confidence
plasma membrane 5
extracellular 2
peroxisome 2
nucleus 2
cytosol 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for GPR119 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005886 plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with GPR119: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR119 Gene

Pathways & Interactions for GPR119 Gene

PathCards logo

SuperPathways for GPR119 Gene

SuperPathway Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
.66
.62
.57
2 GPCR Pathway
.73
.62
.58
3 Incretin synthesis, secretion, and inactivation
4 CREB Pathway
.68
.50
5 TGF-Beta Pathway
.60
.51
genes like me logo Genes that share pathways with GPR119: view

Pathways by source for GPR119 Gene

14 Qiagen pathways for GPR119 Gene
  • Actin-Based Motility by Rho Family GTPases
  • Akt Signaling
  • CREB Pathway
  • GPCR Pathway
  • IL-1 Pathway

SIGNOR curated interactions for GPR119 Gene

Gene Ontology (GO) - Biological Process for GPR119 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA 21873635
GO:0019222 regulation of metabolic process IBA 21873635
GO:0030073 insulin secretion IEA --
genes like me logo Genes that share ontologies with GPR119: view

Drugs & Compounds for GPR119 Gene

(43) Drugs for GPR119 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
APD668 Investigational Pharma Target, agonist Potent GPR119 agonist 0
MBX-2982 Investigational Pharma GPR119 agonist,selective and orally-available 0
oleoylethanolamide Investigational Pharma Agonist 0
PSN632408 Pharma Agonist Human and mouse GPR119 agonist 0
AS 1269574 Pharma GPR119 receptor agonist 0

(2) Tocris Compounds for GPR119 Gene

Compound Action Cas Number
AS 1269574 GPR119 receptor agonist 330981-72-1
PSN 375963 hydrochloride GPR119 receptor agonist 388575-52-8

(7) ApexBio Compounds for GPR119 Gene

Compound Action Cas Number
APD668 Potent GPR119 agonist 832714-46-2
AR 231453 GPR119 agonist,potent and selective 733750-99-7
AS 1269574 GPR119 receptor agonist 330981-72-1
GSK1292263 Novel GPR119 agonist 1032823-75-8
MBX-2982 GPR119 agonist,selective and orally-available 1037792-44-1
PSN 375963 hydrochloride 388575-52-8
PSN632408 Human and mouse GPR119 agonist 857652-30-3
genes like me logo Genes that share compounds with GPR119: view

Drug products for research

Transcripts for GPR119 Gene

mRNA/cDNA for GPR119 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR119

Alternative Splicing Database (ASD) splice patterns (SP) for GPR119 Gene

No ASD Table

Relevant External Links for GPR119 Gene

GeneLoc Exon Structure for
GPR119

Expression for GPR119 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR119 Gene

mRNA differential expression in normal tissues according to GTEx for GPR119 Gene

This gene is overexpressed in Pancreas (x39.8) and Testis (x7.7).

Protein differential expression in normal tissues from HIPED for GPR119 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR119 Gene



Protein tissue co-expression partners for GPR119 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR119

SOURCE GeneReport for Unigene cluster for GPR119 Gene:

Hs.496762

mRNA Expression by UniProt/SwissProt for GPR119 Gene:

Q8TDV5-GP119_HUMAN
Tissue specificity: Predominantly expressed in the pancreas, especially in the islets.

Evidence on tissue expression from TISSUES for GPR119 Gene

  • Pancreas(2.2)
genes like me logo Genes that share expression patterns with GPR119: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR119 Gene

Orthologs for GPR119 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPR119 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GPR119 29 30
  • 99.8 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia GPR119 29 30
  • 88.26 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia GPR119 29 30
  • 84.78 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Gpr119 29 16 30
  • 84.48 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Gpr119 29
  • 84.29 (n)
Oppossum
(Monodelphis domestica)
Mammalia GPR119 30
  • 74 (a)
OneToOne
Chicken
(Gallus gallus)
Aves GPR119 29 30
  • 62.99 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia GPR119 30
  • 50 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii LOC100001479 29
  • 51.5 (n)
GPR119 30
  • 41 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG12796 30
  • 19 (a)
OneToOne
Species where no ortholog for GPR119 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GPR119 Gene

ENSEMBL:
Gene Tree for GPR119 (if available)
TreeFam:
Gene Tree for GPR119 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPR119: view image
Alliance of Genome Resources:
Additional Orthologs for GPR119

Paralogs for GPR119 Gene

genes like me logo Genes that share paralogs with GPR119: view

Variants for GPR119 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR119 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
rs41310452 Likely Benign: not provided 130,384,742(-) G/C
NM_178471.2(GPR119):c.706C>G (p.Leu236Val)
MISSENSE
rs5975187 Benign: not provided 130,384,522(-) G/Ap.Ser309Leu
NM_178471.2(GPR119):c.926C>T (p.Ser309Leu)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for GPR119 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for GPR119 Gene

Variant ID Type Subtype PubMed ID
nsv528290 CNV gain 19592680

Variation tolerance for GPR119 Gene

Residual Variation Intolerance Score: 31.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR119 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR119
Leiden Open Variation Database (LOVD)
GPR119

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR119 Gene

Disorders for GPR119 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPR119 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
type 2 diabetes mellitus
  • t2d
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GPR119

genes like me logo Genes that share disorders with GPR119: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR119 Gene

Publications for GPR119 Gene

  1. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. (PMID: 14623098) Fredriksson R … Schiöth HB (FEBS letters 2003) 2 3 4
  2. Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S … Mitaku S (FEBS letters 2002) 2 3 4
  3. Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. (PMID: 16517404) Overton HA … Reynet C (Cell metabolism 2006) 3 4
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for GPR119 Gene

Sources for GPR119 Gene