Aliases for GPR119 Gene
External Ids for GPR119 Gene
Previous GeneCards Identifiers for GPR119 Gene
This gene encodes a member of the rhodopsin subfamily of G-protein-coupled receptors that is expressed in the pancreas and gastrointestinal tract. The encoded protein is activated by lipid amides including lysophosphatidylcholine and oleoylethanolamide and may be involved in glucose homeostasis. This protein is a potential drug target in the treatment of type 2 diabetes.[provided by RefSeq, Jan 2010]
GeneCards Summary for GPR119 Gene
GPR119 (G Protein-Coupled Receptor 119) is a Protein Coding gene. Diseases associated with GPR119 include Diabetes Mellitus, Noninsulin-Dependent. Among its related pathways are Akt Signaling and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and phosphatidylcholine binding. An important paralog of this gene is S1PR3.
UniProtKB/Swiss-Prot Summary for GPR119 Gene
Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.
GPR119 receptors, also referred to as SNORF25, RUP3, GPCR2 and OSGPR116, are Galphas-protein-coupled receptors with a degree of homology to cannabinoid receptors. They are predominantly expressed in the pancreas and gastrointestinal tract in humans and rodents.