Aliases for GPR108 Gene

Aliases for GPR108 Gene

  • G Protein-Coupled Receptor 108 2 3 5
  • Lung Seven Transmembrane Receptor 2 3 4
  • Protein GPR108 3 4
  • LUSTR2 3 4

External Ids for GPR108 Gene

Previous GeneCards Identifiers for GPR108 Gene

  • GC19M006824
  • GC19M006669
  • GC19M006681
  • GC19M006492

Summaries for GPR108 Gene

GeneCards Summary for GPR108 Gene

GPR108 (G Protein-Coupled Receptor 108) is a Protein Coding gene. Diseases associated with GPR108 include Periosteal Chondrosarcoma and Enchondromatosis, Multiple, Ollier Type. An important paralog of this gene is GPR107.

Additional gene information for GPR108 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR108 Gene

Genomics for GPR108 Gene

GeneHancer (GH) Regulatory Elements for GPR108 Gene

Promoters and enhancers for GPR108 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR108 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR108

Top Transcription factor binding sites by QIAGEN in the GPR108 gene promoter:
  • AML1a
  • AP-1
  • ATF-2
  • c-Jun

Genomic Locations for GPR108 Gene

Genomic Locations for GPR108 Gene
chr19:6,729,914-6,737,622
(GRCh38/hg38)
Size:
7,709 bases
Orientation:
Minus strand
chr19:6,729,925-6,737,633
(GRCh37/hg19)
Size:
7,709 bases
Orientation:
Minus strand

Genomic View for GPR108 Gene

Genes around GPR108 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR108 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR108 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR108 Gene

Proteins for GPR108 Gene

  • Protein details for GPR108 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPR9-GP108_HUMAN
    Recommended name:
    Protein GPR108
    Protein Accession:
    Q9NPR9
    Secondary Accessions:
    • B9EJD7

    Protein attributes for GPR108 Gene

    Size:
    543 amino acids
    Molecular mass:
    60633 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR108 Gene

Post-translational modifications for GPR108 Gene

  • Glycosylation at Asn57, Asn109, Ser177, Thr178, Asn200, Asn204, Asn228, and Asn534
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPR108 Gene

Domains & Families for GPR108 Gene

Gene Families for GPR108 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for GPR108 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR108 Gene

GenScript: Design optimal peptide antigens:
  • G protein-coupled receptor 108 (B9EK73_HUMAN)
  • Lung seven transmembrane receptor 2 (GP108_HUMAN)
  • GPR108 protein (Q96I30_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NPR9

UniProtKB/Swiss-Prot:

GP108_HUMAN :
  • Belongs to the LU7TM family.
Family:
  • Belongs to the LU7TM family.
genes like me logo Genes that share domains with GPR108: view

Function for GPR108 Gene

Phenotypes From GWAS Catalog for GPR108 Gene

genes like me logo Genes that share phenotypes with GPR108: view

Animal Models for GPR108 Gene

MGI Knock Outs for GPR108:

Animal Model Products

miRNA for GPR108 Gene

miRTarBase miRNAs that target GPR108

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR108 Gene

Localization for GPR108 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR108 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR108 gene
Compartment Confidence
plasma membrane 3
golgi apparatus 2
cytoskeleton 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPR108 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR108: view

Pathways & Interactions for GPR108 Gene

PathCards logo

SuperPathways for GPR108 Gene

No Data Available

Interacting Proteins for GPR108 Gene

;

Gene Ontology (GO) - Biological Process for GPR108 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GPR108 Gene

Drugs & Compounds for GPR108 Gene

No Compound Related Data Available

Transcripts for GPR108 Gene

mRNA/cDNA for GPR108 Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR108 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a ·
SP1: - - - - - -
SP2: - - -
SP3: - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - - - - - -
SP8: - - - - -
SP9: - -
SP10:
SP11:
SP12: - - -

ExUns: 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11: -
SP12:

Relevant External Links for GPR108 Gene

GeneLoc Exon Structure for
GPR108

Expression for GPR108 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR108 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR108 Gene

This gene is overexpressed in Whole Blood (x4.3).

Protein differential expression in normal tissues from HIPED for GPR108 Gene

This gene is overexpressed in Bone marrow stromal cell (51.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR108 Gene



Protein tissue co-expression partners for GPR108 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR108

SOURCE GeneReport for Unigene cluster for GPR108 Gene:

Hs.167641

Evidence on tissue expression from TISSUES for GPR108 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with GPR108: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR108 Gene

Orthologs for GPR108 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GPR108 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR108 31 30
  • 98.36 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GPR108 31 30
  • 87.11 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GPR108 31 30
  • 87.11 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr108 30
  • 83.55 (n)
mouse
(Mus musculus)
Mammalia Gpr108 17 31 30
  • 82.41 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR108 31
  • 76 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii GPR108 31
  • 71 (a)
OneToOne
LOC556363 30
  • 61.13 (n)
Dr.11789 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12280 30
fruit fly
(Drosophila melanogaster)
Insecta CG12121 31 32
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C15H9.5 31 32
  • 27 (a)
OneToMany
wheat
(Triticum aestivum)
Liliopsida Ta.9129 30
rice
(Oryza sativa)
Liliopsida Os.4314 30
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 48 (a)
OneToMany
Species where no ortholog for GPR108 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for GPR108 Gene

ENSEMBL:
Gene Tree for GPR108 (if available)
TreeFam:
Gene Tree for GPR108 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPR108: view image

Paralogs for GPR108 Gene

Paralogs for GPR108 Gene

(1) SIMAP similar genes for GPR108 Gene using alignment to 12 proteins:

  • GP108_HUMAN
  • B9EK73_HUMAN
  • G5E9L6_HUMAN
  • M0QYF6_HUMAN
  • M0QZ03_HUMAN
  • M0QZW9_HUMAN
  • M0QZY1_HUMAN
  • M0R1G1_HUMAN
  • M0R1Q3_HUMAN
  • M0R2E1_HUMAN
  • M0R3H4_HUMAN
  • Q96I30_HUMAN
genes like me logo Genes that share paralogs with GPR108: view

Variants for GPR108 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR108 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs340138 - p.Gln36Arg
rs4807897 - p.Leu79Pro

Additional dbSNP identifiers (rs#s) for GPR108 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPR108 Gene

Variant ID Type Subtype PubMed ID
dgv14e196 CNV duplication 17116639
esv2665453 CNV deletion 23128226
nsv470120 CNV loss 18288195
nsv519827 CNV loss 19592680
nsv953955 CNV deletion 24416366

Variation tolerance for GPR108 Gene

Residual Variation Intolerance Score: 93.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.79; 58.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR108 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR108

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR108 Gene

Disorders for GPR108 Gene

MalaCards: The human disease database

(5) MalaCards diseases for GPR108 Gene - From: DISEASES

Disorder Aliases PubMed IDs
periosteal chondrosarcoma
  • juxtacortical chondrosarcoma
enchondromatosis, multiple, ollier type
  • osteochondromatosis
osteoblastoma
multiple enchondromatosis, maffucci type
  • maffucci syndrome
cornelia de lange syndrome
  • cdls
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GPR108

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GPR108: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR108 Gene

Publications for GPR108 Gene

  1. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 41 54
  2. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S … Kang D (Human immunology 2010) 3 41 54
  3. GPR108, an NF-κB activator suppressed by TIRAP, negatively regulates TLR-triggered immune responses. (PMID: 30332431) Dong D … Zhou GL (PloS one 2018) 3 54
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta GD … Pelletier L (Cell 2015) 3 54

Products for GPR108 Gene

Sources for GPR108 Gene