Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GPR108 Gene

Aliases for GPR108 Gene

  • G Protein-Coupled Receptor 108 2 3 5
  • Lung Seven Transmembrane Receptor 2 3 4
  • LUSTR2 3 4
  • Protein GPR108 3

External Ids for GPR108 Gene

Previous GeneCards Identifiers for GPR108 Gene

  • GC19M006824
  • GC19M006669
  • GC19M006681
  • GC19M006492

Summaries for GPR108 Gene

GeneCards Summary for GPR108 Gene

GPR108 (G Protein-Coupled Receptor 108) is a Protein Coding gene. An important paralog of this gene is GPR107.

Additional gene information for GPR108 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR108 Gene

Genomics for GPR108 Gene

GeneHancer (GH) Regulatory Elements for GPR108 Gene

Promoters and enhancers for GPR108 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I006733 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 598.7 -0.1 -131 8.1 ZFP64 FEZF1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF263 SP3 GPR108 TRIP10 MIR6791 DUS3L KHSRP ZNF557 XAB2 ENSG00000269680 ALKBH7
GH19I006527 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 31 +207.0 206978 6.2 YBX1 IRF4 E2F8 ZNF143 ZNF548 MCM3 SP3 MEF2D ZNF610 GLIS1 TNFSF9 ZNF557 KHSRP DUS3L SAFB2 SAFB SNRPEP4 ENSG00000267571 GTF2F1 RANBP3
GH19I005789 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 22.6 +947.0 947000 2.4 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 DUS3L KHSRP ENSG00000267571 SAFB GPR108 VMAC SNRPEP4 KDM4B PTPRS RPL36
GH19I006718 Enhancer 1 ENCODE 46.5 +20.0 19981 0.2 HDGF PKNOX1 ATF1 FOXA2 ARNT YBX1 ZNF2 ZNF280A TCF12 ARID2 ENSG00000276980 XAB2 ZNF557 DUS3L ENSG00000267571 KHSRP VMAC GPR108 RANBP3 TRIP10
GH19I006270 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15.2 +462.3 462270 10.7 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 MLLT1 DUS3L ZNF557 KHSRP SNRPEP4 SAFB ENSG00000267571 VMAC GPR108 RANBP3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GPR108 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR108 gene promoter:

Genomic Locations for GPR108 Gene

Genomic Locations for GPR108 Gene
7,709 bases
Minus strand

Genomic View for GPR108 Gene

Genes around GPR108 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR108 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR108 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR108 Gene

Proteins for GPR108 Gene

  • Protein details for GPR108 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein GPR108
    Protein Accession:
    Secondary Accessions:
    • B9EJD7

    Protein attributes for GPR108 Gene

    543 amino acids
    Molecular mass:
    60633 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR108 Gene

Post-translational modifications for GPR108 Gene

  • Glycosylation at isoforms=57, posLast=109109, isoforms=177, isoforms=200, posLast=204204, posLast=228228, and posLast=534534
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPR108 Gene

Domains & Families for GPR108 Gene

Gene Families for GPR108 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for GPR108 Gene


Suggested Antigen Peptide Sequences for GPR108 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the LU7TM family.
  • Belongs to the LU7TM family.
genes like me logo Genes that share domains with GPR108: view

Function for GPR108 Gene

Phenotypes From GWAS Catalog for GPR108 Gene

genes like me logo Genes that share phenotypes with GPR108: view

miRNA for GPR108 Gene

miRTarBase miRNAs that target GPR108

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPR108 Gene

Localization for GPR108 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR108 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR108 gene
Compartment Confidence
plasma membrane 3
golgi apparatus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPR108 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR108: view

Pathways & Interactions for GPR108 Gene

SuperPathways for GPR108 Gene

No Data Available

Interacting Proteins for GPR108 Gene

Gene Ontology (GO) - Biological Process for GPR108 Gene


No data available for Pathways by source and SIGNOR curated interactions for GPR108 Gene

Drugs & Compounds for GPR108 Gene

No Compound Related Data Available

Transcripts for GPR108 Gene

Unigene Clusters for GPR108 Gene

G protein-coupled receptor 108:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR108 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a ·
SP1: - - - - - -
SP2: - - -
SP3: - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - - - - - -
SP8: - - - - -
SP9: - -
SP12: - - -

ExUns: 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20
SP10: -
SP11: -

Relevant External Links for GPR108 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR108 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR108 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR108 Gene

This gene is overexpressed in Whole Blood (x4.3).

Protein differential expression in normal tissues from HIPED for GPR108 Gene

This gene is overexpressed in Bone marrow stromal cell (51.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR108 Gene

Protein tissue co-expression partners for GPR108 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPR108 Gene:


SOURCE GeneReport for Unigene cluster for GPR108 Gene:


Evidence on tissue expression from TISSUES for GPR108 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with GPR108: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR108 Gene

Orthologs for GPR108 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GPR108 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR108 33 34
  • 98.36 (n)
(Bos Taurus)
Mammalia GPR108 33 34
  • 87.11 (n)
(Canis familiaris)
Mammalia GPR108 33 34
  • 87.11 (n)
(Rattus norvegicus)
Mammalia Gpr108 33
  • 83.55 (n)
(Mus musculus)
Mammalia Gpr108 16 34 33
  • 82.41 (n)
(Monodelphis domestica)
Mammalia GPR108 34
  • 76 (a)
(Danio rerio)
Actinopterygii GPR108 34
  • 71 (a)
LOC556363 33
  • 61.13 (n)
Dr.11789 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12280 33
fruit fly
(Drosophila melanogaster)
Insecta CG12121 35 34
  • 46 (a)
(Caenorhabditis elegans)
Secernentea C15H9.5 35 34
  • 28 (a)
(Oryza sativa)
Liliopsida Os.4314 33
(Triticum aestivum)
Liliopsida Ta.9129 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 48 (a)
Species where no ortholog for GPR108 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for GPR108 Gene

Gene Tree for GPR108 (if available)
Gene Tree for GPR108 (if available)

Paralogs for GPR108 Gene

Paralogs for GPR108 Gene

genes like me logo Genes that share paralogs with GPR108: view

Variants for GPR108 Gene

Sequence variations from dbSNP and Humsavar for GPR108 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000322717 -- 6,734,364(-) C/T intron_variant
rs1000435496 -- 6,736,435(-) T/C intron_variant
rs1000812686 -- 6,729,761(-) C/T downstream_transcript_variant
rs1001119347 -- 6,729,523(-) T/C downstream_transcript_variant
rs1001460123 -- 6,737,957(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GPR108 Gene

Variant ID Type Subtype PubMed ID
dgv14e196 CNV duplication 17116639
esv2665453 CNV deletion 23128226
nsv470120 CNV loss 18288195
nsv519827 CNV loss 19592680
nsv953955 CNV deletion 24416366

Variation tolerance for GPR108 Gene

Residual Variation Intolerance Score: 93.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.79; 58.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR108 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR108 Gene

Disorders for GPR108 Gene

Additional Disease Information for GPR108

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GPR108 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPR108 Gene

Publications for GPR108 Gene

  1. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 44 58
  2. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S … Kang D (Human immunology 2010) 3 44 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta GD … Pelletier L (Cell 2015) 3 58
  5. A Novel GLP1 Receptor Interacting Protein ATP6ap2 Regulates Insulin Secretion in Pancreatic Beta Cells. (PMID: 26272612) Dai FF … Wheeler MB (The Journal of biological chemistry 2015) 3 58

Products for GPR108 Gene

Sources for GPR108 Gene

Loading form....