Aliases for GPR107 Gene

Aliases for GPR107 Gene

  • G Protein-Coupled Receptor 107 2 3 5
  • Lung Seven Transmembrane Receptor 1 3 4
  • Protein GPR107 3 4
  • LUSTR1 3 4
  • BA138E2.2 3
  • KIAA1624 4
  • GCDRP 3

External Ids for GPR107 Gene

Previous GeneCards Identifiers for GPR107 Gene

  • GC09P123930
  • GC09P124462
  • GC09P126269
  • GC09P128192
  • GC09P129895
  • GC09P131855
  • GC09P132815
  • GC09P102415

Summaries for GPR107 Gene

GeneCards Summary for GPR107 Gene

GPR107 (G Protein-Coupled Receptor 107) is a Protein Coding gene. Diseases associated with GPR107 include Focal Dermal Hypoplasia. An important paralog of this gene is GPR108.

UniProtKB/Swiss-Prot Summary for GPR107 Gene

  • Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (PubMed:22933024). Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity).
  • (Microbial infection) Required for intoxication by Pseudomonas aeruginosa exotoxin A and Campylobacter jejuni CDT. May contribute to the retrograde transport of bacterial toxins, including cholera toxin, from the trans-Golgi network to the endoplasmic reticulum.

Gene Wiki entry for GPR107 Gene

Additional gene information for GPR107 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR107 Gene

Genomics for GPR107 Gene

GeneHancer (GH) Regulatory Elements for GPR107 Gene

Promoters and enhancers for GPR107 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR107 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR107

Top Transcription factor binding sites by QIAGEN in the GPR107 gene promoter:
  • c-Myc
  • C/EBPalpha
  • Hlf
  • Max
  • POU2F1
  • POU2F1a
  • PPAR-gamma1
  • PPAR-gamma2
  • SRF
  • SRF (504 AA)

Genomic Locations for GPR107 Gene

Genomic Locations for GPR107 Gene
chr9:130,053,426-130,140,169
(GRCh38/hg38)
Size:
86,744 bases
Orientation:
Plus strand
chr9:132,815,705-132,902,448
(GRCh37/hg19)
Size:
86,744 bases
Orientation:
Plus strand

Genomic View for GPR107 Gene

Genes around GPR107 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR107 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR107 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR107 Gene

Proteins for GPR107 Gene

  • Protein details for GPR107 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VW38-GP107_HUMAN
    Recommended name:
    Protein GPR107
    Protein Accession:
    Q5VW38
    Secondary Accessions:
    • A6NJ53
    • Q2TB81
    • Q5JPA3
    • Q5VW39
    • Q96T26
    • Q9H658
    • Q9HCE8

    Protein attributes for GPR107 Gene

    Size:
    600 amino acids
    Molecular mass:
    66990 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GPR107 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPR107 Gene

Post-translational modifications for GPR107 Gene

  • Cleaved by FURIN to yield two fragments of 17 and 35 kDa that remain associated via a disulfide bond.
  • Glycosylation at Asn70, Ser157, Ser166, Asn169, Thr171, and Asn211
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • GP107_HUMAN (1660)

No data available for DME Specific Peptides for GPR107 Gene

Domains & Families for GPR107 Gene

Gene Families for GPR107 Gene

Protein Domains for GPR107 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR107 Gene

GenScript: Design optimal peptide antigens:
  • GPR107 protein (B7ZL93_HUMAN)
  • Lung seven transmembrane receptor 1 (GP107_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5VW38

UniProtKB/Swiss-Prot:

GP107_HUMAN :
  • Belongs to the LU7TM family.
Family:
  • Belongs to the LU7TM family.
genes like me logo Genes that share domains with GPR107: view

Function for GPR107 Gene

Molecular function for GPR107 Gene

UniProtKB/Swiss-Prot Function:
Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (PubMed:22933024). Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Required for intoxication by Pseudomonas aeruginosa exotoxin A and Campylobacter jejuni CDT. May contribute to the retrograde transport of bacterial toxins, including cholera toxin, from the trans-Golgi network to the endoplasmic reticulum.

Phenotypes From GWAS Catalog for GPR107 Gene

Gene Ontology (GO) - Molecular Function for GPR107 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032050 clathrin heavy chain binding IEA --
genes like me logo Genes that share ontologies with GPR107: view
genes like me logo Genes that share phenotypes with GPR107: view

Animal Models for GPR107 Gene

MGI Knock Outs for GPR107:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR107

CRISPR Products

miRNA for GPR107 Gene

miRTarBase miRNAs that target GPR107

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR107

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR107 Gene

Localization for GPR107 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR107 Gene

Cell membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR107 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 4
nucleus 4
endosome 2
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPR107 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005769 early endosome IEA --
GO:0005794 Golgi apparatus IDA,IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with GPR107: view

Pathways & Interactions for GPR107 Gene

PathCards logo

SuperPathways for GPR107 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GPR107 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0072583 clathrin-dependent endocytosis IEA --
genes like me logo Genes that share ontologies with GPR107: view

No data available for Pathways by source and SIGNOR curated interactions for GPR107 Gene

Drugs & Compounds for GPR107 Gene

No Compound Related Data Available

Transcripts for GPR107 Gene

mRNA/cDNA for GPR107 Gene

4 REFSEQ mRNAs :
23 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPR107

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR107 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^
SP1: - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - - - -
SP5:
SP6:
SP7: -

ExUns: 21a · 21b · 21c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for GPR107 Gene

GeneLoc Exon Structure for
GPR107

Expression for GPR107 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR107 Gene

Protein differential expression in normal tissues from HIPED for GPR107 Gene

This gene is overexpressed in Nasal epithelium (55.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GPR107 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR107

SOURCE GeneReport for Unigene cluster for GPR107 Gene:

Hs.512461

Evidence on tissue expression from TISSUES for GPR107 Gene

  • Nervous system(4.9)
  • Intestine(4.4)
  • Lymph node(4.2)
  • Lung(2.2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with GPR107: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR107 Gene

Orthologs for GPR107 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GPR107 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR107 31 30
  • 99.82 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GPR107 31 30
  • 89.53 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GPR107 31 30
  • 89.22 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr107 17 31 30
  • 83.4 (n)
rat
(Rattus norvegicus)
Mammalia Gpr107 30
  • 82.75 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR107 31
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR107 31
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR107 31 30
  • 74.58 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr107 30
  • 66.73 (n)
zebrafish
(Danio rerio)
Actinopterygii gpr107 31 30
  • 66.47 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG12121 31 30
  • 55.23 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000913 30
  • 54.99 (n)
worm
(Caenorhabditis elegans)
Secernentea C15H9.5 31 30
  • 45.58 (n)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G42090 30
  • 51.88 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.380 30
rice
(Oryza sativa)
Liliopsida Os06g0132100 30
  • 49.68 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 54 (a)
OneToMany
Species where no ortholog for GPR107 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPR107 Gene

ENSEMBL:
Gene Tree for GPR107 (if available)
TreeFam:
Gene Tree for GPR107 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPR107: view image

Paralogs for GPR107 Gene

Paralogs for GPR107 Gene

(1) SIMAP similar genes for GPR107 Gene using alignment to 4 proteins:

  • GP107_HUMAN
  • B7ZL93_HUMAN
  • G5E994_HUMAN
  • U3KQD2_HUMAN
genes like me logo Genes that share paralogs with GPR107: view

Variants for GPR107 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR107 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs640343 - p.Ala189Pro

Additional dbSNP identifiers (rs#s) for GPR107 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPR107 Gene

Variant ID Type Subtype PubMed ID
esv2664800 CNV deletion 23128226
esv3621853 CNV gain 21293372
esv3621854 CNV loss 21293372
nsv1046307 CNV gain 25217958
nsv1141030 CNV deletion 24896259
nsv1141031 CNV deletion 24896259
nsv1153370 CNV insertion 26484159
nsv466590 CNV gain 19166990
nsv474774 CNV novel sequence insertion 20440878
nsv518603 CNV loss 19592680
nsv615498 CNV gain 21841781
nsv6730 CNV insertion 18451855
nsv6732 CNV deletion 18451855
nsv831732 CNV loss 17160897
nsv831733 CNV loss 17160897

Variation tolerance for GPR107 Gene

Residual Variation Intolerance Score: 22.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.71; 46.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR107 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR107

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR107 Gene

Disorders for GPR107 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPR107 Gene - From: DISEASES

Disorder Aliases PubMed IDs
focal dermal hypoplasia
  • fdh
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GPR107

genes like me logo Genes that share disorders with GPR107: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR107 Gene

Publications for GPR107 Gene

  1. GPR107, a G-protein-coupled receptor essential for intoxication by Pseudomonas aeruginosa exotoxin A, localizes to the Golgi and is cleaved by furin. (PMID: 25031321) Tafesse FG … Ploegh HL (The Journal of biological chemistry 2014) 3 4 54
  2. Evidence for an interaction of neuronostatin with the orphan G protein-coupled receptor, GPR107. (PMID: 22933024) Yosten GL … Samson WK (American journal of physiology. Regulatory, integrative and comparative physiology 2012) 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 54
  5. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 54

Products for GPR107 Gene

Sources for GPR107 Gene