The protein encoded by this gene is an orphan G protein-coupled receptor of unknown function. The encoded protein is a member of a family of proteins that contain seven transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. [provided by RefSeq, Sep 2011] See more...

Aliases for GPR101 Gene

Aliases for GPR101 Gene

  • G Protein-Coupled Receptor 101 2 3 5
  • Probable G-Protein Coupled Receptor 101 3 4
  • GPCR6 3
  • PAGH2 3
  • PITA2 3

External Ids for GPR101 Gene

Previous GeneCards Identifiers for GPR101 Gene

  • GC0XM130684
  • GC0XM132957
  • GC0XM134057
  • GC0XM134817
  • GC0XM135837
  • GC0XM135939
  • GC0XM136112
  • GC0XM125379

Summaries for GPR101 Gene

Entrez Gene Summary for GPR101 Gene

  • The protein encoded by this gene is an orphan G protein-coupled receptor of unknown function. The encoded protein is a member of a family of proteins that contain seven transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. [provided by RefSeq, Sep 2011]

GeneCards Summary for GPR101 Gene

GPR101 (G Protein-Coupled Receptor 101) is a Protein Coding gene. Diseases associated with GPR101 include Pituitary Adenoma 2, Growth Hormone-Secreting and Chromosome Xq26.3 Duplication Syndrome. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is ADRA1D.

UniProtKB/Swiss-Prot Summary for GPR101 Gene

Gene Wiki entry for GPR101 Gene

Additional gene information for GPR101 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR101 Gene

Genomics for GPR101 Gene

GeneHancer (GH) Regulatory Elements for GPR101 Gene

Promoters and enhancers for GPR101 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ137032 Promoter 0.9 Ensembl 500.7 +1.6 1646 1.6 NRF1 ZNF639 ZIC2 ZBTB10 ZBTB26 SMC3 ZBTB17 MXI1 ZNF524 ZNF777 GPR101 ARHGEF6 piR-36393-567
GH0XJ137033 Enhancer 0.6 Ensembl 500.7 +0.1 146 0.2 ZNF423 ZBTB26 EZH2 ZNF777 ZSCAN5A ZNF335 ZNF512B ZNF843 SUZ12 ZNF223 GPR101 ARHGEF6 piR-36393-567
GH0XJ137071 Enhancer 0.2 Ensembl 12.9 -37.8 -37754 0.4 GPR101 piR-48553-369
GH0XJ136584 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 1.4 +447.0 446953 5.4 ZBTB40 BCL11A ZNF384 CEBPG BATF IRF4 NFATC3 TBX21 JUNB SPI1 MIR934 VGLL1 ARHGEF6 CD40LG GPR101 RNU6-320P RF00026-1204 LINC00892
GH0XJ136693 Enhancer 1 FANTOM5 ENCODE dbSUPER 1.5 +339.3 339288 1.9 CTCF REST RELA RAD21 TRIM22 SMC3 YY1 POU2F2 ZNF654 ATF7 RNU6-972P ARHGEF6 GPR101 RF00017-8754 CD40LG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR101 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR101

Top Transcription factor binding sites by QIAGEN in the GPR101 gene promoter:
  • AML1a
  • CP2
  • Egr-1
  • Ik-2
  • NF-kappaB1
  • Nkx6-1
  • Pbx1a
  • RFX1

Genomic Locations for GPR101 Gene

Genomic Locations for GPR101 Gene
chrX:137,027,447-137,033,847
(GRCh38/hg38)
Size:
6,401 bases
Orientation:
Minus strand
chrX:136,112,307-136,113,833
(GRCh37/hg19)
Size:
1,527 bases
Orientation:
Minus strand

Genomic View for GPR101 Gene

Genes around GPR101 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR101 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR101 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR101 Gene

Proteins for GPR101 Gene

  • Protein details for GPR101 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96P66-GP101_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 101
    Protein Accession:
    Q96P66
    Secondary Accessions:
    • Q5JSM8
    • Q8NG93

    Protein attributes for GPR101 Gene

    Size:
    508 amino acids
    Molecular mass:
    56716 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC06152.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

neXtProt entry for GPR101 Gene

Post-translational modifications for GPR101 Gene

  • Glycosylation at Asn7 and Asn13
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR101 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR101 Gene

Domains & Families for GPR101 Gene

Gene Families for GPR101 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • G-protein coupled receptors
  • Potential drug targets
  • Predicted membrane proteins

Protein Domains for GPR101 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR101 Gene

GenScript: Design optimal peptide antigens:
  • Probable G-protein coupled receptor 101 (GP101_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96P66

UniProtKB/Swiss-Prot:

GP101_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR101: view

Function for GPR101 Gene

Molecular function for GPR101 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Phenotypes From GWAS Catalog for GPR101 Gene

Gene Ontology (GO) - Molecular Function for GPR101 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004935 adrenergic receptor activity IBA 21873635
genes like me logo Genes that share ontologies with GPR101: view
genes like me logo Genes that share phenotypes with GPR101: view

Human Phenotype Ontology for GPR101 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for GPR101 Gene

MGI Knock Outs for GPR101:
  • Gpr101 Gpr101<tm1b(KOMP)Mbp>

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for GPR101 Gene

Localization for GPR101 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR101 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR101 gene
Compartment Confidence
plasma membrane 5
extracellular 1
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for GPR101 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with GPR101: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR101 Gene

Pathways & Interactions for GPR101 Gene

PathCards logo

SuperPathways for GPR101 Gene

No Data Available

Interacting Proteins for GPR101 Gene

;

Gene Ontology (GO) - Biological Process for GPR101 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA 21873635
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with GPR101: view

No data available for Pathways by source and SIGNOR curated interactions for GPR101 Gene

Drugs & Compounds for GPR101 Gene

No Compound Related Data Available

Transcripts for GPR101 Gene

mRNA/cDNA for GPR101 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR101 Gene

No ASD Table

Relevant External Links for GPR101 Gene

GeneLoc Exon Structure for
GPR101

Expression for GPR101 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR101 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR101 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x30.5), Brain - Hypothalamus (x7.0), Brain - Caudate (basal ganglia) (x6.9), and Brain - Putamen (basal ganglia) (x5.6).

Protein differential expression in normal tissues from HIPED for GPR101 Gene

This gene is overexpressed in Plasma (64.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR101 Gene



Protein tissue co-expression partners for GPR101 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR101

SOURCE GeneReport for Unigene cluster for GPR101 Gene:

Hs.350569

Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR101 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cheek
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • larynx
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • pituitary gland
  • skull
  • tongue
  • tooth
  • vocal cord
Thorax:
  • breast
  • chest wall
  • clavicle
  • heart
  • heart valve
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • kidney
  • pancreas
Pelvis:
  • ovary
  • pelvis
  • penis
  • testicle
  • uterus
  • vagina
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • nail
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood vessel
  • hair
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal column
  • spinal cord
  • sweat gland
  • vertebrae
genes like me logo Genes that share expression patterns with GPR101: view

No data available for mRNA Expression by UniProt/SwissProt and Evidence on tissue expression from TISSUES for GPR101 Gene

Orthologs for GPR101 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR101 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR101 31 30
  • 99.67 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GPR101 31 30
  • 87.84 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GPR101 31 30
  • 87.33 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr101 17 31 30
  • 79.53 (n)
rat
(Rattus norvegicus)
Mammalia Gpr101 30
  • 78.93 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GPR101 31
  • 50 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPR101 31
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr101 30
  • 58.23 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101886313 30
  • 55.03 (n)
GPR101 31
  • 35 (a)
OneToOne
Species where no ortholog for GPR101 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR101 Gene

ENSEMBL:
Gene Tree for GPR101 (if available)
TreeFam:
Gene Tree for GPR101 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPR101: view image

Paralogs for GPR101 Gene

genes like me logo Genes that share paralogs with GPR101: view

Variants for GPR101 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR101 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
709528 Benign: not provided 137,031,509(-) A/G SYNONYMOUS_VARIANT
710256 Likely Benign: not provided 137,031,408(-) C/T SYNONYMOUS_VARIANT
713852 Likely Benign: not provided 137,031,420(-) G/T SYNONYMOUS_VARIANT
714970 Benign: not provided 137,030,450(-) C/T MISSENSE_VARIANT
722009 Likely Benign: not provided 137,030,150(-) A/G STOP_LOST

Additional dbSNP identifiers (rs#s) for GPR101 Gene

Variation tolerance for GPR101 Gene

Residual Variation Intolerance Score: 93.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.38; 92.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR101 Gene

Human Gene Mutation Database (HGMD)
GPR101
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR101

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GPR101 Gene

Disorders for GPR101 Gene

MalaCards: The human disease database

(15) MalaCards diseases for GPR101 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
pituitary adenoma 2, growth hormone-secreting
  • pita2
chromosome xq26.3 duplication syndrome
  • lissencephaly, x-linked, 2
acromegaly
  • somatotroph adenoma
gigantism
pituitary adenoma
  • adenoma of the pituitary gland
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

GP101_HUMAN
  • Pituitary adenoma 2, growth hormone-secreting (PITA2) [MIM:300943]: A form of pituitary adenoma, a neoplasm of the pituitary gland and one of the most common neuroendocrine tumors. Pituitary adenomas are clinically classified as functional and non-functional tumors, and manifest with a variety of features, including local invasion of surrounding structures and excessive hormone secretion. Functional pituitary adenomas are further classified by the type of hormone they secrete. PITA2 is a growth hormone-secreting benign neoplasm, also known as somatotropinoma. It clinically results in acromegaly, a condition characterized by coarse facial features, protruding jaw, and enlarged extremities. Excessive production of growth hormone in children or adolescents before the closure of epiphyses causes gigantism, a condition characterized by abnormally tall stature. {ECO:0000269 PubMed:25470569}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for GPR101

genes like me logo Genes that share disorders with GPR101: view

No data available for Genatlas for GPR101 Gene

Publications for GPR101 Gene

  1. Discovery and mapping of ten novel G protein-coupled receptor genes. (PMID: 11574155) Lee DK … O'Dowd BF (Gene 2001) 2 3 4 54
  2. Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation. (PMID: 25470569) Trivellin G … Stratakis CA (The New England journal of medicine 2014) 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S … Mitaku S (FEBS letters 2002) 3 4 54
  5. Mutations in GPR101 as a potential cause of X-linked acrogigantism and acromegaly. (PMID: 30711029) Hou ZS … Tao YX (Progress in molecular biology and translational science 2019) 3 54

Products for GPR101 Gene

Sources for GPR101 Gene