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Aliases for GPR101 Gene

Aliases for GPR101 Gene

  • G Protein-Coupled Receptor 101 2 3 5
  • Probable G-Protein Coupled Receptor 101 3
  • GPCR6 3
  • PAGH2 3
  • PITA2 3

External Ids for GPR101 Gene

Previous GeneCards Identifiers for GPR101 Gene

  • GC0XM130684
  • GC0XM132957
  • GC0XM134057
  • GC0XM134817
  • GC0XM135837
  • GC0XM135939
  • GC0XM136112
  • GC0XM125379

Summaries for GPR101 Gene

Entrez Gene Summary for GPR101 Gene

  • The protein encoded by this gene is an orphan G protein-coupled receptor of unknown function. The encoded protein is a member of a family of proteins that contain seven transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. [provided by RefSeq, Sep 2011]

GeneCards Summary for GPR101 Gene

GPR101 (G Protein-Coupled Receptor 101) is a Protein Coding gene. Diseases associated with GPR101 include Pituitary Adenoma 2, Growth Hormone-Secreting and Chromosome Xq26.3 Duplication Syndrome. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is GPR161.

UniProtKB/Swiss-Prot for GPR101 Gene

  • Orphan receptor.

Gene Wiki entry for GPR101 Gene

Additional gene information for GPR101 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPR101 Gene

Genomics for GPR101 Gene

GeneHancer (GH) Regulatory Elements for GPR101 Gene

Promoters and enhancers for GPR101 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI137031 Enhancer 0.7 Ensembl 550.8 -0.4 -427 0.6 MXI1 ZNF48 ZIC2 ZNF2 ZNF335 CTBP1 ZBTB48 ZNF366 EZH2 ZBTB10 GPR101 GC0XP137136
GH0XI136693 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 1.5 +337.1 337115 1.9 CTCF ZNF654 TRIM22 REST EBF1 RAD21 RELA IKZF1 ZNF143 SMC3 RNU6-972P ARHGEF6 GPR101 GC0XP136652 PIR61624
GH0XI136584 Enhancer 1 FANTOM5 ENCODE dbSUPER 1.4 +444.6 444567 5 BCL11A CEBPB JUNB CEBPG BATF IRF4 MIR934 VGLL1 ARHGEF6 CD40LG GPR101 RNU6-320P LINC00892
GH0XI137052 Enhancer 1 Ensembl ENCODE 0.3 -20.9 -20927 1.2 CTCF RB1 ZNF2 RAD21 ZNF335 ZFHX2 GLIS2 ZNF316 EGR1 PATZ1 GPR101 GC0XP137136
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GPR101 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPR101 gene promoter:

Genomic Locations for GPR101 Gene

Genomic Locations for GPR101 Gene
1,527 bases
Minus strand

Genomic View for GPR101 Gene

Genes around GPR101 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR101 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR101 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR101 Gene

Proteins for GPR101 Gene

  • Protein details for GPR101 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 101
    Protein Accession:
    Secondary Accessions:
    • Q5JSM8
    • Q8NG93

    Protein attributes for GPR101 Gene

    508 amino acids
    Molecular mass:
    56716 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC06152.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for GPR101 Gene

Post-translational modifications for GPR101 Gene

  • Glycosylation at isoforms=7 and isoforms=13
  • Modification sites at PhosphoSitePlus

Other Protein References for GPR101 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPR101 Gene

Domains & Families for GPR101 Gene

Gene Families for GPR101 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • G-protein coupled receptors
  • Potential drug targets
  • Predicted membrane proteins

Protein Domains for GPR101 Gene

Suggested Antigen Peptide Sequences for GPR101 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR101: view

Function for GPR101 Gene

Molecular function for GPR101 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Phenotypes From GWAS Catalog for GPR101 Gene

Gene Ontology (GO) - Molecular Function for GPR101 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004935 adrenergic receptor activity IBA --
genes like me logo Genes that share ontologies with GPR101: view
genes like me logo Genes that share phenotypes with GPR101: view

Human Phenotype Ontology for GPR101 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for GPR101 Gene

MGI Knock Outs for GPR101:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for GPR101 Gene

Localization for GPR101 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR101 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR101 gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for GPR101 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR101: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPR101 Gene

Pathways & Interactions for GPR101 Gene

SuperPathways for GPR101 Gene

No Data Available

Interacting Proteins for GPR101 Gene

Gene Ontology (GO) - Biological Process for GPR101 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007267 cell-cell signaling IBA --
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway IBA --
genes like me logo Genes that share ontologies with GPR101: view

No data available for Pathways by source and SIGNOR curated interactions for GPR101 Gene

Drugs & Compounds for GPR101 Gene

No Compound Related Data Available

Transcripts for GPR101 Gene

mRNA/cDNA for GPR101 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GPR101 Gene

G protein-coupled receptor 101:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPR101 Gene

No ASD Table

Relevant External Links for GPR101 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPR101 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPR101 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR101 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x30.5), Brain - Hypothalamus (x7.0), Brain - Caudate (basal ganglia) (x6.9), and Brain - Putamen (basal ganglia) (x5.6).

Protein differential expression in normal tissues from HIPED for GPR101 Gene

This gene is overexpressed in Plasma (64.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPR101 Gene

Protein tissue co-expression partners for GPR101 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPR101 Gene:


SOURCE GeneReport for Unigene cluster for GPR101 Gene:


Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR101 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • endocrine
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Head and neck:
  • brain
  • cheek
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • larynx
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • pituitary gland
  • skull
  • tongue
  • tooth
  • vocal cord
  • breast
  • chest wall
  • clavicle
  • heart
  • heart valve
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
  • kidney
  • pancreas
  • ovary
  • pelvis
  • penis
  • testicle
  • uterus
  • vagina
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • nail
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
  • blood vessel
  • hair
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal column
  • spinal cord
  • sweat gland
  • vertebrae
genes like me logo Genes that share expression patterns with GPR101: view

No data available for mRNA Expression by UniProt/SwissProt and Evidence on tissue expression from TISSUES for GPR101 Gene

Orthologs for GPR101 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR101 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR101 33 34
  • 99.67 (n)
(Bos Taurus)
Mammalia GPR101 33 34
  • 87.84 (n)
(Canis familiaris)
Mammalia GPR101 33 34
  • 87.33 (n)
(Mus musculus)
Mammalia Gpr101 16 34 33
  • 79.53 (n)
(Rattus norvegicus)
Mammalia Gpr101 33
  • 78.93 (n)
(Ornithorhynchus anatinus)
Mammalia GPR101 34
  • 50 (a)
(Monodelphis domestica)
Mammalia GPR101 34
  • 47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr101 33
  • 58.23 (n)
(Danio rerio)
Actinopterygii LOC101886313 33
  • 55.03 (n)
GPR101 34
  • 35 (a)
Species where no ortholog for GPR101 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR101 Gene

Gene Tree for GPR101 (if available)
Gene Tree for GPR101 (if available)

Paralogs for GPR101 Gene

Paralogs for GPR101 Gene

genes like me logo Genes that share paralogs with GPR101: view

Variants for GPR101 Gene

Sequence variations from dbSNP and Humsavar for GPR101 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs73637412 pathogenic, likely-benign, Pituitary adenoma, growth hormone-secreting, 2, not provided, Pituitary adenoma 2, growth hormone-secreting (PITA2) [MIM:300943] 137,030,751(-) C/G/T coding_sequence_variant, missense_variant, synonymous_variant
rs139111924 likely-benign, not provided 137,030,963(-) C/T coding_sequence_variant, missense_variant
rs386352311 uncertain-significance, not provided 137,030,519(-) T/G coding_sequence_variant, missense_variant
rs1000716283 -- 137,030,074(-) G/A downstream_transcript_variant
rs1001543946 -- 137,033,286(-) C/T upstream_transcript_variant

Variation tolerance for GPR101 Gene

Residual Variation Intolerance Score: 93.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.38; 92.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR101 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GPR101 Gene

Disorders for GPR101 Gene

MalaCards: The human disease database

(7) MalaCards diseases for GPR101 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
pituitary adenoma 2, growth hormone-secreting
  • pita2
chromosome xq26.3 duplication syndrome
  • chromosome xq26 microduplication syndrome
  • somatotroph adenoma
pituitary adenoma
  • adenoma of the pituitary gland
- elite association - COSMIC cancer census association via MalaCards


  • Pituitary adenoma 2, growth hormone-secreting (PITA2) [MIM:300943]: A form of pituitary adenoma, a neoplasm of the pituitary gland and one of the most common neuroendocrine tumors. Pituitary adenomas are clinically classified as functional and non-functional tumors, and manifest with a variety of features, including local invasion of surrounding structures and excessive hormone secretion. Functional pituitary adenomas are further classified by the type of hormone they secrete. PITA2 is a growth hormone-secreting benign neoplasm, also known as somatotropinoma. It clinically results in acromegaly, a condition characterized by coarse facial features, protruding jaw, and enlarged extremities. Excessive production of growth hormone in children or adolescents before the closure of epiphyses causes gigantism, a condition characterized by abnormally tall stature. {ECO:0000269 PubMed:25470569}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for GPR101

genes like me logo Genes that share disorders with GPR101: view

No data available for Genatlas for GPR101 Gene

Publications for GPR101 Gene

  1. Discovery and mapping of ten novel G protein-coupled receptor genes. (PMID: 11574155) Lee DK … O'Dowd BF (Gene 2001) 2 3 4 58
  2. Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation. (PMID: 25470569) Trivellin G … Stratakis CA (The New England journal of medicine 2014) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S … Mitaku S (FEBS letters 2002) 3 4 58
  5. Very low frequency of germline GPR101 genetic variation and no biallelic defects with AIP in a large cohort of patients with sporadic pituitary adenomas. (PMID: 26792934) Lecoq AL … Kamenický P (European journal of endocrinology 2016) 3 58

Products for GPR101 Gene

Sources for GPR101 Gene

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