Aliases for GPR1 Gene

Aliases for GPR1 Gene

  • G Protein-Coupled Receptor 1 2 3 5
  • G-Protein Coupled Receptor 1 3 4
  • Probable G-Protein Coupled Receptor 1 3

External Ids for GPR1 Gene

Previous GeneCards Identifiers for GPR1 Gene

  • GC02M205257
  • GC02M205764
  • GC02M207003
  • GC02M207242
  • GC02M206865
  • GC02M206748
  • GC02M198888

Summaries for GPR1 Gene

GeneCards Summary for GPR1 Gene

GPR1 (G Protein-Coupled Receptor 1) is a Protein Coding gene. Diseases associated with GPR1 include Diabetes Mellitus, Insulin-Dependent, 22. Among its related pathways are Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and neuropeptide binding. An important paralog of this gene is PTGDR2.

UniProtKB/Swiss-Prot Summary for GPR1 Gene

  • Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation (PubMed:18165312). Receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity).
  • (Microbial infection) Coreceptor for HIV-1.

Gene Wiki entry for GPR1 Gene

Additional gene information for GPR1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPR1 Gene

Genomics for GPR1 Gene

GeneHancer (GH) Regulatory Elements for GPR1 Gene

Promoters and enhancers for GPR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J206211 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE CraniofacialAtlas 512.9 +5.3 5333 2.7 ZNF10 ZIC2 TRIM28 CTBP1 ZNF341 OSR2 WT1 ZBTB17 TCF7L2 FOS GPR1 piR-45035-117 GPR1-AS
GH02J206218 Promoter 0.6 Ensembl 530.7 -0.8 -754 0.4 SPI1 PRDM6 MYC MAX GPR1 RN7SKP200 RF00100-070 lnc-ZDBF2-3 GPR1-AS
GH02J206217 Promoter/Enhancer 0.6 Ensembl CraniofacialAtlas 504.8 +0.6 570 0.8 GLIS1 GPR1 piR-45035-117 GPR1-AS
GH02J206219 Promoter 0.5 Ensembl 507.5 -1.3 -1254 0.2 GATA3 GATA2 GPR1 RN7SKP200 RF00100-070 lnc-ZDBF2-3 GPR1-AS
GH02J206246 Enhancer 0.6 Ensembl 28.3 -27.9 -27854 2.6 ZNF384 NBN SPI1 ELF1 IRF4 NFATC3 ZNF664 TBX21 ATF7 BHLHE40 GPR1 ZDBF2 RN7SKP200 SNORA41 EEF1B2 SNORD51 NDUFS1 ADAM23 MDH1B RF00017-3415
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPR1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPR1

Top Transcription factor binding sites by QIAGEN in the GPR1 gene promoter:
  • AML1a
  • Bach2
  • c-Myc
  • Evi-1
  • Max
  • Nkx6-1
  • POU3F2
  • SEF-1 (1)
  • TBP
  • TFIID

Genomic Locations for GPR1 Gene

Genomic Locations for GPR1 Gene
chr2:206,175,316-206,218,047
(GRCh38/hg38)
Size:
42,732 bases
Orientation:
Minus strand
chr2:207,040,040-207,082,771
(GRCh37/hg19)
Size:
42,732 bases
Orientation:
Minus strand

Genomic View for GPR1 Gene

Genes around GPR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPR1 Gene

Proteins for GPR1 Gene

  • Protein details for GPR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46091-GPR1_HUMAN
    Recommended name:
    G-protein coupled receptor 1
    Protein Accession:
    P46091
    Secondary Accessions:
    • A5JUU6
    • A8K4L1
    • Q53TR9
    • Q6NVX4

    Protein attributes for GPR1 Gene

    Size:
    355 amino acids
    Molecular mass:
    41431 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPR1 Gene

Post-translational modifications for GPR1 Gene

  • Glycosylation at Asn14
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPR1 Gene

Domains & Families for GPR1 Gene

Gene Families for GPR1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for GPR1 Gene

Blocks:
  • GPR1 orphan receptor signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPR1 Gene

GenScript: Design optimal peptide antigens:
  • G-protein coupled receptor 1 (GPR1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P46091

UniProtKB/Swiss-Prot:

GPR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPR1: view

Function for GPR1 Gene

Molecular function for GPR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation (PubMed:18165312). Receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Coreceptor for HIV-1.
GENATLAS Biochemistry:
G protein coupled receptor 1,expressed in hippocampus,functioning in a RAS-independent pathway with a large third cytoplasmic loop and a large cytoplasmic tail

Phenotypes From GWAS Catalog for GPR1 Gene

Gene Ontology (GO) - Molecular Function for GPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IBA 21873635
GO:0005515 protein binding IPI 24955142
GO:0042277 peptide binding IBA 21873635
GO:0042923 neuropeptide binding IBA 21873635
genes like me logo Genes that share ontologies with GPR1: view
genes like me logo Genes that share phenotypes with GPR1: view

Animal Models for GPR1 Gene

MGI Knock Outs for GPR1:
  • Gpr1 Gpr1<tm1.1Dgen>

Animal Model Products

  • Taconic Biosciences Mouse Models for GPR1

miRNA for GPR1 Gene

miRTarBase miRNAs that target GPR1

Clone Products

  • Addgene plasmids for GPR1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPR1 Gene

Localization for GPR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPR1 Gene

Cell membrane; Multi-pass membrane protein. Note=Internalizes in presence of its ligand, TAFA1. {ECO:0000250 UniProtKB:Q8K087}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPR1 gene
Compartment Confidence
plasma membrane 5
nucleus 4
extracellular 2
cytoskeleton 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005886 plasma membrane IEA,IDA --
GO:0005887 integral component of plasma membrane IBA,TAS 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPR1: view

Pathways & Interactions for GPR1 Gene

PathCards logo

SuperPathways for GPR1 Gene

SuperPathway Contained pathways
1 Peptide ligand-binding receptors
genes like me logo Genes that share pathways with GPR1: view

Pathways by source for GPR1 Gene

1 BioSystems pathway for GPR1 Gene

Gene Ontology (GO) - Biological Process for GPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS 7851889
GO:0007218 neuropeptide signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with GPR1: view

No data available for SIGNOR curated interactions for GPR1 Gene

Drugs & Compounds for GPR1 Gene

(2) Drugs for GPR1 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
chemerin Pharma Full agonist, Agonist 0
chemerin C-terminal peptide Pharma Agonist, Full agonist 0
genes like me logo Genes that share compounds with GPR1: view

Transcripts for GPR1 Gene

mRNA/cDNA for GPR1 Gene

6 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

  • Addgene plasmids for GPR1

Alternative Splicing Database (ASD) splice patterns (SP) for GPR1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: - -
SP2: - -
SP3: - - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for GPR1 Gene

GeneLoc Exon Structure for
GPR1

Expression for GPR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPR1 Gene

This gene is overexpressed in Vagina (x4.5) and Skin - Sun Exposed (Lower leg) (x4.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPR1 Gene



Protein tissue co-expression partners for GPR1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPR1

SOURCE GeneReport for Unigene cluster for GPR1 Gene:

Hs.184907

mRNA Expression by UniProt/SwissProt for GPR1 Gene:

P46091-GPR1_HUMAN
Tissue specificity: Expressed in hippocampus.

Evidence on tissue expression from TISSUES for GPR1 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with GPR1: view

No data available for Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPR1 Gene

Orthologs for GPR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR1 31 30
  • 99.62 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GPR1 31 30
  • 89.86 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GPR1 31 30
  • 87.61 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr1 17 31 30
  • 83.14 (n)
rat
(Rattus norvegicus)
Mammalia Gpr1 30
  • 81.76 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GPR1 31
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPR1 31
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR1 31 30
  • 68.83 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR1 31
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr1 30
  • 59.88 (n)
zebrafish
(Danio rerio)
Actinopterygii gpr1 31 30
  • 52.48 (n)
OneToOne
Species where no ortholog for GPR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPR1 Gene

ENSEMBL:
Gene Tree for GPR1 (if available)
TreeFam:
Gene Tree for GPR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPR1: view image

Paralogs for GPR1 Gene

(37) SIMAP similar genes for GPR1 Gene using alignment to 7 proteins:

  • GPR1_HUMAN
  • C9J456_HUMAN
  • C9JCK1_HUMAN
  • C9JFR8_HUMAN
  • C9JKF3_HUMAN
  • C9JQB7_HUMAN
  • C9JSU0_HUMAN
genes like me logo Genes that share paralogs with GPR1: view

Variants for GPR1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPR1 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
709569 Likely Benign: not provided 206,176,385(-) A/AG FRAMESHIFT_VARIANT
rs3732083 - p.Ile307Val

Additional dbSNP identifiers (rs#s) for GPR1 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPR1 Gene

Variant ID Type Subtype PubMed ID
nsv480838 CNV novel sequence insertion 20440878

Variation tolerance for GPR1 Gene

Residual Variation Intolerance Score: 69.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.41; 90.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPR1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPR1 Gene

Disorders for GPR1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPR1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
diabetes mellitus, insulin-dependent, 22
  • iddm22
- elite association - COSMIC cancer census association via MalaCards
Search GPR1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GPR1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GPR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPR1 Gene

Publications for GPR1 Gene

  1. Cloning of human genes encoding novel G protein-coupled receptors. (PMID: 7851889) Marchese A … O'Dowd BF (Genomics 1994) 2 3 4 23 54
  2. An orphan G protein-coupled receptor, GPR1, acts as a coreceptor to allow replication of human immunodeficiency virus types 1 and 2 in brain-derived cells. (PMID: 10233994) Shimizu N … Hoshino H (Journal of virology 1999) 3 4 23 54
  3. Short communication: identification of the conformational requirement for the specificities of coreceptors for human and simian immunodeficiency viruses. (PMID: 20334567) Shimizu N … Hoshino H (AIDS research and human retroviruses 2010) 3 23 54
  4. Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size. (PMID: 19343178) Soranzo N … Deloukas P (PLoS genetics 2009) 3 41 54
  5. G protein-coupled receptor for asthma susceptibility associates with respiratory distress syndrome. (PMID: 16938805) Pulkkinen V … Laitinen T (Annals of medicine 2006) 3 41 54

Products for GPR1 Gene

  • Addgene plasmids for GPR1

Sources for GPR1 Gene