Aliases for GPN2 Gene

Aliases for GPN2 Gene

  • GPN-Loop GTPase 2 2 3 4 5
  • ATP-Binding Domain 1 Family Member B 3 4
  • ATPBD1B 3 4
  • ATP Binding Domain 1 Family, Member B 2
  • FLJ10349 2
  • GPN2 5

External Ids for GPN2 Gene

Previous HGNC Symbols for GPN2 Gene


Previous GeneCards Identifiers for GPN2 Gene

  • GC01M027079
  • GC01M027205
  • GC01M025460

Summaries for GPN2 Gene

GeneCards Summary for GPN2 Gene

GPN2 (GPN-Loop GTPase 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleotide binding and hydrolase activity. An important paralog of this gene is GPN3.

UniProtKB/Swiss-Prot Summary for GPN2 Gene

  • Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

Additional gene information for GPN2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPN2 Gene

Genomics for GPN2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GPN2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPN2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPN2

Top Transcription factor binding sites by QIAGEN in the GPN2 gene promoter:
  • Arnt
  • c-Rel
  • NF-1
  • NF-kappaB
  • NF-kappaB1
  • RelA
  • USF-1
  • USF-1:USF-2
  • USF1
  • USF2

Genomic Locations for GPN2 Gene

Genomic Locations for GPN2 Gene
14,152 bases
Minus strand
14,246 bases
Minus strand

Genomic View for GPN2 Gene

Genes around GPN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPN2 Gene

Proteins for GPN2 Gene

  • Protein details for GPN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GPN-loop GTPase 2
    Protein Accession:
    Secondary Accessions:
    • Q96HG4
    • Q9NUE1
    • Q9NW30

    Protein attributes for GPN2 Gene

    310 amino acids
    Molecular mass:
    34561 Da
    Quaternary structure:
    • Heterodimers with GPN1 or GPN3 (By similarity). Binds to RNA polymerase II (RNAPII) (PubMed:20864038).

neXtProt entry for GPN2 Gene

Post-translational modifications for GPN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GPN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPN2 Gene

Domains & Families for GPN2 Gene

Gene Families for GPN2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GPN2 Gene


Suggested Antigen Peptide Sequences for GPN2 Gene

GenScript: Design optimal peptide antigens:
  • ATP-binding domain 1 family member B (GPN2_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GPN-loop GTPase family.
  • Belongs to the GPN-loop GTPase family.
genes like me logo Genes that share domains with GPN2: view

Function for GPN2 Gene

Molecular function for GPN2 Gene

UniProtKB/Swiss-Prot Function:
Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

Phenotypes From GWAS Catalog for GPN2 Gene

Gene Ontology (GO) - Molecular Function for GPN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003674 molecular_function ND --
GO:0003924 GTPase activity IBA 21873635
GO:0005515 protein binding IPI 28514442
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with GPN2: view
genes like me logo Genes that share phenotypes with GPN2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPN2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPN2 Gene

Localization for GPN2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPN2 gene
Compartment Confidence
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1
lysosome 0

Gene Ontology (GO) - Cellular Components for GPN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with GPN2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for GPN2 Gene

Pathways & Interactions for GPN2 Gene

PathCards logo

SuperPathways for GPN2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GPN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with GPN2: view

No data available for Pathways by source and SIGNOR curated interactions for GPN2 Gene

Drugs & Compounds for GPN2 Gene

No Compound Related Data Available

Transcripts for GPN2 Gene

mRNA/cDNA for GPN2 Gene

8 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPN2

Alternative Splicing Database (ASD) splice patterns (SP) for GPN2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - - -
SP2: -
SP3: -

Relevant External Links for GPN2 Gene

GeneLoc Exon Structure for

Expression for GPN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Liver (Hepatobiliary System)

Protein differential expression in normal tissues from HIPED for GPN2 Gene

This gene is overexpressed in Bone (64.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GPN2 Gene

Protein tissue co-expression partners for GPN2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPN2

SOURCE GeneReport for Unigene cluster for GPN2 Gene:


Evidence on tissue expression from TISSUES for GPN2 Gene

  • Eye(4.1)
  • Skin(2.8)
  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with GPN2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPN2 Gene

Orthologs for GPN2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GPN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPN2 30 31
  • 99.57 (n)
(Canis familiaris)
Mammalia GPN2 30 31
  • 91.61 (n)
(Bos Taurus)
Mammalia GPN2 30 31
  • 91.51 (n)
(Mus musculus)
Mammalia Gpn2 30 17 31
  • 90.97 (n)
(Rattus norvegicus)
Mammalia Gpn2 30
  • 89.46 (n)
(Monodelphis domestica)
Mammalia GPN2 31
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia GPN2 31
  • 79 (a)
(Gallus gallus)
Aves GPN2 30 31
  • 76.22 (n)
(Anolis carolinensis)
Reptilia GPN2 31
  • 66 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia gpn2 30
  • 66.43 (n)
Str.498 30
African clawed frog
(Xenopus laevis)
Amphibia LOC398460 30
(Danio rerio)
Actinopterygii gpn2 30 31
  • 70 (n)
Dr.19021 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5769 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003193 30
  • 60.32 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG10222 30 31
  • 58 (n)
(Caenorhabditis elegans)
Secernentea B0207.6 31
  • 42 (a)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AAL117C 30
  • 56.24 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GPN2 30 33
  • 52.71 (n)
-- 31
  • 38 (a)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C09504g 30
  • 51.42 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons QQT1 30
  • 55.32 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1085 30
(Oryza sativa)
Liliopsida Os02g0555000 30
  • 59.72 (n)
Os.5253 30
(Zea mays)
Liliopsida Zm.4543 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10206 31
  • 57 (a)
Bread mold
(Neurospora crassa)
Ascomycetes NCU09745 30
  • 54.14 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC144.07c 30
  • 48.32 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.7378 30
Species where no ortholog for GPN2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for GPN2 Gene

Gene Tree for GPN2 (if available)
Gene Tree for GPN2 (if available)
Evolutionary constrained regions (ECRs) for GPN2: view image

Paralogs for GPN2 Gene

Paralogs for GPN2 Gene

(1) SIMAP similar genes for GPN2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GPN2: view

Variants for GPN2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPN2 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs17856257 - p.Gln227Arg
rs3170660 - p.Arg264Gly

Additional dbSNP identifiers (rs#s) for GPN2 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPN2 Gene

Variant ID Type Subtype PubMed ID
nsv1000012 CNV gain 25217958
nsv834524 CNV gain+loss 17160897

Variation tolerance for GPN2 Gene

Residual Variation Intolerance Score: 40.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.45; 43.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPN2 Gene

Disorders for GPN2 Gene

No disorders were found for GPN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPN2 Gene

Publications for GPN2 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for GPN2 Gene

  • Signalway Proteins for GPN2

Sources for GPN2 Gene