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Aliases for GPN2 Gene

Aliases for GPN2 Gene

  • GPN-Loop GTPase 2 2 3 5
  • ATP-Binding Domain 1 Family Member B 3 4
  • ATPBD1B 3 4
  • ATP Binding Domain 1 Family, Member B 2

External Ids for GPN2 Gene

Previous HGNC Symbols for GPN2 Gene


Previous GeneCards Identifiers for GPN2 Gene

  • GC01M027079
  • GC01M027205
  • GC01M025460

Summaries for GPN2 Gene

GeneCards Summary for GPN2 Gene

GPN2 (GPN-Loop GTPase 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleotide binding and hydrolase activity.

UniProtKB/Swiss-Prot for GPN2 Gene

  • Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

Additional gene information for GPN2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPN2 Gene

Genomics for GPN2 Gene

GeneHancer (GH) Regulatory Elements for GPN2 Gene

Promoters and enhancers for GPN2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I026888 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.6 603 3.2 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 SLC30A9 POLR2B GPN2 PIGV SFN HMGN2 GPATCH3 ENSG00000226698
GH01I027487 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 73.7 -600.3 -600318 5.8 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 MCM3 WASF2 ARID1A ACTG1P20 GPN2 FAM76A PHACTR4 NPM1P39 MAP3K6 ENSG00000231344 LOC101928728
GH01I026618 Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 64.9 +270.0 269982 4 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 ARID1A HMGN2 ACTG1P20 GPN2 ZNF593 GPATCH3 AHDC1 RPL17P9 LOC101928324 NPM1P39
GH01I027151 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 45.3 -263.7 -263668 4.8 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 SP3 NFYC SLC9A1 ARID1A ACTG1P20 FAM76A HMGN2 GPN2 ENSG00000231344 EYA3 LOC101928324 LOC101928728
GH01I026691 Promoter/Enhancer 3.3 UCNEbase EPDnew FANTOM5 Ensembl ENCODE dbSUPER 28.1 +193.3 193320 12.9 MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 ARID1A LOC101928728 HMGN2 ACTG1P20 PIGV LOC101928324 GPN2 GPATCH3 TMEM222 RPL17P9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GPN2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPN2 gene promoter:

Genomic Locations for GPN2 Gene

Genomic Locations for GPN2 Gene
14,246 bases
Minus strand

Genomic View for GPN2 Gene

Genes around GPN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPN2 Gene

Proteins for GPN2 Gene

  • Protein details for GPN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GPN-loop GTPase 2
    Protein Accession:
    Secondary Accessions:
    • Q96HG4
    • Q9NUE1
    • Q9NW30

    Protein attributes for GPN2 Gene

    310 amino acids
    Molecular mass:
    34561 Da
    Quaternary structure:
    • Heterodimers with GPN1 or GPN3 (By similarity). Binds to RNA polymerase II (RNAPII) (PubMed:20864038).

neXtProt entry for GPN2 Gene

Post-translational modifications for GPN2 Gene

No Post-translational modifications

Other Protein References for GPN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPN2 Gene

Domains & Families for GPN2 Gene

Gene Families for GPN2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GPN2 Gene


Suggested Antigen Peptide Sequences for GPN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GPN-loop GTPase family.
  • Belongs to the GPN-loop GTPase family.
genes like me logo Genes that share domains with GPN2: view

Function for GPN2 Gene

Molecular function for GPN2 Gene

UniProtKB/Swiss-Prot Function:
Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

Phenotypes From GWAS Catalog for GPN2 Gene

Gene Ontology (GO) - Molecular Function for GPN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003924 GTPase activity IBA --
GO:0005525 GTP binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with GPN2: view

Phenotypes for GPN2 Gene

GenomeRNAi human phenotypes for GPN2:
genes like me logo Genes that share phenotypes with GPN2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPN2 Gene

Localization for GPN2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPN2 gene
Compartment Confidence
mitochondrion 2
plasma membrane 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for GPN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with GPN2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for GPN2 Gene

Pathways & Interactions for GPN2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GPN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0044376 RNA polymerase II complex import to nucleus IBA --
GO:1990022 RNA polymerase III complex localization to nucleus IBA --
genes like me logo Genes that share ontologies with GPN2: view

No data available for Pathways by source and SIGNOR curated interactions for GPN2 Gene

Drugs & Compounds for GPN2 Gene

No Compound Related Data Available

Transcripts for GPN2 Gene

Unigene Clusters for GPN2 Gene

GPN-loop GTPase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPN2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - - -
SP2: -
SP3: -

Relevant External Links for GPN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPN2 Gene

Protein differential expression in normal tissues from HIPED for GPN2 Gene

This gene is overexpressed in Bone (64.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GPN2 Gene

Protein tissue co-expression partners for GPN2 Gene

NURSA nuclear receptor signaling pathways regulating expression of GPN2 Gene:


SOURCE GeneReport for Unigene cluster for GPN2 Gene:


Evidence on tissue expression from TISSUES for GPN2 Gene

  • Eye(4.1)
  • Skin(2.3)
  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with GPN2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPN2 Gene

Orthologs for GPN2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GPN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPN2 33 34
  • 99.57 (n)
(Canis familiaris)
Mammalia GPN2 33 34
  • 91.61 (n)
(Bos Taurus)
Mammalia GPN2 33 34
  • 91.51 (n)
(Mus musculus)
Mammalia Gpn2 33 16 34
  • 90.97 (n)
(Rattus norvegicus)
Mammalia Gpn2 33
  • 89.46 (n)
(Monodelphis domestica)
Mammalia GPN2 34
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia GPN2 34
  • 79 (a)
(Gallus gallus)
Aves GPN2 33 34
  • 76.22 (n)
(Anolis carolinensis)
Reptilia GPN2 34
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpn2 33
  • 66.43 (n)
Str.498 33
African clawed frog
(Xenopus laevis)
Amphibia LOC398460 33
(Danio rerio)
Actinopterygii gpn2 33 34
  • 70 (n)
Dr.19021 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5769 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003193 33
  • 60.32 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10222 33 34
  • 58 (n)
(Caenorhabditis elegans)
Secernentea B0207.6 34
  • 42 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL117C 33
  • 56.24 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GPN2 33 36
  • 52.71 (n)
-- 34
  • 38 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C09504g 33
  • 51.42 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons QQT1 33
  • 55.32 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1085 33
(Oryza sativa)
Liliopsida Os02g0555000 33
  • 59.72 (n)
Os.5253 33
(Zea mays)
Liliopsida Zm.4543 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10206 34
  • 57 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09745 33
  • 54.14 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC144.07c 33
  • 48.32 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7378 33
Species where no ortholog for GPN2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPN2 Gene

Gene Tree for GPN2 (if available)
Gene Tree for GPN2 (if available)

Paralogs for GPN2 Gene

(1) SIMAP similar genes for GPN2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GPN2: view

No data available for Paralogs for GPN2 Gene

Variants for GPN2 Gene

Sequence variations from dbSNP and Humsavar for GPN2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs376709877 uncertain-significance, not provided 26,891,164(-) C/T upstream_transcript_variant
rs1000146387 -- 26,879,229(-) G/T downstream_transcript_variant
rs1000200887 -- 26,880,577(-) C/T intron_variant
rs1000218857 -- 26,881,014(-) G/T intron_variant
rs1000431171 -- 26,891,842(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GPN2 Gene

Variant ID Type Subtype PubMed ID
nsv1000012 CNV gain 25217958
nsv834524 CNV gain+loss 17160897

Variation tolerance for GPN2 Gene

Residual Variation Intolerance Score: 40.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.45; 43.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPN2 Gene

Disorders for GPN2 Gene

Additional Disease Information for GPN2

No disorders were found for GPN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPN2 Gene

Publications for GPN2 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for GPN2 Gene

Sources for GPN2 Gene

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