Aliases for GPN1 Gene
External Ids for GPN1 Gene
Previous HGNC Symbols for GPN1 Gene
Previous GeneCards Identifiers for GPN1 Gene
This gene encodes a guanosine triphosphatase enzyme. The encoded protein may play a role in DNA repair and may function in activation of transcription. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]
GeneCards Summary for GPN1 Gene
GPN1 (GPN-Loop GTPase 1) is a Protein Coding gene. Diseases associated with GPN1 include Xeroderma Pigmentosum, Complementation Group A. Gene Ontology (GO) annotations related to this gene include nucleotide binding and GTPase activity. An important paralog of this gene is GPN2.
UniProtKB/Swiss-Prot Summary for GPN1 Gene
Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII) (PubMed:20855544, PubMed:21768307). May act at an RNAP assembly step prior to nuclear import (PubMed:21768307). Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation (PubMed:17643375). May be involved in nuclear localization of XPA (PubMed:11058119).