Aliases for GPLD1 Gene
External Ids for GPLD1 Gene
Previous GeneCards Identifiers for GPLD1 Gene
Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells. The protein encoded by this gene is a GPI degrading enzyme. Glycosylphosphatidylinositol specific phospholipase D1 hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans, thereby releasing the attached protein from the plasma membrane. [provided by RefSeq, Jul 2008]
GeneCards Summary for GPLD1 Gene
GPLD1 (Glycosylphosphatidylinositol Specific Phospholipase D1) is a Protein Coding gene. Diseases associated with GPLD1 include Glandular Tularemia and Oculoglandular Tularemia. Among its related pathways are Sweet Taste Signaling and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include sodium channel regulator activity and glycosylphosphatidylinositol phospholipase D activity.
UniProtKB/Swiss-Prot Summary for GPLD1 Gene
This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane.