Aliases for GPHA2 Gene
External Ids for GPHA2 Gene
Previous GeneCards Identifiers for GPHA2 Gene
GPHA2 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002 [PubMed 12089349]).[supplied by OMIM, Mar 2008]
GeneCards Summary for GPHA2 Gene
GPHA2 (Glycoprotein Hormone Subunit Alpha 2) is a Protein Coding gene. Diseases associated with GPHA2 include Norrie Disease and Malignant Skin Fibrous Histiocytoma. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include hormone activity.
UniProtKB/Swiss-Prot Summary for GPHA2 Gene
Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production (PubMed:12045258). Plays a central role in controlling thyroid cell metabolism (PubMed:12045258).