Aliases for GPER1 Gene
Aliases for GPER1 Gene
- G Protein-Coupled Estrogen Receptor 1 2 3 4 5
- Flow-Induced Endothelial G-Protein Coupled Receptor 1 3 4
- Lymphocyte-Derived G-Protein Coupled Receptor 3 4
- Chemoattractant Receptor-Like 2 3 4
- G Protein-Coupled Receptor 30 2 3
- Membrane Estrogen Receptor 3 4
- IL8-Related Receptor DRY12 3 4
- GPCR-Br 3 4
- CMKRL2 3 4
- GPR30 3 4
- DRY12 3 4
- FEG-1 3 4
- GPER 3 4
External Ids for GPER1 Gene
- HGNC: 4485
- Entrez Gene: 2852
- Ensembl: ENSG00000164850
- OMIM: 601805
- UniProtKB: Q99527
Previous HGNC Symbols for GPER1 Gene
- CMKRL2
- GPR30
- GPER
Summaries for GPER1 Gene
-
This gene encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum and a member of the G-protein coupled receptor 1 family. This receptor binds estrogen and activates multiple downstream signaling pathways, leading to stimulation of adenylate cyclase and an increase in cyclic AMP levels, while also promoting intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. This receptor has been shown to play a role in diverse biological processes, including bone and nervous system development, metabolism, cognition, male fertility and uterine function. [provided by RefSeq, Aug 2017]
GeneCards Summary for GPER1 Gene
GPER1 (G Protein-Coupled Estrogen Receptor 1) is a Protein Coding gene. Diseases associated with GPER1 include Breast Cancer. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and steroid binding. An important paralog of this gene is GPR146.
UniProtKB/Swiss-Prot for GPER1 Gene
-
G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation. Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation. Stimulates uterine epithelial cell proliferation. Enhances uterine contractility in response to oxytocin. Contributes to thymic atrophy by inducing apoptosis. Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules. Promotes neuritogenesis in developing hippocampal neurons. Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death. Increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons. Inhibits early osteoblast proliferation at growth plate during skeletal development. Inhibits mature adipocyte differentiation and lipid accumulation. Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells. Functions also as a receptor for aldosterone mediating rapid regulation of vascular contractibility through the PI3K/ERK signaling pathway. Involved in cancer progression regulation. Stimulates cancer-associated fibroblast (CAF) proliferation by a rapid genomic response through the EGFR/ERK transduction pathway. Associated with EGFR, may act as a transcription factor activating growth regulatory genes (c-fos, cyclin D1). Promotes integrin alpha-5/beta-1 and fibronectin (FN) matrix assembly in breast cancer cells.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPER1 Gene
Genomics for GPER1 Gene
GeneHancer (GH) Regulatory Elements for GPER1 Gene
Promoters and enhancers for GPER1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around GPER1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for GPER1 Gene
Genomic Locations for GPER1 Gene
- chr7:1,082,208-1,093,815
- (GRCh38/hg38)
- Size:
- 11,608 bases
- Orientation:
- Plus strand
- chr7:1,121,844-1,133,451
- (GRCh37/hg19)
- Size:
- 11,608 bases
- Orientation:
- Plus strand
Genomic View for GPER1 Gene
Genes around GPER1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7p22.3 by Entrez Gene
- 7p22.3 by HGNC
- 7p22.3 by Ensembl
GPER1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GPER1 Gene
Proteins for GPER1 Gene
-
Protein details for GPER1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99527-GPER1_HUMAN
- Recommended name:
- G-protein coupled estrogen receptor 1
- Protein Accession:
- Q99527
- A8K6C5
- B5BUJ1
- O00143
- O43494
- Q13631
- Q6FHL1
- Q96F42
- Q99981
Protein attributes for GPER1 Gene
- Size:
- 375 amino acids
- Molecular mass:
- 42248 Da
- Quaternary structure:
-
- Homodimer (Probable). Heterodimer; heterodimerizes with other G-protein-coupled receptor (GPCRs) like CRHR1, HTR1A and PAQR8. Interacts (via C-terminus tail motif) with DLG4 (via N-terminus tandem pair of PDZ domains); the interaction is direct and induces the increase of GPER1 protein levels residing at the plasma membrane surface in a estradiol-independent manner (By similarity). Interacts with RAMP3. Interacts with KRT7 and KRT8. Interacts with EGFR; the interaction increases after agonist-induced stimulation in cancer-associated fibroblasts (CAF). Interacts with EGFR and ESR1.
- Miscellaneous:
-
- Does not bind estradiol according to PubMed:18566127 and PubMed:16645038.
Post-translational modifications for GPER1 Gene
- Ubiquitinated; ubiquitination occurs at the plasma membrane and leads to proteasome-mediated degradation.
- Glycosylated.
- Glycosylation at Asn44, Asn32, and isoforms=25
- Modification sites at PhosphoSitePlus
Other Protein References for GPER1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for GPER1 (GPER/GPR30)
-
Custom Antibody ServicesOriGene Antibodies for GPER1
- Novus Biologicals Antibodies for GPER1
-
Abcam antibodies for GPER1
- Invitrogen Antibodies for GPER1 (AFLGC-GPER1)
- antibodies-online: Search results for 211 available GPER Antibodies ranked by validation data
- Compare Top GPER Antibodies
-
Recommended
- 101 WB Antibodies (anti-human)
- 24 IHC (p) Antibodies (anti-human)
- 20 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IHC (fro) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 2 EIA Antibodies (anti-human)
- 20 WB Antibodies (anti-mouse)
- 6 FACS Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 4 WB Antibodies (anti-rat)
- 101 WB Antibodies (anti-human)
- 24 IHC (p) Antibodies (anti-human)
- 20 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IHC (fro) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 2 EIA Antibodies (anti-human)
- 20 WB Antibodies (anti-mouse)
- 6 FACS Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 4 WB Antibodies (anti-rat)
- 101 WB Antibodies (anti-human)
- 24 IHC (p) Antibodies (anti-human)
- 20 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IHC (fro) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 2 EIA Antibodies (anti-human)
- 20 WB Antibodies (anti-mouse)
- 6 FACS Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 4 WB Antibodies (anti-rat)
- GeneTex GPER1 Antibody for GPER1
-
Boster Bio Antibodies for GPER1
Protein Products
-
OriGene Purified Proteins for GPER1
- Search Origene for MassSpec and Protein Over-expression Lysates for GPER1
- Origene Custom Protein Services for GPER1
- antibodies-online: Search results for available GPER related products ranked by validation data
- Search GeneTex for Proteins for GPER1
-
Abcam proteins for GPER1
Assay Products
- antibodies-online: Search results for 21 available GPER Elisa Kits ranked by validation data
- Compare Top GPER Elisa Kits
-
Recommended
- 1 Chicken ELISA Kit
- 9 Human ELISA Kits
- 1 Monkey ELISA Kit
- 7 Mouse (Murine) ELISA Kits
- 1 Pig (Porcine) ELISA Kit
- 1 Rabbit ELISA Kit
- 1 Rat (Rattus) ELISA Kit
- 1 Chicken ELISA Kit
- 9 Human ELISA Kits
- 1 Monkey ELISA Kit
- 7 Mouse (Murine) ELISA Kits
- 1 Pig (Porcine) ELISA Kit
- 1 Rabbit ELISA Kit
- 1 Rat (Rattus) ELISA Kit
- 1 Chicken ELISA Kit
- 9 Human ELISA Kits
- 1 Monkey ELISA Kit
- 7 Mouse (Murine) ELISA Kits
- 1 Pig (Porcine) ELISA Kit
- 1 Rabbit ELISA Kit
- 1 Rat (Rattus) ELISA Kit
No data available for DME Specific Peptides for GPER1 Gene
Domains & Families for GPER1 Gene
Gene Families for GPER1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- G-protein coupled receptors
- Predicted membrane proteins
- Predicted secreted proteins
- Transporters
Protein Domains for GPER1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for GPER1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q99527- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for GPER1 Gene
Molecular function for GPER1 Gene
- UniProtKB/Swiss-Prot Function:
- G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation. Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation. Stimulates uterine epithelial cell proliferation. Enhances uterine contractility in response to oxytocin. Contributes to thymic atrophy by inducing apoptosis. Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules. Promotes neuritogenesis in developing hippocampal neurons. Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death. Increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons. Inhibits early osteoblast proliferation at growth plate during skeletal development. Inhibits mature adipocyte differentiation and lipid accumulation. Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells. Functions also as a receptor for aldosterone mediating rapid regulation of vascular contractibility through the PI3K/ERK signaling pathway. Involved in cancer progression regulation. Stimulates cancer-associated fibroblast (CAF) proliferation by a rapid genomic response through the EGFR/ERK transduction pathway. Associated with EGFR, may act as a transcription factor activating growth regulatory genes (c-fos, cyclin D1). Promotes integrin alpha-5/beta-1 and fibronectin (FN) matrix assembly in breast cancer cells.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: Note=Binds 17-beta-estradiol (E2) in plasma membranes with high affinity (Kd is 3.3 nM) and displays rapid kinetics of association and dissociation. {ECO:0000269 PubMed:15539556, ECO:0000269 PubMed:15705806, ECO:0000269 PubMed:19931550};
- UniProtKB/Swiss-Prot Induction:
- Up-regulated by EGF and TGF-alpha in endometrial, ovarian and breast tumor cells. Up-regulated by progestin and by phorbol 12-myristate 13-acetate (PMA) in breast cancer cell lines.
Phenotypes From GWAS Catalog for GPER1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003682 | chromatin binding | IDA | 20551055 |
| GO:0004871 | obsolete signal transducer activity | IEA | -- |
| GO:0004930 | G-protein coupled receptor activity | IBA,IEA | -- |
| GO:0005496 | steroid binding | IDA | 15539556 |
| GO:0005515 | protein binding | IPI | 20551055 |
Phenotypes for GPER1 Gene
- MGI mutant phenotypes for GPER1:
-
inferred from 5 alleles
- cardiovascular system phenotype
- limbs/digits/tail phenotype
- homeostasis/metabolism phenotype
- no phenotypic analysis
- endocrine/exocrine gland phenotype
- liver/biliary system phenotype
- reproductive system phenotype
- skeleton phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for GPER1:
-
- Decreased DCP1a protein expression and assembly in processing bodies after arsenite stimulation
- Dynamic nuclei (hole, folded or small irregular)
- Increased virus production
- Decreased homologous recombination repair frequency
- Increased cell death HMECs cells
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Negative genetic interaction between BLM-/- and BLM+/+
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Decreased viability in esophageal squamous lineage
- Decreased cell migration
- Decreased viability
- no effect
- Increased caspase activity
- Increased vaccinia virus (VACV) infection
Animal Models for GPER1 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for GPER1
- Cyagen custom Knockout/knockin (KOKI) mouse models for GPER1
-
CRISPR Products
-
OriGene CRISPR knockouts for GPER1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GPER1
- genomics-online: gRNA clones - Search results for 115 available GPER gene related products
- Overview of 115 available GPER gene related products
- Applied Biological Materials CRISPR for GPER1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GPER1
- GenScript: Design CRISPR guide RNA sequences for GPER1
miRNA for GPER1 Gene
- miRTarBase miRNAs that target GPER1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GPER1
- Browse OriGene Inhibitory RNA Products For GPER1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPER1
- genomics-online: shRNA clones - Search results for 115 available GPER gene related products
- Overview of 115 available GPER gene related products
Clone Products
-
OriGene ORF clones in human for GPER1
- RC203027
- RC203027L1
- RC203027L2
- RC203027L3
- RC203027L4
- RC212278
- RC212278L1
- RC212278L2
- RC212278L3
- RC212278L4
- RC216812
- RC216812L1
- RC216812L2
- RC216812L3
- RC216812L4
- RC503027
- RG203027
- RG212278
- RG216812
- RC203027L1V
- RC203027L2V
- RC203027L3V
- RC203027L4V
- RC212278L1V
- RC212278L2V
- RC212278L3V
- RC212278L4V
- RC216812L1V
- RC216812L2V
- RC216812L3V
- RC216812L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GPER1
- Sino Biological Human cDNA Clone for GPER1
- Addgene plasmids for GPER1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GPER1
- Applied Biological Materials Clones for GPER1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for GPER1 (GPER/GPR30)
Cell Line Products
-
Horizon Cell Lines for GPER1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPER1 Gene
Localization for GPER1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GPER1 Gene
- Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Early endosome. Recycling endosome. Golgi apparatus membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, dendritic spine membrane; Multi-pass membrane protein. Cell projection, axon. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Mitochondrion membrane; Multi-pass membrane protein. Note=Colocalized with BSN to the active zone of presynaptic density. Colocalized with DLG4/PSD95 and neurabin-2 PPP1R9B in neuronal synaptosomes (By similarity). Endocytosed in a agonist- and arrestin-independent manner. Colocalized with RAMP3 and clathrin-coated pits at the plasma membrane. Colocalized with transferrin receptor at the plasma membrane and perinuclear region. Accumulated and colocalized with RAB11 proteins in recycling endosomes and trans-Golgi network (TGN), but does neither recycle back to the cell surface nor traffics to late endosome or lysosome. Colocalized with calnexin in the endoplasmic reticulum. Traffics to intracellular sites via cytokeratin intermediate filaments like KRT7 and KRT8 after constitutive endocytosis in epithelial cells. Colocalized with EGFR in the nucleus of agonist-induced cancer-associated fibroblasts (CAF). {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytoskeleton | 5 |
| mitochondrion | 5 |
| nucleus | 5 |
| endoplasmic reticulum | 5 |
| golgi apparatus | 5 |
| endosome | 5 |
| extracellular | 2 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | -- |
| GO:0005622 | intracellular | ISS | -- |
| GO:0005634 | nucleus | IEA,IDA | 20551055 |
| GO:0005635 | nuclear envelope | IDA | 15705806 |
| GO:0005737 | cytoplasm | ISS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPER1 Gene
Pathways & Interactions for GPER1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors | ||
| 2 | Signaling by GPCR | ||
| 3 | Glioma | ||
| 4 | Circadian entrainment | ||
| 5 | Estrogen signaling pathway | ||
Pathways by source for GPER1 Gene
2 BioSystems pathways for GPER1 Gene
7 Reactome pathways for GPER1 Gene
2 KEGG pathways for GPER1 Gene
Interacting Proteins for GPER1 Gene
GPS-Prot Interaction Network for GPER1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001934 | positive regulation of protein phosphorylation | ISS | -- |
| GO:0001956 | positive regulation of neurotransmitter secretion | ISS | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0002695 | negative regulation of leukocyte activation | IDA | 23285008 |
| GO:0006915 | apoptotic process | IEA | -- |
Drugs & Compounds for GPER1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Estradiol | Approved, Investigational, Vet_approved | Pharma | Target | Sex hormone | 1400 | |
| Estradiol cypionate | Approved, Investigational, Vet_approved | Pharma | Target | 0 | ||
| Fulvestrant | Approved, Investigational | Pharma | Antagonist, inhibitor, antagonist | Estrogen receptor antagonist,high affinity, Hormone therapy | 228 | |
| Estradiol acetate | Approved, Investigational, Vet_approved | Pharma | Target | 0 | ||
| estradiol benzoate | Approved, Investigational, Vet_approved | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| G-15 |
|
1161002-05-6 |
|
|
(3) Tocris Compounds for GPER1 Gene
Drug Products
Transcripts for GPER1 Gene
mRNA/cDNA for GPER1 Gene
- (4) REFSEQ mRNAs :
- (75) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000401670 1542 bps (uc010ksd.2)
- ENST00000413368 1105 bps (uc064awd.1)
- ENST00000297469 2778 bps (uc003ska.2)
- ENST00000397088 2639 bps (uc003skb.3)
- ENST00000397092 2971 bps (uc003sjz.1)
CRISPR Products
-
OriGene CRISPR knockouts for GPER1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GPER1
- genomics-online: gRNA clones - Search results for 115 available GPER gene related products
- Overview of 115 available GPER gene related products
- Applied Biological Materials CRISPR for GPER1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GPER1
- GenScript: Design CRISPR guide RNA sequences for GPER1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GPER1
- Browse OriGene Inhibitory RNA Products For GPER1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPER1
- genomics-online: shRNA clones - Search results for 115 available GPER gene related products
- Overview of 115 available GPER gene related products
Clone Products
-
OriGene ORF clones in human for GPER1
- RC203027
- RC203027L1
- RC203027L2
- RC203027L3
- RC203027L4
- RC212278
- RC212278L1
- RC212278L2
- RC212278L3
- RC212278L4
- RC216812
- RC216812L1
- RC216812L2
- RC216812L3
- RC216812L4
- RC503027
- RG203027
- RG212278
- RG216812
- RC203027L1V
- RC203027L2V
- RC203027L3V
- RC203027L4V
- RC212278L1V
- RC212278L2V
- RC212278L3V
- RC212278L4V
- RC216812L1V
- RC216812L2V
- RC216812L3V
- RC216812L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GPER1
- Sino Biological Human cDNA Clone for GPER1
- Addgene plasmids for GPER1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GPER1
- Applied Biological Materials Clones for GPER1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for GPER1 (GPER/GPR30)
Expression for GPER1 Gene
mRNA differential expression in normal tissues according to GTEx for GPER1 Gene
This gene is overexpressed in Stomach (x4.1).
NURSA nuclear receptor signaling pathways regulating expression of GPER1 Gene:
GPER1mRNA Expression by UniProt/SwissProt for GPER1 Gene:
Q99527-GPER1_HUMAN
Tissue specificity:
Expressed in placenta, endothelial and epithelial cells, non laboring and laboring term myometrium, fibroblasts and cancer-associated fibroblasts (CAF), prostate cancer cells and invasive adenocarcinoma (at protein level). Ubiquitously expressed, but is most abundant in placenta. In brain regions, expressed as a 2.8 kb transcript in basal forebrain, frontal cortex, thalamus, hippocampus, caudate and putamen.
Evidence on tissue expression from TISSUES for GPER1 Gene
- Liver(4.3)
- Nervous system(2.8)
- Muscle(2.4)
- Heart(2.3)
Primer Products
-
OriGene qPCR primer pairs for GPER1
-
OriGene qPCR primer pairs and template standards for GPER1
- genomics-online: primer clones - Search results for 115 available GPER gene related products
- Overview of 115 available GPER gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPER1 Gene
Orthologs for GPER1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| dog (Canis familiaris) |
Mammalia | GPER1 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | GPER 33 |
|
||
| GPER1 34 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Gper1 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Gper1 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | GPER1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | GPER1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | GPER 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | GPER1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | gper1 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | gper1 34 33 |
|
OneToOne |
- Species where no ortholog for GPER1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for GPER1 Gene
- ENSEMBL:
- Gene Tree for GPER1 (if available)
- TreeFam:
- Gene Tree for GPER1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GPER1: view image
Paralogs for GPER1 Gene
Variants for GPER1 Gene
| SNP ID | Clin | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000090736 | -- | 1,092,673(+) | C/T | coding_sequence_variant, synonymous_variant | |
| rs1000988443 | -- | 1,087,821(+) | C/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1001248088 | -- | 1,086,924(+) | T/G | 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant | |
| rs1001630161 | -- | 1,086,610(+) | G/A | upstream_transcript_variant | |
| rs1001830540 | -- | 1,091,384(+) | A/ | intron_variant |
Residual Variation Intolerance Score:
11.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.28;
62.64% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GPER1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GPER1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPER1 Gene
Disorders for GPER1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| breast cancer |
|
Search GPER1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GPER1
No data available for UniProtKB/Swiss-Prot and Genatlas for GPER1 Gene
Publications for GPER1 Gene
- G protein-coupled receptor 30 expression is up-regulated by EGF and TGF alpha in estrogen receptor alpha-positive cancer cells. (PMID: 19749156) Vivacqua A … Maggiolini M (Molecular endocrinology (Baltimore, Md.) 2009) 3 4 22 58
- Coordinate regulation of estrogen-mediated fibronectin matrix assembly and epidermal growth factor receptor transactivation by the G protein-coupled receptor, GPR30. (PMID: 19342448) Quinn JA … Filardo EJ (Molecular endocrinology (Baltimore, Md.) 2009) 3 4 22 58
- G protein-coupled receptor 30 localizes to the endoplasmic reticulum and is not activated by estradiol. (PMID: 18566127) Otto C … Fritzemeier KH (Endocrinology 2008) 3 4 22 58
- Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. (PMID: 15539556) Thomas P … Dong J (Endocrinology 2005) 3 4 22 58
- Progestin upregulates G-protein-coupled receptor 30 in breast cancer cells. (PMID: 12027886) Ahola TM … Ylikomi T (European journal of biochemistry 2002) 3 4 22 58
Products for GPER1 Gene
- R&D Systems Antibodies for GPER1 (GPER/GPR30)
- Browse R&D Systems for Human Recombinant Proteins
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- R&D Systems cDNA Clones for GPER1 (GPER/GPR30)
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- Custom Antibody ServicesOriGene Antibodies for GPER1
- Browse OriGene ELISA Kits
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- OriGene Purified Proteins for GPER1
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for GPER1
- Browse OriGene Inhibitory RNA Products For GPER1
- OriGene qPCR primer pairs for GPER1
- OriGene qPCR primer pairs and template standards for GPER1
- OriGene CRISPR knockouts for GPER1
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- RC203027
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Sino Biological Human cDNA Clone for GPER1
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for GPER1
- Novus Biologicals lysates and proteins for GPER1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
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- Taconic Biosciences Mouse Models for GPER1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for GPER1 (AFLGC-GPER1)
- Cyagen custom Knockout/knockin (KOKI) mouse models for GPER1
- Addgene plasmids for GPER1
- antibodies-online: Search results for 211 available GPER Antibodies ranked by validation data
- Compare Top GPER Antibodies
- Recommended
- 101 WB Antibodies (anti-human)
- 24 IHC (p) Antibodies (anti-human)
- 20 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IHC (fro) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 2 EIA Antibodies (anti-human)
- 20 WB Antibodies (anti-mouse)
- 6 FACS Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 4 WB Antibodies (anti-rat)
- 101 WB Antibodies (anti-human)
- 24 IHC (p) Antibodies (anti-human)
- 20 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IHC (fro) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 2 EIA Antibodies (anti-human)
- 20 WB Antibodies (anti-mouse)
- 6 FACS Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 4 WB Antibodies (anti-rat)
- 101 WB Antibodies (anti-human)
- 24 IHC (p) Antibodies (anti-human)
- 20 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IHC (fro) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 2 EIA Antibodies (anti-human)
- 20 WB Antibodies (anti-mouse)
- 6 FACS Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 4 WB Antibodies (anti-rat)
- antibodies-online: Search results for 21 available GPER Elisa Kits ranked by validation data
- Compare Top GPER Elisa Kits
- Recommended
- 1 Chicken ELISA Kit
- 9 Human ELISA Kits
- 1 Monkey ELISA Kit
- 7 Mouse (Murine) ELISA Kits
- 1 Pig (Porcine) ELISA Kit
- 1 Rabbit ELISA Kit
- 1 Rat (Rattus) ELISA Kit
- 1 Chicken ELISA Kit
- 9 Human ELISA Kits
- 1 Monkey ELISA Kit
- 7 Mouse (Murine) ELISA Kits
- 1 Pig (Porcine) ELISA Kit
- 1 Rabbit ELISA Kit
- 1 Rat (Rattus) ELISA Kit
- 1 Chicken ELISA Kit
- 9 Human ELISA Kits
- 1 Monkey ELISA Kit
- 7 Mouse (Murine) ELISA Kits
- 1 Pig (Porcine) ELISA Kit
- 1 Rabbit ELISA Kit
- 1 Rat (Rattus) ELISA Kit
- antibodies-online: Search results for available GPER related products ranked by validation data
- GeneTex GPER1 Antibody for GPER1
- Search GeneTex for Proteins for GPER1
- Horizon Cell Lines for GPER1
- genomics-online: cdna clones - Search results for 115 available GPER gene related products
- Overview of 115 available GPER gene related products
- orf clones - Search results for 115 available GPER gene related products
- Overview of 115 available GPER gene related products
- genomics-online: gRNA clones - Search results for 115 available GPER gene related products
- Overview of 115 available GPER gene related products
- genomics-online: primer clones - Search results for 115 available GPER gene related products
- Overview of 115 available GPER gene related products
- genomics-online: shRNA clones - Search results for 115 available GPER gene related products
- Overview of 115 available GPER gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GPER1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GPER1
- GeneCopoeia miRNA 3'UTR Target clone products for GPER1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPER1
- Boster Bio Antibodies for GPER1
- Browse Boster Bio ELISA Kits
Sources for GPER1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
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- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
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- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt