Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum and a member of the G-protein coupled receptor 1 family. This receptor binds estrogen and activates multiple downstream signaling pathways, leading to stimulation of adenylate cyclase and an increase in cyclic AMP levels, while also promoting intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. This receptor has been shown to play a role in diverse biological processes, including bone and nervous system development, metabolism, cognition, male fertility and uterine function. [provided by RefSeq, Aug 2017]
GPER1 (G Protein-Coupled Estrogen Receptor 1) is a Protein Coding gene. Diseases associated with GPER1 include Estrogen-Receptor Negative Breast Cancer and Teeth Hard Tissue Disease. Among its related pathways are Estrogen signaling pathway and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and steroid binding. An important paralog of this gene is GPR182.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003682 | chromatin binding | IDA | 20551055 |
GO:0003707 | steroid hormone receptor activity | ISS | -- |
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0005496 | steroid binding | IDA | 15539556 |
GO:0005515 | protein binding | IPI | 20551055 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000139 | Golgi membrane | IEA | -- |
GO:0005623 | cell | IEA | -- |
GO:0005634 | nucleus | IEA,IDA | 20551055 |
GO:0005635 | nuclear envelope | IDA | 15705806 |
GO:0005737 | cytoplasm | ISS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide ligand-binding receptors | ||
2 | Signaling by GPCR | ||
3 | Glioma | ||
4 | Relaxin signaling pathway | ||
5 | GnRH secretion |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001934 | positive regulation of protein phosphorylation | ISS | -- |
GO:0001956 | positive regulation of neurotransmitter secretion | ISS | -- |
GO:0002376 | immune system process | IEA | -- |
GO:0002695 | negative regulation of leukocyte activation | IDA | 23285008 |
GO:0006915 | apoptotic process | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Estradiol | Approved, Investigational, Vet_approved | Pharma | Target, binder | Sex hormone | 1113 | |
Estradiol cypionate | Approved, Investigational, Vet_approved | Pharma | Target | 0 | ||
Fulvestrant | Approved, Investigational | Pharma | Antagonist, inhibitor, antagonist | Estrogen receptor antagonist,high affinity, Hormone therapy | 295 | |
Estradiol acetate | Approved, Investigational, Vet_approved | Pharma | Target | 0 | ||
estradiol benzoate | Approved, Investigational, Vet_approved | Pharma | Target | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
G-15 |
|
1161002-05-6 |
|
|
Compound | Action | Cas Number |
---|---|---|
Altrenogest | 850-52-2 | |
Bazedoxifene HCl | 198480-56-7 | |
Clomiphene citrate | 50-41-9 | |
Equol | 531-95-3 | |
Estradiol | Sex hormone | 50-28-2 |
Estradiol Cypionate | 313-06-4 | |
Estriol | 50-27-1 | |
Estrone | Estrogenic hormone | 53-16-7 |
Ethinyl Estradiol | Oral contraceptive | 57-63-6 |
Ethisterone | Progestogen hormone | 434-03-7 |
Ethynodiol diacetate | 297-76-7 | |
Fulvestrant | Estrogen receptor antagonist,high affinity | 129453-61-8 |
Gestodene | 60282-87-3 | |
Hexestrol | 84-16-2 | |
Medroxyprogesterone acetate | Steroidal progestin | 71-58-9 |
Ospemifene | 128607-22-7 | |
Raloxifene HCl | Estrogen receptor (ER) | 82640-04-8 |
Tamoxifen Citrate | Antiestrogen drug | 54965-24-1 |
Toremifene Citrate | 89778-27-8 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Dog (Canis familiaris) |
Mammalia | GPER1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | GPER 30 |
|
||
GPER1 31 |
|
OneToOne | |||
Mouse (Mus musculus) |
Mammalia | Gper1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Gper1 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | GPER1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | GPER1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | GPER 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | GPER1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | gper1 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | gper1 30 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 07 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
770179 | Benign: not provided | 1,091,742(+) | C/T | MISSENSE_VARIANT,INTRON_VARIANT | |
rs11544331 | - | p.Pro16Leu |
Disorder | Aliases | PubMed IDs |
---|---|---|
estrogen-receptor negative breast cancer |
|
|
teeth hard tissue disease |
|
|
amelogenesis imperfecta, type ig |
|
|
gynecomastia |
|
|
adenomyosis |
|
|