Aliases for GPD2 Gene
External Ids for GPD2 Gene
Previous GeneCards Identifiers for GPD2 Gene
The protein encoded by this gene localizes to the inner mitochondrial membrane and catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate, using FAD as a cofactor. Along with GDP1, the encoded protein constitutes the glycerol phosphate shuttle, which reoxidizes NADH formed during glycolysis. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010]
GeneCards Summary for GPD2 Gene
GPD2 (Glycerol-3-Phosphate Dehydrogenase 2) is a Protein Coding gene. Diseases associated with GPD2 include Diabetes Mellitus, Noninsulin-Dependent and Rare Diabetes Mellitus Type 2. Among its related pathways are glycerol degradation and Metabolism. Gene Ontology (GO) annotations related to this gene include calcium ion binding and glycerol-3-phosphate dehydrogenase (quinone) activity.
UniProtKB/Swiss-Prot Summary for GPD2 Gene
Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device.