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Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq, Jul 2008]
GPC5 (Glypican 5) is a Protein Coding gene. Diseases associated with GPC5 include Omodysplasia and Tumoral Calcinosis, Hyperphosphatemic, Familial, 1. Among its related pathways are Signaling by GPCR and Metabolism of fat-soluble vitamins. Gene Ontology (GO) annotations related to this gene include heparan sulfate proteoglycan binding. An important paralog of this gene is GPC3.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH13J091398 | Promoter/Enhancer | 1.7 | EPDnew Ensembl ENCODE CraniofacialAtlas | 606.5 | +0.2 | 153 | 1.3 | PRDM10 REST ZIC2 POLR2A EZH2 ZNF341 ZBTB44 KLF9 RAD21 RCOR1 | GPC5 piR-35674-129 | |
GH13J091399 | Promoter | 0.5 | Ensembl | 600.7 | +1.1 | 1080 | 0.2 | EZH2 RELA | GPC5 piR-35674-129 | |
GH13J091346 | Promoter/Enhancer | 1.8 | Ensembl ENCODE CraniofacialAtlas dbSUPER | 4.6 | -49.6 | -49620 | 5.2 | GATAD2A CTCF TFE3 POLR2A BACH1 TARDBP FOXA1 LARP7 PRDM1 ZNF143 | MIR17 MIR17HG MIR18A MIR19A piR-37523 GPC5 AB372624 MIR19B1 MIR20A MIR92A1 | |
GH13J091329 | Enhancer | 0.6 | Ensembl | 10 | -68.7 | -68720 | 0.6 | ZNF140 ZXDB CEBPB ZNF623 ZNF189 ZNF213 ZNF202 ZNF433 ZFP37 REST | GPC5 MIR17HG PPIAP23 | |
GH13J092103 | Enhancer | 0.6 | Ensembl ENCODE | 4.6 | +705.4 | 705380 | 0.8 | FOXA1 ESR1 NR2F2 RXRA TRIM28 PKNOX1 | GPC5 piR-52225-001 piR-38051-088 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IBA,TAS | -- |
GO:0005615 | extracellular space | IEA | -- |
GO:0005796 | Golgi lumen | TAS | -- |
GO:0005886 | plasma membrane | IEA,TAS | -- |
GO:0009986 | cell surface | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001523 | retinoid metabolic process | TAS | -- |
GO:0006024 | glycosaminoglycan biosynthetic process | TAS | -- |
GO:0006027 | glycosaminoglycan catabolic process | TAS | -- |
GO:0009966 | regulation of signal transduction | IEA | -- |
GO:0016477 | cell migration | IBA | 21873635 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | GPC5 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | GPC5 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | GPC5 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Gpc5 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Gpc5 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | GPC5 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | GPC5 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | GPC5 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Zebrafish (Danio rerio) |
Actinopterygii | LOC559454 30 |
|
||
GPC5 31 |
|
OneToOne | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | dally 30 31 32 |
|
OneToMany | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005799 30 |
|
Disorder | Aliases | PubMed IDs |
---|---|---|
omodysplasia |
|
|
tumoral calcinosis, hyperphosphatemic, familial, 1 |
|
|
tetralogy of fallot |
|
|
hypotrichosis 2 |
|
|