Aliases for GPC4 Gene
External Ids for GPC4 Gene
Previous GeneCards Identifiers for GPC4 Gene
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome. [provided by RefSeq, Jul 2008]
GeneCards Summary for GPC4 Gene
GPC4 (Glypican 4) is a Protein Coding gene. Diseases associated with GPC4 include Simpson-Golabi-Behmel Syndrome and Wilms Tumor 1. Among its related pathways are Glycosaminoglycan metabolism and Chondroitin sulfate/dermatan sulfate metabolism. Gene Ontology (GO) annotations related to this gene include heparan sulfate proteoglycan binding. An important paralog of this gene is GPC6.
UniProtKB/Swiss-Prot for GPC4 Gene
Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity).