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Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the con... See more...
Aliases for GPC3 Gene
Aliases for GPC3 Gene
External Ids for GPC3 Gene
- HGNC: 4451
- Entrez Gene: 2719
- Ensembl: ENSG00000147257
- OMIM: 300037
- UniProtKB: P51654
Previous HGNC Symbols for GPC3 Gene
- SDYS
Previous GeneCards Identifiers for GPC3 Gene
- GC0XM127315
- GC0XM129515
- GC0XM130614
- GC0XM131375
- GC0XM132395
- GC0XM132497
- GC0XM132669
- GC0XM122070
Summaries for GPC3 Gene
-
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
GeneCards Summary for GPC3 Gene
GPC3 (Glypican 3) is a Protein Coding gene. Diseases associated with GPC3 include Simpson-Golabi-Behmel Syndrome, Type 1 and Wilms Tumor 1. Among its related pathways are Signaling by GPCR and Metabolism of fat-soluble vitamins. Gene Ontology (GO) annotations related to this gene include heparan sulfate proteoglycan binding and peptidyl-dipeptidase inhibitor activity. An important paralog of this gene is GPC5.
UniProtKB/Swiss-Prot Summary for GPC3 Gene
-
Cell surface proteoglycan that bears heparan sulfate (PubMed:14610063). Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity). Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands (PubMed:16227623, PubMed:24496449). Positively regulates the non-canonical Wnt signaling pathway (By similarity). Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression (By similarity). Inhibits the dipeptidyl peptidase activity of DPP4 (PubMed:17549790). Plays a role in limb patterning and skeletal development by controlling the cellular response to BMP4 (By similarity). Modulates the effects of growth factors BMP2, BMP7 and FGF7 on renal branching morphogenesis (By similarity). Required for coronary vascular development (By similarity). Plays a role in regulating cell movements during gastrulation (By similarity).
Additional gene information for GPC3 Gene
- HGNC(4451)
- Entrez Gene(2719)
- Ensembl(ENSG00000147257)
- OMIM(300037)
- UniProtKB(P51654)
- Open Targets Platform(ENSG00000147257)
- Monarch Initiative
- Search for GPC3 at DataMed
- Search for GPC3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPC3 Gene
Genomics for GPC3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for GPC3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around GPC3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPC3
- Top Transcription factor binding sites by QIAGEN in the GPC3 gene promoter:
-
- AP-1
- c-Fos
- c-Jun
- C/EBPalpha
- Egr-3
- POU2F1
- POU2F1a
- Sox9
- SRY
- STAT5A
Genomic Locations for GPC3 Gene
Genomic Locations for GPC3 Gene
- chrX:133,535,745-133,985,616
- (GRCh38/hg38)
- Size:
- 449,872 bases
- Orientation:
- Minus strand
- chrX:132,669,773-133,119,922
- (GRCh37/hg19)
- Size:
- 450,150 bases
- Orientation:
- Minus strand
Genomic View for GPC3 Gene
Genes around GPC3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xq26.2 by HGNC
- Xq26.2 by Entrez Gene
- Xq26.2 by Ensembl
GPC3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GPC3 Gene
Proteins for GPC3 Gene
-
Protein details for GPC3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P51654-GPC3_HUMAN
- Recommended name:
- Glypican-3
- Protein Accession:
- P51654
- C9JLE3
- G3V1R0
- Q2L880
- Q2L882
Protein attributes for GPC3 Gene
- Size:
- 580 amino acids
- Molecular mass:
- 65563 Da
- Quaternary structure:
-
- Heterodimer; disulfide-linked (PubMed:14610063). Cleavage by a furin-like convertase results in production of alpha and beta chains which form a disulfide-linked heterodimer (PubMed:14610063). Interacts with DPP4 (PubMed:17549790). Interacts with FGF2 (By similarity). Interacts with WNT5A (PubMed:14610063). Also interacts with WNT3A and WNT7B (PubMed:16227623). Interacts with hedgehog protein SHH; the heparan sulfate chains are not required for the interaction (By similarity). Also interacts with hedgehog protein IHH (By similarity). Interacts with CD81 (By similarity). Interacts with Wnt receptors FZD4, FZD7 and FZD8; the heparan sulfate chains are required for the interaction (PubMed:24496449).
- Miscellaneous:
-
- Used as a marker for hepatocellular carcinoma (HCC) as it is expressed in HCC but is not detectable in hepatocytes from normal or benign liver diseases (PubMed:12851874). When attached to the cell surface, stimulates the growth of HCC cells by increasing canonical Wnt signaling (PubMed:16024626). Cleavage is not required for stimulation of Wnt signaling or HCC growth (PubMed:16227623).
Protein Expression for GPC3 Gene
Post-translational modifications for GPC3 Gene
- O-glycosylated; contains heparan sulfate.
- Cleaved intracellularly by a furin-like convertase to generate 2 subunits, alpha and beta, which remain associated through disulfide bonds and are associated with the cell surface via the GPI-anchor (PubMed:14610063). This processing is essential for its role in inhibition of hedgehog signaling (PubMed:25653284). A second proteolytic event may result in cleavage of the protein on the cell surface, separating it from the GPI-anchor and leading to its shedding from the cell surface (PubMed:14610063).
-
Glycosylation at Asn124, Asn241, Ser359, Asn418, Ser495, and Ser509
- NX_P51654 (NX_P51654-1)
- Modification sites at PhosphoSitePlus
Other Protein References for GPC3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences GPC3 / Glypican 3 Antibody (LS-B11249) and GPC3 / Glypican 3 Antibody (LS-B13373)
- G Biosciences Immunotag™ GPC3 Antibody
- NSJ Bioreagents Glypican 3 Antibody (GPC3)
-
Custom Antibody ServicesOriGene Antibodies for GPC3
- Novus Biologicals Antibodies for GPC3
-
Abcam antibodies for GPC3
- Invitrogen Antibodies for GPC3 (AFLGC-GPC3)
- antibodies-online: Show 55 available Glypican 3 Antibodies ranked by validation data
- Compare Top Glypican 3 Antibodies
-
Recommended
- 155 IHC (p) Antibodies (anti-human)
- 114 WB Antibodies (anti-human)
- 63 IHC (f) Antibodies (anti-human)
- 59 IHC Antibodies (anti-human)
- 32 FACS Antibodies (anti-human)
- 12 IF Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 54 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 70 IHC (p) Antibodies (anti-rat)
- 49 IHC Antibodies (anti-rat)
- 28 WB Antibodies (anti-rat)
- 21 IHC (f) Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 8 FACS Antibodies (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for GPC3
- Sino Biological Antibodies for GPC3
Protein Products
- G Biosciences Human Glypican 3/GPC3/OCI5, Lyophilized
-
OriGene Purified Proteins for GPC3
- Search Origene for MassSpec and Protein Over-expression Lysates for GPC3
- Origene Custom Protein Services for GPC3
- Sino Biological Recombinant Proteins for GPC3
- Sino Biological Cell Lysates for GPC3
- ProSpec Recombinant Proteins for GPC3
-
ProSci Proteins for GPC3
-
Abcam proteins for GPC3
Assay Products
- G Biosciences Immunotag™ Human GPC3 (Glypican-3) ELISA
- RayBiotech Human Glypican 3 ELISA
- Novus Biologicals ELISA Kits for GPC3
- antibodies-online: Show 54 available Glypican 3 Elisa Kits ranked by validation data
- Compare Top Glypican 3 Elisa Kits
-
Quality Products:
- ABIN414787
- ABIN1115231
- ABIN365731
- ABIN1028748
- ABIN5676186
- ABIN2703060
- ABIN5520733
- ABIN455244
- ABIN5668585
- ABIN511363
- ABIN857192
- ABIN1884417
- ABIN5520734
- ABIN5669804
- ABIN627904
- ABIN2947982
- ABIN5069025
- ABIN1135309
- ABIN840429
- ABIN431855
- ABIN1570114
- ABIN1884418
- ABIN5520735
- ABIN5670472
- ABIN627090
- ABIN5654781
- ABIN2534048
- ABIN2947983
No data available for DME Specific Peptides for GPC3 Gene
Domains & Families for GPC3 Gene
Gene Families for GPC3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for GPC3 Gene
- InterPro:
- Blocks:
-
- Glypican
- ProtoNet:
Suggested Antigen Peptide Sequences for GPC3 Gene
- GenScript: Design optimal peptide antigens:
-
- Glypican 3 (B1AJP6_HUMAN)
- MXR7 (GPC3_HUMAN)
- Glypican-3 splice variant C (Q2L880_HUMAN)
- Glypican-3 splice variant B (Q2L882_HUMAN)
- Glypican-3 splice variant A (Q53H15_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P51654- Family:
-
- Belongs to the glypican family.
Function for GPC3 Gene
Molecular function for GPC3 Gene
- UniProtKB/Swiss-Prot Function:
- Cell surface proteoglycan that bears heparan sulfate (PubMed:14610063). Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity). Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands (PubMed:16227623, PubMed:24496449). Positively regulates the non-canonical Wnt signaling pathway (By similarity). Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression (By similarity). Inhibits the dipeptidyl peptidase activity of DPP4 (PubMed:17549790). Plays a role in limb patterning and skeletal development by controlling the cellular response to BMP4 (By similarity). Modulates the effects of growth factors BMP2, BMP7 and FGF7 on renal branching morphogenesis (By similarity). Required for coronary vascular development (By similarity). Plays a role in regulating cell movements during gastrulation (By similarity).
- GENATLAS Biochemistry:
- glypican 3,60kDa,putative extracellular proteoglycan,involved in growth control in embryonic mesodermal tissues,complexing with and putative modulator of IGF2,juxtaposed to GPC4,with tumor suppression activity
Phenotypes From GWAS Catalog for GPC3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 17549790 |
| GO:0030414 | peptidase inhibitor activity | IEA | -- |
| GO:0060422 | peptidyl-dipeptidase inhibitor activity | IDA | 17549790 |
Phenotypes for GPC3 Gene
- MGI mutant phenotypes for GPC3:
-
inferred from 4 alleles
- immune system phenotype
- respiratory system phenotype
- cardiovascular system phenotype
- cellular phenotype
- mortality/aging
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- renal/urinary system phenotype
- digestive/alimentary phenotype
- reproductive system phenotype
- limbs/digits/tail phenotype
- skeleton phenotype
- hematopoietic system phenotype
- integument phenotype
- embryo phenotype
- pigmentation phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for GPC3:
-
- Decreased hepcidin::fluc mRNA expression
- no effect
- Decreased vaccinia virus (VACV) infection
- Decreased viability ratio
- Increased IL-8 secretion
- Increased endosome-nucleus distance (endosomes dispersed in the cell periphery)
- Strongly decreased CFP-tsO45G cell surface transport
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Increased Sindbis virus (SINV) infection
Animal Models for GPC3 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GPC3 - Select products 50% OFF >
- * GPC3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GPC3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GPC3
-
Santa Cruz Biotechnology (SCBT) CRISPR for GPC3
miRNA for GPC3 Gene
- miRTarBase miRNAs that target GPC3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GPC3
- Browse OriGene Inhibitory RNA Products For GPC3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPC3
Clone Products
- Applied Biological Materials (abm): Clones for GPC3 - Select products 50% OFF >
- * GPC3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG209076
- MR209076
- MR209076L3
- MR209076L4
- RC205911
- RC205911L1
- RC205911L2
- RC205911L3
- RC205911L4
- RC228429
- RC228429L3
- RC228429L4
- RC228459
- RC228459L3
- RC228459L4
- RC228491
- RC228491L1
- RC228491L2
- RC228491L3
- RC228491L4
- RG205911
- RG228429
- RG228459
- RG228491
- RR204246
- RR204246L3
- RR204246L4
- MR209076L3V
- MR209076L4V
- RC205911L1V
- RC205911L2V
- RC205911L3V
- RC205911L4V
- RC228429L3V
- RC228429L4V
- RC228459L3V
- RC228459L4V
- RC228491L1V
- RC228491L2V
- RC228491L3V
- RC228491L4V
- RR204246L3V
- RR204246L4V
- RC402730
- RC402731
- RC402732
- RC402733
- RC402734
- RC402735
- RC402736
- RC402737
- RC402738
- RC402739
- RC402740
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GPC3
- Addgene plasmids for GPC3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GPC3
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for GPC3 Gene
Localization for GPC3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GPC3 Gene
- Cell membrane. Lipid-anchor, GPI-anchor. Extracellular side.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 4 |
| endoplasmic reticulum | 4 |
| lysosome | 4 |
| golgi apparatus | 4 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| peroxisome | 2 |
| nucleus | 2 |
| cytosol | 2 |
| endosome | 1 |
- Plasma membrane (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IBA | 21873635 |
| GO:0005764 | lysosome | IEA | -- |
| GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
| GO:0005796 | Golgi lumen | TAS | -- |
| GO:0005886 | plasma membrane | IEA,TAS | -- |
Pathways & Interactions for GPC3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Chondroitin sulfate/dermatan sulfate metabolism |
.01
|
|
| 2 | Glycosaminoglycan metabolism | ||
| 3 | Metabolism of fat-soluble vitamins | ||
| 4 | Proteoglycans in cancer | ||
| 5 | mTOR signaling pathway (KEGG) |
.38
|
|
Pathways by source for GPC3 Gene
2 BioSystems pathways for GPC3 Gene
1 KEGG pathway for GPC3 Gene
3 R&D Systems pathways for GPC3 Gene
Interacting Proteins for GPC3 Gene
GPS-Prot Interaction Network for GPC3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001523 | retinoid metabolic process | TAS | -- |
| GO:0001658 | branching involved in ureteric bud morphogenesis | IEA | -- |
| GO:0001822 | kidney development | IEA | -- |
| GO:0006024 | glycosaminoglycan biosynthetic process | TAS | -- |
| GO:0006027 | glycosaminoglycan catabolic process | TAS | -- |
Drugs & Compounds for GPC3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Fludarabine | Approved | Pharma | DNA synthsis inhibitor | 1533,1533 | ||
| Cyclophosphamide | Approved, Investigational | Pharma | Nitrogen mustard alkylating agent and prodrug. | 3670 | ||
| Decitabine | Approved, Investigational | Pharma | DNA methyltransferase inhibitor | 388 | ||
| Tyrosine | Approved, Investigational | Nutra | 1044 | |||
| Alkylating Agents | Pharma | 5372 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for GPC3 Gene
mRNA/cDNA for GPC3 Gene
- 4 REFSEQ mRNAs :
- 17 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000370818 2267 nts (view in UCSC)
- ENST00000394299 2336 nts (view in UCSC)
- ENST00000406757 836 nts (view in UCSC)
- ENST00000631057 1581 nts (view in UCSC)
- ENST00000666017 596 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GPC3 - Select products 50% OFF >
- * GPC3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GPC3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GPC3
-
Santa Cruz Biotechnology (SCBT) CRISPR for GPC3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GPC3
- Browse OriGene Inhibitory RNA Products For GPC3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPC3
Clone Products
- Applied Biological Materials (abm): Clones for GPC3 - Select products 50% OFF >
- * GPC3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG209076
- MR209076
- MR209076L3
- MR209076L4
- RC205911
- RC205911L1
- RC205911L2
- RC205911L3
- RC205911L4
- RC228429
- RC228429L3
- RC228429L4
- RC228459
- RC228459L3
- RC228459L4
- RC228491
- RC228491L1
- RC228491L2
- RC228491L3
- RC228491L4
- RG205911
- RG228429
- RG228459
- RG228491
- RR204246
- RR204246L3
- RR204246L4
- MR209076L3V
- MR209076L4V
- RC205911L1V
- RC205911L2V
- RC205911L3V
- RC205911L4V
- RC228429L3V
- RC228429L4V
- RC228459L3V
- RC228459L4V
- RC228491L1V
- RC228491L2V
- RC228491L3V
- RC228491L4V
- RR204246L3V
- RR204246L4V
- RC402730
- RC402731
- RC402732
- RC402733
- RC402734
- RC402735
- RC402736
- RC402737
- RC402738
- RC402739
- RC402740
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GPC3
- Addgene plasmids for GPC3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GPC3
Relevant External Links for GPC3 Gene
- GeneLoc Exon Structure for
- GPC3
Expression for GPC3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
-
Pancreas (Endocrine System)
- Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Ventral Pancreatic Bud
-
Epithelial Cells
- Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Ventral Pancreatic Bud
- Cartilage (Muscoskeletal System)
- Bone (Muscoskeletal System)
-
Liver (Hepatobiliary System)
- Fetal Hepatocytes Liver Lobule
-
Kidney (Urinary System)
- Ureteric Bud Cells Ureteric Bud
-
Testis (Reproductive System)
- Testicular Interstitial Cells Testis Interstitium
-
Heart (Cardiovascular System)
- Cardiac Fibroblasts Myocardium
-
Fibroblasts
- Cardiac Fibroblasts Myocardium
-
Brain (Nervous System)
- Choroid Plexus Progenitor Cells Choroid Plexus
- Head Mesenchyme (Muscoskeletal System)
- Epiblast (Early Embryonic Tissues)
- Neural Crest (Gastrulation Derivatives)
-
Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for GPC3 Gene
This gene is overexpressed in Lung (x7.5), Adipose - Subcutaneous (x6.3), Nerve - Tibial (x4.6), Adipose - Visceral (Omentum) (x4.1), and Breast - Mammary Tissue (x4.0).
This gene is overexpressed in Urine (52.6) and Placenta (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GPC3 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPC3
SOURCE GeneReport for Unigene cluster for GPC3 Gene:
Hs.644108mRNA Expression by UniProt/SwissProt for GPC3 Gene:
P51654-GPC3_HUMAN
Tissue specificity:
Highly expressed in lung, liver and kidney.
Evidence on tissue expression from TISSUES for GPC3 Gene
- Liver(4.7)
- Kidney(3.4)
- Lung(3.3)
- Heart(2.8)
- Blood(2.7)
- Muscle(2.7)
- Skin(2.6)
- Gall bladder(2.6)
- Adrenal gland(2.5)
- Pancreas(2.4)
- Intestine(2.4)
- Nervous system(2.4)
- Lymph node(2.4)
- Stomach(2.4)
- Thyroid gland(2.3)
- Spleen(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for GPC3 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- endocrine
- integumentary
- lymphatic
- nervous
- reproductive
- respiratory
- skeletal muscle
- skeleton
- urinary
Regions:
Head and neck:
- brain
- cerebellum
- cerebrospinal fluid
- ear
- eye
- eyelid
- face
- head
- jaw
- lip
- mandible
- maxilla
- meninges
- mouth
- neck
- nose
- outer ear
- skull
- tongue
- tooth
Thorax:
- breast
- chest wall
- clavicle
- diaphragm
- esophagus
- heart
- heart valve
- lung
- rib
- rib cage
- scapula
- sternum
Abdomen:
- abdominal wall
- adrenal gland
- appendix
- biliary tract
- duodenum
- intestine
- kidney
- large intestine
- liver
- pancreas
- small intestine
- spleen
- stomach
Pelvis:
- pelvis
- penis
- placenta
- testicle
- ureter
- urethra
- uterus
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- nail
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- blood
- blood vessel
- peripheral nerve
- peripheral nervous system
- skin
- spinal column
- sweat gland
- vertebrae
Primer Products
-
OriGene qPCR primer pairs for GPC3
-
OriGene qPCR primer pairs and template standards for GPC3
Gene Expression Assay Products
Orthologs for GPC3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | GPC3 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | GPC3 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | GPC3 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Gpc3 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Gpc3 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | GPC3 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | GPC3 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | GPC3 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | GPC3 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | gpc3 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | gpc3 30 31 |
|
OneToOne | |
| -- 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | dally 31 |
|
OneToMany |
- Species where no ortholog for GPC3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for GPC3 Gene
- ENSEMBL:
- Gene Tree for GPC3 (if available)
- TreeFam:
- Gene Tree for GPC3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GPC3: view image
Paralogs for GPC3 Gene
Variants for GPC3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPC3 Gene
| SNP ID | Clinical significance and condition | Chr 0X pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 639319 | Uncertain Significance: Wilms tumor 1 | 133,536,273(-) | C/A | MISSENSE_VARIANT | |
| 640214 | Uncertain Significance: Wilms tumor 1 | 133,596,497(-) | T/C | MISSENSE_VARIANT | |
| 640240 | Uncertain Significance: Wilms tumor 1 | 133,754,163(-) | A/C | MISSENSE_VARIANT | |
| 641491 | Uncertain Significance: Wilms tumor 1 | 133,753,994(-) | G/C | MISSENSE_VARIANT | |
| 641745 | Uncertain Significance: Wilms tumor 1 | 133,753,943(-) | C/T | MISSENSE_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2740486 | CNV | deletion | 23290073 |
| esv3559353 | CNV | deletion | 23714750 |
| esv3574595 | CNV | loss | 25503493 |
| esv3574596 | CNV | loss | 25503493 |
| esv3574597 | CNV | loss | 25503493 |
| esv3574599 | CNV | loss | 25503493 |
| esv3577259 | CNV | gain | 25503493 |
| esv3577260 | CNV | gain | 25503493 |
Residual Variation Intolerance Score:
44.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.60;
30.79% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GPC3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPC3 Gene
Disorders for GPC3 Gene
(55) MalaCards diseases for GPC3 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| simpson-golabi-behmel syndrome, type 1 |
|
|
| wilms tumor 1 |
|
|
| simpson-golabi-behmel syndrome |
|
|
| perlman syndrome |
|
|
| gigantism |
|
Search GPC3 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
GPC3_HUMAN- Simpson-Golabi-Behmel syndrome 1 (SGBS1) [MIM:312870]: A condition characterized by pre- and postnatal overgrowth (gigantism), facial dysmorphism and a variety of inconstant visceral and skeletal malformations. Characteristic dysmorphic features include macrocephaly with coarse, distinctive facies with a large protruding jaw, broad nasal bridge and cleft palate. Cardiac defects are frequent. {ECO:0000269 PubMed:10814714}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for GPC3
No data available for Genatlas for GPC3 Gene
Publications for GPC3 Gene
- Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome. (PMID: 8589713) Pilia G … Schlessinger D (Nature genetics 1996) 2 3 4 23
- The Simpson-Golabi-Behmel syndrome causative glypican-3, binds to and inhibits the dipeptidyl peptidase activity of CD26. (PMID: 17549790) Davoodi J … MacKenzie AE (Proteomics 2007) 3 4 23
- Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss-of-function mutations in the GPC3 gene. (PMID: 10814714) Veugelers M … David G (Human molecular genetics 2000) 3 4 23
- GPC4, the gene for human K-glypican, flanks GPC3 on xq26: deletion of the GPC3-GPC4 gene cluster in one family with Simpson-Golabi-Behmel syndrome. (PMID: 9787072) Veugelers M … David G (Genomics 1998) 2 3 23
- Analysis of exon/intron structure and 400 kb of genomic sequence surrounding the 5'-promoter and 3'-terminal ends of the human glypican 3 (GPC3) gene. (PMID: 9339360) Huber R … Pilia G (Genomics 1997) 3 4 23
ExternalLinks
Products for GPC3 Gene
- View all 17 R&D Systems GPC3 (Glypican 3) Products
- View all R&D Systems GPC3 (Glypican 3) Proteins and Enzymes
- View all 12 R&D Systems GPC3 (Glypican 3) Primary Antibodies
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- View all R&D Systems GPC3 (Glypican 3) cDNA Clones
- Learn more about R&D Systems custom GPC3 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for GPC3
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- Browse OriGene Inhibitory RNA Products For GPC3
- OriGene qPCR primer pairs for GPC3
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- OriGene CRISPR knockouts for GPC3
- MG209076
- MR209076
- MR209076L3
- MR209076L4
- RC205911
- RC205911L1
- RC205911L2
- RC205911L3
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- RC228429
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- RC228459
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- RR204246
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- RC205911L1V
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- RC228459L3V
- RC228459L4V
- RC228491L1V
- RC228491L2V
- RC228491L3V
- RC228491L4V
- RR204246L3V
- RR204246L4V
- RC402730
- RC402731
- RC402732
- RC402733
- RC402734
- RC402735
- RC402736
- RC402737
- RC402738
- RC402739
- RC402740
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For GPC3
- Sino Biological Human cDNA Clone for GPC3
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- Browse Antibodies
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- ProSpec Recombinant Proteins for GPC3
- ESI BIO PureStem MEL2, NCr-fac Progenitor for GPC3
- Invitrogen Antibodies for GPC3 (AFLGC-GPC3)
- VectorBuilder Custom and pre-made DNA vectors for GPC3 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for GPC3 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for GPC3 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for GPC3 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for GPC3
- Addgene plasmids for GPC3
- antibodies-online: Show 55 available Glypican 3 Antibodies ranked by validation data
- Compare Top Glypican 3 Antibodies
- Recommended
- 155 IHC (p) Antibodies (anti-human)
- 114 WB Antibodies (anti-human)
- 63 IHC (f) Antibodies (anti-human)
- 59 IHC Antibodies (anti-human)
- 32 FACS Antibodies (anti-human)
- 12 IF Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 54 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 70 IHC (p) Antibodies (anti-rat)
- 49 IHC Antibodies (anti-rat)
- 28 WB Antibodies (anti-rat)
- 21 IHC (f) Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 8 FACS Antibodies (anti-rat)
- antibodies-online: Show 54 available Glypican 3 Elisa Kits ranked by validation data
- Compare Top Glypican 3 Elisa Kits
- Quality Products:
- ABIN414787
- ABIN1115231
- ABIN365731
- ABIN1028748
- ABIN5676186
- ABIN2703060
- ABIN5520733
- ABIN455244
- ABIN5668585
- ABIN511363
- ABIN857192
- ABIN1884417
- ABIN5520734
- ABIN5669804
- ABIN627904
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- ABIN5069025
- ABIN1135309
- ABIN840429
- ABIN431855
- ABIN1570114
- ABIN1884418
- ABIN5520735
- ABIN5670472
- ABIN627090
- ABIN5654781
- ABIN2534048
- ABIN2947983
- antibodies-online: Show 37 available Glypican 3 Proteins ranked by validation data
- Compare Top Glypican 3 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for GPC3
- Search Santa Cruz Biotechnology (SCBT) for GPC3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for GPC3
- Horizon Cell Lines for GPC3
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GPC3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GPC3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for GPC3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPC3
Sources for GPC3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB