GPC3 Gene (Protein Coding)

Glypican 3

GC0XM133535
GIFtS:
45
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the con... See more...

Aliases for GPC3 Gene

Aliases for GPC3 Gene

  • Glypican 3 2 3 5
  • Intestinal Protein OCI-5 3 4
  • Glypican Proteoglycan 3 2 3
  • Glypican-3 3 4
  • GTR2-2 3 4
  • OCI-5 2 3
  • SGBS1 2 3
  • DGSX 2 3
  • MXR7 3 4
  • SGBS 2 3
  • SGB 2 3
  • Heparan Sulphate Proteoglycan 3
  • Secreted Glypican-3 3
  • SDYS 3
  • GPC3 5
  • OCI5 4

External Ids for GPC3 Gene

Previous HGNC Symbols for GPC3 Gene

  • SDYS

Previous GeneCards Identifiers for GPC3 Gene

  • GC0XM127315
  • GC0XM129515
  • GC0XM130614
  • GC0XM131375
  • GC0XM132395
  • GC0XM132497
  • GC0XM132669
  • GC0XM122070

Summaries for GPC3 Gene

Entrez Gene Summary for GPC3 Gene

  • Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

GeneCards Summary for GPC3 Gene

GPC3 (Glypican 3) is a Protein Coding gene. Diseases associated with GPC3 include Simpson-Golabi-Behmel Syndrome, Type 1 and Wilms Tumor 1. Among its related pathways are Signaling by GPCR and Metabolism of fat-soluble vitamins. Gene Ontology (GO) annotations related to this gene include heparan sulfate proteoglycan binding and peptidyl-dipeptidase inhibitor activity. An important paralog of this gene is GPC5.

UniProtKB/Swiss-Prot Summary for GPC3 Gene

  • Cell surface proteoglycan that bears heparan sulfate (PubMed:14610063). Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity). Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands (PubMed:16227623, PubMed:24496449). Positively regulates the non-canonical Wnt signaling pathway (By similarity). Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression (By similarity). Inhibits the dipeptidyl peptidase activity of DPP4 (PubMed:17549790). Plays a role in limb patterning and skeletal development by controlling the cellular response to BMP4 (By similarity). Modulates the effects of growth factors BMP2, BMP7 and FGF7 on renal branching morphogenesis (By similarity). Required for coronary vascular development (By similarity). Plays a role in regulating cell movements during gastrulation (By similarity).

Gene Wiki entry for GPC3 Gene

Additional gene information for GPC3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPC3 Gene

Genomics for GPC3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for GPC3 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH0XJ133978 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 606.4 +2.9 2858 8.1 HNRNPL ZNF692 RBFOX2 PATZ1 ZNF501 ZNF600 CEBPA ZNF561 SCRT2 MGA GPC3 GPC3-AS1 GPC4
GH0XJ133987 Enhancer 0.9 FANTOM5 dbSUPER 608.4 -1.8 -1830 0.3 GATAD2A TFE3 SOX13 RXRB GABPA CEBPA TCF7 FOXA2 TEAD1 CREM GPC3 ENSG00000232068 lnc-CCDC160-4 CCDC160
GH0XJ134171 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 5.6 -187.5 -187503 5.8 PRDM10 ZNF143 ZIC2 PATZ1 MGA SP2 ZBTB10 ZNF580 USF1 ZBTB26 ENSG00000283638 CCDC160 GPC3 PHF6 MIR106A
GH0XJ134025 Enhancer 1 FANTOM5 ENCODE 7.4 -40.9 -40870 1.9 GATAD2A CTCF PRDM10 RXRB IRF2 GABPA ZNF600 CEBPA KMT2B CEBPB GPC3 piR-50444-508 RF00017-8727 CCDC160
GH0XJ134021 Enhancer 0.5 ENCODE 12.6 -35.9 -35909 0.6 GATAD2A CTCF ZNF654 RAD21 SMC3 piR-50444-508 ENSG00000232068 GPC3 RF00017-8726 CCDC160
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPC3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPC3

Top Transcription factor binding sites by QIAGEN in the GPC3 gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • C/EBPalpha
  • Egr-3
  • POU2F1
  • POU2F1a
  • Sox9
  • SRY
  • STAT5A

Genomic Locations for GPC3 Gene

Genomic Locations for GPC3 Gene
chrX:133,535,745-133,985,616
(GRCh38/hg38)
Size:
449,872 bases
Orientation:
Minus strand
chrX:132,669,773-133,119,922
(GRCh37/hg19)
Size:
450,150 bases
Orientation:
Minus strand

Genomic View for GPC3 Gene

Genes around GPC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPC3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GPC3 Gene

Proteins for GPC3 Gene

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  • Protein details for GPC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51654-GPC3_HUMAN
    Recommended name:
    Glypican-3
    Protein Accession:
    P51654
    Secondary Accessions:
    • C9JLE3
    • G3V1R0
    • Q2L880
    • Q2L882

    Protein attributes for GPC3 Gene

    Size:
    580 amino acids
    Molecular mass:
    65563 Da
    Quaternary structure:
    • Heterodimer; disulfide-linked (PubMed:14610063). Cleavage by a furin-like convertase results in production of alpha and beta chains which form a disulfide-linked heterodimer (PubMed:14610063). Interacts with DPP4 (PubMed:17549790). Interacts with FGF2 (By similarity). Interacts with WNT5A (PubMed:14610063). Also interacts with WNT3A and WNT7B (PubMed:16227623). Interacts with hedgehog protein SHH; the heparan sulfate chains are not required for the interaction (By similarity). Also interacts with hedgehog protein IHH (By similarity). Interacts with CD81 (By similarity). Interacts with Wnt receptors FZD4, FZD7 and FZD8; the heparan sulfate chains are required for the interaction (PubMed:24496449).
    Miscellaneous:
    • Used as a marker for hepatocellular carcinoma (HCC) as it is expressed in HCC but is not detectable in hepatocytes from normal or benign liver diseases (PubMed:12851874). When attached to the cell surface, stimulates the growth of HCC cells by increasing canonical Wnt signaling (PubMed:16024626). Cleavage is not required for stimulation of Wnt signaling or HCC growth (PubMed:16227623).

    Alternative splice isoforms for GPC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPC3 Gene

Protein Expression for GPC3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for GPC3 Gene

  • O-glycosylated; contains heparan sulfate.
  • Cleaved intracellularly by a furin-like convertase to generate 2 subunits, alpha and beta, which remain associated through disulfide bonds and are associated with the cell surface via the GPI-anchor (PubMed:14610063). This processing is essential for its role in inhibition of hedgehog signaling (PubMed:25653284). A second proteolytic event may result in cleavage of the protein on the cell surface, separating it from the GPI-anchor and leading to its shedding from the cell surface (PubMed:14610063).
  • Glycosylation at Asn124, Asn241, Ser359, Asn418, Ser495, and Ser509
  • Modification sites at PhosphoSitePlus

Other Protein References for GPC3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for GPC3 Gene

Domains & Families for GPC3 Gene

Gene Families for GPC3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for GPC3 Gene

InterPro:
Blocks:
  • Glypican
ProtoNet:

Suggested Antigen Peptide Sequences for GPC3 Gene

GenScript: Design optimal peptide antigens:
  • Glypican 3 (B1AJP6_HUMAN)
  • MXR7 (GPC3_HUMAN)
  • Glypican-3 splice variant C (Q2L880_HUMAN)
  • Glypican-3 splice variant B (Q2L882_HUMAN)
  • Glypican-3 splice variant A (Q53H15_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P51654

UniProtKB/Swiss-Prot:

GPC3_HUMAN :
  • Belongs to the glypican family.
Family:
  • Belongs to the glypican family.
genes like me logo Genes that share domains with GPC3: view

Function for GPC3 Gene

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  6. Cell Line

Molecular function for GPC3 Gene

UniProtKB/Swiss-Prot Function:
Cell surface proteoglycan that bears heparan sulfate (PubMed:14610063). Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity). Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands (PubMed:16227623, PubMed:24496449). Positively regulates the non-canonical Wnt signaling pathway (By similarity). Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression (By similarity). Inhibits the dipeptidyl peptidase activity of DPP4 (PubMed:17549790). Plays a role in limb patterning and skeletal development by controlling the cellular response to BMP4 (By similarity). Modulates the effects of growth factors BMP2, BMP7 and FGF7 on renal branching morphogenesis (By similarity). Required for coronary vascular development (By similarity). Plays a role in regulating cell movements during gastrulation (By similarity).
GENATLAS Biochemistry:
glypican 3,60kDa,putative extracellular proteoglycan,involved in growth control in embryonic mesodermal tissues,complexing with and putative modulator of IGF2,juxtaposed to GPC4,with tumor suppression activity

Phenotypes From GWAS Catalog for GPC3 Gene

Gene Ontology (GO) - Molecular Function for GPC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17549790
GO:0030414 peptidase inhibitor activity IEA --
GO:0060422 peptidyl-dipeptidase inhibitor activity IDA 17549790
genes like me logo Genes that share ontologies with GPC3: view
genes like me logo Genes that share phenotypes with GPC3: view

Human Phenotype Ontology for GPC3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for GPC3 Gene

MGI Knock Outs for GPC3:

Animal Model Products

CRISPR Products

miRNA for GPC3 Gene

miRTarBase miRNAs that target GPC3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPC3

Clone Products

  • Addgene plasmids for GPC3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for GPC3 Gene

Localization for GPC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPC3 Gene

Cell membrane. Lipid-anchor, GPI-anchor. Extracellular side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPC3 gene
Compartment Confidence
plasma membrane 5
extracellular 4
endoplasmic reticulum 4
lysosome 4
golgi apparatus 4
cytoskeleton 2
mitochondrion 2
peroxisome 2
nucleus 2
cytosol 2
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IBA 21873635
GO:0005764 lysosome IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005796 Golgi lumen TAS --
GO:0005886 plasma membrane IEA,TAS --
genes like me logo Genes that share ontologies with GPC3: view

Pathways & Interactions for GPC3 Gene

genes like me logo Genes that share pathways with GPC3: view

SIGNOR curated interactions for GPC3 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for GPC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0001658 branching involved in ureteric bud morphogenesis IEA --
GO:0001822 kidney development IEA --
GO:0006024 glycosaminoglycan biosynthetic process TAS --
GO:0006027 glycosaminoglycan catabolic process TAS --
genes like me logo Genes that share ontologies with GPC3: view

Drugs & Compounds for GPC3 Gene

Products:

  1. Drug

(15) Drugs for GPC3 Gene - From: ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fludarabine Approved Pharma DNA synthsis inhibitor 1533,1533
Cyclophosphamide Approved, Investigational Pharma Nitrogen mustard alkylating agent and prodrug. 3670
Decitabine Approved, Investigational Pharma DNA methyltransferase inhibitor 388
Tyrosine Approved, Investigational Nutra 1044
Alkylating Agents Pharma 5372

(5) Additional Compounds for GPC3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with GPC3: view

Transcripts for GPC3 Gene

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  2. miRNA
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mRNA/cDNA for GPC3 Gene

4 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPC3

Clone Products

  • Addgene plasmids for GPC3

Alternative Splicing Database (ASD) splice patterns (SP) for GPC3 Gene

No ASD Table

Relevant External Links for GPC3 Gene

GeneLoc Exon Structure for
GPC3

Expression for GPC3 Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPC3 Gene

mRNA expression in normal human tissues for GPC3 Gene
mRNA expression by BioGPS for GPC3 GenemRNA expression by GTEx for GPC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPC3 Gene

This gene is overexpressed in Lung (x7.5), Adipose - Subcutaneous (x6.3), Nerve - Tibial (x4.6), Adipose - Visceral (Omentum) (x4.1), and Breast - Mammary Tissue (x4.0).

Protein differential expression in normal tissues from HIPED for GPC3 Gene

This gene is overexpressed in Urine (52.6) and Placenta (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GPC3 Gene



Protein tissue co-expression partners for GPC3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPC3

SOURCE GeneReport for Unigene cluster for GPC3 Gene:

Hs.644108

mRNA Expression by UniProt/SwissProt for GPC3 Gene:

P51654-GPC3_HUMAN
Tissue specificity: Highly expressed in lung, liver and kidney.

Evidence on tissue expression from TISSUES for GPC3 Gene

  • Liver(4.7)
  • Kidney(3.4)
  • Lung(3.3)
  • Heart(2.8)
  • Blood(2.7)
  • Muscle(2.7)
  • Skin(2.6)
  • Gall bladder(2.6)
  • Adrenal gland(2.5)
  • Pancreas(2.4)
  • Intestine(2.4)
  • Nervous system(2.4)
  • Lymph node(2.4)
  • Stomach(2.4)
  • Thyroid gland(2.3)
  • Spleen(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for GPC3 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cerebellum
  • cerebrospinal fluid
  • ear
  • eye
  • eyelid
  • face
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • meninges
  • mouth
  • neck
  • nose
  • outer ear
  • skull
  • tongue
  • tooth
Thorax:
  • breast
  • chest wall
  • clavicle
  • diaphragm
  • esophagus
  • heart
  • heart valve
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • abdominal wall
  • adrenal gland
  • appendix
  • biliary tract
  • duodenum
  • intestine
  • kidney
  • large intestine
  • liver
  • pancreas
  • small intestine
  • spleen
  • stomach
Pelvis:
  • pelvis
  • penis
  • placenta
  • testicle
  • ureter
  • urethra
  • uterus
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • nail
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal column
  • sweat gland
  • vertebrae
genes like me logo Genes that share expression patterns with GPC3: view

Orthologs for GPC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPC3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia GPC3 30 31
  • 99.14 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia GPC3 30 31
  • 93.28 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia GPC3 30 31
  • 92.18 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Gpc3 30
  • 90.78 (n)
Mouse
(Mus musculus)
 Mammalia Gpc3 30 17 31
  • 90.73 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia GPC3 31
  • 74 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia GPC3 31
  • 70 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves GPC3 30 31
  • 69.84 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia GPC3 31
  • 59 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia gpc3 30
  • 63.69 (n)
Zebrafish
(Danio rerio)
 Actinopterygii gpc3 30 31
  • 53.76 (n)
 OneToOne
-- 30
Fruit Fly
(Drosophila melanogaster)
 Insecta dally 31
  • 19 (a)
 OneToMany
Species where no ortholog for GPC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GPC3 Gene

ENSEMBL:
Gene Tree for GPC3 (if available)
TreeFam:
Gene Tree for GPC3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPC3: view image

Paralogs for GPC3 Gene

Paralogs for GPC3 Gene

(1) SIMAP similar genes for GPC3 Gene using alignment to 5 proteins:

  • GPC3_HUMAN
  • H0Y3U6_HUMAN
  • I6QTG3_HUMAN
  • Q53H15_HUMAN
  • Q8IYG2_HUMAN
genes like me logo Genes that share paralogs with GPC3: view

Variants for GPC3 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPC3 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
639319 Uncertain Significance: Wilms tumor 1 133,536,273(-) C/A MISSENSE_VARIANT
640214 Uncertain Significance: Wilms tumor 1 133,596,497(-) T/C MISSENSE_VARIANT
640240 Uncertain Significance: Wilms tumor 1 133,754,163(-) A/C MISSENSE_VARIANT
641491 Uncertain Significance: Wilms tumor 1 133,753,994(-) G/C MISSENSE_VARIANT
641745 Uncertain Significance: Wilms tumor 1 133,753,943(-) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for GPC3 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPC3 Gene

Variant ID Type Subtype PubMed ID
esv2740486 CNV deletion 23290073
esv3559353 CNV deletion 23714750
esv3574595 CNV loss 25503493
esv3574596 CNV loss 25503493
esv3574597 CNV loss 25503493
esv3574599 CNV loss 25503493
esv3577259 CNV gain 25503493
esv3577260 CNV gain 25503493

Variation tolerance for GPC3 Gene

Residual Variation Intolerance Score: 44.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.60; 30.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPC3 Gene

Human Gene Mutation Database (HGMD)
GPC3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPC3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPC3 Gene

Disorders for GPC3 Gene

MalaCards: The human disease database

(55) MalaCards diseases for GPC3 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search GPC3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

GPC3_HUMAN
  • Simpson-Golabi-Behmel syndrome 1 (SGBS1) [MIM:312870]: A condition characterized by pre- and postnatal overgrowth (gigantism), facial dysmorphism and a variety of inconstant visceral and skeletal malformations. Characteristic dysmorphic features include macrocephaly with coarse, distinctive facies with a large protruding jaw, broad nasal bridge and cleft palate. Cardiac defects are frequent. {ECO:0000269 PubMed:10814714}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for GPC3

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with GPC3: view

No data available for Genatlas for GPC3 Gene

Publications for GPC3 Gene

  1. Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome. (PMID: 8589713) Pilia G … Schlessinger D (Nature genetics 1996) 2 3 4 23
  2. The Simpson-Golabi-Behmel syndrome causative glypican-3, binds to and inhibits the dipeptidyl peptidase activity of CD26. (PMID: 17549790) Davoodi J … MacKenzie AE (Proteomics 2007) 3 4 23
  3. Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss-of-function mutations in the GPC3 gene. (PMID: 10814714) Veugelers M … David G (Human molecular genetics 2000) 3 4 23
  4. GPC4, the gene for human K-glypican, flanks GPC3 on xq26: deletion of the GPC3-GPC4 gene cluster in one family with Simpson-Golabi-Behmel syndrome. (PMID: 9787072) Veugelers M … David G (Genomics 1998) 2 3 23
  5. Analysis of exon/intron structure and 400 kb of genomic sequence surrounding the 5'-promoter and 3'-terminal ends of the human glypican 3 (GPC3) gene. (PMID: 9339360) Huber R … Pilia G (Genomics 1997) 3 4 23

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Sources for GPC3 Gene