Aliases for GPC2 Gene

Aliases for GPC2 Gene

  • Glypican 2 2 3 5
  • Glypican Proteoglycan 2, Cerebroglycan Proteoglycan 2 3
  • Glypican-2 3 4
  • Cerebroglycan Proteoglycan 3
  • Glypican 2 (Cerebroglycan) 2

External Ids for GPC2 Gene

Previous GeneCards Identifiers for GPC2 Gene

  • GC00U990124
  • GC07M099364
  • GC07M099378
  • GC07M099411
  • GC07M099595
  • GC07M099768
  • GC07M094402
  • GC07M099777
  • GC07M099792
  • GC07M100173
  • GC07M100195
  • GC07M100207
  • GC07M100213
  • GC07M100174
  • GC07M100182

Summaries for GPC2 Gene

GeneCards Summary for GPC2 Gene

GPC2 (Glypican 2) is a Protein Coding gene. Diseases associated with GPC2 include Central Corneal Ulcer and Tumoral Calcinosis, Hyperphosphatemic, Familial, 1. Among its related pathways are Microglia Activation During Neuroinflammation: Overview and Chondroitin sulfate/dermatan sulfate metabolism. Gene Ontology (GO) annotations related to this gene include heparan sulfate proteoglycan binding. An important paralog of this gene is GPC6.

UniProtKB/Swiss-Prot Summary for GPC2 Gene

  • Cell surface proteoglycan that bears heparan sulfate. May fulfill a function related to the motile behaviors of developing neurons (By similarity).

Gene Wiki entry for GPC2 Gene

Additional gene information for GPC2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPC2 Gene

Genomics for GPC2 Gene

GeneHancer (GH) Regulatory Elements for GPC2 Gene

Promoters and enhancers for GPC2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPC2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPC2

Top Transcription factor binding sites by QIAGEN in the GPC2 gene promoter:
  • AREB6
  • c-Myc
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Max1
  • Sp1

Genomic Locations for GPC2 Gene

Genomic Locations for GPC2 Gene
chr7:100,169,606-100,177,426
(GRCh38/hg38)
Size:
7,821 bases
Orientation:
Minus strand
chr7:99,767,229-99,774,995
(GRCh37/hg19)
Size:
7,767 bases
Orientation:
Minus strand

Genomic View for GPC2 Gene

Genes around GPC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPC2 Gene

Proteins for GPC2 Gene

  • Protein details for GPC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N158-GPC2_HUMAN
    Recommended name:
    Glypican-2
    Protein Accession:
    Q8N158
    Secondary Accessions:
    • A4D2A7

    Protein attributes for GPC2 Gene

    Size:
    579 amino acids
    Molecular mass:
    62830 Da
    Quaternary structure:
    • Interacts (via heparan sulfate) with PTN; this interaction promotes neurite outgrowth through binding of PTN with chondroitin sulfate of proteoglycans, thereby releasing PTPRS of chondroitin sulfate proteoglycans (CSPGs) and leading to binding with heparan sulfate of GPC2. Interacts (heparan sulfate chain) with MDK; this interaction is inhibited by heparin followed by chondroitin sulfate E; this interaction induces GPC2 clustering through heparan sulfate chain; this interaction induces neuronal cell adhesion and neurite outgrowth (By similarity).

neXtProt entry for GPC2 Gene

Post-translational modifications for GPC2 Gene

  • Glycosylation at Ser55, Ser92, Ser155, Ser500, and Ser502
  • Modification sites at PhosphoSitePlus

Other Protein References for GPC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPC2 Gene

Domains & Families for GPC2 Gene

Gene Families for GPC2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GPC2 Gene

Blocks:
  • Glypican
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPC2 Gene

GenScript: Design optimal peptide antigens:
  • Glypican-2 (GPC2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N158

UniProtKB/Swiss-Prot:

GPC2_HUMAN :
  • Belongs to the glypican family.
Family:
  • Belongs to the glypican family.
genes like me logo Genes that share domains with GPC2: view

Function for GPC2 Gene

Molecular function for GPC2 Gene

UniProtKB/Swiss-Prot Function:
Cell surface proteoglycan that bears heparan sulfate. May fulfill a function related to the motile behaviors of developing neurons (By similarity).

Phenotypes From GWAS Catalog for GPC2 Gene

Gene Ontology (GO) - Molecular Function for GPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 29162697
genes like me logo Genes that share ontologies with GPC2: view
genes like me logo Genes that share phenotypes with GPC2: view

Animal Models for GPC2 Gene

MGI Knock Outs for GPC2:
  • Gpc2 Gpc2<tm1.1(KOMP)Vlcg>
  • Gpc2 Gpc2<tm1Alan>

Animal Model Products

  • Taconic Biosciences Mouse Models for GPC2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPC2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GPC2 Gene

Localization for GPC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPC2 Gene

Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.
[Secreted glypican-2]: Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPC2 gene
Compartment Confidence
plasma membrane 4
extracellular 4
endoplasmic reticulum 4
lysosome 4
golgi apparatus 4
cytoskeleton 2
nucleus 2
cytosol 2
mitochondrion 1
peroxisome 1
endosome 1

Gene Ontology (GO) - Cellular Components for GPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IBA 21873635
GO:0005615 extracellular space IEA --
GO:0005783 endoplasmic reticulum IDA --
GO:0005796 Golgi lumen TAS --
GO:0005886 plasma membrane TAS,IEA --
genes like me logo Genes that share ontologies with GPC2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPC2 Gene

Pathways & Interactions for GPC2 Gene

genes like me logo Genes that share pathways with GPC2: view

Gene Ontology (GO) - Biological Process for GPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0006024 glycosaminoglycan biosynthetic process TAS --
GO:0006027 glycosaminoglycan catabolic process TAS --
GO:0007224 smoothened signaling pathway IEA,IBA 21873635
GO:0009966 regulation of signal transduction IEA --
genes like me logo Genes that share ontologies with GPC2: view

No data available for SIGNOR curated interactions for GPC2 Gene

Drugs & Compounds for GPC2 Gene

No Compound Related Data Available

Transcripts for GPC2 Gene

mRNA/cDNA for GPC2 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPC2

Alternative Splicing Database (ASD) splice patterns (SP) for GPC2 Gene

No ASD Table

Relevant External Links for GPC2 Gene

GeneLoc Exon Structure for
GPC2

Expression for GPC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPC2 Gene

This gene is overexpressed in Testis (x8.9) and Skin - Not Sun Exposed (Suprapubic) (x4.8).

Protein differential expression in normal tissues from HIPED for GPC2 Gene

This gene is overexpressed in Fetal Brain (56.2) and Testis (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPC2 Gene



Protein tissue co-expression partners for GPC2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPC2

SOURCE GeneReport for Unigene cluster for GPC2 Gene:

Hs.211701

Evidence on tissue expression from TISSUES for GPC2 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with GPC2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPC2 Gene

Orthologs for GPC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPC2 31 30
  • 99.21 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GPC2 31 30
  • 82.98 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GPC2 31 30
  • 82.87 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gpc2 17 31 30
  • 81.56 (n)
rat
(Rattus norvegicus)
Mammalia Gpc2 30
  • 81.47 (n)
oppossum
(Monodelphis domestica)
Mammalia GPC2 31
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPC2 31
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 31
  • 20 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 24 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii gpc2 31
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta dlp 31
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gpn-1 31
  • 21 (a)
OneToMany
Species where no ortholog for GPC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GPC2 Gene

ENSEMBL:
Gene Tree for GPC2 (if available)
TreeFam:
Gene Tree for GPC2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPC2: view image

Paralogs for GPC2 Gene

Paralogs for GPC2 Gene

(3) SIMAP similar genes for GPC2 Gene using alignment to 1 proteins:

  • GPC2_HUMAN
genes like me logo Genes that share paralogs with GPC2: view

Variants for GPC2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPC2 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs1333017606 A breast cancer sample p.Asp200Asn

Additional dbSNP identifiers (rs#s) for GPC2 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPC2 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV deletion 23290073
nsv428180 CNV gain 18775914
nsv5867 CNV deletion 18451855
nsv607931 CNV loss 21841781

Variation tolerance for GPC2 Gene

Residual Variation Intolerance Score: 35.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.08; 21.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPC2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPC2 Gene

Disorders for GPC2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GPC2 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search GPC2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GPC2

genes like me logo Genes that share disorders with GPC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPC2 Gene

Publications for GPC2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 54
  4. Cerebroglycan: an integral membrane heparan sulfate proteoglycan that is unique to the developing nervous system and expressed specifically during neuronal differentiation. (PMID: 8294498) Stipp CS … Lander AD (The Journal of cell biology 1994) 2 3 54
  5. EB1-binding-myomegalin protein complex promotes centrosomal microtubules functions. (PMID: 29162697) Bouguenina H … Badache A (Proceedings of the National Academy of Sciences of the United States of America 2017) 3 54

Products for GPC2 Gene

  • Signalway ELISA kits for GPC2
  • Signalway Proteins for GPC2

Sources for GPC2 Gene