Free for academic non-profit institutions. Other users need a Commercial license

Aliases for GPC2 Gene

Aliases for GPC2 Gene

  • Glypican 2 2 3 5
  • Glypican Proteoglycan 2, Cerebroglycan Proteoglycan 2 3
  • Glypican 2 (Cerebroglycan) 2
  • Cerebroglycan Proteoglycan 3
  • Glypican-2 3

External Ids for GPC2 Gene

Previous GeneCards Identifiers for GPC2 Gene

  • GC00U990124
  • GC07M099364
  • GC07M099378
  • GC07M099411
  • GC07M099595
  • GC07M099768
  • GC07M094402
  • GC07M099777
  • GC07M099792

Summaries for GPC2 Gene

GeneCards Summary for GPC2 Gene

GPC2 (Glypican 2) is a Protein Coding gene. Among its related pathways are Glycosaminoglycan metabolism and Chondroitin sulfate/dermatan sulfate metabolism. Gene Ontology (GO) annotations related to this gene include heparan sulfate proteoglycan binding. An important paralog of this gene is GPC6.

UniProtKB/Swiss-Prot for GPC2 Gene

  • Cell surface proteoglycan that bears heparan sulfate. May fulfill a function related to the motile behaviors of developing neurons (By similarity).

Gene Wiki entry for GPC2 Gene

Additional gene information for GPC2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPC2 Gene

Genomics for GPC2 Gene

GeneHancer (GH) Regulatory Elements for GPC2 Gene

Promoters and enhancers for GPC2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I100176 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 554.8 -0.1 -50 1.4 PKNOX1 CLOCK SIN3A YY1 ZNF335 EGR1 FOS ATF7 SP3 NFYA GPC2 STAG3 SRRT AP4M1 STAG3L5P GIGYF1 PVRIG MEPCE PTCD1 ENSG00000242798
GH07I099373 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.8 +799.1 799118 9 HDGF PKNOX1 SMAD1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 ARPC1B ZSCAN25 TRRAP ZNF655 ZNF394 TRIM4 PTCD1 LOC101927550 ZNF3 STAG3L5P
GH07I100427 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 10.8 -255.8 -255773 10.8 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 PPP1R35 MEPCE PIR54054 ZCWPW1 ZSCAN25 TRIM4 SRRT GIGYF1 ZNF3 PILRA
GH07I100894 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.8 -719.0 -718981 4.6 HDGF PKNOX1 ARID4B SIN3A ZNF2 ZBTB7B ZNF143 SP3 REST ZNF592 ACHE MOSPD3 ENSG00000242798 PPP1R35 SRRT MEPCE SLC12A9 MUC3A TRIP6 ZNF3
GH07I100581 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.8 -407.2 -407241 5.9 DMAP1 YY1 ZNF213 ZNF143 SP3 NFYC ZFP41 MEF2D SSRP1 ZNF610 FBXO24 LRCH4 ZSCAN25 AP4M1 ZSCAN21 SRRT SAP25 MEPCE PPP1R35 GIGYF1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GPC2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPC2 gene promoter:

Genomic Locations for GPC2 Gene

Genomic Locations for GPC2 Gene
chr7:100,169,606-100,177,426
(GRCh38/hg38)
Size:
7,821 bases
Orientation:
Minus strand
chr7:99,767,229-99,774,995
(GRCh37/hg19)

Genomic View for GPC2 Gene

Genes around GPC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPC2 Gene

Proteins for GPC2 Gene

  • Protein details for GPC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N158-GPC2_HUMAN
    Recommended name:
    Glypican-2
    Protein Accession:
    Q8N158
    Secondary Accessions:
    • A4D2A7

    Protein attributes for GPC2 Gene

    Size:
    579 amino acids
    Molecular mass:
    62830 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPC2 Gene

Post-translational modifications for GPC2 Gene

  • Glycosylation at isoforms=55, posLast=9292, isoforms=155, isoforms=500, and isoforms=502

Other Protein References for GPC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GPC2 Gene

Domains & Families for GPC2 Gene

Gene Families for GPC2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for GPC2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GPC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N158

UniProtKB/Swiss-Prot:

GPC2_HUMAN :
  • Belongs to the glypican family.
Family:
  • Belongs to the glypican family.
genes like me logo Genes that share domains with GPC2: view

Function for GPC2 Gene

Molecular function for GPC2 Gene

UniProtKB/Swiss-Prot Function:
Cell surface proteoglycan that bears heparan sulfate. May fulfill a function related to the motile behaviors of developing neurons (By similarity).

Phenotypes From GWAS Catalog for GPC2 Gene

Gene Ontology (GO) - Molecular Function for GPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043395 heparan sulfate proteoglycan binding IEA --
genes like me logo Genes that share ontologies with GPC2: view
genes like me logo Genes that share phenotypes with GPC2: view

Animal Models for GPC2 Gene

MGI Knock Outs for GPC2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GPC2 Gene

Localization for GPC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPC2 Gene

Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.
Secreted glypican-2: Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPC2 gene
Compartment Confidence
lysosome 5
plasma membrane 4
extracellular 4
endoplasmic reticulum 4
golgi apparatus 4
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (1)
  • Nucleoli (1)
  • Nucleus (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IEA --
GO:0005783 endoplasmic reticulum IDA --
GO:0005796 Golgi lumen TAS --
genes like me logo Genes that share ontologies with GPC2: view

Pathways & Interactions for GPC2 Gene

genes like me logo Genes that share pathways with GPC2: view

Gene Ontology (GO) - Biological Process for GPC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0006024 glycosaminoglycan biosynthetic process TAS --
GO:0006027 glycosaminoglycan catabolic process TAS --
GO:0007224 smoothened signaling pathway IEA --
GO:0030182 neuron differentiation IEA --
genes like me logo Genes that share ontologies with GPC2: view

No data available for SIGNOR curated interactions for GPC2 Gene

Drugs & Compounds for GPC2 Gene

No Compound Related Data Available

Transcripts for GPC2 Gene

Unigene Clusters for GPC2 Gene

Glypican 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPC2 Gene

No ASD Table

Relevant External Links for GPC2 Gene

GeneLoc Exon Structure for
GPC2
ECgene alternative splicing isoforms for
GPC2

Expression for GPC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPC2 Gene

This gene is overexpressed in Testis (x8.9) and Skin - Not Sun Exposed (Suprapubic) (x4.8).

Protein differential expression in normal tissues from HIPED for GPC2 Gene

This gene is overexpressed in Fetal Brain (56.2) and Testis (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPC2 Gene



Protein tissue co-expression partners for GPC2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPC2 Gene:

GPC2

SOURCE GeneReport for Unigene cluster for GPC2 Gene:

Hs.211701

Evidence on tissue expression from TISSUES for GPC2 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with GPC2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPC2 Gene

Orthologs for GPC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPC2 33 34
  • 99.21 (n)
dog
(Canis familiaris)
Mammalia GPC2 33 34
  • 82.98 (n)
cow
(Bos Taurus)
Mammalia GPC2 33 34
  • 82.87 (n)
mouse
(Mus musculus)
Mammalia Gpc2 33 16 34
  • 81.56 (n)
rat
(Rattus norvegicus)
Mammalia Gpc2 33
  • 81.47 (n)
oppossum
(Monodelphis domestica)
Mammalia GPC2 34
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPC2 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 20 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 24 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii gpc2 34
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta dlp 34
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gpn-1 34
  • 21 (a)
OneToMany
Species where no ortholog for GPC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GPC2 Gene

ENSEMBL:
Gene Tree for GPC2 (if available)
TreeFam:
Gene Tree for GPC2 (if available)

Paralogs for GPC2 Gene

Paralogs for GPC2 Gene

(3) SIMAP similar genes for GPC2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GPC2: view

Variants for GPC2 Gene

Sequence variations from dbSNP and Humsavar for GPC2 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
VAR_036045 A breast cancer sample p.Asp200Asn
rs1000133510 -- 100,178,744(-) A/G upstream_transcript_variant
rs1000195303 -- 100,176,809(-) G/A/T intron_variant
rs1000444312 -- 100,170,683(-) A/G intron_variant
rs1000485949 -- 100,179,075(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GPC2 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV deletion 23290073
nsv428180 CNV gain 18775914
nsv5867 CNV deletion 18451855
nsv607931 CNV loss 21841781

Variation tolerance for GPC2 Gene

Residual Variation Intolerance Score: 35.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.08; 21.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPC2 Gene

Disorders for GPC2 Gene

Additional Disease Information for GPC2

No disorders were found for GPC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPC2 Gene

Publications for GPC2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  4. Cerebroglycan: an integral membrane heparan sulfate proteoglycan that is unique to the developing nervous system and expressed specifically during neuronal differentiation. (PMID: 8294498) Stipp CS … Lander AD (The Journal of cell biology 1994) 2 3 58
  5. Identification of GPC2 as an Oncoprotein and Candidate Immunotherapeutic Target in High-Risk Neuroblastoma. (PMID: 28898695) Bosse KR … Maris JM (Cancer cell 2017) 3 58

Products for GPC2 Gene

Sources for GPC2 Gene

Content
Loading form....