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GPC2 (Glypican 2) is a Protein Coding gene. Diseases associated with GPC2 include Omodysplasia and Hereditary Multiple Exostoses. Among its related pathways are Signaling by GPCR and Metabolism of fat-soluble vitamins. Gene Ontology (GO) annotations related to this gene include heparan sulfate proteoglycan binding. An important paralog of this gene is GPC6.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 29162697 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IBA | 21873635 |
GO:0005615 | extracellular space | IEA | -- |
GO:0005783 | endoplasmic reticulum | IDA | -- |
GO:0005796 | Golgi lumen | TAS | -- |
GO:0005886 | plasma membrane | IEA,TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Chondroitin sulfate/dermatan sulfate metabolism |
.01
|
|
2 | Glycosaminoglycan metabolism | ||
3 | Metabolism of fat-soluble vitamins | ||
4 | mTOR signaling pathway (KEGG) |
.38
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5 | Development VEGF signaling via VEGFR2 - generic cascades |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001523 | retinoid metabolic process | TAS | -- |
GO:0006024 | glycosaminoglycan biosynthetic process | TAS | -- |
GO:0006027 | glycosaminoglycan catabolic process | TAS | -- |
GO:0007224 | smoothened signaling pathway | IEA,IBA | 21873635 |
GO:0009966 | regulation of signal transduction | IEA | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | GPC2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | GPC2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | GPC2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Gpc2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Gpc2 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | GPC2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | GPC2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | -- 31 |
|
ManyToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
ManyToMany | |
Zebrafish (Danio rerio) |
Actinopterygii | gpc2 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | dlp 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | gpn-1 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 07 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1333017606 | A breast cancer sample | p.Asp200Asn |
Disorder | Aliases | PubMed IDs |
---|---|---|
omodysplasia |
|
|
hereditary multiple exostoses |
|
|
hypotrichosis 2 |
|
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tumoral calcinosis, hyperphosphatemic, familial, 1 |
|
|