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Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq, Jul 2008]
GPC1 (Glypican 1) is a Protein Coding gene. Diseases associated with GPC1 include Biliary Atresia, Extrahepatic and Omodysplasia. Among its related pathways are Chondroitin sulfate/dermatan sulfate metabolism and Signaling by Robo receptor. Gene Ontology (GO) annotations related to this gene include copper ion binding and fibroblast growth factor binding. An important paralog of this gene is GPC6.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005507 | copper ion binding | IDA | 12732622 |
GO:0017134 | fibroblast growth factor binding | IBA,ISS | -- |
GO:0043236 | laminin binding | IEA,ISS | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IBA,HDA | 21873635 |
GO:0005615 | extracellular space | TAS | 2148568 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005768 | endosome | IEA | -- |
GO:0005796 | Golgi lumen | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Chondroitin sulfate/dermatan sulfate metabolism |
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2 | Signaling by Robo receptor | ||
3 | Glycosaminoglycan metabolism | ||
4 | Metabolism of fat-soluble vitamins | ||
5 | Microglia Activation During Neuroinflammation: Overview |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001523 | retinoid metabolic process | TAS | -- |
GO:0006024 | glycosaminoglycan biosynthetic process | TAS | -- |
GO:0006027 | glycosaminoglycan catabolic process | TAS | -- |
GO:0007411 | axon guidance | TAS | -- |
GO:0009966 | regulation of signal transduction | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Triethylenetetramine | Approved, Investigational | Pharma | Transporter, substrate | 0 |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP6: | - | - | |||||||||||||||||||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||||||||||||||||||
SP8: | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | GPC1 32 |
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cow (Bos Taurus) |
Mammalia | GPC1 33 32 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | GPC1 33 32 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Gpc1 17 33 32 |
|
||
rat (Rattus norvegicus) |
Mammalia | Gpc1 32 |
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||
oppossum (Monodelphis domestica) |
Mammalia | GPC1 33 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | GPC1 33 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | GPC1 33 32 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | GPC1 33 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | gpc1 32 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | gpc1a 33 32 |
|
OneToMany | |
GPC1 (2 of 3) 33 |
|
OneToMany | |||
gpc1b 33 |
|
OneToMany | |||
zgc63947 32 |
|
||||
fruit fly (Drosophila melanogaster) |
Insecta | dlp 33 |
|
OneToMany | |
worm (Caenorhabditis elegans) |
Secernentea | gpn-1 33 |
|
OneToMany |
SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
VAR_036044 | A breast cancer sample | p.Ala337Asp | |||
rs1000087580 | -- | 240,457,918(+) | T/C | intron_variant | |
rs1000129114 | -- | 240,438,139(+) | T/C | genic_upstream_transcript_variant, intron_variant | |
rs1000205312 | -- | 240,455,237(+) | C/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
rs1000283780 | -- | 240,442,527(+) | C/A | genic_upstream_transcript_variant, intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv7359n54 | CNV | loss | 21841781 |
esv1000024 | CNV | deletion | 20482838 |
esv1515337 | CNV | insertion | 17803354 |
esv2721931 | CNV | deletion | 23290073 |
esv2721932 | CNV | deletion | 23290073 |
esv2721933 | CNV | deletion | 23290073 |
esv2759119 | CNV | gain | 17122850 |
esv3594796 | CNV | gain | 21293372 |
esv3594798 | CNV | gain | 21293372 |
nsv1071663 | CNV | deletion | 25765185 |
nsv1122025 | CNV | deletion | 24896259 |
nsv1126584 | CNV | deletion | 24896259 |
nsv460157 | CNV | loss | 19166990 |
nsv460158 | CNV | loss | 19166990 |
nsv473084 | CNV | novel sequence insertion | 20440878 |
nsv508899 | CNV | insertion | 20534489 |
nsv516179 | CNV | loss | 19592680 |
nsv584809 | CNV | gain | 21841781 |
nsv584810 | CNV | loss | 21841781 |
nsv584811 | CNV | loss | 21841781 |
nsv819854 | CNV | gain | 19587683 |
nsv834585 | CNV | loss | 17160897 |
nsv955288 | CNV | deletion | 24416366 |
nsv997288 | CNV | gain | 25217958 |
Disorder | Aliases | PubMed IDs |
---|---|---|
biliary atresia, extrahepatic |
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omodysplasia |
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simpson-golabi-behmel syndrome, type 1 |
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body dysmorphic disorder |
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alzheimer disease |
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