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Aliases for GPBAR1 Gene

Aliases for GPBAR1 Gene

  • G Protein-Coupled Bile Acid Receptor 1 2 3 5
  • Membrane-Type Receptor For Bile Acids 3 4
  • G-Protein Coupled Receptor GPCR19 3 4
  • M-BAR 3 4
  • BG37 3 4
  • TGR5 3 4
  • G-Protein Coupled Bile Acid Receptor BG37 3
  • G-Protein Coupled Bile Acid Receptor 1 3
  • Membrane Bile Acid Receptor 3
  • HGPCR19 4
  • GPCR19 3
  • GPR131 3
  • HBG37 4

External Ids for GPBAR1 Gene

Previous GeneCards Identifiers for GPBAR1 Gene

  • GC02P217847
  • GC02P219090
  • GC02P219328
  • GC02P218949
  • GC02P218832
  • GC02P219124
  • GC02P210978

Summaries for GPBAR1 Gene

Entrez Gene Summary for GPBAR1 Gene

  • This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for GPBAR1 Gene

GPBAR1 (G Protein-Coupled Bile Acid Receptor 1) is a Protein Coding gene. Diseases associated with GPBAR1 include Sclerosing Cholangitis and Ocular Albinism. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and G-protein coupled bile acid receptor activity.

UniProtKB/Swiss-Prot for GPBAR1 Gene

  • Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids.

Tocris Summary for GPBAR1 Gene

  • GPBA receptors (TGR5, GPBAR1, M-BAR) are G protein-coupled receptors (GPCRs) that are activated by bile acids. They are highly expressed in the gallbladder, ileum and colon, and are important in the regulation of glucose and lipid metabolism, and energy utilization.

Gene Wiki entry for GPBAR1 Gene

Additional gene information for GPBAR1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPBAR1 Gene

Genomics for GPBAR1 Gene

GeneHancer (GH) Regulatory Elements for GPBAR1 Gene

Promoters and enhancers for GPBAR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I218256 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 555.8 +1.7 1676 8.9 HDGF PKNOX1 FOXA2 RB1 SIN3A IRF4 RAD21 RARA ZNF121 EGR1 GPBAR1 ENSG00000261338 ARPC2 BCS1L AAMP
GH02I218216 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 16.8 -38.9 -38911 9 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 SLC30A9 ARPC2 ENSG00000261338 GPBAR1 AAMP PNKD CXCR2P1 GC02M218215 LOC101928487 TRY-ATA1-1
GH02I218281 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.4 +30.7 30742 17.9 MLX DMAP1 IRF4 YY1 ZNF143 SP3 NFYC MEF2D GLIS1 RCOR2 TMBIM1 ENSG00000261338 SLC11A1 ANKZF1 CTDSP1 MIR26B CNOT9 ARPC2 PNKD CATIP-AS1
GH02I218228 Enhancer 1.2 Ensembl ENCODE dbSUPER 12.2 -29.3 -29273 3.7 HDGF BATF IRF4 YY1 EGR1 ATF7 ETV6 IKZF2 BCLAF1 RUNX3 ENSG00000261338 GPBAR1 AAMP CXCR1 CATIP-AS1 ARPC2 GC02M218215 TRY-ATA1-1
GH02I218321 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.6 +63.9 63885 3 PKNOX1 FOXA2 SMAD1 ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 KLF13 PNKD LOC105373881 ENSG00000261338 SLC11A1 GPBAR1 ARPC2 TMBIM1 CYP27A1 TTLL4 MIR6810
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GPBAR1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPBAR1 gene promoter:

Genomic Locations for GPBAR1 Gene

Genomic Locations for GPBAR1 Gene
chr2:218,259,496-218,263,861
(GRCh38/hg38)
Size:
4,366 bases
Orientation:
Plus strand
chr2:219,124,219-219,128,582
(GRCh37/hg19)

Genomic View for GPBAR1 Gene

Genes around GPBAR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPBAR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPBAR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPBAR1 Gene

Proteins for GPBAR1 Gene

  • Protein details for GPBAR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDU6-GPBAR_HUMAN
    Recommended name:
    G-protein coupled bile acid receptor 1
    Protein Accession:
    Q8TDU6
    Secondary Accessions:
    • B3KV35

    Protein attributes for GPBAR1 Gene

    Size:
    330 amino acids
    Molecular mass:
    35248 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPBAR1 Gene

Post-translational modifications for GPBAR1 Gene

  • Glycosylation at isoforms=4 and isoforms=76

No data available for DME Specific Peptides for GPBAR1 Gene

Domains & Families for GPBAR1 Gene

Gene Families for GPBAR1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins
  • Transporters

Protein Domains for GPBAR1 Gene

Suggested Antigen Peptide Sequences for GPBAR1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TDU6

UniProtKB/Swiss-Prot:

GPBAR_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GPBAR1: view

Function for GPBAR1 Gene

Molecular function for GPBAR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids.

Phenotypes From GWAS Catalog for GPBAR1 Gene

Gene Ontology (GO) - Molecular Function for GPBAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0038181 bile acid receptor activity IDA 12419312
GO:0038182 G-protein coupled bile acid receptor activity NAS 12419312
genes like me logo Genes that share ontologies with GPBAR1: view
genes like me logo Genes that share phenotypes with GPBAR1: view

Animal Models for GPBAR1 Gene

MGI Knock Outs for GPBAR1:

Animal Model Products

miRNA for GPBAR1 Gene

miRTarBase miRNAs that target GPBAR1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPBAR1 Gene

Localization for GPBAR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPBAR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPBAR1 gene
Compartment Confidence
plasma membrane 5
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for GPBAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 12524422
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GPBAR1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPBAR1 Gene

Pathways & Interactions for GPBAR1 Gene

genes like me logo Genes that share pathways with GPBAR1: view

Gene Ontology (GO) - Biological Process for GPBAR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0038184 cell surface bile acid receptor signaling pathway IC 12524422
GO:2000810 regulation of bicellular tight junction assembly IEA --
genes like me logo Genes that share ontologies with GPBAR1: view

No data available for SIGNOR curated interactions for GPBAR1 Gene

Drugs & Compounds for GPBAR1 Gene

(20) Drugs for GPBAR1 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
deoxycholic acid Approved Pharma Antagonist, Target 43
chenodeoxycholic acid Approved Pharma Antagonist, Target 35
cholic acid Approved Pharma Full agonist, Agonist, Target 0
cyclic amp Experimental Pharma 0
Betulinic acid Investigational Pharma Full agonist, Agonist Anti-HIV and antitumor compound,pentacyclic triterpenoid 1

(6) Additional Compounds for GPBAR1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(4) ApexBio Compounds for GPBAR1 Gene

Compound Action Cas Number
Betulinic acid Anti-HIV and antitumor compound,pentacyclic triterpenoid 472-15-1
GPBAR-A agonist of bile acid receptor GPBAR1 877052-79-4
INT-777 TGR5 receptor agonist, potent and selective 1199796-29-6
TGR5 Receptor Agonist TGR5 G-protein receptor agonist 1197300-24-5
genes like me logo Genes that share compounds with GPBAR1: view

Drug Products

Transcripts for GPBAR1 Gene

Unigene Clusters for GPBAR1 Gene

G protein-coupled bile acid receptor 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPBAR1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c
SP1: - - - - -
SP2:
SP3: - -
SP4: -

Relevant External Links for GPBAR1 Gene

GeneLoc Exon Structure for
GPBAR1
ECgene alternative splicing isoforms for
GPBAR1

Expression for GPBAR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPBAR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPBAR1 Gene

This gene is overexpressed in Whole Blood (x10.9), Adipose - Visceral (Omentum) (x7.4), and Adipose - Subcutaneous (x7.0).

NURSA nuclear receptor signaling pathways regulating expression of GPBAR1 Gene:

GPBAR1

SOURCE GeneReport for Unigene cluster for GPBAR1 Gene:

Hs.160954

mRNA Expression by UniProt/SwissProt for GPBAR1 Gene:

Q8TDU6-GPBAR_HUMAN
Tissue specificity: Ubiquitously expressed. Expressed at higher level in spleen and placenta. Expressed at lower level in other tissues. In digestive tissues, it is expressed in stomach, duodenum, ileocecum, ileum, jejunum, ascending colon, transverse colon, descending colon, cecum and liver, but not in esophagus and rectum.

Evidence on tissue expression from TISSUES for GPBAR1 Gene

  • Pancreas(4.2)
  • Spleen(4.1)
  • Gall bladder(2.9)
  • Intestine(2.5)
  • Liver(2.4)
genes like me logo Genes that share expression patterns with GPBAR1: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPBAR1 Gene

Orthologs for GPBAR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPBAR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPBAR1 33 34
  • 99.29 (n)
cow
(Bos Taurus)
Mammalia GPBAR1 33 34
  • 86.42 (n)
dog
(Canis familiaris)
Mammalia GPBAR1 33 34
  • 85.86 (n)
mouse
(Mus musculus)
Mammalia Gpbar1 33 16 34
  • 83.13 (n)
rat
(Rattus norvegicus)
Mammalia Gpbar1 33
  • 81.97 (n)
oppossum
(Monodelphis domestica)
Mammalia GPBAR1 34
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPBAR1 34
  • 32 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii GPBAR1 (1 of 2) 34
  • 39 (a)
OneToMany
GPBAR1 (2 of 2) 34
  • 39 (a)
OneToMany
Species where no ortholog for GPBAR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPBAR1 Gene

ENSEMBL:
Gene Tree for GPBAR1 (if available)
TreeFam:
Gene Tree for GPBAR1 (if available)

Paralogs for GPBAR1 Gene

No data available for Paralogs for GPBAR1 Gene

Variants for GPBAR1 Gene

Sequence variations from dbSNP and Humsavar for GPBAR1 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000235956 -- 218,259,509(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000249021 -- 218,259,150(+) C/T upstream_transcript_variant
rs1000442478 -- 218,261,514(+) G/T intron_variant
rs1000601545 -- 218,260,743(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1002239900 -- 218,262,344(+) C/G 5_prime_UTR_variant, intron_variant

Variation tolerance for GPBAR1 Gene

Residual Variation Intolerance Score: 80.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.82; 34.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPBAR1 Gene

Human Gene Mutation Database (HGMD)
GPBAR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPBAR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GPBAR1 Gene

Disorders for GPBAR1 Gene

MalaCards: The human disease database

(10) MalaCards diseases for GPBAR1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
sclerosing cholangitis
  • fibrosing cholangitis
ocular albinism
  • albinism, ocular
cholangitis
functional diarrhea
obstructive jaundice
  • cholestatic jaundice
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GPBAR1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GPBAR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPBAR1 Gene

Publications for GPBAR1 Gene

  1. Identification of membrane-type receptor for bile acids (M-BAR). (PMID: 12419312) Maruyama T … Tanaka K (Biochemical and biophysical research communications 2002) 2 3 4 22 58
  2. Genome-wide association analysis in primary sclerosing cholangitis. (PMID: 19944697) Karlsen TH … Schreiber S (Gastroenterology 2010) 3 44 58
  3. Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis. (PMID: 20811628) Hov JR … Karlsen TH (PloS one 2010) 3 44 58
  4. Preliminary report: genetic variation within the GPBAR1 gene is not associated with metabolic traits in white subjects at an increased risk for type 2 diabetes mellitus. (PMID: 19716570) Müssig K … Häring HU (Metabolism: clinical and experimental 2009) 3 44 58
  5. Involvement of membrane-type bile acid receptor M-BAR/TGR5 in bile acid-induced activation of epidermal growth factor receptor and mitogen-activated protein kinases in gastric carcinoma cells. (PMID: 17214962) Yasuda H … Yoshiba M (Biochemical and biophysical research communications 2007) 3 22 58

Products for GPBAR1 Gene

Sources for GPBAR1 Gene

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