Aliases for GPATCH3 Gene
External Ids for GPATCH3 Gene
Previous HGNC Symbols for GPATCH3 Gene
Previous GeneCards Identifiers for GPATCH3 Gene
GeneCards Summary for GPATCH3 Gene
GPATCH3 (G-Patch Domain Containing 3) is a Protein Coding gene. Diseases associated with GPATCH3 include Corneal Edema. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.
UniProtKB/Swiss-Prot Summary for GPATCH3 Gene
Involved in transcriptional regulation. It is able to activate transcription from the CXCR4 promoter and therefore it might control neural crest cell migration involved in ocular and craniofacial development (PubMed:28397860). Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial MAVS and inhibition of MAVS assembly with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6 (PubMed:28414768).