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Aliases for GPATCH2L Gene

Aliases for GPATCH2L Gene

  • G-Patch Domain Containing 2 Like 2 3 5
  • C14orf118 3 4
  • G Patch Domain-Containing Protein 2-Like 3
  • Chromosome 14 Open Reading Frame 118 2
  • KIAA1152 4

External Ids for GPATCH2L Gene

Previous HGNC Symbols for GPATCH2L Gene

  • C14orf118

Previous GeneCards Identifiers for GPATCH2L Gene

  • GC14P076619

Summaries for GPATCH2L Gene

GeneCards Summary for GPATCH2L Gene

GPATCH2L (G-Patch Domain Containing 2 Like) is a Protein Coding gene. An important paralog of this gene is GPATCH2.

Additional gene information for GPATCH2L Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPATCH2L Gene

Genomics for GPATCH2L Gene

GeneHancer (GH) Regulatory Elements for GPATCH2L Gene

Promoters and enhancers for GPATCH2L Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I076151 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 573.7 +0.5 512 2.4 SMAD1 SIN3A FEZF1 DMAP1 YBX1 POLR2B FOS KLF13 SP3 SP5 GPATCH2L ENSG00000283629 ESRRB ENSG00000258454
GH14I076154 Promoter 0.7 EPDnew 550.8 +2.5 2536 0.1 ZNF335 MLLT1 ENSG00000283629 GPATCH2L GC14P076173
GH14I075273 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 31.7 -874.1 -874065 9.2 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARID4B NEUROD1 SIN3A ZNF2 ZBTB7B FOS GC14P075279 GC14P075280 GPATCH2L FCF1 ENSG00000258559 NEK9 ABCD4 ACYP1 MLH3
GH14I077021 Promoter/Enhancer 3.1 VISTA EPDnew FANTOM5 Ensembl ENCODE dbSUPER 22.2 +882.5 882494 25.6 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 SP3 IRF2BPL LOC105370579 SNW1 ALKBH1 RPL22P2 VIPAS39 POMT2 ZMYND19P1 GPATCH2L RPL21P10
GH14I077096 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 22.6 +946.6 946580 4.4 HDGF PKNOX1 CLOCK MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B CIPC GC14M077096 ENSG00000259164 SNW1 VIPAS39 ZMYND19P1 RPL22P2 ALKBH1 IRF2BPL GPATCH2L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GPATCH2L on UCSC Golden Path with GeneCards custom track

Genomic Locations for GPATCH2L Gene

Genomic Locations for GPATCH2L Gene
chr14:76,151,885-76,254,342
(GRCh38/hg38)
Size:
102,458 bases
Orientation:
Plus strand
chr14:76,618,259-76,720,685
(GRCh37/hg19)

Genomic View for GPATCH2L Gene

Genes around GPATCH2L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPATCH2L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPATCH2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPATCH2L Gene

Proteins for GPATCH2L Gene

  • Protein details for GPATCH2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWQ4-GPT2L_HUMAN
    Recommended name:
    G patch domain-containing protein 2-like
    Protein Accession:
    Q9NWQ4
    Secondary Accessions:
    • B3KN42
    • Q6PEJ7
    • Q9H3M3
    • Q9NWH0
    • Q9ULR8

    Protein attributes for GPATCH2L Gene

    Size:
    482 amino acids
    Molecular mass:
    54260 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA86466.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA91325.1; Type=Frameshift; Positions=344; Evidence={ECO:0000305}; Sequence=BAA91411.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for GPATCH2L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPATCH2L Gene

Post-translational modifications for GPATCH2L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for GPATCH2L Gene

Domains & Families for GPATCH2L Gene

Gene Families for GPATCH2L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GPATCH2L Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GPATCH2L: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for GPATCH2L Gene

Function for GPATCH2L Gene

Phenotypes From GWAS Catalog for GPATCH2L Gene

Gene Ontology (GO) - Molecular Function for GPATCH2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23455924
genes like me logo Genes that share ontologies with GPATCH2L: view
genes like me logo Genes that share phenotypes with GPATCH2L: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPATCH2L Gene

Localization for GPATCH2L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPATCH2L gene
Compartment Confidence
nucleus 4
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GPATCH2L Gene

Pathways & Interactions for GPATCH2L Gene

SuperPathways for GPATCH2L Gene

No Data Available

Gene Ontology (GO) - Biological Process for GPATCH2L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GPATCH2L Gene

Drugs & Compounds for GPATCH2L Gene

No Compound Related Data Available

Transcripts for GPATCH2L Gene

Unigene Clusters for GPATCH2L Gene

G patch domain containing 2-like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPATCH2L Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a ·
SP1: - - - -
SP2: - - - - - - -
SP3: - - -
SP4: - - - - -
SP5: - - - -
SP6: -
SP7: - -
SP8:
SP9:

ExUns: 15b · 15c · 15d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for GPATCH2L Gene

GeneLoc Exon Structure for
GPATCH2L
ECgene alternative splicing isoforms for
GPATCH2L

Expression for GPATCH2L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPATCH2L Gene

Protein differential expression in normal tissues from HIPED for GPATCH2L Gene

This gene is overexpressed in Lung (67.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GPATCH2L Gene



Protein tissue co-expression partners for GPATCH2L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPATCH2L Gene:

GPATCH2L

SOURCE GeneReport for Unigene cluster for GPATCH2L Gene:

Hs.410231
genes like me logo Genes that share expression patterns with GPATCH2L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPATCH2L Gene

Orthologs for GPATCH2L Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPATCH2L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C14H14orf118 33 34
  • 99.93 (n)
cow
(Bos Taurus)
Mammalia GPATCH2L 33
  • 92.49 (n)
MGC166084 34
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPATCH2L 33 34
  • 92.48 (n)
rat
(Rattus norvegicus)
Mammalia Gpatch2l 33
  • 86.77 (n)
mouse
(Mus musculus)
Mammalia Gpatch2l 33 16 34
  • 85.42 (n)
oppossum
(Monodelphis domestica)
Mammalia GPATCH2L 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPATCH2L 34
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPATCH2L 34
  • 80 (a)
OneToOne
C5H14ORF118 33
  • 77.92 (n)
lizard
(Anolis carolinensis)
Reptilia GPATCH2L 34
  • 76 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 24 (a)
OneToMany
Species where no ortholog for GPATCH2L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GPATCH2L Gene

ENSEMBL:
Gene Tree for GPATCH2L (if available)
TreeFam:
Gene Tree for GPATCH2L (if available)

Paralogs for GPATCH2L Gene

Paralogs for GPATCH2L Gene

(2) SIMAP similar genes for GPATCH2L Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with GPATCH2L: view

Variants for GPATCH2L Gene

Sequence variations from dbSNP and Humsavar for GPATCH2L Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000029146 -- 76,204,695(+) T/A 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000035171 -- 76,182,127(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000091942 -- 76,166,588(+) A/C intron_variant
rs1000276509 -- 76,207,891(+) A/G 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000309202 -- 76,207,549(+) A/G 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GPATCH2L Gene

Variant ID Type Subtype PubMed ID
esv3581315 CNV loss 25503493
nsv516141 CNV loss 19592680

Variation tolerance for GPATCH2L Gene

Residual Variation Intolerance Score: 14.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPATCH2L Gene

Human Gene Mutation Database (HGMD)
GPATCH2L
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPATCH2L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPATCH2L Gene

Disorders for GPATCH2L Gene

Additional Disease Information for GPATCH2L

No disorders were found for GPATCH2L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPATCH2L Gene

Publications for GPATCH2L Gene

  1. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58

Products for GPATCH2L Gene

Sources for GPATCH2L Gene

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