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The gene encodes a nuclear factor that may play a role in spermatogenesis and in tumor growth during breast cancer. The encoded protein contains a G-patch domain with an RNA binding motif. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
GPATCH2 (G-Patch Domain Containing 2) is a Protein Coding gene. Diseases associated with GPATCH2 include Lymphogranuloma Venereum. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is GPATCH2L.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003676 | nucleic acid binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005730 | nucleolus | IEA | -- |
GO:0016607 | nuclear speck | IDA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0010923 | negative regulation of phosphatase activity | IBA,IDA | 19389623 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | · | 12c | ^ | 13 | ^ | 14a | · | 14b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||||||||
SP5: | - | ||||||||||||||||||||||||||||||||||||||
SP6: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | GPATCH2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | GPATCH2 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | GPATCH2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Gpatch2 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | GPATCH2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | GPATCH2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | GPATCH2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | GPATCH2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | gpatch2 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | LOC100330499 30 |
|
||
gpatch2 31 |
|
OneToOne | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs796052151 | Likely Benign: Long QT syndrome | 217,431,205(-) | TC/T | FRAMESHIFT_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv263n106 | CNV | deletion | 24896259 |
esv1658318 | CNV | deletion | 17803354 |
esv2015860 | CNV | deletion | 18987734 |
esv2572444 | CNV | deletion | 19546169 |
esv2673939 | CNV | deletion | 23128226 |
esv2722929 | CNV | deletion | 23290073 |
esv2762164 | CNV | gain | 21179565 |
esv2762166 | CNV | loss | 21179565 |
esv3546755 | CNV | deletion | 23714750 |
esv3588843 | CNV | gain | 21293372 |
esv3588845 | CNV | loss | 21293372 |
esv3588846 | CNV | loss | 21293372 |
esv3768 | CNV | loss | 18987735 |
esv8618 | CNV | loss | 19470904 |
nsv1003999 | CNV | loss | 25217958 |
nsv1008328 | CNV | gain | 25217958 |
nsv1068860 | CNV | deletion | 25765185 |
nsv1137848 | CNV | deletion | 24896259 |
nsv1147085 | CNV | deletion | 26484159 |
nsv159790 | CNV | deletion | 16902084 |
nsv826631 | CNV | gain | 20364138 |
nsv832559 | CNV | loss | 17160897 |
nsv832570 | CNV | gain | 17160897 |
nsv832581 | CNV | gain+loss | 17160897 |
nsv952123 | CNV | duplication | 24416366 |
nsv957533 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
lymphogranuloma venereum |
|
|