Aliases for GPATCH11 Gene

Aliases for GPATCH11 Gene

  • G-Patch Domain Containing 11 2 3 5
  • G Patch Domain-Containing Protein 11 3 3 4
  • CENP-Y 2 3 4
  • Coiled-Coil Domain-Containing Protein 75 3 4
  • Coiled-Coil Domain Containing 75 2 3
  • Centromere Protein Y 2 3
  • CCDC75 3 4
  • CENPY 2 3
  • GPATCH11 5
  • FLJ38348 2

External Ids for GPATCH11 Gene

Previous HGNC Symbols for GPATCH11 Gene

  • CCDC75

Previous GeneCards Identifiers for GPATCH11 Gene

  • GC02P037314

Summaries for GPATCH11 Gene

GeneCards Summary for GPATCH11 Gene

GPATCH11 (G-Patch Domain Containing 11) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.

Additional gene information for GPATCH11 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPATCH11 Gene

Genomics for GPATCH11 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GPATCH11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J037083 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.1 93 3.1 PRDM10 REST ZNF629 IKZF1 NFKBIZ ZNF692 POLR2A RCOR2 JUND FOXA1 HEATR5B GPATCH11 CEBPZ RF01045-062 EIF2AK2
GH02J037103 Enhancer 1 Ensembl ENCODE 13 +20.1 20050 2.2 ZNF629 JUND RXRB SP1 DPF2 CEBPA SOX13 TCF7 CEBPB FOXA1 HEATR5B GPATCH11 RF01045-062 lnc-HEATR5B-1 EIF2AK2
GH02J036961 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 5.5 -119.2 -119239 7.3 SP1 HNRNPL GATAD2A PRDM10 ZNF512 RFX1 SIX5 LEF1 SOX13 IKZF1 STRN GPATCH11 piR-50437-373 HEATR5B VIT
GH02J037079 Enhancer 0.6 ENCODE dbSUPER 12.4 -3.8 -3786 2.6 RFX1 RUNX3 SPI1 TBX21 piR-54987-064 GPATCH11 CEBPZOS HEATR5B lnc-EIF2AK2-1 STRN
GH02J037110 Enhancer 0.6 Ensembl ENCODE 13 +26.6 26615 0.7 ZNF316 MAFK EMSY HEATR5B GPATCH11 lnc-HEATR5B-1 RF01045-062 EIF2AK2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPATCH11 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPATCH11

Genomic Locations for GPATCH11 Gene

Genomic Locations for GPATCH11 Gene
chr2:37,084,451-37,099,244
(GRCh38/hg38)
Size:
14,794 bases
Orientation:
Plus strand
chr2:37,311,594-37,326,387
(GRCh37/hg19)
Size:
14,794 bases
Orientation:
Plus strand

Genomic View for GPATCH11 Gene

Genes around GPATCH11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPATCH11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPATCH11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPATCH11 Gene

Proteins for GPATCH11 Gene

  • Protein details for GPATCH11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N954-GPT11_HUMAN
    Recommended name:
    G patch domain-containing protein 11
    Protein Accession:
    Q8N954
    Secondary Accessions:
    • A0A0A0MSF9
    • A8K0D9
    • B7Z2G4
    • B8ZZ44

    Protein attributes for GPATCH11 Gene

    Size:
    285 amino acids
    Molecular mass:
    33277 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAH11850.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for GPATCH11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GPATCH11 Gene

Post-translational modifications for GPATCH11 Gene

  • Ubiquitination at Lys98
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPATCH11 Gene

Domains & Families for GPATCH11 Gene

Gene Families for GPATCH11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GPATCH11 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPATCH11 Gene

GenScript: Design optimal peptide antigens:
  • G patch domain-containing protein 11 (CCD75_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N954

UniProtKB/Swiss-Prot:

GPT11_HUMAN :
  • Belongs to the GPATCH11 family.
Family:
  • Belongs to the GPATCH11 family.
genes like me logo Genes that share domains with GPATCH11: view

Function for GPATCH11 Gene

Phenotypes From GWAS Catalog for GPATCH11 Gene

Gene Ontology (GO) - Molecular Function for GPATCH11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with GPATCH11: view
genes like me logo Genes that share phenotypes with GPATCH11: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPATCH11

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GPATCH11 Gene

Localization for GPATCH11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPATCH11 Gene

Chromosome, centromere, kinetochore.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPATCH11 gene
Compartment Confidence
nucleus 3
cytosol 3
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GPATCH11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0000776 kinetochore IBA,IDA 20813266
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with GPATCH11: view

Pathways & Interactions for GPATCH11 Gene

PathCards logo

SuperPathways for GPATCH11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GPATCH11 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GPATCH11 Gene

Drugs & Compounds for GPATCH11 Gene

No Compound Related Data Available

Transcripts for GPATCH11 Gene

mRNA/cDNA for GPATCH11 Gene

9 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPATCH11

Alternative Splicing Database (ASD) splice patterns (SP) for GPATCH11 Gene

No ASD Table

Relevant External Links for GPATCH11 Gene

GeneLoc Exon Structure for
GPATCH11

Expression for GPATCH11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPATCH11 Gene

Protein differential expression in normal tissues from HIPED for GPATCH11 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (57.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GPATCH11 Gene



Protein tissue co-expression partners for GPATCH11 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPATCH11

SOURCE GeneReport for Unigene cluster for GPATCH11 Gene:

Hs.595250

Evidence on tissue expression from TISSUES for GPATCH11 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with GPATCH11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPATCH11 Gene

Orthologs for GPATCH11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GPATCH11 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CCDC75 30 31
  • 99.18 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia GPATCH11 30 31
  • 91.25 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia GPATCH11 30 31
  • 90.84 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Gpatch11 30 17 31
  • 84.79 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Gpatch11 30
  • 83.91 (n)
Oppossum
(Monodelphis domestica)
Mammalia GPATCH11 31
  • 79 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia GPATCH11 31
  • 79 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CCDC75 30 31
  • 72.78 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia GPATCH11 31
  • 55 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia gpatch11 30
  • 66.93 (n)
Zebrafish
(Danio rerio)
Actinopterygii gpatch11 30 31
  • 57.46 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG10053 30 31
  • 47.41 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea CELE_T04H1.5 30
  • 48.83 (n)
T04H1.5 31
  • 29 (a)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT3G57910 30
  • 49.15 (n)
Rice
(Oryza sativa)
Liliopsida Os08g0509500 30
  • 41.7 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 37 (a)
OneToOne
Species where no ortholog for GPATCH11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for GPATCH11 Gene

ENSEMBL:
Gene Tree for GPATCH11 (if available)
TreeFam:
Gene Tree for GPATCH11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPATCH11: view image

Paralogs for GPATCH11 Gene

Pseudogenes.org Pseudogenes for GPATCH11 Gene

genes like me logo Genes that share paralogs with GPATCH11: view

No data available for Paralogs for GPATCH11 Gene

Variants for GPATCH11 Gene

Additional dbSNP identifiers (rs#s) for GPATCH11 Gene

Variation tolerance for GPATCH11 Gene

Residual Variation Intolerance Score: 72.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.61; 45.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPATCH11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPATCH11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for GPATCH11 Gene

Disorders for GPATCH11 Gene

No disorders were found for GPATCH11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPATCH11 Gene

Publications for GPATCH11 Gene

  1. The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. (PMID: 20813266) Ohta S … Rappsilber J (Cell 2010) 3 4
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for GPATCH11 Gene

Sources for GPATCH11 Gene