Aliases for GPAT2 Gene
External Ids for GPAT2 Gene
Previous GeneCards Identifiers for GPAT2 Gene
GeneCards Summary for GPAT2 Gene
GPAT2 (Glycerol-3-Phosphate Acyltransferase 2, Mitochondrial) is a Protein Coding gene. Diseases associated with GPAT2 include Congenital Generalized Lipodystrophy and Leber Congenital Amaurosis 1. Among its related pathways are Acyl chain remodelling of PE and Glycerophospholipid biosynthesis. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring acyl groups and glycerol-3-phosphate O-acyltransferase activity. An important paralog of this gene is GPAM.
UniProtKB/Swiss-Prot Summary for GPAT2 Gene
Transfers an acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate producing a lysophosphatidic acid (LPA), an essential step for the triacylglycerol (TAG) and glycerophospholipids. In vitro also transfers an acyl-group from acyl-ACP to the LPA producing a phosphatidic acid (PA). Prefers arachidonoyl-CoA as the acyl donor. Required for primary processing step during piRNA biosynthesis. Molecular mechanisms by which it promotes piRNA biosynthesis are unclear and do not involve its acyltransferase activity.