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Aliases for GPANK1 Gene

Aliases for GPANK1 Gene

  • G-Patch Domain And Ankyrin Repeats 1 2 3 5
  • Ankyrin Repeat Domain-Containing Protein 59 3 4
  • G Patch Domain-Containing Protein 10 3 4
  • HLA-B-Associated Transcript 4 3 4
  • G Patch Domain Containing 10 2 3
  • Protein G5 3 4
  • GPATCH10 3 4
  • ANKRD59 3 4
  • BAT4 3 4
  • G5 3 4
  • G Patch Domain And Ankyrin Repeats-Containing Protein 1 3
  • G Patch Domain And Ankyrin Repeat-Containing Protein 1 3
  • HLA-B Associated Transcript 4 2
  • Ankyrin Repeat Domain 59 2
  • Protein BAT4 3
  • D6S54E 3

External Ids for GPANK1 Gene

Previous HGNC Symbols for GPANK1 Gene

  • BAT4

Previous GeneCards Identifiers for GPANK1 Gene

  • GC06M031417
  • GC06M031631
  • GC06M031635
  • GC06M031638
  • GC06M031642
  • GC06M031647
  • GC06M031651
  • GC06M031695
  • GC06M031668
  • GC06M031675
  • GC06M031728
  • GC06M031793
  • GC06M031817
  • GC06M031848
  • GC06M031891
  • GC06M031942

Summaries for GPANK1 Gene

Entrez Gene Summary for GPANK1 Gene

  • This gene is located in a cluster of HLA-B-associated transcripts, which is included in the human major histocompatability complex III region. This gene encodes a protein which is thought to play a role in immunity. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2010]

GeneCards Summary for GPANK1 Gene

GPANK1 (G-Patch Domain And Ankyrin Repeats 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.

Gene Wiki entry for GPANK1 Gene

Additional gene information for GPANK1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPANK1 Gene

Genomics for GPANK1 Gene

GeneHancer (GH) Regulatory Elements for GPANK1 Gene

Promoters and enhancers for GPANK1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J031662 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 670.4 +1.2 1237 5 MLX ZFP64 YBX1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 ZNF263 SP3 CSNK2B GPANK1 GC06P032214 ENSG00000201207 ENSG00000263020 DDX39B LY6G5B ATF6B MDC1 GTF2H4
GH06J031813 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 80.3 -159.6 -159593 25.6 CLOCK ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 C6orf48 HSPA1B HSPA1A HSPA1L GC06P032216 ATF6B DDX39B LY6G5B BAG6 LSM2
GH06J031733 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 67.1 -71.2 -71172 8.5 CLOCK MLX ZFP64 YBX1 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 MSH5 CLIC1 MSH5-SAPCD1 DDX39B LY6G5B ATF6B LSM2 SKIV2L CSNK2B GPANK1
GH06J031538 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 60.8 +125.1 125144 4.9 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF263 DDX39B DDX39B-AS1 GC06M031542 GC06M031543 GC06M031550 GC06M031555 GC06M031573 GC06M032007 GC06M032013 GC06M032015
GH06J031861 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 49.4 -197.8 -197833 4.5 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 NEU1 LY6G5B DDX39B ATF6B LSM2 GPANK1 SKIV2L MSH5 TCF19 CSNK2B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPANK1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for GPANK1 Gene

Genomic Locations for GPANK1 Gene
5,055 bases
Minus strand
5,055 bases
Minus strand

Genomic View for GPANK1 Gene

Genes around GPANK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPANK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPANK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for GPANK1 Gene

  • Protein details for GPANK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    G patch domain and ankyrin repeat-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • A6NG25
    • B0UXA2
    • Q5SQ49

    Protein attributes for GPANK1 Gene

    356 amino acids
    Molecular mass:
    39314 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPANK1 Gene

Post-translational modifications for GPANK1 Gene

  • Ubiquitination at isoforms=261 and Lys103
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPANK1 Gene

Domains & Families for GPANK1 Gene

Gene Families for GPANK1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GPANK1: view

No data available for UniProtKB/Swiss-Prot for GPANK1 Gene

Function for GPANK1 Gene

Phenotypes From GWAS Catalog for GPANK1 Gene

Gene Ontology (GO) - Molecular Function for GPANK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with GPANK1: view
genes like me logo Genes that share phenotypes with GPANK1: view

Animal Models for GPANK1 Gene

MGI Knock Outs for GPANK1:
  • Gpank1 Gpank1<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

miRNA for GPANK1 Gene

miRTarBase miRNAs that target GPANK1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPANK1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPANK1 Gene

Localization for GPANK1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPANK1 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GPANK1 Gene

Pathways & Interactions for GPANK1 Gene

SuperPathways for GPANK1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GPANK1 Gene


No data available for Pathways by source and SIGNOR curated interactions for GPANK1 Gene

Drugs & Compounds for GPANK1 Gene

No Compound Related Data Available

Transcripts for GPANK1 Gene

Unigene Clusters for GPANK1 Gene

G patch domain and ankyrin repeats 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPANK1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPANK1 Gene

No ASD Table

Relevant External Links for GPANK1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPANK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPANK1 Gene

Protein differential expression in normal tissues from HIPED for GPANK1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (24.7), CD8 Tcells (21.5), and Liver (14.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPANK1 Gene

Protein tissue co-expression partners for GPANK1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GPANK1 Gene:


SOURCE GeneReport for Unigene cluster for GPANK1 Gene:

genes like me logo Genes that share expression patterns with GPANK1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPANK1 Gene

Orthologs for GPANK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPANK1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPANK1 34 33
  • 99.72 (n)
(Canis familiaris)
Mammalia GPANK1 34 33
  • 85.09 (n)
(Bos Taurus)
Mammalia GPANK1 33
  • 84.62 (n)
BAT4 34
  • 83 (a)
(Rattus norvegicus)
Mammalia Gpank1 33
  • 81.03 (n)
(Mus musculus)
Mammalia Gpank1 16 34 33
  • 80.6 (n)
(Monodelphis domestica)
Mammalia GPANK1 34
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpank1 33
  • 48.51 (n)
(Danio rerio)
Actinopterygii zgc:171777 33
  • 49.59 (n)
  • 39 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8152 34 33
  • 44.93 (n)
(Caenorhabditis elegans)
Secernentea ZK1320.7 34
  • 23 (a)
Species where no ortholog for GPANK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPANK1 Gene

Gene Tree for GPANK1 (if available)
Gene Tree for GPANK1 (if available)
Evolutionary constrained regions (ECRs) for GPANK1: view image

Paralogs for GPANK1 Gene

No data available for Paralogs for GPANK1 Gene

Variants for GPANK1 Gene

Sequence variations from dbSNP and Humsavar for GPANK1 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1085307703 uncertain-significance, not specified 31,667,934(-) C/T upstream_transcript_variant
rs1000552968 -- 31,665,533(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000896848 -- 31,665,677(-) C/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001235811 -- 31,663,052(-) G/A intron_variant
rs1002270126 -- 31,660,913(-) C/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GPANK1 Gene

Variant ID Type Subtype PubMed ID
dgv10403n54 CNV loss 21841781
dgv10404n54 CNV loss 21841781
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1126749 CNV deletion 24896259
nsv1161370 CNV deletion 26073780
nsv462871 CNV loss 19166990
nsv601942 CNV loss 21841781
nsv830627 CNV loss 17160897

Variation tolerance for GPANK1 Gene

Residual Variation Intolerance Score: 74.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.13; 80.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPANK1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPANK1 Gene

Disorders for GPANK1 Gene

Additional Disease Information for GPANK1

No disorders were found for GPANK1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPANK1 Gene

Publications for GPANK1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  3. Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PMID: 14656967) Xie T … Hood L (Genome research 2003) 3 4 58
  4. Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B. (PMID: 2813433) Spies T … Strominger JL (Proceedings of the National Academy of Sciences of the United States of America 1989) 2 3 58
  5. A new cluster of genes within the human major histocompatibility complex. (PMID: 2911734) Spies T … Strominger JL (Science (New York, N.Y.) 1989) 2 3 58

Products for GPANK1 Gene

Sources for GPANK1 Gene

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