This gene is located in a cluster of HLA-B-associated transcripts, which is included in the human major histocompatability complex III region. This gene encodes a protein which is thought to play a role in immunity. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2010] See more...

Aliases for GPANK1 Gene

Aliases for GPANK1 Gene

  • G-Patch Domain And Ankyrin Repeats 1 2 3 5
  • G Patch Domain And Ankyrin Repeat-Containing Protein 1 3 4
  • Ankyrin Repeat Domain-Containing Protein 59 3 4
  • G Patch Domain-Containing Protein 10 3 4
  • HLA-B-Associated Transcript 4 3 4
  • G Patch Domain Containing 10 2 3
  • Protein G5 3 4
  • GPATCH10 3 4
  • ANKRD59 3 4
  • BAT4 3 4
  • G5 3 4
  • G Patch Domain And Ankyrin Repeats-Containing Protein 1 3
  • HLA-B Associated Transcript 4 2
  • Ankyrin Repeat Domain 59 2
  • Protein BAT4 3
  • D6S54E 3

External Ids for GPANK1 Gene

Previous HGNC Symbols for GPANK1 Gene

  • BAT4

Previous GeneCards Identifiers for GPANK1 Gene

  • GC06M031417
  • GC06M031631
  • GC06M031635
  • GC06M031638
  • GC06M031642
  • GC06M031647
  • GC06M031651
  • GC06M031695
  • GC06M031668
  • GC06M031675
  • GC06M032069
  • GC06M032138
  • GC06M032210
  • GC06M031728
  • GC06M031793
  • GC06M031817
  • GC06M031848
  • GC06M031891
  • GC06M031942
  • GC06M031985
  • GC06M032019

Summaries for GPANK1 Gene

Entrez Gene Summary for GPANK1 Gene

  • This gene is located in a cluster of HLA-B-associated transcripts, which is included in the human major histocompatability complex III region. This gene encodes a protein which is thought to play a role in immunity. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2010]

GeneCards Summary for GPANK1 Gene

GPANK1 (G-Patch Domain And Ankyrin Repeats 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.

Gene Wiki entry for GPANK1 Gene

Additional gene information for GPANK1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPANK1 Gene

Genomics for GPANK1 Gene

GeneHancer (GH) Regulatory Elements for GPANK1 Gene

Promoters and enhancers for GPANK1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPANK1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPANK1

Genomic Locations for GPANK1 Gene

Genomic Locations for GPANK1 Gene
chr6:31,661,228-31,666,283
(GRCh38/hg38)
Size:
5,056 bases
Orientation:
Minus strand
chr6:31,629,006-31,634,060
(GRCh37/hg19)
Size:
5,055 bases
Orientation:
Minus strand

Genomic View for GPANK1 Gene

Genes around GPANK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPANK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPANK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for GPANK1 Gene

  • Protein details for GPANK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95872-GPAN1_HUMAN
    Recommended name:
    G patch domain and ankyrin repeat-containing protein 1
    Protein Accession:
    O95872
    Secondary Accessions:
    • A6NG25
    • B0UXA2
    • Q5SQ49

    Protein attributes for GPANK1 Gene

    Size:
    356 amino acids
    Molecular mass:
    39314 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPANK1 Gene

Post-translational modifications for GPANK1 Gene

  • Ubiquitination at Lys103 and Lys261
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GPANK1 Gene

Domains & Families for GPANK1 Gene

Gene Families for GPANK1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for GPANK1 Gene

Blocks:
  • Ankyrin repeat signature
  • D111/G-patch domain
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPANK1 Gene

GenScript: Design optimal peptide antigens:
  • HLA-B associated transcript 4 (A2ABR7_HUMAN)
  • HLA-B associated transcript 4 (A2ABR8_HUMAN)
  • HLA-B associated transcript 4 (A2ABR9_HUMAN)
  • HLA-B associated transcript 4 (A2ABS0_HUMAN)
  • HLA-B associated transcript 4 (A2ABS1_HUMAN)
genes like me logo Genes that share domains with GPANK1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for GPANK1 Gene

Function for GPANK1 Gene

Phenotypes From GWAS Catalog for GPANK1 Gene

Gene Ontology (GO) - Molecular Function for GPANK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with GPANK1: view
genes like me logo Genes that share phenotypes with GPANK1: view

Animal Models for GPANK1 Gene

MGI Knock Outs for GPANK1:
  • Gpank1 Gpank1<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

miRNA for GPANK1 Gene

miRTarBase miRNAs that target GPANK1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPANK1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GPANK1 Gene

Localization for GPANK1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPANK1 gene
Compartment Confidence
nucleus 3
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for GPANK1 Gene

Pathways & Interactions for GPANK1 Gene

PathCards logo

SuperPathways for GPANK1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GPANK1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GPANK1 Gene

Drugs & Compounds for GPANK1 Gene

No Compound Related Data Available

Transcripts for GPANK1 Gene

mRNA/cDNA for GPANK1 Gene

5 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GPANK1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GPANK1 Gene

No ASD Table

Relevant External Links for GPANK1 Gene

GeneLoc Exon Structure for
GPANK1

Expression for GPANK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPANK1 Gene

Protein differential expression in normal tissues from HIPED for GPANK1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (24.7), CD8 Tcells (21.5), and Liver (14.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GPANK1 Gene



Protein tissue co-expression partners for GPANK1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPANK1

SOURCE GeneReport for Unigene cluster for GPANK1 Gene:

Hs.247478
genes like me logo Genes that share expression patterns with GPANK1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GPANK1 Gene

Orthologs for GPANK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GPANK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPANK1 31 30
  • 99.72 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GPANK1 31 30
  • 85.09 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GPANK1 30
  • 84.62 (n)
BAT4 31
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpank1 30
  • 81.03 (n)
mouse
(Mus musculus)
Mammalia Gpank1 17 31 30
  • 80.6 (n)
oppossum
(Monodelphis domestica)
Mammalia GPANK1 31
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpank1 30
  • 48.51 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:171777 30
  • 49.59 (n)
GPANK1 31
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8152 31 30
  • 44.93 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ZK1320.7 31
  • 23 (a)
OneToOne
Species where no ortholog for GPANK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GPANK1 Gene

ENSEMBL:
Gene Tree for GPANK1 (if available)
TreeFam:
Gene Tree for GPANK1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPANK1: view image

Paralogs for GPANK1 Gene

No data available for Paralogs for GPANK1 Gene

Variants for GPANK1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPANK1 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs2295666 - p.Ala235Val
rs3130618 - p.Arg41Leu
rs34082689 - p.Ser210Ala
rs35265780 - p.Ala112Val
VAR_064698 - p.Thr314Asn

Additional dbSNP identifiers (rs#s) for GPANK1 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPANK1 Gene

Variant ID Type Subtype PubMed ID
dgv10403n54 CNV loss 21841781
dgv10404n54 CNV loss 21841781
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1126749 CNV deletion 24896259
nsv1161370 CNV deletion 26073780
nsv462871 CNV loss 19166990
nsv601942 CNV loss 21841781
nsv830627 CNV loss 17160897

Variation tolerance for GPANK1 Gene

Residual Variation Intolerance Score: 74.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.13; 80.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPANK1 Gene

Human Gene Mutation Database (HGMD)
GPANK1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPANK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPANK1 Gene

Disorders for GPANK1 Gene

Additional Disease Information for GPANK1

No disorders were found for GPANK1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GPANK1 Gene

Publications for GPANK1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 54
  3. Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PMID: 14656967) Xie T … Hood L (Genome research 2003) 3 4 54
  4. A new cluster of genes within the human major histocompatibility complex. (PMID: 2911734) Spies T … Strominger JL (Science (New York, N.Y.) 1989) 2 3 54
  5. Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B. (PMID: 2813433) Spies T … Strominger JL (Proceedings of the National Academy of Sciences of the United States of America 1989) 2 3 54

Products for GPANK1 Gene

Sources for GPANK1 Gene