Aliases for GPAM Gene
External Ids for GPAM Gene
Previous GeneCards Identifiers for GPAM Gene
This gene encodes a mitochondrial enzyme which prefers saturated fatty acids as its substrate for the synthesis of glycerolipids. This metabolic pathway's first step is catalyzed by the encoded enzyme. Two forms for this enzyme exist, one in the mitochondria and one in the endoplasmic reticulum. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]
GeneCards Summary for GPAM Gene
GPAM (Glycerol-3-Phosphate Acyltransferase, Mitochondrial) is a Protein Coding gene. Diseases associated with GPAM include Congenital Generalized Lipodystrophy and Fanconi Anemia, Complementation Group D2. Among its related pathways are Acyl chain remodelling of PE and Glycerophospholipid biosynthesis. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring acyl groups and glycerol-3-phosphate O-acyltransferase activity. An important paralog of this gene is GPAT2.
UniProtKB/Swiss-Prot Summary for GPAM Gene
Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.