The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-a... See more...

Aliases for GPA33 Gene

Aliases for GPA33 Gene

  • Glycoprotein A33 2 3 4 5
  • Glycoprotein A33 (Transmembrane) 2 3
  • Cell Surface A33 Antigen 3 4
  • Transmembrane Glycoprotein A33 3
  • A33 3

External Ids for GPA33 Gene

Previous GeneCards Identifiers for GPA33 Gene

  • GC01M164656
  • GC01M162672
  • GC01M163718
  • GC01M164209
  • GC01M163753
  • GC01M165288
  • GC01M167022
  • GC01M138268

Summaries for GPA33 Gene

Entrez Gene Summary for GPA33 Gene

  • The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 2 domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily. [provided by RefSeq, Jul 2008]

GeneCards Summary for GPA33 Gene

GPA33 (Glycoprotein A33) is a Protein Coding gene. Diseases associated with GPA33 include Foodborne Botulism and Wound Botulism. An important paralog of this gene is CXADR.

UniProtKB/Swiss-Prot Summary for GPA33 Gene

Gene Wiki entry for GPA33 Gene

Additional gene information for GPA33 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GPA33 Gene

Genomics for GPA33 Gene

GeneHancer (GH) Regulatory Elements for GPA33 Gene

Promoters and enhancers for GPA33 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J167088 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 516 +76.2 76224 2.9 SPI1 NRF1 ATF2 VEZF1 NFIC MAX ZNF687 RAD51 EBF1 SRF GPA33 LOC105371598 DUSP27
GH01J167165 Promoter/Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas 500.7 0.0 -14 2.3 ZSCAN5C TEAD4 ZNF423 TRIM28 RFX1 KLF7 ZNF341 POLR2A OSR2 WT1 GPA33 HSALNG0008213 LOC105371601 LINC01363 DUSP27
GH01J167445 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 9.7 -285.8 -285753 13.8 NRF1 USF1 PHF8 TEAD4 ZFX ZIC2 POLR2A ZBTB26 TARDBP HES1 piR-43107-023 CD247 AKR1D1P1 CREG1 GPA33 ENSG00000273160 RCSD1 POU2F1 ENSG00000287218 LOC101928512
GH01J167507 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.9 -346.8 -346803 12.2 ZBTB11 MYC CTBP1 HDAC2 RBM25 NFRKB NEUROD1 ZNF316 ARNT FOSL1 CD247 GPA33 RCSD1 ENSG00000272033 CREG1 POU2F1 lnc-CD247-1 ENSG00000273160
GH01J167059 Enhancer 1 ENCODE dbSUPER 18.2 +107.0 107011 0.8 CTCF TEAD4 REST MYC RAD21 TRIM22 SMC3 RBM25 ZNF316 ZNF76 GPA33 TADA1 DUSP27 RF00017-383 ENSG00000227907 LOC105371600
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPA33 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GPA33

Top Transcription factor binding sites by QIAGEN in the GPA33 gene promoter:
  • AP-1
  • c-Fos
  • c-Myb
  • c-Rel
  • C/EBPalpha
  • HNF-4alpha1
  • HNF-4alpha2
  • Pbx1a
  • RSRFC4

Genomic Locations for GPA33 Gene

Genomic Locations for GPA33 Gene
chr1:167,052,836-167,166,479
(GRCh38/hg38)
Size:
113,644 bases
Orientation:
Minus strand
chr1:167,022,073-167,059,868
(GRCh37/hg19)
Size:
37,796 bases
Orientation:
Minus strand

Genomic View for GPA33 Gene

Genes around GPA33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPA33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPA33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPA33 Gene

Proteins for GPA33 Gene

  • Protein details for GPA33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99795-GPA33_HUMAN
    Recommended name:
    Cell surface A33 antigen
    Protein Accession:
    Q99795
    Secondary Accessions:
    • Q5VZP6

    Protein attributes for GPA33 Gene

    Size:
    319 amino acids
    Molecular mass:
    35632 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPA33 Gene

Post-translational modifications for GPA33 Gene

Other Protein References for GPA33 Gene

No data available for DME Specific Peptides for GPA33 Gene

Domains & Families for GPA33 Gene

Gene Families for GPA33 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for GPA33 Gene

Blocks:
  • Immunoglobulin C-2 type
  • Immunoglobulin V-set
  • Immunoglobulin V-type
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GPA33 Gene

GenScript: Design optimal peptide antigens:
  • Glycoprotein A33 (GPA33_HUMAN)
  • cDNA, FLJ93270, Homo sapiens glycoprotein A33 (transmembrane) (GPA33), mRNA (Q5VZP6_HUMAN)
genes like me logo Genes that share domains with GPA33: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for GPA33 Gene

Function for GPA33 Gene

Molecular function for GPA33 Gene

UniProtKB/Swiss-Prot Function:
May play a role in cell-cell recognition and signaling.

Phenotypes From GWAS Catalog for GPA33 Gene

Gene Ontology (GO) - Molecular Function for GPA33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21044950
GO:0038023 signaling receptor activity TAS 9012807
genes like me logo Genes that share ontologies with GPA33: view
genes like me logo Genes that share phenotypes with GPA33: view

Animal Models for GPA33 Gene

MGI Knock Outs for GPA33:
  • Gpa33 Gpa33<tm2b(KOMP)Wtsi>
  • Gpa33 Gpa33<tm1Jkhh>

Animal Model Products

  • Taconic Biosciences Mouse Models for GPA33

CRISPR Products

Clone Products

  • Addgene plasmids for GPA33

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GPA33 Gene

Localization for GPA33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPA33 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPA33 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytosol 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for GPA33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA 21873635
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA 11487543
genes like me logo Genes that share ontologies with GPA33: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPA33 Gene

Pathways & Interactions for GPA33 Gene

PathCards logo

SuperPathways for GPA33 Gene

No Data Available

Interacting Proteins for GPA33 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: Q99795-GPA33_HUMAN ENSP00000356842 for GPA33 Gene via UniProtKB STRING IID

;

Gene Ontology (GO) - Biological Process for GPA33 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GPA33 Gene

Drugs & Compounds for GPA33 Gene

(1) Drugs for GPA33 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
KRN-330 Pharma 0
genes like me logo Genes that share compounds with GPA33: view

Transcripts for GPA33 Gene

mRNA/cDNA for GPA33 Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for GPA33

Alternative Splicing Database (ASD) splice patterns (SP) for GPA33 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: -
SP2:

Relevant External Links for GPA33 Gene

GeneLoc Exon Structure for
GPA33

Expression for GPA33 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GPA33 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPA33 Gene

This gene is overexpressed in Colon - Transverse (x37.2) and Small Intestine - Terminal Ileum (x11.9).

Protein differential expression in normal tissues from HIPED for GPA33 Gene

This gene is overexpressed in Rectum (36.7) and Colon (25.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GPA33 Gene



Protein tissue co-expression partners for GPA33 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GPA33

SOURCE GeneReport for Unigene cluster for GPA33 Gene:

Hs.651244

mRNA Expression by UniProt/SwissProt for GPA33 Gene:

Q99795-GPA33_HUMAN
Tissue specificity: Expressed in normal gastrointestinal epithelium and in 95% of colon cancers.

Evidence on tissue expression from TISSUES for GPA33 Gene

  • Lung(4.1)
  • Intestine(4)
genes like me logo Genes that share expression patterns with GPA33: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GPA33 Gene

Orthologs for GPA33 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPA33 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPA33 31 30
  • 98.64 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GPA33 31 30
  • 81.1 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GPA33 31 30
  • 79.09 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpa33 30
  • 76.79 (n)
mouse
(Mus musculus)
Mammalia Gpa33 17 31 30
  • 76.58 (n)
oppossum
(Monodelphis domestica)
Mammalia GPA33 31
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPA33 31 30
  • 55.51 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPA33 31
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpa33 30
  • 53.85 (n)
MGC75653 30
zebrafish
(Danio rerio)
Actinopterygii LOC101885644 30
  • 47.66 (n)
GPA33 (1 of 2) 31
  • 24 (a)
OneToMany
gpa33 31
  • 21 (a)
OneToMany
Species where no ortholog for GPA33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPA33 Gene

ENSEMBL:
Gene Tree for GPA33 (if available)
TreeFam:
Gene Tree for GPA33 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GPA33: view image

Paralogs for GPA33 Gene

(3) SIMAP similar genes for GPA33 Gene using alignment to 2 proteins:

  • GPA33_HUMAN
  • E9PMB2_HUMAN
genes like me logo Genes that share paralogs with GPA33: view

Variants for GPA33 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GPA33 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
727135 Likely Benign: not provided 167,055,097(-) C/T MISSENSE_VARIANT
739915 Likely Benign: not provided 167,068,943(-) G/A MISSENSE_VARIANT
772820 Benign: not provided 167,063,658(-) C/A MISSENSE_VARIANT
rs2228399 - p.Lys165Asn
rs2274531 - p.Asp20Asn

Additional dbSNP identifiers (rs#s) for GPA33 Gene

Structural Variations from Database of Genomic Variants (DGV) for GPA33 Gene

Variant ID Type Subtype PubMed ID
esv1004965 CNV deletion 20482838
esv2649114 CNV insertion 19546169
esv2750815 CNV gain 17911159
esv3392289 CNV duplication 20981092
nsv1078878 OTHER inversion 25765185

Variation tolerance for GPA33 Gene

Residual Variation Intolerance Score: 80.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.99; 49.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPA33 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GPA33

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPA33 Gene

Disorders for GPA33 Gene

MalaCards: The human disease database

(5) MalaCards diseases for GPA33 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
foodborne botulism
  • wound botulism
wound botulism
  • cutaneous infectious botulism
intestinal botulism
  • intestinal colonization botulism
infant botulism
  • infant intestinal botulism
colorectal cancer
  • crc
- elite association - COSMIC cancer census association via MalaCards
Search GPA33 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GPA33

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GPA33: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPA33 Gene

Publications for GPA33 Gene

  1. Characterization of posttranslational modifications of human A33 antigen, a novel palmitoylated surface glycoprotein of human gastrointestinal epithelium. (PMID: 9245713) Ritter G … Simpson RJ (Biochemical and biophysical research communications 1997) 2 3 4 23 54
  2. The human A33 antigen is a transmembrane glycoprotein and a novel member of the immunoglobulin superfamily. (PMID: 9012807) Heath JK … Burgess AW (Proceedings of the National Academy of Sciences of the United States of America 1997) 2 3 4 23 54
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  4. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret GB … Chakravarti A (European journal of human genetics : EJHG 2009) 3 41 54
  5. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PMID: 19064610) Cheung CL … Kung AW (Human molecular genetics 2009) 3 41 54

Products for GPA33 Gene

Sources for GPA33 Gene