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Aliases for GPA33 Gene

Aliases for GPA33 Gene

  • Glycoprotein A33 2 3 4 5
  • Glycoprotein A33 (Transmembrane) 2 3
  • Transmembrane Glycoprotein A33 3
  • Cell Surface A33 Antigen 3
  • A33 3

External Ids for GPA33 Gene

Previous GeneCards Identifiers for GPA33 Gene

  • GC01M164656
  • GC01M162672
  • GC01M163718
  • GC01M164209
  • GC01M163753
  • GC01M165288
  • GC01M138268

Summaries for GPA33 Gene

Entrez Gene Summary for GPA33 Gene

  • The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 2 domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily. [provided by RefSeq, Jul 2008]

GeneCards Summary for GPA33 Gene

GPA33 (Glycoprotein A33) is a Protein Coding gene. Diseases associated with GPA33 include Infant Botulism. An important paralog of this gene is CXADR.

UniProtKB/Swiss-Prot for GPA33 Gene

  • May play a role in cell-cell recognition and signaling.

Gene Wiki entry for GPA33 Gene

Additional gene information for GPA33 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GPA33 Gene

Genomics for GPA33 Gene

GeneHancer (GH) Regulatory Elements for GPA33 Gene

Promoters and enhancers for GPA33 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J167088 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 666 +76.2 76224 2.9 ZNF687 VEZF1 NRF1 MAX EBF1 ATF2 SPI1 GPA33 LOC105371598 DUSP27
GH01J167165 Enhancer 0.8 ENCODE 650.7 -0.2 -179 1.9 MZF1 FEZF1 ZNF335 ZNF213 ZNF366 ZSCAN5C KLF7 ZBTB11 ZNF843 SP1 LOC105371601 GPA33 LINC01363 DUSP27
GH01J167066 Enhancer 1.2 Ensembl ENCODE dbSUPER 18.6 +99.6 99636 0.7 RB1 ZFP64 ZBTB40 ZNF2 ZNF48 RAD21 ZNF335 ARID2 ZNF143 SMARCA5 GPA33 DUSP27 POU2F1 ILDR2 MAEL LOC105371600 LOC105371598
GH01J167059 Enhancer 1.2 Ensembl ENCODE dbSUPER 18.2 +107.0 107042 0.9 RB1 MZF1 SIN3A ZNF2 RAD21 CHAMP1 ZNF213 ZNF143 BCLAF1 RUNX3 GPA33 TADA1 DUSP27 LOC105371600 LOC105371598
GH01J167507 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.9 -346.8 -346803 12.2 HDGF PTBP1 PKNOX1 ATF1 ARNT NFRKB NFXL1 ZBTB40 ZNF766 EGR1 CD247 GPA33 RCSD1 ENSG00000272033 CREG1 POU2F1 ENSG00000273160
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GPA33 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GPA33 gene promoter:
  • c-Myb
  • C/EBPalpha
  • RSRFC4
  • Pbx1a
  • HNF-4alpha1
  • HNF-4alpha2
  • c-Rel
  • AP-1
  • c-Fos

Genomic Locations for GPA33 Gene

Genomic Locations for GPA33 Gene
113,644 bases
Minus strand
37,796 bases
Minus strand

Genomic View for GPA33 Gene

Genes around GPA33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GPA33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GPA33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GPA33 Gene

Proteins for GPA33 Gene

  • Protein details for GPA33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cell surface A33 antigen
    Protein Accession:
    Secondary Accessions:
    • Q5VZP6

    Protein attributes for GPA33 Gene

    319 amino acids
    Molecular mass:
    35632 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GPA33 Gene

Post-translational modifications for GPA33 Gene

Other Protein References for GPA33 Gene

No data available for DME Specific Peptides for GPA33 Gene

Domains & Families for GPA33 Gene

Gene Families for GPA33 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for GPA33 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GPA33: view

No data available for UniProtKB/Swiss-Prot for GPA33 Gene

Function for GPA33 Gene

Molecular function for GPA33 Gene

UniProtKB/Swiss-Prot Function:
May play a role in cell-cell recognition and signaling.

Phenotypes From GWAS Catalog for GPA33 Gene

Gene Ontology (GO) - Molecular Function for GPA33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21044950
GO:0038023 signaling receptor activity TAS 9012807
genes like me logo Genes that share ontologies with GPA33: view
genes like me logo Genes that share phenotypes with GPA33: view

Animal Models for GPA33 Gene

MGI Knock Outs for GPA33:

Animal Model Products

  • Taconic Biosciences Mouse Models for GPA33

Clone Products

  • Addgene plasmids for GPA33

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for GPA33 Gene

Localization for GPA33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GPA33 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GPA33 gene
Compartment Confidence
plasma membrane 5
extracellular 5
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for GPA33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 9012807
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA 11487543
genes like me logo Genes that share ontologies with GPA33: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GPA33 Gene

Pathways & Interactions for GPA33 Gene

SuperPathways for GPA33 Gene

No Data Available

Interacting Proteins for GPA33 Gene

Gene Ontology (GO) - Biological Process for GPA33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with GPA33: view

No data available for Pathways by source and SIGNOR curated interactions for GPA33 Gene

Drugs & Compounds for GPA33 Gene

(1) Drugs for GPA33 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
KRN-330 Pharma 0
genes like me logo Genes that share compounds with GPA33: view

Transcripts for GPA33 Gene

mRNA/cDNA for GPA33 Gene

Unigene Clusters for GPA33 Gene

Glycoprotein A33 (transmembrane):
Representative Sequences:

Clone Products

  • Addgene plasmids for GPA33

Alternative Splicing Database (ASD) splice patterns (SP) for GPA33 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: -

Relevant External Links for GPA33 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GPA33 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GPA33 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GPA33 Gene

This gene is overexpressed in Colon - Transverse (x37.2) and Small Intestine - Terminal Ileum (x11.9).

Protein differential expression in normal tissues from HIPED for GPA33 Gene

This gene is overexpressed in Rectum (36.7) and Colon (25.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GPA33 Gene

Protein tissue co-expression partners for GPA33 Gene

NURSA nuclear receptor signaling pathways regulating expression of GPA33 Gene:


SOURCE GeneReport for Unigene cluster for GPA33 Gene:


mRNA Expression by UniProt/SwissProt for GPA33 Gene:

Tissue specificity: Expressed in normal gastrointestinal epithelium and in 95% of colon cancers.

Evidence on tissue expression from TISSUES for GPA33 Gene

  • Lung(4.1)
  • Intestine(4)
genes like me logo Genes that share expression patterns with GPA33: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GPA33 Gene

Orthologs for GPA33 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GPA33 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPA33 34 33
  • 98.64 (n)
(Canis familiaris)
Mammalia GPA33 34 33
  • 81.1 (n)
(Bos Taurus)
Mammalia GPA33 34 33
  • 79.09 (n)
(Rattus norvegicus)
Mammalia Gpa33 33
  • 76.79 (n)
(Mus musculus)
Mammalia Gpa33 16 34 33
  • 76.58 (n)
(Monodelphis domestica)
Mammalia GPA33 34
  • 60 (a)
(Gallus gallus)
Aves GPA33 34 33
  • 55.51 (n)
(Anolis carolinensis)
Reptilia GPA33 34
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpa33 33
  • 53.85 (n)
MGC75653 33
(Danio rerio)
Actinopterygii LOC101885644 33
  • 47.66 (n)
GPA33 (1 of 2) 34
  • 24 (a)
gpa33 34
  • 21 (a)
Species where no ortholog for GPA33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GPA33 Gene

Gene Tree for GPA33 (if available)
Gene Tree for GPA33 (if available)
Evolutionary constrained regions (ECRs) for GPA33: view image

Paralogs for GPA33 Gene

Paralogs for GPA33 Gene

(3) SIMAP similar genes for GPA33 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with GPA33: view

Variants for GPA33 Gene

Sequence variations from dbSNP and Humsavar for GPA33 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000008862 -- 167,090,573(-) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000076985 -- 167,079,455(-) G/A intron_variant
rs1000106831 -- 167,059,168(-) A/C intron_variant
rs1000169540 -- 167,058,168(-) C/T intron_variant
rs1000228067 -- 167,090,944(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GPA33 Gene

Variant ID Type Subtype PubMed ID
esv1004965 CNV deletion 20482838
esv2649114 CNV insertion 19546169
esv2750815 CNV gain 17911159
esv3392289 CNV duplication 20981092
nsv1078878 OTHER inversion 25765185

Variation tolerance for GPA33 Gene

Residual Variation Intolerance Score: 80.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.99; 49.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GPA33 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GPA33 Gene

Disorders for GPA33 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GPA33 Gene - From: DISEASES

Disorder Aliases PubMed IDs
infant botulism
  • infant intestinal botulism
- elite association - COSMIC cancer census association via MalaCards
Search GPA33 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GPA33

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GPA33: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GPA33 Gene

Publications for GPA33 Gene

  1. Characterization of posttranslational modifications of human A33 antigen, a novel palmitoylated surface glycoprotein of human gastrointestinal epithelium. (PMID: 9245713) Ritter G … Simpson RJ (Biochemical and biophysical research communications 1997) 2 3 4 22 58
  2. The human A33 antigen is a transmembrane glycoprotein and a novel member of the immunoglobulin superfamily. (PMID: 9012807) Heath JK … Burgess AW (Proceedings of the National Academy of Sciences of the United States of America 1997) 2 3 4 22 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PMID: 19064610) Cheung CL … Kung AW (Human molecular genetics 2009) 3 44 58
  5. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret GB … Chakravarti A (European journal of human genetics : EJHG 2009) 3 44 58

Products for GPA33 Gene

Sources for GPA33 Gene

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