Aliases for GP6 Gene
External Ids for GP6 Gene
Previous GeneCards Identifiers for GP6 Gene
This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
GeneCards Summary for GP6 Gene
GP6 (Glycoprotein VI Platelet) is a Protein Coding gene. Diseases associated with GP6 include Bleeding Disorder, Platelet-Type, 11 and Sticky Platelet Syndrome. Among its related pathways are Cell surface interactions at the vascular wall and Platelet Aggregation Inhibitor Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include collagen binding. An important paralog of this gene is LILRB1.
UniProtKB/Swiss-Prot Summary for GP6 Gene
Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2.