Aliases for GP5 Gene
External Ids for GP5 Gene
Previous GeneCards Identifiers for GP5 Gene
Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 613160) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder (review by Lopez et al., 1998 [PubMed 9616133]).[supplied by OMIM, Nov 2010]
GeneCards Summary for GP5 Gene
GP5 (Glycoprotein V Platelet) is a Protein Coding gene. Diseases associated with GP5 include Bernard-Soulier Syndrome and Ureter Inverted Papilloma. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Integrin alphaIIb beta3 signaling. Gene Ontology (GO) annotations related to this gene include collagen binding. An important paralog of this gene is LRRC15.
UniProtKB/Swiss-Prot for GP5 Gene
The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis.