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Aliases for GOT2 Gene

Aliases for GOT2 Gene

  • Glutamic-Oxaloacetic Transaminase 2 2 3 5
  • Kynurenine Aminotransferase IV 2 3 4
  • Plasma Membrane-Associated Fatty Acid-Binding Protein 3 4
  • Glutamic-Oxaloacetic Transaminase 2, Mitochondrial 2 3
  • Kynurenine--Oxoglutarate Transaminase IV 3 4
  • Kynurenine--Oxoglutarate Transaminase 4 3 4
  • Glutamate Oxaloacetate Transaminase 2 3 4
  • Kynurenine Aminotransferase 4 3 4
  • Aspartate Aminotransferase 2 2 3
  • Fatty Acid-Binding Protein 3 4
  • Aspartate Transaminase 2 2 3
  • Transaminase A 3 4
  • EC 4 56
  • FABP-1 3 4
  • FABPpm 3 4
  • MAspAT 3 4
  • Glutamic-Oxaloacetic Transaminase 2, Mitochondrial (Aspartate Aminotransferase 2) 2
  • Aspartate Aminotransferase, Mitochondrial 3
  • EC 4
  • EC 2.6.1 56
  • MitAAT 3
  • KATIV 3
  • KYAT4 3
  • KAT4 3

External Ids for GOT2 Gene

Previous GeneCards Identifiers for GOT2 Gene

  • GC16M049137
  • GC16M058827
  • GC16M058475
  • GC16M058516
  • GC16M057298
  • GC16M058741
  • GC16M044606

Summaries for GOT2 Gene

Entrez Gene Summary for GOT2 Gene

  • Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

GeneCards Summary for GOT2 Gene

GOT2 (Glutamic-Oxaloacetic Transaminase 2) is a Protein Coding gene. Diseases associated with GOT2 include Acute Vascular Insufficiency Of Intestine and Coenurosis. Among its related pathways are Glycosaminoglycan metabolism and Phenylalanine metabolism. Gene Ontology (GO) annotations related to this gene include kynurenine-oxoglutarate transaminase activity. An important paralog of this gene is GOT1.

UniProtKB/Swiss-Prot for GOT2 Gene

  • Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids.

Gene Wiki entry for GOT2 Gene

Additional gene information for GOT2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOT2 Gene

Genomics for GOT2 Gene

GeneHancer (GH) Regulatory Elements for GOT2 Gene

Promoters and enhancers for GOT2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I058731 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 572.6 +0.9 913 3.3 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 SLC30A9 GOT2 ENSG00000245768 GC16M058732 CNOT1 CSNK2A2 LOC101927556 SLC38A7
GH16I058683 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.5 +49.8 49820 1.7 PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF143 FOS NFYC ZHX2 MXD4 SLC38A7 CNOT1 SETD6 GOT2 ENSG00000245768 RNU6-1155P
GH16I058755 Enhancer 1 Ensembl ENCODE 22 -22.0 -22001 1.6 ELF3 FOXA2 ARID4B ZNF2 IRF4 RAD21 ARID2 ZNF143 THAP11 DEK GOT2 SLC38A7 GC16M058744 RN7SL143P RNU6-1155P ENSG00000245768
GH16I058514 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.8 +218.8 218827 2.5 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B E2F8 ZNF143 SETD6 GC16M058513 GC16M058514 PIR59635 CNOT1 SNORA46 GOT2 GINS3
GH16I058654 Enhancer 0.7 ENCODE 16.1 +79.3 79298 1.4 SOX13 FOXA2 ARID4B CEBPG POLR2A GATAD2A L3MBTL2 NFIA HDAC8 TGIF2 GOT2 GINS3 CNOT1 SLC38A7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GOT2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GOT2 gene promoter:

Genomic Locations for GOT2 Gene

Genomic Locations for GOT2 Gene
27,227 bases
Minus strand

Genomic View for GOT2 Gene

Genes around GOT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GOT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GOT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOT2 Gene

Proteins for GOT2 Gene

  • Protein details for GOT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Aspartate aminotransferase, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • B4DJA6
    • E7ERW2
    • Q53FL3
    • Q9BWA3

    Protein attributes for GOT2 Gene

    430 amino acids
    Molecular mass:
    47518 Da
    Name=pyridoxal 5-phosphate; Xref=ChEBI:CHEBI:597326;
    Quaternary structure:
    • Homodimer.
    • In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

    Three dimensional structures from OCA and Proteopedia for GOT2 Gene

    Alternative splice isoforms for GOT2 Gene


neXtProt entry for GOT2 Gene

Selected DME Specific Peptides for GOT2 Gene


Post-translational modifications for GOT2 Gene

  • Ubiquitination at isoforms=2, 1, 1, 1396
  • Modification sites at PhosphoSitePlus

Other Protein References for GOT2 Gene

Domains & Families for GOT2 Gene

Gene Families for GOT2 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Candidate cardiovascular disease genes
  • Enzymes
  • Plasma proteins
  • Predicted secreted proteins
  • Transporters

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
  • Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
genes like me logo Genes that share domains with GOT2: view

Function for GOT2 Gene

Molecular function for GOT2 Gene

GENATLAS Biochemistry:
glutamic-oxaloacetic transaminase 2,mitochondrial (aspartate aminotransferase 1)
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 8.5. {ECO:0000269 PubMed:26902786}; Temperature dependence: Optimum temperature is 47.5 degrees Celsius. {ECO:0000269 PubMed:26902786};
UniProtKB/Swiss-Prot CatalyticActivity:
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
UniProtKB/Swiss-Prot CatalyticActivity:
L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.
UniProtKB/Swiss-Prot Function:
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids.
UniProtKB/Swiss-Prot Induction:
Up-regulated by long-time exposure to alcohol.

Enzyme Numbers (IUBMB) for GOT2 Gene

Phenotypes From GWAS Catalog for GOT2 Gene

Gene Ontology (GO) - Molecular Function for GOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0003824 catalytic activity IEA --
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity ISS,EXP --
GO:0005543 phospholipid binding IEA --
GO:0008483 transaminase activity IEA --
genes like me logo Genes that share ontologies with GOT2: view
genes like me logo Genes that share phenotypes with GOT2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GOT2 Gene

Localization for GOT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOT2 Gene

Mitochondrion matrix. Cell membrane. Note=Exposure to alcohol promotes translocation to the cell membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GOT2 gene
Compartment Confidence
plasma membrane 5
extracellular 5
mitochondrion 5
peroxisome 3
cytosol 3
cytoskeleton 2
nucleus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion ISS --
GO:0005743 mitochondrial inner membrane IEA --
GO:0005759 mitochondrial matrix TAS --
GO:0005886 plasma membrane IDA,IEA 9537447
GO:0009986 cell surface IEA --
genes like me logo Genes that share ontologies with GOT2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GOT2 Gene

Pathways & Interactions for GOT2 Gene

genes like me logo Genes that share pathways with GOT2: view

Gene Ontology (GO) - Biological Process for GOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006094 gluconeogenesis TAS --
GO:0006103 2-oxoglutarate metabolic process ISS --
GO:0006107 oxaloacetate metabolic process IEA --
GO:0006520 cellular amino acid metabolic process IEA --
GO:0006531 aspartate metabolic process ISS --
genes like me logo Genes that share ontologies with GOT2: view

No data available for SIGNOR curated interactions for GOT2 Gene

Drugs & Compounds for GOT2 Gene

(12) Drugs for GOT2 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutamic Acid Approved Nutra Full agonist, Agonist, Target 251
L-Aspartic acid Approved Nutra Target 0
Pyridoxal Phosphate Approved, Investigational Nutra Target, cofactor 17
Famotidine Approved Pharma Histamine H2-receptor antagonist 64
L-Cysteine Approved Nutra 0

(11) Additional Compounds for GOT2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-Mercaptopyruvic acid
  • 3-Mercapto-pyruvate
  • 3-Mercapto-pyruvic acid
  • 3-Mercaptopyruvate
  • 3-Mercaptopyruvic acid
  • beta-3-Mercapto-2-oxo-propanoate
3-Sulfinylpyruvic acid
  • 3-Sulfinopyruvate
  • 3-Sulfinyl-pyruvate
  • 3-Sulfinylpyruvate
  • 3-Sulphinyl-pyruvate
  • beta-Sulfinylpyruvate
4-(2-Aminophenyl)-2,4-dioxobutanoic acid
  • 4-(2-Aminophenyl)-2,4-dioxo-butanoate
  • 4-(2-Aminophenyl)-2,4-dioxo-butanoic acid
  • 4-(2-Aminophenyl)-2,4-dioxobutanoate
  • 4-(2-Aminophenyl)-2,4-dioxobutanoic acid
4-Hydroxy-L-glutamic acid
  • (2S)-2-amino-4-hydroxypentanedioate
  • (2S)-2-amino-4-hydroxypentanedioic acid
  • 4-Hydroxy-L-glutamate
  • 4-Hydroxy-L-glutamic acid
  • Erythro-4-hydroxyglutamate
4-Hydroxyphenylpyruvic acid
  • (p-hydroxyphenyl)-Pyruvate
  • (p-hydroxyphenyl)-Pyruvic acid
  • (p-Hydroxyphenyl)pyruvate
  • (p-Hydroxyphenyl)pyruvic acid
  • 3-(4-Hydroxyphenyl)-2-oxo-propanoate
genes like me logo Genes that share compounds with GOT2: view

Transcripts for GOT2 Gene

Unigene Clusters for GOT2 Gene

Glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GOT2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11
SP1: - - - -
SP2: - - - -
SP3: -
SP4: -
SP5: - -
SP6: - - -

Relevant External Links for GOT2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GOT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GOT2 Gene

mRNA differential expression in normal tissues according to GTEx for GOT2 Gene

This gene is overexpressed in Heart - Left Ventricle (x6.1) and Muscle - Skeletal (x5.5).

Protein differential expression in normal tissues from HIPED for GOT2 Gene

This gene is overexpressed in Liver, secretome (20.2) and Heart (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GOT2 Gene

Protein tissue co-expression partners for GOT2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GOT2 Gene:


SOURCE GeneReport for Unigene cluster for GOT2 Gene:


Evidence on tissue expression from TISSUES for GOT2 Gene

  • Nervous system(5)
  • Liver(4.9)
  • Muscle(4.8)
  • Stomach(4.6)
  • Heart(4.4)
  • Intestine(4.4)
  • Kidney(4.4)
  • Lung(4.3)
  • Skin(4.1)
  • Eye(3.5)
  • Blood(3)
  • Spleen(2.2)
genes like me logo Genes that share expression patterns with GOT2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GOT2 Gene

Orthologs for GOT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GOT2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GOT2 33 34
  • 99.38 (n)
(Ornithorhynchus anatinus)
Mammalia GOT2 34
  • 95 (a)
(Monodelphis domestica)
Mammalia GOT2 34
  • 92 (a)
(Canis familiaris)
Mammalia GOT2 33
  • 90.78 (n)
-- 34
  • 84 (a)
(Bos Taurus)
Mammalia GOT2 33 34
  • 90 (n)
(Mus musculus)
Mammalia Got2 33 16 34
  • 88.76 (n)
(Rattus norvegicus)
Mammalia Got2 33
  • 88.29 (n)
(Gallus gallus)
Aves GOT2 33 34
  • 78.15 (n)
(Anolis carolinensis)
Reptilia GOT2 34
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia got2 33
  • 72.68 (n)
Str.1247 33
African clawed frog
(Xenopus laevis)
Amphibia got2-prov 33
(Danio rerio)
Actinopterygii got2b 34
  • 77 (a)
got2a 33 34
  • 72.35 (n)
wufb64g01 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9809 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009685 33
  • 64.33 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4233 35
  • 63 (a)
Got2 33 34
  • 62.94 (n)
CG8430 35
  • 48 (a)
(Caenorhabditis elegans)
Secernentea got-2.2 33 34
  • 64.15 (n)
got-2.1 34
  • 61 (a)
C44E4.3 35
  • 58 (a)
T01C8.4 35
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AAT2 34
  • 43 (a)
AAT1 36
thale cress
(Arabidopsis thaliana)
eudicotyledons ASP1 33
  • 58.94 (n)
(Glycine max)
eudicotyledons Gma.1611 33
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3126 33
(Oryza sativa)
Liliopsida Os02g0236000 33
  • 58.04 (n)
Os.4772 33
(Hordeum vulgare)
Liliopsida Hv.7187 33
(Triticum aestivum)
Liliopsida Ta.5314 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 65 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU10383 33
  • 61.05 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC725.01 33
  • 58.14 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14130 33
Species where no ortholog for GOT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for GOT2 Gene

Gene Tree for GOT2 (if available)
Gene Tree for GOT2 (if available)

Paralogs for GOT2 Gene

Paralogs for GOT2 Gene

(3) SIMAP similar genes for GOT2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with GOT2: view

Variants for GOT2 Gene

Sequence variations from dbSNP and Humsavar for GOT2 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000116019 -- 58,716,379(-) T/A intron_variant
rs1000270956 -- 58,712,426(-) G/A intron_variant
rs1000495685 -- 58,735,917(-) A/G upstream_transcript_variant
rs1000522007 -- 58,725,182(-) T/C intron_variant
rs1000582946 -- 58,731,334(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GOT2 Gene

Variant ID Type Subtype PubMed ID
esv1039184 CNV deletion 17803354
esv2714558 CNV deletion 23290073
esv2758650 CNV loss 17122850
nsv1065296 CNV loss 25217958
nsv1817 CNV insertion 18451855
nsv509623 CNV insertion 20534489
nsv510686 CNV deletion 20534489
nsv511049 OTHER complex 20534489
nsv954067 CNV deletion 24416366
nsv984340 CNV duplication 23825009

Variation tolerance for GOT2 Gene

Residual Variation Intolerance Score: 59.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.08; 75.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GOT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOT2 Gene

Disorders for GOT2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for GOT2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
acute vascular insufficiency of intestine
  • acute gastrointestinal tract vascular insuffic.
  • coenuriasis
histidine metabolism disease
  • disturbances of histidine metabolism
  • histidine ammonia-lyase deficiency
pleomorphic lipoma
  • lipomatosis, multiple
- elite association - COSMIC cancer census association via MalaCards
Search GOT2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GOT2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GOT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GOT2 Gene

Publications for GOT2 Gene

  1. Genome-wide joint SNP and CNV analysis of aortic root diameter in African Americans: the HyperGEN study. (PMID: 21223598) Wineinger NE … Tiwari HK (BMC medical genomics 2011) 3 44 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. Common variants at ten loci influence QT interval duration in the QTGEN Study. (PMID: 19305408) Newton-Cheh C … Stricker BH (Nature genetics 2009) 3 44 58
  4. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler HE … Kim SK (PLoS genetics 2009) 3 44 58
  5. Mitochondrial aspartate aminotransferase: a third kynurenate-producing enzyme in the mammalian brain. (PMID: 17442055) Guidetti P … Schwarcz R (Journal of neurochemistry 2007) 2 3 58

Products for GOT2 Gene

Sources for GOT2 Gene

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