Aliases for GOT1L1 Gene

Aliases for GOT1L1 Gene

  • Glutamic-Oxaloacetic Transaminase 1 Like 1 2 3 5
  • Glutamate Oxaloacetate Transaminase 1-Like Protein 1 3 4
  • Putative Aspartate Aminotransferase, Cytoplasmic 2 3 4
  • Transaminase A-Like Protein 1 3 4
  • EC 4

External Ids for GOT1L1 Gene

Previous GeneCards Identifiers for GOT1L1 Gene

  • GC08M037912
  • GC08M037791
  • GC08M036326

Summaries for GOT1L1 Gene

GeneCards Summary for GOT1L1 Gene

GOT1L1 (Glutamic-Oxaloacetic Transaminase 1 Like 1) is a Protein Coding gene. Among its related pathways are Valproic Acid Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include pyridoxal phosphate binding and transaminase activity. An important paralog of this gene is GOT1.

Additional gene information for GOT1L1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GOT1L1 Gene

Genomics for GOT1L1 Gene

GeneHancer (GH) Regulatory Elements for GOT1L1 Gene

Promoters and enhancers for GOT1L1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GOT1L1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GOT1L1

Top Transcription factor binding sites by QIAGEN in the GOT1L1 gene promoter:
  • CP2
  • CUTL1
  • E47
  • Evi-1
  • ITF-2
  • LCR-F1
  • Lmo2
  • p53
  • Tal-1beta

Genomic Locations for GOT1L1 Gene

Genomic Locations for GOT1L1 Gene
5,877 bases
Minus strand
5,849 bases
Minus strand

Genomic View for GOT1L1 Gene

Genes around GOT1L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GOT1L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GOT1L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOT1L1 Gene

Proteins for GOT1L1 Gene

  • Protein details for GOT1L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative aspartate aminotransferase, cytoplasmic 2
    Protein Accession:
    Secondary Accessions:
    • A8MWL4

    Protein attributes for GOT1L1 Gene

    421 amino acids
    Molecular mass:
    47305 Da
    Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
    Quaternary structure:
    • Homodimer.
    • In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

neXtProt entry for GOT1L1 Gene

Post-translational modifications for GOT1L1 Gene

No Post-translational modifications

Other Protein References for GOT1L1 Gene

No data available for DME Specific Peptides for GOT1L1 Gene

Domains & Families for GOT1L1 Gene

Gene Families for GOT1L1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GOT1L1 Gene

  • Aspartate aminotransferase signature

Suggested Antigen Peptide Sequences for GOT1L1 Gene

GenScript: Design optimal peptide antigens:
  • Transaminase A-like protein 1 (AATC2_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
  • Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
genes like me logo Genes that share domains with GOT1L1: view

Function for GOT1L1 Gene

Molecular function for GOT1L1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-oxoglutarate + L-aspartate = L-glutamate + oxaloacetate; Xref=Rhea:RHEA:21824, ChEBI:CHEBI:16452, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:29991; EC=;.

Enzyme Numbers (IUBMB) for GOT1L1 Gene

Phenotypes From GWAS Catalog for GOT1L1 Gene

Gene Ontology (GO) - Molecular Function for GOT1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity IBA 21873635
GO:0008483 transaminase activity IEA --
GO:0016740 transferase activity IEA --
GO:0030170 pyridoxal phosphate binding IEA --
genes like me logo Genes that share ontologies with GOT1L1: view
genes like me logo Genes that share phenotypes with GOT1L1: view

Animal Model Products

CRISPR Products

miRNA for GOT1L1 Gene

miRTarBase miRNAs that target GOT1L1

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GOT1L1 Gene

Localization for GOT1L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOT1L1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GOT1L1 gene
Compartment Confidence
cytosol 4
nucleus 1
mitochondrion 0
peroxisome 0

Gene Ontology (GO) - Cellular Components for GOT1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IBA 21873635
genes like me logo Genes that share ontologies with GOT1L1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GOT1L1 Gene

Pathways & Interactions for GOT1L1 Gene

PathCards logo

SuperPathways for GOT1L1 Gene

genes like me logo Genes that share pathways with GOT1L1: view

Pathways by source for GOT1L1 Gene

1 BioSystems pathway for GOT1L1 Gene
1 PharmGKB pathway for GOT1L1 Gene

Gene Ontology (GO) - Biological Process for GOT1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006520 cellular amino acid metabolic process IEA --
GO:0006532 aspartate biosynthetic process IBA 21873635
GO:0009058 biosynthetic process IEA --
genes like me logo Genes that share ontologies with GOT1L1: view

No data available for SIGNOR curated interactions for GOT1L1 Gene

Drugs & Compounds for GOT1L1 Gene

(4) Drugs for GOT1L1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aspartic acid Approved Nutra 175
Glutamic acid Approved Nutra Full agonist, Agonist 289
Pyridoxal Phosphate Approved, Investigational Nutra 20
Oxogluric acid Experimental, Investigational Nutra 0

(1) Additional Compounds for GOT1L1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Oxalacetic acid
  • 2-Oxobutanedioic acid
  • 2-Oxosuccinic acid
  • 3-Carboxy-3-oxopropanoic acid
  • keto-Succinic acid
  • Ketosuccinic acid
genes like me logo Genes that share compounds with GOT1L1: view

Transcripts for GOT1L1 Gene

mRNA/cDNA for GOT1L1 Gene

2 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GOT1L1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: -

Relevant External Links for GOT1L1 Gene

GeneLoc Exon Structure for

Expression for GOT1L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GOT1L1 Gene

mRNA differential expression in normal tissues according to GTEx for GOT1L1 Gene

This gene is overexpressed in Testis (x49.2).

Protein differential expression in normal tissues from HIPED for GOT1L1 Gene

This gene is overexpressed in Synovial fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GOT1L1 Gene

Protein tissue co-expression partners for GOT1L1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GOT1L1

SOURCE GeneReport for Unigene cluster for GOT1L1 Gene:

genes like me logo Genes that share expression patterns with GOT1L1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GOT1L1 Gene

Orthologs for GOT1L1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GOT1L1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GOT1L1 30
  • 98.82 (n)
(Canis familiaris)
Mammalia GOT1L1 30
  • 84.32 (n)
-- 31
  • 27 (a)
(Bos Taurus)
Mammalia GOT1L1 31 30
  • 82.35 (n)
(Mus musculus)
Mammalia Got1l1 17 31 30
  • 80.56 (n)
(Rattus norvegicus)
Mammalia Got1l1 30
  • 80 (n)
(Monodelphis domestica)
Mammalia GOT1L1 31
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia GOT1L1 31
  • 46 (a)
(Anolis carolinensis)
Reptilia GOT1L1 31
  • 44 (a)
(Danio rerio)
Actinopterygii got1l1 31
  • 36 (a)
fruit fly
(Drosophila melanogaster)
Insecta Got1 31
  • 35 (a)
(Caenorhabditis elegans)
Secernentea got-1.2 31
  • 35 (a)
got-1.1 31
  • 35 (a)
got-1.3 31
  • 27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AAT2 31
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6560 31
  • 36 (a)
Species where no ortholog for GOT1L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GOT1L1 Gene

Gene Tree for GOT1L1 (if available)
Gene Tree for GOT1L1 (if available)
Evolutionary constrained regions (ECRs) for GOT1L1: view image

Paralogs for GOT1L1 Gene

Paralogs for GOT1L1 Gene

(3) SIMAP similar genes for GOT1L1 Gene using alignment to 3 proteins:

  • E5RI59_HUMAN
genes like me logo Genes that share paralogs with GOT1L1: view

Variants for GOT1L1 Gene

Additional dbSNP identifiers (rs#s) for GOT1L1 Gene

Structural Variations from Database of Genomic Variants (DGV) for GOT1L1 Gene

Variant ID Type Subtype PubMed ID
nsv610947 CNV loss 21841781

Variation tolerance for GOT1L1 Gene

Residual Variation Intolerance Score: 82.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.62; 65.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GOT1L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GOT1L1 Gene

Disorders for GOT1L1 Gene

Additional Disease Information for GOT1L1

No disorders were found for GOT1L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GOT1L1 Gene

Publications for GOT1L1 Gene

  1. Biosynthesis of D-aspartate in mammals: the rat and human homologs of mouse aspartate racemase are not responsible for the biosynthesis of D-aspartate. (PMID: 25646960) Matsuda S … Homma H (Amino acids 2015) 2 3 54
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  3. Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PMID: 22952844) Wu Z … Ma L (PloS one 2012) 3 54
  4. Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. (PMID: 22360420) Martins-de-Souza D … Bahn S (Journal of proteome research 2012) 3 54
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54

Products for GOT1L1 Gene

Sources for GOT1L1 Gene