Aliases for GOPC Gene
External Ids for GOPC Gene
Previous GeneCards Identifiers for GOPC Gene
This gene encodes a Golgi protein with a PDZ domain. The PDZ domain is globular and proteins which contain them bind other proteins through short motifs near the C-termini. Mice which are deficient in the orthologous protein have globozoospermia and are infertile. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
GeneCards Summary for GOPC Gene
GOPC (Golgi Associated PDZ And Coiled-Coil Motif Containing) is a Protein Coding gene. Diseases associated with GOPC include Spermatogenic Failure 6 and Acute Laryngitis. Among its related pathways are wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF) and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and ion channel binding. An important paralog of this gene is ENSG00000282218.
UniProtKB/Swiss-Prot Summary for GOPC Gene
Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.