Aliases for GOPC Gene
External Ids for GOPC Gene
Previous GeneCards Identifiers for GOPC Gene
This gene encodes a Golgi protein with a PDZ domain. The PDZ domain is globular and proteins which contain them bind other proteins through short motifs near the C-termini. Mice which are deficient in the orthologous protein have globozoospermia and are infertile. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
GeneCards Summary for GOPC Gene
GOPC (Golgi Associated PDZ And Coiled-Coil Motif Containing) is a Protein Coding gene. Diseases associated with GOPC include Spermatogenic Failure 6 and Cystic Fibrosis. Among its related pathways are Cytoskeletal Signaling and wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF). Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and ion channel binding. An important paralog of this gene is ENSG00000282218.
UniProtKB/Swiss-Prot for GOPC Gene
Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.