Aliases for GOLT1B Gene
Aliases for GOLT1B Gene
External Ids for GOLT1B Gene
- HGNC: 20175
- Entrez Gene: 51026
- Ensembl: ENSG00000111711
- OMIM: 615078
- UniProtKB: Q9Y3E0
Previous GeneCards Identifiers for GOLT1B Gene
- GC12P021547
- GC12P021654
- GC12P021428
Summaries for GOLT1B Gene
GeneCards Summary for GOLT1B Gene
GOLT1B (Golgi Transport 1B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and lipase activity. An important paralog of this gene is GOLT1A.
UniProtKB/Swiss-Prot for GOLT1B Gene
-
May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
Additional gene information for GOLT1B Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOLT1B Gene
Genomics for GOLT1B Gene
GeneHancer (GH) Regulatory Elements for GOLT1B Gene
Promoters and enhancers for GOLT1B Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH12J021500 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE | 657.5 | -0.1 | -61 | 2.7 | PKNOX1 SMAD1 ARID4B SIN3A DMAP1 IRF4 YY1 POLR2B E2F8 ZNF207 | RECQL GOLT1B PYROXD1 | |
| GH12J021526 | Promoter | 0.9 | EPDnew | 0.3 | +24.5 | 24515 | 0.1 | MEIS2 PKNOX1 HLF CEBPB CEBPG ATF4 JUND CEBPA | SPX GOLT1B | |
| GH12J021509 | Enhancer | 0.4 | ENCODE | 0.4 | +8.1 | 8064 | 1 | SMARCA5 SRF ZFP36 | PYROXD1 SPX ENSG00000256615 LDHB RECQL GOLT1B | |
| GH12J021513 | Enhancer | 0.3 | FANTOM5 | 0.4 | +11.5 | 11491 | 0.4 | GYS2 ENSG00000256615 LDHB GOLT1B SPX |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around GOLT1B on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the GOLT1B gene promoter:
-
- CUTL1
- IRF-2
- HFH-1
- ATF6
- SREBP-1c
- SREBP-1b
- SREBP-1a
- C/EBPalpha
- c-Myb
- En-1
Regulatory Element Products
Genomic Locations for GOLT1B Gene
Genomic Locations for GOLT1B Gene
- chr12:21,501,765-21,518,408
- (GRCh38/hg38)
- Size:
- 16,644 bases
- Orientation:
- Plus strand
- chr12:21,654,699-21,671,342
- (GRCh37/hg19)
- Size:
- 16,644 bases
- Orientation:
- Plus strand
Genomic View for GOLT1B Gene
Genes around GOLT1B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p12.1 by Entrez Gene
- 12p12.1 by HGNC
- 12p12.1 by Ensembl
GOLT1B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GOLT1B Gene
Proteins for GOLT1B Gene
-
Protein details for GOLT1B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y3E0-GOT1B_HUMAN
- Recommended name:
- Vesicle transport protein GOT1B
- Protein Accession:
- Q9Y3E0
- B2R4R4
- Q54A40
- Q6I9W6
- Q9P1R9
Protein attributes for GOLT1B Gene
- Size:
- 138 amino acids
- Molecular mass:
- 15426 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAF65181.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for GOLT1B Gene
Post-translational modifications for GOLT1B Gene
Other Protein References for GOLT1B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for GOLT1B
- Invitrogen Antibodies for GOLT1B
- Search GeneTex for Antibodies for GOLT1B
Protein Products
-
OriGene Purified Proteins for GOLT1B
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- antibodies-online: Search results for 3 available GOLT1B Proteins ranked by validation data
- Compare Top GOLT1B Proteins
-
Quality Products:
- Search GeneTex for Proteins for GOLT1B
Assay Products
No data available for DME Specific Peptides for GOLT1B Gene
Domains & Families for GOLT1B Gene
Gene Families for GOLT1B Gene
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Protein Domains for GOLT1B Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for GOLT1B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y3E0- Family:
-
- Belongs to the GOT1 family.
Function for GOLT1B Gene
Molecular function for GOLT1B Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004871 | obsolete signal transducer activity | HMP | -- |
| GO:0016298 | lipase activity | IBA | -- |
Phenotypes for GOLT1B Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
CRISPR Products
-
OriGene CRISPR knockouts for GOLT1B
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- Applied Biological Materials CRISPR for GOLT1B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GOLT1B
- GenScript: Design CRISPR guide RNA sequences for GOLT1B
miRNA for GOLT1B Gene
- miRTarBase miRNAs that target GOLT1B
-
- hsa-mir-155-5p (MIRT020930)
- hsa-mir-124-3p (MIRT022871)
- hsa-mir-103a-3p (MIRT027188)
- hsa-mir-16-5p (MIRT031937)
- hsa-let-7d-5p (MIRT032134)
- hsa-mir-106b-5p (MIRT044282)
- hsa-mir-338-5p (MIRT063301)
- hsa-mir-4461 (MIRT063302)
- hsa-mir-3591-5p (MIRT231999)
- hsa-mir-2116-5p (MIRT384296)
- hsa-mir-4677-5p (MIRT384298)
- hsa-mir-142-3p (MIRT493747)
- hsa-mir-22-5p (MIRT493748)
- hsa-mir-3611 (MIRT525678)
- hsa-mir-4699-3p (MIRT562269)
- hsa-mir-641 (MIRT562270)
- hsa-mir-3617-5p (MIRT562271)
miRNA Products
Inhibitory RNA Products
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Clone Products
- Sino Biological Human cDNA Clone for GOLT1B
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GOLT1B
- genomics-online: cdna clones - Search results for available GOLT1B gene related products
- orf clones - Search results for available GOLT1B gene related products
- Applied Biological Materials Clones for GOLT1B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GOLT1B Gene
Localization for GOLT1B Gene
Subcellular locations from UniProtKB/Swiss-Prot for GOLT1B Gene
- Golgi apparatus membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| endoplasmic reticulum | 5 |
| golgi apparatus | 3 |
| plasma membrane | 2 |
| lysosome | 1 |
- Vesicles (3)
- Nucleoplasm (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | -- |
| GO:0005783 | endoplasmic reticulum | IDA | -- |
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0016020 | membrane | IBA,IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for GOLT1B Gene
No Data Available
Interacting Proteins for GOLT1B Gene
GPS-Prot Interaction Network for GOLT1B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006629 | lipid metabolic process | IBA | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0015031 | protein transport | IEA | -- |
| GO:0016192 | vesicle-mediated transport | IEA | -- |
| GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | HMP | 12761501 |
No data available for Pathways by source and SIGNOR curated interactions for GOLT1B Gene
Transcripts for GOLT1B Gene
mRNA/cDNA for GOLT1B Gene
- (2) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (230) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000535593 813 bps (uc009ziu.3)
- ENST00000542038 933 bps (uc058lva.1)
- ENST00000545113 555 bps (uc058lvb.1)
- ENST00000540141 1055 bps (uc058lvc.1)
- ENST00000229314 3227 bps (uc001rez.3)
CRISPR Products
-
OriGene CRISPR knockouts for GOLT1B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GOLT1B
- genomics-online: gRNA clones - Search results for available GOLT1B gene related products
- Applied Biological Materials CRISPR for GOLT1B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GOLT1B
- GenScript: Design CRISPR guide RNA sequences for GOLT1B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GOLT1B
- Browse OriGene Inhibitory RNA Products For GOLT1B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GOLT1B
- genomics-online: shRNA clones - Search results for available GOLT1B gene related products
Clone Products
- Sino Biological Human cDNA Clone for GOLT1B
- VectorBuilder custom plasmid, inducible vectors for GOLT1B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GOLT1B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GOLT1B
- genomics-online: cdna clones - Search results for available GOLT1B gene related products
- orf clones - Search results for available GOLT1B gene related products
- Applied Biological Materials Clones for GOLT1B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||||||||||
| SP6: | - | - | - | - | - | - | |||||||||||||||||||
| SP7: |
Expression for GOLT1B Gene
This gene is overexpressed in Nasal epithelium (49.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GOLT1B Gene
NURSA nuclear receptor signaling pathways regulating expression of GOLT1B Gene:
GOLT1BSOURCE GeneReport for Unigene cluster for GOLT1B Gene:
Hs.62275mRNA Expression by UniProt/SwissProt for GOLT1B Gene:
Q9Y3E0-GOT1B_HUMAN
Tissue specificity:
Widely expressed. Tends to be up-regulated in seminomas compared to normal testis.
Evidence on tissue expression from TISSUES for GOLT1B Gene
- Nervous system(4.7)
- Lung(4.2)
- Lymph node(4.2)
- Spleen(4.2)
- Blood(4.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for GOLT1B
-
OriGene qPCR primer pairs for GOLT1B
- genomics-online: primer clones - Search results for available GOLT1B gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GOLT1B Gene
Orthologs for GOLT1B Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GOLT1B 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | GOLT1B 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | GOLT1B 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | GOLT1B 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Golt1b 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Golt1b 16 34 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | GOLT1B 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | GOLT1B 33 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | GOLT1B 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | golt1b 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.33070 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | golt1ba 34 |
|
OneToMany | |
| golt1bb 34 33 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CG32576 34 33 |
|
OneToMany | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002357 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | F41C3.4 34 33 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | GOT1 36 34 33 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0A09801g 33 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AGR337W 33 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT3G49420 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os03g0209400 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.5537 34 |
|
OneToMany | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU06396 33 |
|
- Species where no ortholog for GOLT1B was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for GOLT1B Gene
- ENSEMBL:
- Gene Tree for GOLT1B (if available)
- TreeFam:
- Gene Tree for GOLT1B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GOLT1B: view image
Paralogs for GOLT1B Gene
Variants for GOLT1B Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000209483 | -- | 21,511,986(+) | T/A | intron_variant | |
| rs1000300399 | -- | 21,510,608(+) | T/G | intron_variant | |
| rs1000575319 | -- | 21,499,900(+) | C/A | upstream_transcript_variant | |
| rs1000678648 | -- | 21,518,512(+) | A/G | downstream_transcript_variant | |
| rs1000728860 | -- | 21,511,676(+) | G/A | intron_variant |
Residual Variation Intolerance Score:
59.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.34;
26.58% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GOLT1B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GOLT1B
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOLT1B Gene
Disorders for GOLT1B Gene
Additional Disease Information for GOLT1B
No disorders were found for GOLT1B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GOLT1B Gene
Publications for GOLT1B Gene
- Genomic and expression analysis of the 12p11-p12 amplicon using EST arrays identifies two novel amplified and overexpressed genes. (PMID: 12414650) Bourdon V … Chaganti RS (Cancer research 2002) 2 3 4 58
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
- Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PMID: 12761501) Matsuda A … Sugano S (Oncogene 2003) 3 4 58
Products for GOLT1B Gene
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- VectorBuilder custom plasmid, inducible vectors for GOLT1B
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 20 available GOLT1B Antibodies ranked by validation data
- Compare Top GOLT1B Antibodies
- antibodies-online: Search results for available GOLT1B related products ranked by validation data
- antibodies-online: Search results for 3 available GOLT1B Proteins ranked by validation data
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- Quality Products:
- Search GeneTex for Antibodies for GOLT1B
- Search GeneTex for Proteins for GOLT1B
- genomics-online: cdna clones - Search results for available GOLT1B gene related products
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- genomics-online: gRNA clones - Search results for available GOLT1B gene related products
- genomics-online: primer clones - Search results for available GOLT1B gene related products
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Sources for GOLT1B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
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