GOLT1B Gene (Protein Coding)

Golgi Transport 1B

GC12P021501
GIFtS:
34

Aliases for GOLT1B Gene

Aliases for GOLT1B Gene

  • Golgi Transport 1B 2 3 5
  • Putative NF-Kappa-B-Activating Protein 470 3 4
  • Vesicle Transport Protein GOT1B 3 4
  • Germ Cell Tumor 2 3 4
  • HGOT1a 3 4
  • GCT2 3 4
  • Golgi Transport 1 Homolog B (S. Cerevisiae) 2
  • Golgi Transport 1 Homolog B 4
  • CGI-141 3
  • YMR292W 3
  • GOT1B 3
  • GOT1A 4
  • GOT1 3

External Ids for GOLT1B Gene

Previous GeneCards Identifiers for GOLT1B Gene

  • GC12P021547
  • GC12P021654
  • GC12P021428

Summaries for GOLT1B Gene

GeneCards Summary for GOLT1B Gene

GOLT1B (Golgi Transport 1B) is a Protein Coding gene. Diseases associated with GOLT1B include Cervical Adenosquamous Carcinoma and Cone-Rod Dystrophy 6. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and lipase activity. An important paralog of this gene is GOLT1A.

UniProtKB/Swiss-Prot Summary for GOLT1B Gene

  • May be involved in fusion of ER-derived transport vesicles with the Golgi complex.

Gene Wiki entry for GOLT1B Gene

Additional gene information for GOLT1B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GOLT1B Gene

Genomics for GOLT1B Gene

GeneHancer (GH) Regulatory Elements for GOLT1B Gene

Promoters and enhancers for GOLT1B Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH12J021500 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 507.5 -0.1 -64 4.2 FOXK2 ZBTB40 ZNF217 SIN3A NRF1 TCF12 POLR2G SP1 PHF8 FOS RECQL GOLT1B HSALNG0089764 HSALNG0089765 PYROXD1
GH12J021507 Enhancer 0.2 Ensembl 8 +5.6 5636 0.8 PYROXD1 ENSG00000256615 LDHB GOLT1B HSALNG0089765 RF01045-030
GH12J021509 Enhancer 0.6 Ensembl ENCODE 0.4 +8.3 8336 1.8 SRF SMARCA5 ASH2L RAD51 ZFP36 PYROXD1 SPX ENSG00000256615 LDHB RECQL GOLT1B HSALNG0089765 RF01045-030
GH12J021513 Enhancer 0.2 FANTOM5 0.4 +11.5 11491 0.4 GYS2 ENSG00000256615 LDHB RF01045-030 HSALNG0089765 GOLT1B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GOLT1B on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GOLT1B

Top Transcription factor binding sites by QIAGEN in the GOLT1B gene promoter:
  • ATF6
  • c-Myb
  • C/EBPalpha
  • CUTL1
  • En-1
  • HFH-1
  • IRF-2
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for GOLT1B Gene

Genomic Locations for GOLT1B Gene
chr12:21,501,765-21,518,408
(GRCh38/hg38)
Size:
16,644 bases
Orientation:
Plus strand
chr12:21,654,699-21,671,342
(GRCh37/hg19)
Size:
16,644 bases
Orientation:
Plus strand

Genomic View for GOLT1B Gene

Genes around GOLT1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GOLT1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GOLT1B Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for GOLT1B Gene

Proteins for GOLT1B Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for GOLT1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3E0-GOT1B_HUMAN
    Recommended name:
    Vesicle transport protein GOT1B
    Protein Accession:
    Q9Y3E0
    Secondary Accessions:
    • B2R4R4
    • Q54A40
    • Q6I9W6
    • Q9P1R9

    Protein attributes for GOLT1B Gene

    Size:
    138 amino acids
    Molecular mass:
    15426 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF65181.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

neXtProt entry for GOLT1B Gene

Protein Expression for GOLT1B Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for GOLT1B Gene

  • Ubiquitination at Lys62
  • Modification sites at PhosphoSitePlus

Other Protein References for GOLT1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GOLT1B Gene

Domains & Families for GOLT1B Gene

Gene Families for GOLT1B Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for GOLT1B Gene

Blocks:
  • Got1-like protein
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GOLT1B Gene

GenScript: Design optimal peptide antigens:
  • hGOT1a (GOT1B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y3E0

UniProtKB/Swiss-Prot:

GOT1B_HUMAN :
  • Belongs to the GOT1 family.
Family:
  • Belongs to the GOT1 family.
genes like me logo Genes that share domains with GOLT1B: view

Function for GOLT1B Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for GOLT1B Gene

UniProtKB/Swiss-Prot Function:
May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
genes like me logo Genes that share phenotypes with GOLT1B: view

Animal Models for GOLT1B Gene

MGI Knock Outs for GOLT1B:
  • Golt1b Golt1b<tm1b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GOLT1B

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GOLT1B Gene

Localization for GOLT1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOLT1B Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GOLT1B gene
Compartment Confidence
endoplasmic reticulum 4
golgi apparatus 4
plasma membrane 2
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (3)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GOLT1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005783 endoplasmic reticulum IDA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane HDA,IEA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GOLT1B: view

Pathways & Interactions for GOLT1B Gene

PathCards logo

SuperPathways for GOLT1B Gene

No Data Available

Gene Ontology (GO) - Biological Process for GOLT1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling HMP 12761501
genes like me logo Genes that share ontologies with GOLT1B: view

No data available for Pathways by source and SIGNOR curated interactions for GOLT1B Gene

Drugs & Compounds for GOLT1B Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for GOLT1B Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for GOLT1B Gene

1 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GOLT1B

Alternative Splicing Database (ASD) splice patterns (SP) for GOLT1B Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d
SP1: - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: - - - - -
SP6: - - - - - -
SP7:

Relevant External Links for GOLT1B Gene

GeneLoc Exon Structure for
GOLT1B

Expression for GOLT1B Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GOLT1B Gene

mRNA expression in normal human tissues for GOLT1B Gene
mRNA expression by GTEx for GOLT1B GenemRNA expression by BioGPS for GOLT1B Gene

Protein differential expression in normal tissues from HIPED for GOLT1B Gene

This gene is overexpressed in Nasal epithelium (49.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GOLT1B Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GOLT1B

SOURCE GeneReport for Unigene cluster for GOLT1B Gene:

Hs.62275

mRNA Expression by UniProt/SwissProt for GOLT1B Gene:

Q9Y3E0-GOT1B_HUMAN
Tissue specificity: Widely expressed. Tends to be up-regulated in seminomas compared to normal testis.

Evidence on tissue expression from TISSUES for GOLT1B Gene

  • Nervous system(4.7)
  • Lung(4.2)
  • Lymph node(4.2)
  • Spleen(4.2)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with GOLT1B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GOLT1B Gene

Orthologs for GOLT1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GOLT1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia GOLT1B 31 30
  • 100 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia GOLT1B 31 30
  • 96.14 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia GOLT1B 31 30
  • 94.44 (n)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia GOLT1B 31
  • 93 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Golt1b 30
  • 89.86 (n)
mouse
(Mus musculus)
 Mammalia Golt1b 17 31 30
  • 89.37 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia GOLT1B 31
  • 88 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves GOLT1B 30
  • 86.96 (n)
lizard
(Anolis carolinensis)
 Reptilia GOLT1B 31
  • 90 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia golt1b 30
  • 75.33 (n)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.33070 30
zebrafish
(Danio rerio)
 Actinopterygii golt1ba 31
  • 86 (a)
 OneToMany
golt1bb 31 30
  • 73.43 (n)
 OneToMany
fruit fly
(Drosophila melanogaster)
 Insecta CG32576 31 30
  • 61.76 (n)
 OneToMany
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP002357 30
  • 60.54 (n)
worm
(Caenorhabditis elegans)
 Secernentea F41C3.4 31 30
  • 57.21 (n)
 OneToMany
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes GOT1 33 31 30
  • 55.3 (n)
K. lactis yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0A09801g 30
  • 50.65 (n)
A. gosspyii yeast
(Ashbya gossypii)
 Saccharomycetes AGOS_AGR337W 30
  • 46.25 (n)
thale cress
(Arabidopsis thaliana)
 eudicotyledons AT3G49420 30
  • 57.55 (n)
rice
(Oryza sativa)
 Liliopsida Os03g0209400 30
  • 58.07 (n)
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.5537 31
  • 62 (a)
 OneToMany
bread mold
(Neurospora crassa)
 Ascomycetes NCU06396 30
  • 54.79 (n)
Species where no ortholog for GOLT1B was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GOLT1B Gene

ENSEMBL:
Gene Tree for GOLT1B (if available)
TreeFam:
Gene Tree for GOLT1B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GOLT1B: view image

Paralogs for GOLT1B Gene

Paralogs for GOLT1B Gene

(1) SIMAP similar genes for GOLT1B Gene using alignment to 5 proteins:

  • GOT1B_HUMAN
  • F5GWD8_HUMAN
  • F5GXH6_HUMAN
  • F5H6U7_HUMAN
  • G3V1U5_HUMAN
genes like me logo Genes that share paralogs with GOLT1B: view

Variants for GOLT1B Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GOLT1B Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
679678 Benign: not provided 21,501,473(+) G/A FIVE_PRIME_UTR_VARIANT
679709 Benign: not provided 21,501,535(+) T/G FIVE_PRIME_UTR_VARIANT
679742 Likely Benign: not provided 21,501,558(+) C/T FIVE_PRIME_UTR_VARIANT
679753 Benign: not provided 21,501,331(+) G/A FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT
801392 Likely Benign: Hereditary cancer-predisposing syndrome 21,501,191(+) A/G FIVE_PRIME_UTR_VARIANT

Additional dbSNP identifiers (rs#s) for GOLT1B Gene

Structural Variations from Database of Genomic Variants (DGV) for GOLT1B Gene

Variant ID Type Subtype PubMed ID
nsv1054220 CNV gain 25217958
nsv528556 CNV gain 19592680
nsv557741 CNV gain 21841781
nsv557743 CNV gain 21841781

Variation tolerance for GOLT1B Gene

Residual Variation Intolerance Score: 59.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.34; 26.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GOLT1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GOLT1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOLT1B Gene

Disorders for GOLT1B Gene

MalaCards: The human disease database

(2) MalaCards diseases for GOLT1B Gene - From: DISEASES

Disorder Aliases PubMed IDs
cervical adenosquamous carcinoma
  • adenosquamous carcinoma of cervix
cone-rod dystrophy 6
  • retinitis pigmentosa 6
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GOLT1B

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GOLT1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GOLT1B Gene

Publications for GOLT1B Gene

  1. Genomic and expression analysis of the 12p11-p12 amplicon using EST arrays identifies two novel amplified and overexpressed genes. (PMID: 12414650) Bourdon V … Chaganti RS (Cancer research 2002) 2 3 4 54
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 54
  5. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PMID: 12761501) Matsuda A … Sugano S (Oncogene 2003) 3 4 54

ExternalLinks

View latest publications for GOLT1B gene in Mastermind

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Sources for GOLT1B Gene