Aliases for GOLT1A Gene

Aliases for GOLT1A Gene

  • Golgi Transport 1A 2 3 5
  • Vesicle Transport Protein GOT1A 3 4
  • HGOT1b 3 4
  • Golgi Transport 1 Homolog A (S. Cerevisiae) 2
  • Golgi Transport 1 Homolog A 4
  • HMFN1187 3
  • CGI-141 3
  • YMR292W 3
  • GOT1B 4
  • GOT1 3

External Ids for GOLT1A Gene

Previous GeneCards Identifiers for GOLT1A Gene

  • GC01M200899
  • GC01M202433
  • GC01M204167
  • GC01M175332

Summaries for GOLT1A Gene

GeneCards Summary for GOLT1A Gene

GOLT1A (Golgi Transport 1A) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include lipase activity. An important paralog of this gene is GOLT1B.

UniProtKB/Swiss-Prot Summary for GOLT1A Gene

  • May be involved in fusion of ER-derived transport vesicles with the Golgi complex.

Additional gene information for GOLT1A Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GOLT1A Gene

Genomics for GOLT1A Gene

GeneHancer (GH) Regulatory Elements for GOLT1A Gene

Promoters and enhancers for GOLT1A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GOLT1A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GOLT1A gene promoter:
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • AP-2alpha isoform 4
  • AP-2alphaA
  • GATA-2
  • NF-kappaB
  • NF-kappaB1
  • oct-B2
  • Sp1

Genomic Locations for GOLT1A Gene

Genomic Locations for GOLT1A Gene
chr1:204,198,160-204,214,092
(GRCh38/hg38)
Size:
15,933 bases
Orientation:
Minus strand
chr1:204,167,288-204,183,220
(GRCh37/hg19)
Size:
15,933 bases
Orientation:
Minus strand

Genomic View for GOLT1A Gene

Genes around GOLT1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GOLT1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GOLT1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOLT1A Gene

Proteins for GOLT1A Gene

  • Protein details for GOLT1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZVE7-GOT1A_HUMAN
    Recommended name:
    Vesicle transport protein GOT1A
    Protein Accession:
    Q6ZVE7

    Protein attributes for GOLT1A Gene

    Size:
    132 amino acids
    Molecular mass:
    14887 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GOLT1A Gene

Post-translational modifications for GOLT1A Gene

No Post-translational modifications

Other Protein References for GOLT1A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GOLT1A Gene

Domains & Families for GOLT1A Gene

Gene Families for GOLT1A Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for GOLT1A Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GOLT1A Gene

GenScript: Design optimal peptide antigens:
  • hGOT1b (GOT1A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6ZVE7

UniProtKB/Swiss-Prot:

GOT1A_HUMAN :
  • Belongs to the GOT1 family.
Family:
  • Belongs to the GOT1 family.
genes like me logo Genes that share domains with GOLT1A: view

Function for GOLT1A Gene

Molecular function for GOLT1A Gene

UniProtKB/Swiss-Prot Function:
May be involved in fusion of ER-derived transport vesicles with the Golgi complex.

Phenotypes From GWAS Catalog for GOLT1A Gene

Gene Ontology (GO) - Molecular Function for GOLT1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with GOLT1A: view

Phenotypes for GOLT1A Gene

genes like me logo Genes that share phenotypes with GOLT1A: view

Animal Model Products

CRISPR Products

miRNA for GOLT1A Gene

miRTarBase miRNAs that target GOLT1A

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GOLT1A

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GOLT1A Gene

Localization for GOLT1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOLT1A Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GOLT1A gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 5
golgi apparatus 5
plasma membrane 1

Gene Ontology (GO) - Cellular Components for GOLT1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000137 Golgi cis cisterna IDA 10406798
GO:0000139 Golgi membrane IEA --
GO:0005635 nuclear envelope IDA 10406798
GO:0005783 endoplasmic reticulum IBA,IDA 10406798
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with GOLT1A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GOLT1A Gene

Pathways & Interactions for GOLT1A Gene

PathCards logo

SuperPathways for GOLT1A Gene

No Data Available

Interacting Proteins for GOLT1A Gene

Gene Ontology (GO) - Biological Process for GOLT1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006888 ER to Golgi vesicle-mediated transport ISS 10406798
GO:0008150 biological_process ND --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with GOLT1A: view

No data available for Pathways by source and SIGNOR curated interactions for GOLT1A Gene

Drugs & Compounds for GOLT1A Gene

No Compound Related Data Available

Transcripts for GOLT1A Gene

mRNA/cDNA for GOLT1A Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(42) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GOLT1A

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GOLT1A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6
SP1: - -
SP2: - -
SP3: -
SP4:

Relevant External Links for GOLT1A Gene

GeneLoc Exon Structure for
GOLT1A
ECgene alternative splicing isoforms for
GOLT1A

Expression for GOLT1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GOLT1A Gene

mRNA differential expression in normal tissues according to GTEx for GOLT1A Gene

This gene is overexpressed in Liver (x23.3) and Pituitary (x4.4).

Protein differential expression in normal tissues from HIPED for GOLT1A Gene

This gene is overexpressed in Liver (60.1) and Heart (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GOLT1A Gene



Protein tissue co-expression partners for GOLT1A Gene

NURSA nuclear receptor signaling pathways regulating expression of GOLT1A Gene:

GOLT1A

SOURCE GeneReport for Unigene cluster for GOLT1A Gene:

Hs.532401
genes like me logo Genes that share expression patterns with GOLT1A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GOLT1A Gene

Orthologs for GOLT1A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GOLT1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GOLT1A 33 32
  • 98.56 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GOLT1A 33 32
  • 87.37 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GOLT1A 33 32
  • 86.93 (n)
OneToOne
mouse
(Mus musculus)
Mammalia GOLT1A 33
  • 86 (a)
OneToMany
Golt1a 17 33 32
  • 83.33 (n)
rat
(Rattus norvegicus)
Mammalia Golt1a 32
  • 84.1 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GOLT1A 33
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GOLT1A 33
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GOLT1A 33
  • 68 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii GOLT1A 33
  • 68 (a)
OneToOne
LOC100001834 32
  • 65.91 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32576 33
  • 52 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F41C3.4 33
  • 38 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GOT1 33
  • 39 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5537 33
  • 54 (a)
OneToMany
Species where no ortholog for GOLT1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for GOLT1A Gene

ENSEMBL:
Gene Tree for GOLT1A (if available)
TreeFam:
Gene Tree for GOLT1A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GOLT1A: view image

Paralogs for GOLT1A Gene

Paralogs for GOLT1A Gene

(1) SIMAP similar genes for GOLT1A Gene using alignment to 1 proteins:

  • GOT1A_HUMAN
genes like me logo Genes that share paralogs with GOLT1A: view

Variants for GOLT1A Gene

Sequence variations from dbSNP and Humsavar for GOLT1A Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000497746 -- 204,213,482(-) A/G intron_variant
rs1000550081 -- 204,213,232(-) C/A intron_variant
rs1000783564 -- 204,206,375(-) C/G intron_variant
rs1000984642 -- 204,201,049(-) C/T intron_variant
rs1001447992 -- 204,205,658(-) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GOLT1A Gene

Variant ID Type Subtype PubMed ID
esv2477162 CNV deletion 19546169
esv2762138 CNV gain 21179565
esv3545444 CNV deletion 23714750
esv3588614 CNV gain 21293372
esv3588615 CNV gain 21293372
nsv1007228 CNV gain 25217958
nsv1137841 CNV deletion 24896259
nsv549039 CNV gain 21841781

Variation tolerance for GOLT1A Gene

Residual Variation Intolerance Score: 66.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GOLT1A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GOLT1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOLT1A Gene

Disorders for GOLT1A Gene

Additional Disease Information for GOLT1A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GOLT1A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GOLT1A Gene

Publications for GOLT1A Gene

  1. miR-378a-3p modulates tamoxifen sensitivity in breast cancer MCF-7 cells through targeting GOLT1A. (PMID: 26255816) Ikeda K … Inoue S (Scientific reports 2015) 2 3 56
  2. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret GB … Chakravarti A (European journal of human genetics : EJHG 2009) 3 43 56
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 56
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56

Products for GOLT1A Gene

Sources for GOLT1A Gene