The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is localized at the Golgi stack and may have a regulatory role in Golgi trafficking. [provided by RefSeq, Jul 2008] See more...

Aliases for GOLPH3L Gene

Aliases for GOLPH3L Gene

  • Golgi Phosphoprotein 3 Like 2 3 5
  • Golgi Phosphoprotein 3-Like 2 3 4
  • GPP34-Related Protein 3 4
  • GPP34R 3 4

External Ids for GOLPH3L Gene

Previous GeneCards Identifiers for GOLPH3L Gene

  • GC01M147432
  • GC01M148885
  • GC01M150618
  • GC01M121996
  • GC01M150649

Summaries for GOLPH3L Gene

Entrez Gene Summary for GOLPH3L Gene

  • The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is localized at the Golgi stack and may have a regulatory role in Golgi trafficking. [provided by RefSeq, Jul 2008]

GeneCards Summary for GOLPH3L Gene

GOLPH3L (Golgi Phosphoprotein 3 Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include phosphatidylinositol-4-phosphate binding. An important paralog of this gene is GOLPH3.

UniProtKB/Swiss-Prot Summary for GOLPH3L Gene

  • Phosphatidylinositol-4-phosphate-binding protein that may antagonize the action of GOLPH3 which is required for the process of vesicle budding at the Golgi and anterograde transport to the plasma membrane.

Additional gene information for GOLPH3L Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GOLPH3L Gene

Genomics for GOLPH3L Gene

GeneHancer (GH) Regulatory Elements for GOLPH3L Gene

Promoters and enhancers for GOLPH3L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GOLPH3L on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GOLPH3L gene promoter:
  • FOXI1
  • FOXJ2
  • FOXJ2 (long isoform)
  • GATA-1
  • HFH-3
  • POU2F1
  • POU2F1a
  • RP58
  • SRF
  • SRF (504 AA)

Genomic Locations for GOLPH3L Gene

Genomic Locations for GOLPH3L Gene
chr1:150,646,225-150,697,956
(GRCh38/hg38)
Size:
51,732 bases
Orientation:
Minus strand
chr1:150,618,701-150,669,672
(GRCh37/hg19)
Size:
50,972 bases
Orientation:
Minus strand

Genomic View for GOLPH3L Gene

Genes around GOLPH3L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GOLPH3L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GOLPH3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOLPH3L Gene

Proteins for GOLPH3L Gene

  • Protein details for GOLPH3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4A5-GLP3L_HUMAN
    Recommended name:
    Golgi phosphoprotein 3-like
    Protein Accession:
    Q9H4A5
    Secondary Accessions:
    • B1AN09
    • B7Z6N3
    • Q9NVK0

    Protein attributes for GOLPH3L Gene

    Size:
    285 amino acids
    Molecular mass:
    32767 Da
    Quaternary structure:
    • Homooligomer (By similarity). Does not interact MYO18; differs from GOLPH3 by its inability to interact with MYO18. May interact with ARF1.
    SequenceCaution:
    • Sequence=BAA91750.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for GOLPH3L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GOLPH3L Gene

Post-translational modifications for GOLPH3L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GOLPH3L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GOLPH3L Gene

Domains & Families for GOLPH3L Gene

Gene Families for GOLPH3L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GOLPH3L Gene

Suggested Antigen Peptide Sequences for GOLPH3L Gene

GenScript: Design optimal peptide antigens:
  • GPP34-related protein (GLP3L_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H4A5

UniProtKB/Swiss-Prot:

GLP3L_HUMAN :
  • Belongs to the GOLPH3/VPS74 family.
Family:
  • Belongs to the GOLPH3/VPS74 family.
genes like me logo Genes that share domains with GOLPH3L: view

Function for GOLPH3L Gene

Molecular function for GOLPH3L Gene

UniProtKB/Swiss-Prot Function:
Phosphatidylinositol-4-phosphate-binding protein that may antagonize the action of GOLPH3 which is required for the process of vesicle budding at the Golgi and anterograde transport to the plasma membrane.

Phenotypes From GWAS Catalog for GOLPH3L Gene

Gene Ontology (GO) - Molecular Function for GOLPH3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23275563
GO:0008289 lipid binding IEA --
GO:0070273 phosphatidylinositol-4-phosphate binding IEA,IDA 23345592
genes like me logo Genes that share ontologies with GOLPH3L: view
genes like me logo Genes that share phenotypes with GOLPH3L: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GOLPH3L Gene

Localization for GOLPH3L Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOLPH3L Gene

Golgi apparatus, Golgi stack membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side. Note=Phosphatidylinositol 4-phosphate (PtdIns4P)-binding mediates recruitment to Golgi membranes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GOLPH3L gene
Compartment Confidence
cytosol 4
golgi apparatus 4
nucleus 3
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GOLPH3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IC 23345592
GO:0005794 Golgi apparatus IEA --
GO:0005802 trans-Golgi network IBA 21873635
GO:0005829 cytosol IBA 21873635
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with GOLPH3L: view

Pathways & Interactions for GOLPH3L Gene

PathCards logo

SuperPathways for GOLPH3L Gene

No Data Available

Gene Ontology (GO) - Biological Process for GOLPH3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER IBA 21873635
GO:0007030 Golgi organization IMP 23345592
GO:0043001 Golgi to plasma membrane protein transport IBA 21873635
GO:0048194 Golgi vesicle budding IBA 21873635
GO:0050714 positive regulation of protein secretion IMP 23345592
genes like me logo Genes that share ontologies with GOLPH3L: view

No data available for Pathways by source and SIGNOR curated interactions for GOLPH3L Gene

Drugs & Compounds for GOLPH3L Gene

No Compound Related Data Available

Transcripts for GOLPH3L Gene

mRNA/cDNA for GOLPH3L Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(156) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GOLPH3L Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - - -
SP2: - - -
SP3: - -
SP4: - -
SP5: - - - -
SP6: - - - - -
SP7: -

Relevant External Links for GOLPH3L Gene

GeneLoc Exon Structure for
GOLPH3L
ECgene alternative splicing isoforms for
GOLPH3L

Expression for GOLPH3L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GOLPH3L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GOLPH3L Gene

This gene is overexpressed in Nasal epithelium (19.2), Skin (9.1), Oral epithelium (7.3), and Salivary gland (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GOLPH3L Gene



Protein tissue co-expression partners for GOLPH3L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GOLPH3L Gene:

GOLPH3L

SOURCE GeneReport for Unigene cluster for GOLPH3L Gene:

Hs.203699

Evidence on tissue expression from TISSUES for GOLPH3L Gene

  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with GOLPH3L: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GOLPH3L Gene

Orthologs for GOLPH3L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for GOLPH3L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GOLPH3L 33 32
  • 99.65 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GOLPH3L 33 32
  • 93.33 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GOLPH3L 33 32
  • 92.63 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Golph3l 32
  • 89.94 (n)
mouse
(Mus musculus)
Mammalia Golph3l 17 33 32
  • 89.59 (n)
oppossum
(Monodelphis domestica)
Mammalia GOLPH3L 33
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GOLPH3L 33
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves GOLPH3L 33 32
  • 68.22 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GOLPH3L 33
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia golph3l 32
  • 73.21 (n)
zebrafish
(Danio rerio)
Actinopterygii golph3l 33 32
  • 63.5 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta l(2)s5379 33
  • 59 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y47G6A.18 33
  • 54 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E02355g 32
  • 53.99 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL165C 32
  • 53.86 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS74 33 32
  • 53.62 (n)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC5D6.13 32
  • 53.86 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.486 33
  • 53 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU06091 32
  • 52.17 (n)
Species where no ortholog for GOLPH3L was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GOLPH3L Gene

ENSEMBL:
Gene Tree for GOLPH3L (if available)
TreeFam:
Gene Tree for GOLPH3L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GOLPH3L: view image

Paralogs for GOLPH3L Gene

Paralogs for GOLPH3L Gene

(1) SIMAP similar genes for GOLPH3L Gene using alignment to 3 proteins:

  • GLP3L_HUMAN
  • F5H4M3_HUMAN
  • Q5T5I6_HUMAN
genes like me logo Genes that share paralogs with GOLPH3L: view

Variants for GOLPH3L Gene

Sequence variations from dbSNP and Humsavar for GOLPH3L Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000028554 -- 150,682,095(-) C/A intron_variant
rs1000048454 -- 150,689,981(-) C/A intron_variant
rs1000151668 -- 150,682,528(-) C/G intron_variant
rs1000156933 -- 150,649,712(-) T/C intron_variant
rs1000206613 -- 150,685,978(-) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GOLPH3L Gene

Variant ID Type Subtype PubMed ID
esv2427260 CNV deletion 19546169
nsv1006838 CNV gain 25217958
nsv1014638 CNV gain 25217958
nsv1113176 CNV deletion 24896259
nsv1133906 CNV deletion 24896259
nsv437158 CNV loss 16327808

Variation tolerance for GOLPH3L Gene

Residual Variation Intolerance Score: 76.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.47; 28.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GOLPH3L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GOLPH3L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOLPH3L Gene

Disorders for GOLPH3L Gene

Additional Disease Information for GOLPH3L

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GOLPH3L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GOLPH3L Gene

Publications for GOLPH3L Gene

  1. GOLPH3L antagonizes GOLPH3 to determine Golgi morphology. (PMID: 23345592) Ng MM … Field SJ (Molecular biology of the cell 2013) 3 4 56
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 43 56
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  4. Proteomics characterization of abundant Golgi membrane proteins. (PMID: 11042173) Bell AW … Bergeron JJ (The Journal of biological chemistry 2001) 3 4 56
  5. Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis. (PMID: 30575818) Tiemann K … Kani K (Oncogene 2019) 3 56

Products for GOLPH3L Gene

Sources for GOLPH3L Gene