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The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a peripheral membrane protein of the Golgi stack and may have a regulatory role in Golgi trafficking. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Jul 2008]
GOLPH3 (Golgi Phosphoprotein 3) is a Protein Coding gene. Diseases associated with GOLPH3 include Anemia, Congenital Dyserythropoietic, Type Ii and Dyggve-Melchior-Clausen Disease. Gene Ontology (GO) annotations related to this gene include enzyme binding and phosphatidylinositol-4-phosphate binding. An important paralog of this gene is GOLPH3L.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 19553991 |
GO:0008289 | lipid binding | IEA | -- |
GO:0019899 | enzyme binding | IPI | 23027862 |
GO:0070273 | phosphatidylinositol-4-phosphate binding | IEA,IDA | 19837035 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005739 | mitochondrion | IEA,IDA | 16263763 |
GO:0005758 | mitochondrial intermembrane space | IEA | -- |
GO:0005768 | endosome | IEA | -- |
GO:0005794 | Golgi apparatus | IEA,IMP | 18410729 |
GO:0005802 | trans-Golgi network | IBA,IDA | 16263763 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER | IBA | 21873635 |
GO:0007030 | Golgi organization | IMP | 19837035 |
GO:0009101 | glycoprotein biosynthetic process | IMP | 23027862 |
GO:0009306 | protein secretion | IMP | 23500462 |
GO:0010467 | gene expression | IMP | 23500462 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||
SP2: | - | - | |||||||||||||||
SP3: | - | - | - | ||||||||||||||
SP4: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | GOLPH3 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | GOLPH3 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | GOLPH3 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | GOLPH3 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Golph3 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Golph3 30 17 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | GOLPH3 30 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | GOLPH3 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | GOLPH3 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | golph3 30 |
|
||
Str.3289 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.11551 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | golph3 30 31 |
|
OneToOne | |
si:dkey-27b3.2 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | l(2)s5379 30 31 |
|
OneToMany | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012606 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | Y47G6A.18 31 32 |
|
OneToMany | |
CELE_Y47G6A.18 30 |
|
||||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | VPS74 31 33 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.486 31 |
|
OneToMany | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.2445 30 |
|
Disorder | Aliases | PubMed IDs |
---|---|---|
anemia, congenital dyserythropoietic, type ii |
|
|
dyggve-melchior-clausen disease |
|
|
craniolenticulosutural dysplasia |
|
|
geroderma osteodysplasticum |
|
|
alzheimer disease 15 |
|
|