The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a type II Golgi-resident protein. It may process proteins synthesized in the rough endoplasmic reticulum and assist in the transport of protein cargo through the Golgi apparatus. [provided by RefSeq, Jul 2008] See more...

Aliases for GOLIM4 Gene

Aliases for GOLIM4 Gene

  • Golgi Integral Membrane Protein 4 2 3 3 4 5
  • Golgi Phosphoprotein 4 2 3 4
  • GPP130 2 3 4
  • GIMPC 2 3 4
  • Golgi-Localized Phosphoprotein Of 130 KDa 3 4
  • Golgi Integral Membrane Protein, Cis 3 4
  • Golgi Phosphoprotein Of 130 KDa 3 4
  • GOLPH4 3 4
  • P138 2 3
  • Cis Golgi-Localized Calcium-Binding Protein 3
  • 130 KDa Golgi-Localized Phosphoprotein 3
  • Type II Golgi Membrane Protein 3
  • GOLIM4 5
  • GIMPc 4

External Ids for GOLIM4 Gene

Previous HGNC Symbols for GOLIM4 Gene

  • GOLPH4

Previous GeneCards Identifiers for GOLIM4 Gene

  • GC03M169210
  • GC03M167727
  • GC03M165097

Summaries for GOLIM4 Gene

Entrez Gene Summary for GOLIM4 Gene

  • The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a type II Golgi-resident protein. It may process proteins synthesized in the rough endoplasmic reticulum and assist in the transport of protein cargo through the Golgi apparatus. [provided by RefSeq, Jul 2008]

GeneCards Summary for GOLIM4 Gene

GOLIM4 (Golgi Integral Membrane Protein 4) is a Protein Coding gene. Diseases associated with GOLIM4 include Spinal Muscular Atrophy, Distal, Autosomal Recessive, 3 and Immunodeficiency 47. Among its related pathways are Intra-Golgi traffic and Golgi-to-ER retrograde transport.

UniProtKB/Swiss-Prot Summary for GOLIM4 Gene

  • Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi.

Additional gene information for GOLIM4 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GOLIM4 Gene

Genomics for GOLIM4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GOLIM4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J168090 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +1.7 1697 6.6 SP1 HNRNPL CREB1 GATAD2A PRDM10 ZNF629 REST KDM1A ZNF692 POLR2A ENSG00000286994 GOLIM4 HMGN1P8 SERPINI2 lnc-PDCD10-2 PDCD10
GH03J168047 Enhancer 0.9 Ensembl ENCODE 13 +48.5 48494 0.7 CTCF ARID3A ZNF143 PKNOX1 REST RAD21 TRIM22 SMARCA5 ZNF444 BCLAF1 GOLIM4 lnc-PDCD10-2 ENSG00000286994 PDCD10
GH03J168061 Enhancer 0.7 Ensembl 13.1 +33.1 33123 2.8 BACH1 FOXA1 JUND PRDM1 IKZF2 ARID3A CTCF DPF2 RELB RUNX3 GOLIM4 LRRC77P lnc-PDCD10-2 ENSG00000286994 PDCD10
GH03J168051 Enhancer 0.7 FANTOM5 13 +44.2 44210 0.2 ZNF629 IKZF2 EED DPF2 CEBPB RUNX3 ZBTB17 ATF2 BCL11A NBN GOLIM4 lnc-PDCD10-2 ENSG00000286994 PDCD10
GH03J168049 Enhancer 0.6 Ensembl 13 +46.7 46724 2 ZNF629 FOXA1 CEBPB ZBTB48 YY1 ZBTB17 JUND ZFHX2 GATA3 BHLHE40 GOLIM4 lnc-PDCD10-2 ENSG00000286994 PDCD10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GOLIM4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GOLIM4

Top Transcription factor binding sites by QIAGEN in the GOLIM4 gene promoter:
  • CREB
  • deltaCREB
  • FOXD3
  • FOXJ2
  • FOXJ2 (long isoform)
  • NF-kappaB
  • NF-kappaB1
  • RelA
  • RFX1
  • STAT1

Genomic Locations for GOLIM4 Gene

Genomic Locations for GOLIM4 Gene
chr3:168,008,672-168,095,924
(GRCh38/hg38)
Size:
87,253 bases
Orientation:
Minus strand
chr3:167,726,465-167,813,763
(GRCh37/hg19)
Size:
87,299 bases
Orientation:
Minus strand

Genomic View for GOLIM4 Gene

Genes around GOLIM4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GOLIM4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GOLIM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOLIM4 Gene

Proteins for GOLIM4 Gene

  • Protein details for GOLIM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00461-GOLI4_HUMAN
    Recommended name:
    Golgi integral membrane protein 4
    Protein Accession:
    O00461

    Protein attributes for GOLIM4 Gene

    Size:
    696 amino acids
    Molecular mass:
    81880 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GOLIM4 Gene

Post-translational modifications for GOLIM4 Gene

  • Phosphorylated probably by c-AMP-dependent kinases in its lumenal part.
  • O-glycosylated; modified by sialic acid residues.
  • N-glycosylated; N-glycans are probably of the complex type and modified by sialic acid residues.
  • Glycosylation at Thr194, Thr216, Ser222, Thr229, Asn257, Thr270, Thr276, Ser283, Thr302, Thr308, Ser396, and Ser405
  • Modification sites at PhosphoSitePlus

Other Protein References for GOLIM4 Gene

No data available for DME Specific Peptides for GOLIM4 Gene

Domains & Families for GOLIM4 Gene

Gene Families for GOLIM4 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for GOLIM4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GOLIM4 Gene

GenScript: Design optimal peptide antigens:
  • Golgi-localized phosphoprotein of 130 kDa (GOLI4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O00461

UniProtKB/Swiss-Prot:

GOLI4_HUMAN :
  • Belongs to the GOLIM4 family.
Family:
  • Belongs to the GOLIM4 family.
genes like me logo Genes that share domains with GOLIM4: view

Function for GOLIM4 Gene

Molecular function for GOLIM4 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi.

Phenotypes From GWAS Catalog for GOLIM4 Gene

genes like me logo Genes that share phenotypes with GOLIM4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GOLIM4

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GOLIM4 Gene

Localization for GOLIM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOLIM4 Gene

Golgi apparatus, Golgi stack membrane. Single-pass type II membrane protein. Endosome membrane. Single-pass type II membrane protein. Membrane. Lipid-anchor. Note=Localizes to cis and medial Golgi cisternae. Probably cycles between early Golgi and distal compartments like endosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GOLIM4 gene
Compartment Confidence
golgi apparatus 5
endosome 4
extracellular 3
nucleus 3
cytoskeleton 2
endoplasmic reticulum 2
lysosome 2
plasma membrane 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GOLIM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA,TAS --
GO:0005768 endosome IEA --
GO:0005794 Golgi apparatus IDA 9201717
GO:0005796 Golgi lumen TAS 9201717
GO:0005801 cis-Golgi network TAS 9201717
genes like me logo Genes that share ontologies with GOLIM4: view

Pathways & Interactions for GOLIM4 Gene

genes like me logo Genes that share pathways with GOLIM4: view

Pathways by source for GOLIM4 Gene

Gene Ontology (GO) - Biological Process for GOLIM4 Gene

None

No data available for SIGNOR curated interactions for GOLIM4 Gene

Drugs & Compounds for GOLIM4 Gene

No Compound Related Data Available

Transcripts for GOLIM4 Gene

mRNA/cDNA for GOLIM4 Gene

2 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GOLIM4

Alternative Splicing Database (ASD) splice patterns (SP) for GOLIM4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1:
SP2: -

Relevant External Links for GOLIM4 Gene

GeneLoc Exon Structure for
GOLIM4

Expression for GOLIM4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GOLIM4 Gene

Protein differential expression in normal tissues from HIPED for GOLIM4 Gene

This gene is overexpressed in Lavage (16.7), Vitreous humor (14.1), and Pancreas (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GOLIM4 Gene



Protein tissue co-expression partners for GOLIM4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GOLIM4

SOURCE GeneReport for Unigene cluster for GOLIM4 Gene:

Hs.143600

Evidence on tissue expression from TISSUES for GOLIM4 Gene

  • Liver(4.6)
  • Intestine(4.5)
  • Kidney(3)
  • Heart(2.8)
  • Nervous system(2.8)
  • Muscle(2.1)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with GOLIM4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GOLIM4 Gene

Orthologs for GOLIM4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GOLIM4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GOLIM4 30 31
  • 99.33 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia GOLIM4 30 31
  • 87.32 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia GOLIM4 30 31
  • 86.88 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Golim4 30 17 31
  • 84.05 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Golim4 30
  • 82.89 (n)
Oppossum
(Monodelphis domestica)
Mammalia GOLIM4 31
  • 74 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia GOLIM4 31
  • 70 (a)
OneToOne
Chicken
(Gallus gallus)
Aves GOLIM4 30 31
  • 71.2 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia GOLIM4 31
  • 62 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia golim4 30
  • 65.54 (n)
Str.10991 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.14113 30
Zebrafish
(Danio rerio)
Actinopterygii golim4a 30 31
  • 62.82 (n)
OneToMany
golim4b 31
  • 45 (a)
OneToMany
wufc54e03 30
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 19 (a)
OneToOne
Species where no ortholog for GOLIM4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GOLIM4 Gene

ENSEMBL:
Gene Tree for GOLIM4 (if available)
TreeFam:
Gene Tree for GOLIM4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GOLIM4: view image

Paralogs for GOLIM4 Gene

No data available for Paralogs for GOLIM4 Gene

Variants for GOLIM4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GOLIM4 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
775922 Benign: not provided 168,027,842(-) C/A INTRON_VARIANT
775923 Benign: not provided 168,029,855(-) T/C MISSENSE_VARIANT
791958 Benign: not provided 168,030,041(-) G/A INTRON_VARIANT
VAR_036611 A breast cancer sample p.Ala312Val

Additional dbSNP identifiers (rs#s) for GOLIM4 Gene

Structural Variations from Database of Genomic Variants (DGV) for GOLIM4 Gene

Variant ID Type Subtype PubMed ID
nsv829787 CNV gain 17160897

Variation tolerance for GOLIM4 Gene

Residual Variation Intolerance Score: 29.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.71; 73.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GOLIM4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GOLIM4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOLIM4 Gene

Disorders for GOLIM4 Gene

MalaCards: The human disease database

(4) MalaCards diseases for GOLIM4 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GOLIM4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with GOLIM4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GOLIM4 Gene

Publications for GOLIM4 Gene

  1. Sequence and overexpression of GPP130/GIMPc: evidence for saturable pH-sensitive targeting of a type II early Golgi membrane protein. (PMID: 9201717) Linstedt AD … Hauri HP (Molecular biology of the cell 1997) 2 3 4 23
  2. Lumenal endosomal and Golgi-retrieval determinants involved in pH-sensitive targeting of an early Golgi protein. (PMID: 11598199) Bachert C … Linstedt AD (Molecular biology of the cell 2001) 3 4 23
  3. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson DF … Stefansson K (Nature genetics 2008) 3 41
  4. Both post-Golgi and intra-Golgi cycling affect the distribution of the Golgi phosphoprotein GPP130. (PMID: 17605763) Starr T … Storrie B (Traffic (Copenhagen, Denmark) 2007) 3 23
  5. A cycling cis-Golgi protein mediates endosome-to-Golgi traffic. (PMID: 15331763) Natarajan R … Linstedt AD (Molecular biology of the cell 2004) 3 4

Products for GOLIM4 Gene

Sources for GOLIM4 Gene