Aliases for GOLGA8O Gene

Aliases for GOLGA8O Gene

  • Golgin A8 Family Member O 2 3 5
  • Golgin Subfamily A Member 8O 3 3 4
  • Golgin Subfamily A Member 8-Like Protein 2-Like 3
  • Golgin Subfamily A Member 6-Like Protein 11 3
  • Golgin A8 Family, Member O 2
  • GOLGA8O 5

External Ids for GOLGA8O Gene

Previous GeneCards Identifiers for GOLGA8O Gene

  • GC15M032748
  • GC15M032749
  • GC15M032752

Summaries for GOLGA8O Gene

GeneCards Summary for GOLGA8O Gene

GOLGA8O (Golgin A8 Family Member O) is a Protein Coding gene. An important paralog of this gene is GOLGA8N.

Additional gene information for GOLGA8O Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GOLGA8O Gene

Genomics for GOLGA8O Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GOLGA8O Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J032461 Promoter 0.3 Ensembl 600.7 +1.5 1452 0.2 ENSG00000270789 GOLGA8O LOC100289543 GOLGA8K
GH15J032460 Promoter 0.3 Ensembl 600.7 +0.3 252 1.8 ENSG00000270789 GOLGA8O LOC100289543 GOLGA8K
GH15J032613 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.5 -153.9 -153948 5.8 PRDM10 ZNF629 PRDM1 PATZ1 TRIM22 HDAC1 ZNF341 CEBPA SCRT2 KMT2B ENSG00000262728 ENSG00000244952 ARHGAP11A ARHGAP11A-SCG5 LOC101928042 ENSG00000223509 GOLGA8N GOLGA8O HSALNG0104774-002 SCG5
GH15J032668 Enhancer 1.4 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 5.1 -208.8 -208843 4.4 GATAD2A ATF7 TEAD4 ZNF629 TFE3 FOXA1 CEBPA SOX13 CEBPB TGIF2 lnc-ARHGAP11A-7 SCG5 ENSG00000212415 ARHGAP11A GREM1 GOLGA8O SCG5-AS1 ARHGAP11A-SCG5
GH15J032610 Enhancer 0.6 dbSUPER 12.5 -148.9 -148885 2.1 PRDM10 FOXA1 CTCF CEBPA RAD21 RFX1 SMARCA5 GATA3 ZNF654 HLF GOLGA8O ARHGAP11A ENSG00000244952 ENSG00000262728 LOC101928042 piR-40963-010 GOLGA8N
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GOLGA8O on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GOLGA8O

Genomic Locations for GOLGA8O Gene

Genomic Locations for GOLGA8O Gene
chr15:32,441,914-32,461,753
(GRCh38/hg38)
Size:
19,840 bases
Orientation:
Minus strand
chr15:32,737,307-32,747,835
(GRCh37/hg19)
Size:
10,529 bases
Orientation:
Minus strand

Genomic View for GOLGA8O Gene

Genes around GOLGA8O on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GOLGA8O Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GOLGA8O Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOLGA8O Gene

Proteins for GOLGA8O Gene

  • Protein details for GOLGA8O Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NCC3-GOG8O_HUMAN
    Recommended name:
    Golgin subfamily A member 8O
    Protein Accession:
    A6NCC3
    Secondary Accessions:
    • A6NHZ1
    • E7ENU5

    Protein attributes for GOLGA8O Gene

    Size:
    632 amino acids
    Molecular mass:
    71536 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for GOLGA8O Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GOLGA8O Gene

Post-translational modifications for GOLGA8O Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GOLGA8O Gene

No data available for DME Specific Peptides for GOLGA8O Gene

Domains & Families for GOLGA8O Gene

Gene Families for GOLGA8O Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GOLGA8O Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

A6NCC3

UniProtKB/Swiss-Prot:

GOG8O_HUMAN :
  • Belongs to the GOLGA6 family.
Family:
  • Belongs to the GOLGA6 family.
genes like me logo Genes that share domains with GOLGA8O: view

No data available for Suggested Antigen Peptide Sequences for GOLGA8O Gene

Function for GOLGA8O Gene

Gene Ontology (GO) - Molecular Function for GOLGA8O Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21911577
genes like me logo Genes that share ontologies with GOLGA8O: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GOLGA8O Gene

Localization for GOLGA8O Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GOLGA8O gene
Compartment Confidence
nucleus 3
golgi apparatus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for GOLGA8O Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000137 Golgi cis cisterna IBA 21873635
GO:0005794 Golgi apparatus IEA,IBA 21873635
GO:0005801 cis-Golgi network IBA 21873635
GO:0032580 Golgi cisterna membrane IBA 21873635
genes like me logo Genes that share ontologies with GOLGA8O: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for GOLGA8O Gene

Pathways & Interactions for GOLGA8O Gene

PathCards logo

SuperPathways for GOLGA8O Gene

No Data Available

Interacting Proteins for GOLGA8O Gene

Gene Ontology (GO) - Biological Process for GOLGA8O Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007030 Golgi organization IBA 21873635
GO:0051225 NOT spindle assembly IBA 21873635
genes like me logo Genes that share ontologies with GOLGA8O: view

No data available for Pathways by source and SIGNOR curated interactions for GOLGA8O Gene

Drugs & Compounds for GOLGA8O Gene

No Compound Related Data Available

Transcripts for GOLGA8O Gene

mRNA/cDNA for GOLGA8O Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GOLGA8O

Alternative Splicing Database (ASD) splice patterns (SP) for GOLGA8O Gene

No ASD Table

Relevant External Links for GOLGA8O Gene

GeneLoc Exon Structure for
GOLGA8O

Expression for GOLGA8O Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GOLGA8O Gene

Protein differential expression in normal tissues from HIPED for GOLGA8O Gene

This gene is overexpressed in Frontal cortex (37.8) and NK cells (30.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GOLGA8O Gene



Protein tissue co-expression partners for GOLGA8O Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GOLGA8O

genes like me logo Genes that share expression patterns with GOLGA8O: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GOLGA8O Gene

Orthologs for GOLGA8O Gene

This gene was present in the common ancestor of chordates.

Orthologs for GOLGA8O Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 90 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 28 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Golga2 31
  • 27 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 27 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 26 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 26 (a)
OneToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 23 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 21 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii golga2 31
  • 17 (a)
OneToMany
Species where no ortholog for GOLGA8O was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GOLGA8O Gene

ENSEMBL:
Gene Tree for GOLGA8O (if available)
TreeFam:
Gene Tree for GOLGA8O (if available)

Paralogs for GOLGA8O Gene

Variants for GOLGA8O Gene

Additional dbSNP identifiers (rs#s) for GOLGA8O Gene

Structural Variations from Database of Genomic Variants (DGV) for GOLGA8O Gene

Variant ID Type Subtype PubMed ID
dgv2538n100 CNV loss 25217958
dgv2542n100 CNV loss 25217958
dgv2543n100 CNV gain 25217958
dgv2544n100 CNV gain+loss 25217958
dgv2546n100 CNV loss 25217958
dgv2547n100 CNV loss 25217958
dgv2548n100 CNV loss 25217958
dgv30n68 CNV gain+loss 17160897
dgv4446n54 CNV loss 21841781
esv1000078 CNV gain 20482838
esv22947 CNV gain+loss 19812545
esv2760023 CNV gain+loss 17122850
esv2760365 CNV gain+loss 21179565
esv2761877 CNV gain+loss 21179565
esv33337 CNV gain+loss 17666407
esv3892661 CNV gain 25118596
nsv1145806 CNV duplication 26484159
nsv1160277 CNV duplication 26073780
nsv428302 CNV gain+loss 18775914
nsv433433 CNV gain 18776910
nsv517740 CNV gain+loss 19592680
nsv568908 CNV loss 21841781
nsv821681 CNV gain 15273396
nsv9238 CNV gain+loss 18304495
nsv952602 CNV deletion 24416366
nsv952603 CNV deletion 24416366
nsv974553 CNV duplication 23825009

Variation tolerance for GOLGA8O Gene

Gene Damage Index Score: 4.95; 68.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GOLGA8O Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GOLGA8O

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GOLGA8O Gene

Disorders for GOLGA8O Gene

No disorders were found for GOLGA8O Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GOLGA8O Gene

Publications for GOLGA8O Gene

  1. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody MC … Nusbaum C (Nature 2006) 3 4
  2. A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells. (PMID: 28700943) Martin TD … Elledge SJ (Cell reports 2017) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. A physical interaction network of dengue virus and human proteins. (PMID: 21911577) Khadka S … LaCount DJ (Molecular & cellular proteomics : MCP 2011) 3
  5. The golgin coiled-coil proteins of the Golgi apparatus. (PMID: 21436057) Munro S (Cold Spring Harbor perspectives in biology 2011) 3

Products for GOLGA8O Gene

Sources for GOLGA8O Gene