Aliases for GOLGA8B Gene

Aliases for GOLGA8B Gene

  • Golgin A8 Family Member B 2 3 5
  • Golgi Autoantigen, Golgin Subfamily A, 8B 2 3
  • Golgin Subfamily A Member 8B 3 4
  • Golgin-67 3 4
  • Golgin A8 Family, Member B 2
  • GOLGA8B 5
  • GOLGA5 3

External Ids for GOLGA8B Gene

Previous GeneCards Identifiers for GOLGA8B Gene

  • GC15M032460
  • GC15M032605
  • GC15M034817

Summaries for GOLGA8B Gene

GeneCards Summary for GOLGA8B Gene

GOLGA8B (Golgin A8 Family Member B) is a Protein Coding gene. Diseases associated with GOLGA8B include Smith-Mccort Dysplasia 1 and Myopia. An important paralog of this gene is GOLGA8A.

UniProtKB/Swiss-Prot Summary for GOLGA8B Gene

Additional gene information for GOLGA8B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GOLGA8B Gene

Genomics for GOLGA8B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GOLGA8B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J034582 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 610.7 +5.3 5302 3.2 TEAD4 KDM1A POLR2A BACH1 LARP7 ZNF143 ZNF24 PATZ1 ZNF501 TRIM22 GOLGA8B GOLGA8A lnc-GOLGA8A-5 lnc-GOLGA8A-6 lnc-NUTM1-7 AQR HNRNPLP2 ENSG00000259287 ENSG00000259336 NUTM1
GH15J034588 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 611 +0.1 103 0.8 BRCA1 ARHGAP35 CTCF REST IKZF1 PRDM1 PKNOX1 SMAD5 RAD21 POLR2A GOLGA8B GOLGA8A lnc-GOLGA8A-6 lnc-NUTM1-7
GH15J034536 Promoter 0.7 EPDnew Ensembl 600.2 +52.8 52773 0.7 piR-41940-006 piR-42117-002 piR-57601-002 GOLGA8B GOLGA8A
GH15J034587 Promoter 0.6 Ensembl 600.7 +0.8 802 0.2 CTCF ZBTB40 ZNF335 ZNF18 ZBTB33 GOLGA8B lnc-GOLGA8A-6 lnc-NUTM1-7 GOLGA8A
GH15J034533 Promoter 0.3 EPDnew 600.2 +55.4 55419 0.1 piR-34638-018 piR-41940-006 piR-55800-002 piR-57601-002 piR-56117-011 piR-43151-019 piR-44215-006 piR-51363-013 piR-51577-009 GOLGA8B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GOLGA8B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GOLGA8B

Top Transcription factor binding sites by QIAGEN in the GOLGA8B gene promoter:
  • AML1a
  • AREB6
  • c-Myb
  • CUTL1
  • E2F
  • E2F-1
  • FOXJ2
  • FOXJ2 (long isoform)
  • Ik-1
  • Pax-2

Genomic Locations for GOLGA8B Gene

Genomic Locations for GOLGA8B Gene
63,409 bases
Minus strand
63,297 bases
Minus strand

Genomic View for GOLGA8B Gene

Genes around GOLGA8B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GOLGA8B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GOLGA8B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOLGA8B Gene

Proteins for GOLGA8B Gene

  • Protein details for GOLGA8B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Golgin subfamily A member 8B
    Protein Accession:
    Secondary Accessions:
    • A6NLZ2
    • O94937
    • Q2M3S9
    • Q9NZG8
    • Q9NZW0
    • Q9NZW3

    Protein attributes for GOLGA8B Gene

    603 amino acids
    Molecular mass:
    67278 Da
    Quaternary structure:
    No Data Available
    • Antibodies against GM88 are present in serum from a patient with Sjoegren syndrome. Sera from patients with Sjoegren syndrome often contain antibodies that react with normal components of the Golgi complex.

    Alternative splice isoforms for GOLGA8B Gene


neXtProt entry for GOLGA8B Gene

Post-translational modifications for GOLGA8B Gene

  • Glycosylation at Asn89
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • GOG8B_HUMAN (1283)

Other Protein References for GOLGA8B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GOLGA8B Gene

Domains & Families for GOLGA8B Gene

Gene Families for GOLGA8B Gene

Protein Domains for GOLGA8B Gene


Suggested Antigen Peptide Sequences for GOLGA8B Gene

GenScript: Design optimal peptide antigens:
  • Golgi autoantigen, golgin subfamily a, 8B (B7ZKM1_HUMAN)
  • GOLGA8B protein (B7ZMK6_HUMAN)
  • Golgin-67 (GOG8B_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Extended rod-like protein with coiled-coil domains.
  • Belongs to the GOLGA8 family.
  • Extended rod-like protein with coiled-coil domains.
  • Belongs to the GOLGA8 family.
genes like me logo Genes that share domains with GOLGA8B: view

Function for GOLGA8B Gene

Molecular function for GOLGA8B Gene

UniProtKB/Swiss-Prot Function:
May be involved in maintaining Golgi structure.

Phenotypes From GWAS Catalog for GOLGA8B Gene

Phenotypes for GOLGA8B Gene

genes like me logo Genes that share phenotypes with GOLGA8B: view

Animal Model Products

CRISPR Products

miRNA for GOLGA8B Gene

miRTarBase miRNAs that target GOLGA8B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GOLGA8B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GOLGA8B Gene

Localization for GOLGA8B Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOLGA8B Gene

Golgi apparatus, Golgi stack membrane. Peripheral membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GOLGA8B gene
Compartment Confidence
cytosol 4
golgi apparatus 4
nucleus 2
extracellular 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GOLGA8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000137 Golgi cis cisterna IBA 21873635
GO:0005794 Golgi apparatus IDA --
GO:0005801 cis-Golgi network IBA 21873635
GO:0005829 cytosol IDA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with GOLGA8B: view

Pathways & Interactions for GOLGA8B Gene

PathCards logo

SuperPathways for GOLGA8B Gene

No Data Available

Interacting Proteins for GOLGA8B Gene

Gene Ontology (GO) - Biological Process for GOLGA8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007030 Golgi organization IBA 21873635
GO:0051225 spindle assembly IBA 21873635
genes like me logo Genes that share ontologies with GOLGA8B: view

No data available for Pathways by source and SIGNOR curated interactions for GOLGA8B Gene

Drugs & Compounds for GOLGA8B Gene

No Compound Related Data Available

Transcripts for GOLGA8B Gene

mRNA/cDNA for GOLGA8B Gene

5 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GOLGA8B

Alternative Splicing Database (ASD) splice patterns (SP) for GOLGA8B Gene

No ASD Table

Relevant External Links for GOLGA8B Gene

GeneLoc Exon Structure for

Expression for GOLGA8B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GOLGA8B Gene

mRNA differential expression in normal tissues according to GTEx for GOLGA8B Gene

This gene is overexpressed in Pancreas (x5.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GOLGA8B

SOURCE GeneReport for Unigene cluster for GOLGA8B Gene:


mRNA Expression by UniProt/SwissProt for GOLGA8B Gene:

Tissue specificity: Highly expressed in brain, heart and kidney. Detected at lower levels in liver, thymus, spleen, lung and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for GOLGA8B Gene

  • Nervous system(4.5)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with GOLGA8B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GOLGA8B Gene

Orthologs for GOLGA8B Gene

This gene was present in the common ancestor of chordates.

Orthologs for GOLGA8B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 31
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 30 (a)
(Bos Taurus)
Mammalia -- 31
  • 26 (a)
(Mus musculus)
Mammalia Golga2 31
  • 25 (a)
(Canis familiaris)
Mammalia -- 31
  • 24 (a)
(Monodelphis domestica)
Mammalia -- 31
  • 23 (a)
(Gallus gallus)
Aves -- 31
  • 21 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 21 (a)
(Danio rerio)
Actinopterygii golga2 31
  • 17 (a)
Species where no ortholog for GOLGA8B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GOLGA8B Gene

Gene Tree for GOLGA8B (if available)
Gene Tree for GOLGA8B (if available)

Paralogs for GOLGA8B Gene

(28) SIMAP similar genes for GOLGA8B Gene using alignment to 4 proteins:

  • C9J1B5_HUMAN
genes like me logo Genes that share paralogs with GOLGA8B: view

Variants for GOLGA8B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GOLGA8B Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
774220 Benign: not provided 34,531,704(-) A/G INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for GOLGA8B Gene

Structural Variations from Database of Genomic Variants (DGV) for GOLGA8B Gene

Variant ID Type Subtype PubMed ID
dgv107n111 CNV duplication 26073780
dgv21e213 CNV loss 24956385
dgv22e213 CNV gain 24956385
dgv2550n100 CNV gain 25217958
dgv2552n100 CNV gain 25217958
dgv2553n100 CNV loss 25217958
dgv2554n100 CNV loss 25217958
dgv2557n100 CNV loss 25217958
dgv2558n100 CNV gain+loss 25217958
dgv2559n100 CNV gain+loss 25217958
dgv2562n100 CNV gain+loss 25217958
dgv2563n100 CNV loss 25217958
dgv2569n100 CNV loss 25217958
dgv2570n100 CNV loss 25217958
dgv2571n100 CNV gain 25217958
dgv2572n100 CNV gain 25217958
dgv2574n100 CNV loss 25217958
dgv302e201 CNV deletion 23290073
dgv313n27 CNV loss 19166990
dgv314n27 CNV gain 19166990
dgv43e203 CNV gain+loss 21179565
dgv4456n54 CNV gain 21841781
dgv4459n54 CNV loss 21841781
dgv4460n54 CNV loss 21841781
dgv4461n54 CNV gain 21841781
dgv4468n54 CNV loss 21841781
dgv4474n54 CNV loss 21841781
dgv4475n54 CNV gain 21841781
dgv4476n54 CNV loss 21841781
dgv4477n54 CNV loss 21841781
dgv4482n54 CNV loss 21841781
esv2281816 CNV deletion 18987734
esv2663546 CNV deletion 23128226
esv2751533 CNV loss 17911159
esv2760024 CNV gain+loss 17122850
esv27955 CNV gain+loss 19812545
esv33337 CNV gain+loss 17666407
esv3368932 CNV insertion 20981092
esv3569431 CNV gain 25503493
esv3581626 CNV loss 25503493
esv3636115 CNV loss 21293372
esv3636116 CNV gain 21293372
esv3636119 CNV loss 21293372
esv3892664 CNV gain+loss 25118596
esv992827 CNV gain 20482838
nsv1039201 CNV gain 25217958
nsv1041189 CNV loss 25217958
nsv1052620 CNV gain 25217958
nsv1053730 CNV gain 25217958
nsv110 CNV deletion 15895083
nsv1160280 CNV deletion 26073780
nsv1160285 CNV duplication 26073780
nsv1485 CNV deletion 18451855
nsv428303 CNV gain 18775914
nsv442698 CNV gain+loss 18776908
nsv469685 CNV loss 16826518
nsv471682 CNV gain+loss 15918152
nsv510658 CNV deletion 20534489
nsv517751 CNV gain+loss 19592680
nsv569004 CNV gain+loss 21841781
nsv569130 CNV loss 21841781
nsv569131 CNV gain 21841781
nsv819187 CNV gain 19587683
nsv820603 CNV deletion 20802225
nsv820789 CNV deletion 20802225
nsv821682 CNV loss 15273396
nsv827290 CNV loss 20364138
nsv827291 CNV gain 20364138
nsv827294 CNV loss 20364138
nsv832965 CNV loss 17160897
nsv832966 CNV loss 17160897
nsv9241 CNV gain+loss 18304495
nsv974557 CNV duplication 23825009
nsv974558 CNV duplication 23825009
nsv984051 CNV duplication 23825009

Variation tolerance for GOLGA8B Gene

Gene Damage Index Score: 8.97; 87.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GOLGA8B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOLGA8B Gene

Disorders for GOLGA8B Gene

MalaCards: The human disease database

(2) MalaCards diseases for GOLGA8B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
smith-mccort dysplasia 1
  • smc1
  • near vision
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GOLGA8B

genes like me logo Genes that share disorders with GOLGA8B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GOLGA8B Gene

Publications for GOLGA8B Gene

  1. A genome-wide association study identifies a susceptibility locus for refractive errors and myopia at 15q14. (PMID: 20835239) Solouki AM … Klaver CC (Nature genetics 2010) 3 41
  2. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody MC … Nusbaum C (Nature 2006) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Human autoantibodies to a novel Golgi protein golgin-67: high similarity with golgin-95/gm 130 autoantigen. (PMID: 10677249) Eystathioy T … Chan EK (Journal of autoimmunity 2000) 3 4
  5. Identification and characterization of a novel Golgi protein, golgin-67. (PMID: 10660574) Jakymiw A … Fujita DJ (The Journal of biological chemistry 2000) 3 4

Products for GOLGA8B Gene

  • Biorbyt antibodies for GOLGA8B

Sources for GOLGA8B Gene