Aliases for GOLGA8B Gene
Aliases for GOLGA8B Gene
External Ids for GOLGA8B Gene
- HGNC: 31973
- Entrez Gene: 440270
- Ensembl: ENSG00000215252
- OMIM: 609619
- UniProtKB: A8MQT2
Previous GeneCards Identifiers for GOLGA8B Gene
- GC15M032460
- GC15M032605
- GC15M034817
Summaries for GOLGA8B Gene
GeneCards Summary for GOLGA8B Gene
GOLGA8B (Golgin A8 Family Member B) is a Protein Coding gene. An important paralog of this gene is GOLGA8A.
UniProtKB/Swiss-Prot for GOLGA8B Gene
-
May be involved in maintaining Golgi structure.
Additional gene information for GOLGA8B Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOLGA8B Gene
Genomics for GOLGA8B Gene
GeneHancer (GH) Regulatory Elements for GOLGA8B Gene
Promoters and enhancers for GOLGA8B Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH15J034588 | Promoter/Enhancer | 1.9 | EPDnew Ensembl ENCODE | 661.1 | +0.2 | 202 | 0.6 | PKNOX1 ATF1 ARID4B BRCA1 YY1 POLR2B ZNF766 ZNF143 ZFP91 ATF7 | GOLGA8B GOLGA8A AQR HNRNPLP2 LOC100422492 | |
| GH15J034582 | Promoter/Enhancer | 1.9 | EPDnew Ensembl ENCODE | 660.6 | +5.0 | 5020 | 2.4 | ZFP64 ARID4B SIN3A ZNF48 YY1 ZNF121 GLIS2 ZNF143 ATF7 RUNX3 | GOLGA8B GOLGA8A HNRNPLP2 FSCN1P1 LOC100422492 | |
| GH15J034536 | Promoter | 0.5 | EPDnew | 650.2 | +52.5 | 52473 | 0.1 | PIR35116 PIR51600 GOLGA8B | ||
| GH15J034533 | Promoter | 0.5 | EPDnew | 650.2 | +55.4 | 55419 | 0.1 | PIR51600 GOLGA8B GOLGA8A PIR59229 | ||
| GH15J034968 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE | 13.7 | -381.0 | -380965 | 1.9 | HDGF FOXA2 PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 | AQR HNRNPLP2 NUTM1 ENSG00000259336 GOLGA8A GOLGA8B ENSG00000259665 ZNF770 GC15P034944 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around GOLGA8B on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the GOLGA8B gene promoter:
-
- Ik-1
- AML1a
- AREB6
- c-Myb
- FOXJ2
- FOXJ2 (long isoform)
- E2F-1
- E2F
- CUTL1
- Pax-2
Regulatory Element Products
Genomic Locations for GOLGA8B Gene
Genomic Locations for GOLGA8B Gene
- chr15:34,525,207-34,588,503
- (GRCh38/hg38)
- Size:
- 63,297 bases
- Orientation:
- Minus strand
- chr15:34,817,408-34,880,704
- (GRCh37/hg19)
- Size:
- 63,297 bases
- Orientation:
- Minus strand
Genomic View for GOLGA8B Gene
Genes around GOLGA8B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q14 by Entrez Gene
- 15q14 by HGNC
- 15q14 by Ensembl
GOLGA8B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GOLGA8B Gene
Proteins for GOLGA8B Gene
-
Protein details for GOLGA8B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- A8MQT2-GOG8B_HUMAN
- Recommended name:
- Golgin subfamily A member 8B
- Protein Accession:
- A8MQT2
- A6NLZ2
- O94937
- Q2M3S9
- Q9NZG8
- Q9NZW0
- Q9NZW3
Protein attributes for GOLGA8B Gene
- Size:
- 603 amino acids
- Molecular mass:
- 67278 Da
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- Antibodies against GM88 are present in serum from a patient with Sjoegren syndrome. Sera from patients with Sjoegren syndrome often contain antibodies that react with normal components of the Golgi complex.
Post-translational modifications for GOLGA8B Gene
Other Protein References for GOLGA8B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Invitrogen Antibodies for GOLGA8B (AFLGC-GOLGA8B)
- Search GeneTex for Antibodies for GOLGA8B
Protein Products
-
OriGene Purified Proteins for GOLGA8B
- Search Origene for MassSpec and Protein Over-expression Lysates for GOLGA8B
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- Search GeneTex for Proteins for GOLGA8B
Assay Products
No data available for DME Specific Peptides for GOLGA8B Gene
Domains & Families for GOLGA8B Gene
Gene Families for GOLGA8B Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for GOLGA8B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
A8MQT2UniProtKB/Swiss-Prot:
GOG8B_HUMAN :- Extended rod-like protein with coiled-coil domains.
- Belongs to the GOLGA8 family.
- Domain:
-
- Extended rod-like protein with coiled-coil domains.
- Family:
-
- Belongs to the GOLGA8 family.
Function for GOLGA8B Gene
Molecular function for GOLGA8B Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in maintaining Golgi structure.
Phenotypes From GWAS Catalog for GOLGA8B Gene
Phenotypes for GOLGA8B Gene
- GenomeRNAi human phenotypes for GOLGA8B:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for GOLGA8B
-
CRISPR Products
-
OriGene CRISPR knockouts for GOLGA8B
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- genomics-online: gRNA clones - Search results for 38 available GOLGA8B gene related products
- Overview of 38 available GOLGA8B gene related products
- Applied Biological Materials CRISPR for GOLGA8B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GOLGA8B
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miRNA for GOLGA8B Gene
- miRTarBase miRNAs that target GOLGA8B
-
- hsa-mir-335-5p (MIRT018688)
- hsa-mir-32-5p (MIRT028332)
- hsa-mir-378a-3p (MIRT043895)
- hsa-mir-578 (MIRT446534)
- hsa-mir-526b-5p (MIRT446535)
- hsa-mir-5705 (MIRT446536)
- hsa-mir-4468 (MIRT446537)
- hsa-mir-646 (MIRT446538)
- hsa-mir-513c-3p (MIRT446539)
- hsa-mir-513a-3p (MIRT446540)
- hsa-mir-3606-3p (MIRT446541)
- hsa-mir-4282 (MIRT446542)
- hsa-mir-548c-3p (MIRT446543)
- hsa-mir-5047 (MIRT476157)
- hsa-mir-1301-3p (MIRT476159)
- hsa-mir-7156-3p (MIRT476160)
- hsa-mir-376a-2-5p (MIRT476161)
- hsa-mir-107 (MIRT476162)
- hsa-mir-103a-3p (MIRT476163)
- hsa-mir-4302 (MIRT476164)
- hsa-mir-936 (MIRT476165)
- hsa-mir-3681-3p (MIRT476166)
- hsa-mir-216a-3p (MIRT476167)
- hsa-mir-128-3p (MIRT476168)
- hsa-mir-30c-5p (MIRT476169)
- hsa-mir-30d-5p (MIRT476170)
- hsa-mir-30e-5p (MIRT476171)
- hsa-mir-30a-5p (MIRT476172)
- hsa-mir-30b-5p (MIRT476173)
- hsa-mir-1291 (MIRT507104)
- hsa-mir-4439 (MIRT507105)
- hsa-mir-3136-5p (MIRT507106)
- hsa-mir-670-5p (MIRT507107)
- hsa-mir-6857-3p (MIRT507108)
- hsa-mir-6855-3p (MIRT507109)
- hsa-mir-4513 (MIRT507110)
- hsa-mir-4319 (MIRT507111)
- hsa-mir-125b-5p (MIRT507112)
- hsa-mir-125a-5p (MIRT507113)
- hsa-mir-4732-3p (MIRT507114)
- hsa-mir-345-3p (MIRT507115)
- hsa-mir-6834-3p (MIRT507116)
- hsa-mir-25-3p (MIRT507117)
- hsa-mir-363-3p (MIRT507118)
- hsa-mir-367-3p (MIRT507119)
- hsa-mir-92a-3p (MIRT507120)
- hsa-mir-92b-3p (MIRT507121)
- hsa-mir-4705 (MIRT548053)
- hsa-mir-450b-5p (MIRT714022)
- hsa-mir-383-3p (MIRT714023)
- hsa-mir-181c-5p (MIRT727539)
- hsa-mir-181d-5p (MIRT727540)
- hsa-mir-181b-5p (MIRT727541)
- hsa-mir-181a-5p (MIRT727542)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GOLGA8B
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- genomics-online: shRNA clones - Search results for 38 available GOLGA8B gene related products
- Overview of 38 available GOLGA8B gene related products
Clone Products
- Sino Biological Human cDNA Clone for GOLGA8B
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- Applied Biological Materials Clones for GOLGA8B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for GOLGA8B
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GOLGA8B Gene
Localization for GOLGA8B Gene
Subcellular locations from UniProtKB/Swiss-Prot for GOLGA8B Gene
- Golgi apparatus, Golgi stack membrane; Peripheral membrane protein.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| golgi apparatus | 5 |
| nucleus | 3 |
- Cytosol (2)
- Golgi apparatus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000137 | Golgi cis cisterna | IBA | -- |
| GO:0005794 | Golgi apparatus | IDA | -- |
| GO:0005801 | cis-Golgi network | IBA | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for GOLGA8B Gene
No Data Available
Interacting Proteins for GOLGA8B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007030 | Golgi organization | IBA | -- |
| GO:0051225 | NOT spindle assembly | IBA | -- |
No data available for Pathways by source and SIGNOR curated interactions for GOLGA8B Gene
Transcripts for GOLGA8B Gene
mRNA/cDNA for GOLGA8B Gene
- (7) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (47) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000342314 4335 bps (uc001ziq.4)
- ENST00000569100 6488 bps (uc059hig.1)
- ENST00000484716 6114 bps (uc059hih.1)
- ENST00000568555 2328 bps (uc059hii.1)
- ENST00000562282 463 bps (uc059hij.1)
Unigene Clusters for GOLGA8B Gene
CRISPR Products
-
OriGene CRISPR knockouts for GOLGA8B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GOLGA8B
- genomics-online: gRNA clones - Search results for 38 available GOLGA8B gene related products
- Overview of 38 available GOLGA8B gene related products
- Applied Biological Materials CRISPR for GOLGA8B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GOLGA8B
- GenScript: Design CRISPR guide RNA sequences for GOLGA8B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GOLGA8B
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GOLGA8B
- genomics-online: shRNA clones - Search results for 38 available GOLGA8B gene related products
- Overview of 38 available GOLGA8B gene related products
Clone Products
- Sino Biological Human cDNA Clone for GOLGA8B
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- Applied Biological Materials Clones for GOLGA8B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for GOLGA8B Gene
mRNA differential expression in normal tissues according to GTEx for GOLGA8B Gene
This gene is overexpressed in Pancreas (x5.6).
NURSA nuclear receptor signaling pathways regulating expression of GOLGA8B Gene:
GOLGA8BSOURCE GeneReport for Unigene cluster for GOLGA8B Gene:
Hs.720151mRNA Expression by UniProt/SwissProt for GOLGA8B Gene:
A8MQT2-GOG8B_HUMAN
Tissue specificity:
Highly expressed in brain, heart and kidney. Detected at lower levels in liver, thymus, spleen, lung and peripheral blood leukocytes.
Evidence on tissue expression from TISSUES for GOLGA8B Gene
- Nervous system(4.5)
- Thyroid gland(2)
Primer Products
-
OriGene qPCR primer pairs for GOLGA8B
- genomics-online: primer clones - Search results for 38 available GOLGA8B gene related products
- Overview of 38 available GOLGA8B gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GOLGA8B Gene
Orthologs for GOLGA8B Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | -- 34 |
|
OneToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| cow (Bos Taurus) |
Mammalia | -- 34 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | Golga2 34 |
|
OneToMany | |
| dog (Canis familiaris) |
Mammalia | -- 34 |
|
OneToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | -- 34 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | golga2 34 |
|
OneToMany |
- Species where no ortholog for GOLGA8B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for GOLGA8B Gene
Paralogs for GOLGA8B Gene
(28) SIMAP similar genes for GOLGA8B Gene using alignment to 4 proteins:
- GOG8B_HUMAN
- B7ZKM1_HUMAN
- B7ZMK6_HUMAN
- C9J1B5_HUMAN
Pseudogenes.org Pseudogenes for GOLGA8B Gene
- PGOHUM00000292867
- PGOHUM00000292880
- PGOHUM00000292891
- PGOHUM00000292894
- PGOHUM00000292979
- PGOHUM00000293051
- PGOHUM00000293055
- PGOHUM00000293093
- PGOHUM00000293164
- PGOHUM00000293175
- PGOHUM00000293178
- PGOHUM00000293195
- PGOHUM00000293287
- PGOHUM00000293322
- PGOHUM00000293343
- PGOHUM00000297774
- PGOHUM00000302086
- PGOHUM00000288000
- PGOHUM00000288046
- PGOHUM00000307470
- PGOHUM00000307472
- PGOHUM00000307483
- PGOHUM00000305570
- PGOHUM00000305585
- PGOHUM00000305749
- PGOHUM00000305765
Variants for GOLGA8B Gene
| SNP ID | Clin | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000021874 | -- | 34,557,116(-) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000048982 | -- | 34,580,126(-) | C/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000079509 | -- | 34,527,281(-) | C/T | 3_prime_UTR_variant, non_coding_transcript_variant | |
| rs1000368100 | -- | 34,583,551(-) | G/A | 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant | |
| rs1000369302 | -- | 34,570,094(-) | A/T | genic_upstream_transcript_variant, intron_variant |
Gene Damage Index Score:
8.97;
87.31% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GOLGA8B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GOLGA8B
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOLGA8B Gene
Disorders for GOLGA8B Gene
Additional Disease Information for GOLGA8B
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for GOLGA8B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GOLGA8B Gene
Publications for GOLGA8B Gene
- A genome-wide association study identifies a susceptibility locus for refractive errors and myopia at 15q14. (PMID: 20835239) Solouki AM … Klaver CC (Nature genetics 2010) 3 44 58
- Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody MC … Nusbaum C (Nature 2006) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Identification and characterization of a novel Golgi protein, golgin-67. (PMID: 10660574) Jakymiw A … Fujita DJ (The Journal of biological chemistry 2000) 3 4 58
- Human autoantibodies to a novel Golgi protein golgin-67: high similarity with golgin-95/gm 130 autoantigen. (PMID: 10677249) Eystathioy T … Chan EK (Journal of autoimmunity 2000) 3 4 58
Products for GOLGA8B Gene
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- Overview of 38 available GOLGA8B gene related products
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- Overview of 38 available GOLGA8B gene related products
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Sources for GOLGA8B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
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