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Aliases for GOLGA8B Gene

Aliases for GOLGA8B Gene

  • Golgin A8 Family Member B 2 3 5
  • Golgi Autoantigen, Golgin Subfamily A, 8B 2 3
  • Golgin-67 3 4
  • Golgin Subfamily A Member 8B 3
  • Golgin A8 Family, Member B 2
  • GOLGA5 3

External Ids for GOLGA8B Gene

Previous GeneCards Identifiers for GOLGA8B Gene

  • GC15M032460
  • GC15M032605
  • GC15M034817

Summaries for GOLGA8B Gene

GeneCards Summary for GOLGA8B Gene

GOLGA8B (Golgin A8 Family Member B) is a Protein Coding gene. An important paralog of this gene is GOLGA8A.

UniProtKB/Swiss-Prot for GOLGA8B Gene

  • May be involved in maintaining Golgi structure.

Additional gene information for GOLGA8B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOLGA8B Gene

Genomics for GOLGA8B Gene

GeneHancer (GH) Regulatory Elements for GOLGA8B Gene

Promoters and enhancers for GOLGA8B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J034588 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 661.1 +0.2 202 0.6 PKNOX1 ATF1 ARID4B BRCA1 YY1 POLR2B ZNF766 ZNF143 ZFP91 ATF7 GOLGA8B GOLGA8A AQR HNRNPLP2 LOC100422492
GH15J034582 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 660.6 +5.0 5020 2.4 ZFP64 ARID4B SIN3A ZNF48 YY1 ZNF121 GLIS2 ZNF143 ATF7 RUNX3 GOLGA8B GOLGA8A HNRNPLP2 FSCN1P1 LOC100422492
GH15J034536 Promoter 0.5 EPDnew 650.2 +52.5 52473 0.1 PIR35116 PIR51600 GOLGA8B
GH15J034533 Promoter 0.5 EPDnew 650.2 +55.4 55419 0.1 PIR51600 GOLGA8B GOLGA8A PIR59229
GH15J034968 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 13.7 -381.0 -380965 1.9 HDGF FOXA2 PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 AQR HNRNPLP2 NUTM1 ENSG00000259336 GOLGA8A GOLGA8B ENSG00000259665 ZNF770 GC15P034944
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GOLGA8B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GOLGA8B gene promoter:
  • Ik-1
  • AML1a
  • AREB6
  • c-Myb
  • FOXJ2
  • FOXJ2 (long isoform)
  • E2F-1
  • E2F
  • CUTL1
  • Pax-2

Genomic Locations for GOLGA8B Gene

Genomic Locations for GOLGA8B Gene
chr15:34,525,207-34,588,503
(GRCh38/hg38)
Size:
63,297 bases
Orientation:
Minus strand
chr15:34,817,408-34,880,704
(GRCh37/hg19)
Size:
63,297 bases
Orientation:
Minus strand

Genomic View for GOLGA8B Gene

Genes around GOLGA8B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GOLGA8B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GOLGA8B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOLGA8B Gene

Proteins for GOLGA8B Gene

  • Protein details for GOLGA8B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MQT2-GOG8B_HUMAN
    Recommended name:
    Golgin subfamily A member 8B
    Protein Accession:
    A8MQT2
    Secondary Accessions:
    • A6NLZ2
    • O94937
    • Q2M3S9
    • Q9NZG8
    • Q9NZW0
    • Q9NZW3

    Protein attributes for GOLGA8B Gene

    Size:
    603 amino acids
    Molecular mass:
    67278 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Antibodies against GM88 are present in serum from a patient with Sjoegren syndrome. Sera from patients with Sjoegren syndrome often contain antibodies that react with normal components of the Golgi complex.

    Alternative splice isoforms for GOLGA8B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GOLGA8B Gene

Post-translational modifications for GOLGA8B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GOLGA8B Gene

No data available for DME Specific Peptides for GOLGA8B Gene

Domains & Families for GOLGA8B Gene

Gene Families for GOLGA8B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GOLGA8B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GOLGA8B Gene

Graphical View of Domain Structure for InterPro Entry

A8MQT2

UniProtKB/Swiss-Prot:

GOG8B_HUMAN :
  • Extended rod-like protein with coiled-coil domains.
  • Belongs to the GOLGA8 family.
Domain:
  • Extended rod-like protein with coiled-coil domains.
Family:
  • Belongs to the GOLGA8 family.
genes like me logo Genes that share domains with GOLGA8B: view

Function for GOLGA8B Gene

Molecular function for GOLGA8B Gene

UniProtKB/Swiss-Prot Function:
May be involved in maintaining Golgi structure.

Phenotypes From GWAS Catalog for GOLGA8B Gene

Phenotypes for GOLGA8B Gene

genes like me logo Genes that share phenotypes with GOLGA8B: view

Animal Model Products

miRNA for GOLGA8B Gene

miRTarBase miRNAs that target GOLGA8B

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GOLGA8B Gene

Localization for GOLGA8B Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOLGA8B Gene

Golgi apparatus, Golgi stack membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GOLGA8B gene
Compartment Confidence
cytosol 5
golgi apparatus 5
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GOLGA8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000137 Golgi cis cisterna IBA --
GO:0005794 Golgi apparatus IDA --
GO:0005801 cis-Golgi network IBA --
GO:0005829 cytosol IDA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with GOLGA8B: view

Pathways & Interactions for GOLGA8B Gene

SuperPathways for GOLGA8B Gene

No Data Available

Interacting Proteins for GOLGA8B Gene

Selected Interacting proteins: A8MQT2-GOG8B_HUMAN for GOLGA8B Gene via IID

Symbol External ID(s) Details
PRKCE

Gene Ontology (GO) - Biological Process for GOLGA8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007030 Golgi organization IBA --
GO:0051225 NOT spindle assembly IBA --
genes like me logo Genes that share ontologies with GOLGA8B: view

No data available for Pathways by source and SIGNOR curated interactions for GOLGA8B Gene

Drugs & Compounds for GOLGA8B Gene

No Compound Related Data Available

Transcripts for GOLGA8B Gene

Unigene Clusters for GOLGA8B Gene

Golgin A8 family, member B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GOLGA8B Gene

No ASD Table

Relevant External Links for GOLGA8B Gene

GeneLoc Exon Structure for
GOLGA8B
ECgene alternative splicing isoforms for
GOLGA8B

Expression for GOLGA8B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GOLGA8B Gene

mRNA differential expression in normal tissues according to GTEx for GOLGA8B Gene

This gene is overexpressed in Pancreas (x5.6).

NURSA nuclear receptor signaling pathways regulating expression of GOLGA8B Gene:

GOLGA8B

SOURCE GeneReport for Unigene cluster for GOLGA8B Gene:

Hs.720151

mRNA Expression by UniProt/SwissProt for GOLGA8B Gene:

A8MQT2-GOG8B_HUMAN
Tissue specificity: Highly expressed in brain, heart and kidney. Detected at lower levels in liver, thymus, spleen, lung and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for GOLGA8B Gene

  • Nervous system(4.5)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with GOLGA8B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GOLGA8B Gene

Orthologs for GOLGA8B Gene

This gene was present in the common ancestor of chordates.

Orthologs for GOLGA8B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 96 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 30 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 26 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Golga2 34
  • 25 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 24 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 23 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 21 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 21 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii golga2 34
  • 17 (a)
OneToMany
Species where no ortholog for GOLGA8B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GOLGA8B Gene

ENSEMBL:
Gene Tree for GOLGA8B (if available)
TreeFam:
Gene Tree for GOLGA8B (if available)

Paralogs for GOLGA8B Gene

(28) SIMAP similar genes for GOLGA8B Gene using alignment to 4 proteins:

  • GOG8B_HUMAN
  • B7ZKM1_HUMAN
  • B7ZMK6_HUMAN
  • C9J1B5_HUMAN
genes like me logo Genes that share paralogs with GOLGA8B: view

Variants for GOLGA8B Gene

Sequence variations from dbSNP and Humsavar for GOLGA8B Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000021874 -- 34,557,116(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000048982 -- 34,580,126(-) C/G genic_upstream_transcript_variant, intron_variant
rs1000079509 -- 34,527,281(-) C/T 3_prime_UTR_variant, non_coding_transcript_variant
rs1000368100 -- 34,583,551(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant
rs1000369302 -- 34,570,094(-) A/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GOLGA8B Gene

Variant ID Type Subtype PubMed ID
dgv107n111 CNV duplication 26073780
dgv21e213 CNV loss 24956385
dgv22e213 CNV gain 24956385
dgv2550n100 CNV gain 25217958
dgv2552n100 CNV gain 25217958
dgv2553n100 CNV loss 25217958
dgv2554n100 CNV loss 25217958
dgv2557n100 CNV loss 25217958
dgv2558n100 CNV gain+loss 25217958
dgv2559n100 CNV gain+loss 25217958
dgv2562n100 CNV gain+loss 25217958
dgv2563n100 CNV loss 25217958
dgv2569n100 CNV loss 25217958
dgv2570n100 CNV loss 25217958
dgv2571n100 CNV gain 25217958
dgv2572n100 CNV gain 25217958
dgv2574n100 CNV loss 25217958
dgv302e201 CNV deletion 23290073
dgv313n27 CNV loss 19166990
dgv314n27 CNV gain 19166990
dgv43e203 CNV gain+loss 21179565
dgv4456n54 CNV gain 21841781
dgv4459n54 CNV loss 21841781
dgv4460n54 CNV loss 21841781
dgv4461n54 CNV gain 21841781
dgv4468n54 CNV loss 21841781
dgv4474n54 CNV loss 21841781
dgv4475n54 CNV gain 21841781
dgv4476n54 CNV loss 21841781
dgv4477n54 CNV loss 21841781
dgv4482n54 CNV loss 21841781
esv2281816 CNV deletion 18987734
esv2663546 CNV deletion 23128226
esv2751533 CNV loss 17911159
esv2760024 CNV gain+loss 17122850
esv27955 CNV gain+loss 19812545
esv33337 CNV gain+loss 17666407
esv3368932 CNV insertion 20981092
esv3569431 CNV gain 25503493
esv3581626 CNV loss 25503493
esv3636115 CNV loss 21293372
esv3636116 CNV gain 21293372
esv3636119 CNV loss 21293372
esv3892664 CNV gain+loss 25118596
esv992827 CNV gain 20482838
nsv1039201 CNV gain 25217958
nsv1041189 CNV loss 25217958
nsv1052620 CNV gain 25217958
nsv1053730 CNV gain 25217958
nsv110 CNV deletion 15895083
nsv1160280 CNV deletion 26073780
nsv1160285 CNV duplication 26073780
nsv1485 CNV deletion 18451855
nsv428303 CNV gain 18775914
nsv442698 CNV gain+loss 18776908
nsv469685 CNV loss 16826518
nsv471682 CNV gain+loss 15918152
nsv510658 CNV deletion 20534489
nsv517751 CNV gain+loss 19592680
nsv569004 CNV gain+loss 21841781
nsv569130 CNV loss 21841781
nsv569131 CNV gain 21841781
nsv819187 CNV gain 19587683
nsv820603 CNV deletion 20802225
nsv820789 CNV deletion 20802225
nsv821682 CNV loss 15273396
nsv827290 CNV loss 20364138
nsv827291 CNV gain 20364138
nsv827294 CNV loss 20364138
nsv832965 CNV loss 17160897
nsv832966 CNV loss 17160897
nsv9241 CNV gain+loss 18304495
nsv974557 CNV duplication 23825009
nsv974558 CNV duplication 23825009
nsv984051 CNV duplication 23825009

Variation tolerance for GOLGA8B Gene

Gene Damage Index Score: 8.97; 87.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GOLGA8B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GOLGA8B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOLGA8B Gene

Disorders for GOLGA8B Gene

Additional Disease Information for GOLGA8B

No disorders were found for GOLGA8B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GOLGA8B Gene

Publications for GOLGA8B Gene

  1. A genome-wide association study identifies a susceptibility locus for refractive errors and myopia at 15q14. (PMID: 20835239) Solouki AM … Klaver CC (Nature genetics 2010) 3 44 58
  2. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody MC … Nusbaum C (Nature 2006) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Identification and characterization of a novel Golgi protein, golgin-67. (PMID: 10660574) Jakymiw A … Fujita DJ (The Journal of biological chemistry 2000) 3 4 58
  5. Human autoantibodies to a novel Golgi protein golgin-67: high similarity with golgin-95/gm 130 autoantigen. (PMID: 10677249) Eystathioy T … Chan EK (Journal of autoimmunity 2000) 3 4 58

Products for GOLGA8B Gene

Sources for GOLGA8B Gene

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