The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked, flattened membrane sacs referred to as cisternae. Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. The golgins constitute a famil... See more...

Aliases for GOLGA8A Gene

Aliases for GOLGA8A Gene

  • Golgin A8 Family Member A 2 3 5
  • Golgi Autoantigen, Golgin Subfamily A, 8A 2 3
  • Golgin Subfamily A Member 8A 3 4
  • 88 KDa Golgi Matrix Protein 3 4
  • GM88 Autoantigen 3 4
  • GM88 3 4
  • Golgin Subfamily A Member 8B 3
  • Golgin A8 Family, Member A 2
  • 88-KDa Golgi Protein 3
  • Golgin-67 3
  • KIAA0855 4
  • GOLGA8B 3

External Ids for GOLGA8A Gene

Previous GeneCards Identifiers for GOLGA8A Gene

  • GC15M032461
  • GC15M034671
  • GC15M011684
  • GC15M034380
  • GC15M034458

Summaries for GOLGA8A Gene

Entrez Gene Summary for GOLGA8A Gene

  • The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked, flattened membrane sacs referred to as cisternae. Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. The golgins constitute a family of proteins which are localized to the Golgi. This gene encodes a golgin which structurally resembles its family member GOLGA2, suggesting that they may share a similar function. There are many similar copies of this gene on chromosome 15. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]

GeneCards Summary for GOLGA8A Gene

GOLGA8A (Golgin A8 Family Member A) is a Protein Coding gene. Diseases associated with GOLGA8A include Smith-Mccort Dysplasia 1 and Dyschromatosis Universalis Hereditaria. An important paralog of this gene is GOLGA8B.

UniProtKB/Swiss-Prot Summary for GOLGA8A Gene

Additional gene information for GOLGA8A Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GOLGA8A Gene

Genomics for GOLGA8A Gene

GeneHancer (GH) Regulatory Elements for GOLGA8A Gene

Promoters and enhancers for GOLGA8A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J034582 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 504.6 -145.7 -145735 3.2 HNRNPK NRF1 POLR2G PHF8 TEAD4 ZFX ZNF10 POLR2A ZBTB11 ZNF423 GOLGA8B GOLGA8A lnc-GOLGA8A-5 lnc-GOLGA8A-6 lnc-NUTM1-7 AQR HNRNPLP2 ENSG00000259287 ENSG00000259336 NUTM1
GH15J034435 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas 525.1 +0.4 366 2.6 ZBTB40 NRF1 POLR2G CTCF ZIC2 POLR2A ZBTB26 TOE1 MYC TGIF2 GOLGA8A lnc-GOLGA8A-1 ACTG1P15 FSCN1P1 EMC4 ENSG00000279092
GH15J034588 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 500.1 -150.9 -150934 0.8 ZBTB40 CTCF TCF12 POLR2G PHF8 POLR2A ZBTB11 AFF1 REST RAD21 GOLGA8B GOLGA8A lnc-GOLGA8A-6 lnc-NUTM1-7
GH15J034389 Promoter 0.7 EPDnew Ensembl 500.3 +47.9 47945 0.6 piR-41940-005 piR-42117-001 piR-57601-001 GOLGA8A
GH15J034533 Promoter 0.3 EPDnew 500.2 -95.6 -95618 0.1 piR-43151-019 piR-34638-018 piR-44215-006 piR-41940-006 piR-51363-013 piR-51577-009 piR-57601-002 piR-55800-002 piR-56117-011 GOLGA8B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GOLGA8A on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GOLGA8A

Top Transcription factor binding sites by QIAGEN in the GOLGA8A gene promoter:
  • AML1a
  • c-Myc
  • Evi-1
  • Max1
  • MyoD
  • Nkx6-1
  • Pax-3
  • POU3F2
  • S8
  • STAT5A

Genomic Locations for GOLGA8A Gene

Genomic Locations for GOLGA8A Gene
58,399 bases
Minus strand
209,436 bases
Minus strand

Genomic View for GOLGA8A Gene

Genes around GOLGA8A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GOLGA8A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GOLGA8A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOLGA8A Gene

Proteins for GOLGA8A Gene

  • Protein details for GOLGA8A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Golgin subfamily A member 8A
    Protein Accession:
    Secondary Accessions:
    • A7MCY9
    • B7ZMK5
    • O94937
    • Q52M46
    • Q68DK6
    • Q9NZG8
    • Q9NZW0
    • Q9NZW3

    Protein attributes for GOLGA8A Gene

    631 amino acids
    Molecular mass:
    70117 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI44610.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAI50330.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAI52411.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAA74878.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=CAH18214.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Alternative splice isoforms for GOLGA8A Gene


neXtProt entry for GOLGA8A Gene

Post-translational modifications for GOLGA8A Gene

  • Glycosylation at Asn117
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • GOG8A_HUMAN (1282)

Other Protein References for GOLGA8A Gene

No data available for DME Specific Peptides for GOLGA8A Gene

Domains & Families for GOLGA8A Gene

Gene Families for GOLGA8A Gene

Protein Domains for GOLGA8A Gene


Suggested Antigen Peptide Sequences for GOLGA8A Gene

GenScript: Design optimal peptide antigens:
  • GOLGA8A protein (A1A4C0_HUMAN)
  • GM88 autoantigen (GOG8A_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GOLGA8 family.
  • Belongs to the GOLGA8 family.
genes like me logo Genes that share domains with GOLGA8A: view

Function for GOLGA8A Gene

Molecular function for GOLGA8A Gene

UniProtKB/Swiss-Prot Function:
May be involved in maintaining Golgi structure.

Phenotypes From GWAS Catalog for GOLGA8A Gene

Phenotypes for GOLGA8A Gene

genes like me logo Genes that share phenotypes with GOLGA8A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GOLGA8A

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GOLGA8A Gene

Localization for GOLGA8A Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOLGA8A Gene

Golgi apparatus, Golgi stack membrane; Peripheral membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GOLGA8A gene
Compartment Confidence
cytosol 4
golgi apparatus 4
nucleus 3
cytoskeleton 1
endoplasmic reticulum 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GOLGA8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000137 Golgi cis cisterna IBA 21873635
GO:0005794 Golgi apparatus IBA,IDA --
GO:0005801 cis-Golgi network IBA 21873635
GO:0005829 cytosol IDA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with GOLGA8A: view

Pathways & Interactions for GOLGA8A Gene

PathCards logo

SuperPathways for GOLGA8A Gene

No Data Available

Interacting Proteins for GOLGA8A Gene


Gene Ontology (GO) - Biological Process for GOLGA8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007030 Golgi organization IBA 21873635
GO:0051225 NOT spindle assembly IBA 21873635
genes like me logo Genes that share ontologies with GOLGA8A: view

No data available for Pathways by source and SIGNOR curated interactions for GOLGA8A Gene

Drugs & Compounds for GOLGA8A Gene

No Compound Related Data Available

Transcripts for GOLGA8A Gene

mRNA/cDNA for GOLGA8A Gene

16 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GOLGA8A

Alternative Splicing Database (ASD) splice patterns (SP) for GOLGA8A Gene

No ASD Table

Relevant External Links for GOLGA8A Gene

GeneLoc Exon Structure for

Expression for GOLGA8A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GOLGA8A Gene

Protein differential expression in normal tissues from HIPED for GOLGA8A Gene

This gene is overexpressed in Platelet (42.4) and Adipocyte (26.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GOLGA8A Gene

Protein tissue co-expression partners for GOLGA8A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GOLGA8A

SOURCE GeneReport for Unigene cluster for GOLGA8A Gene:


Evidence on tissue expression from TISSUES for GOLGA8A Gene

  • Nervous system(4.8)
  • Liver(4.4)
  • Lung(2.9)
  • Pancreas(2.2)
genes like me logo Genes that share expression patterns with GOLGA8A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GOLGA8A Gene

Orthologs for GOLGA8A Gene

This gene was present in the common ancestor of chordates.

Orthologs for GOLGA8A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 31
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 30 (a)
(Bos Taurus)
Mammalia -- 31
  • 26 (a)
(Mus musculus)
Mammalia Golga2 31
  • 25 (a)
(Canis familiaris)
Mammalia -- 31
  • 24 (a)
(Monodelphis domestica)
Mammalia -- 31
  • 23 (a)
(Gallus gallus)
Aves -- 31
  • 21 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 21 (a)
(Danio rerio)
Actinopterygii golga2 31
  • 17 (a)
Species where no ortholog for GOLGA8A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GOLGA8A Gene

Gene Tree for GOLGA8A (if available)
Gene Tree for GOLGA8A (if available)

Paralogs for GOLGA8A Gene

genes like me logo Genes that share paralogs with GOLGA8A: view

Variants for GOLGA8A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GOLGA8A Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
768693 Benign: not provided 34,381,521(-) C/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
rs238639 - p.Ser530Asn
rs347879 - p.Arg541Gln
rs347880 - p.Lys480Asn

Additional dbSNP identifiers (rs#s) for GOLGA8A Gene

Structural Variations from Database of Genomic Variants (DGV) for GOLGA8A Gene

Variant ID Type Subtype PubMed ID
dgv107n111 CNV duplication 26073780
dgv21e213 CNV loss 24956385
dgv21n64 CNV gain+loss 17921354
dgv22e213 CNV gain 24956385
dgv2550n100 CNV gain 25217958
dgv2551n100 CNV gain 25217958
dgv2552n100 CNV gain 25217958
dgv2553n100 CNV loss 25217958
dgv2554n100 CNV loss 25217958
dgv2555n100 CNV loss 25217958
dgv2556n100 CNV loss 25217958
dgv2557n100 CNV loss 25217958
dgv2558n100 CNV gain+loss 25217958
dgv2559n100 CNV gain+loss 25217958
dgv2560n100 CNV loss 25217958
dgv2561n100 CNV gain+loss 25217958
dgv2562n100 CNV gain+loss 25217958
dgv2563n100 CNV loss 25217958
dgv2564n100 CNV loss 25217958
dgv2565n100 CNV loss 25217958
dgv2566n100 CNV gain 25217958
dgv302e201 CNV deletion 23290073
dgv311n27 CNV gain 19166990
dgv312n27 CNV loss 19166990
dgv313n27 CNV loss 19166990
dgv314n27 CNV gain 19166990
dgv43e203 CNV gain+loss 21179565
dgv4456n54 CNV gain 21841781
dgv4458n54 CNV loss 21841781
dgv4459n54 CNV loss 21841781
dgv4460n54 CNV loss 21841781
dgv4461n54 CNV gain 21841781
dgv4462n54 CNV loss 21841781
dgv4463n54 CNV loss 21841781
dgv4464n54 CNV loss 21841781
dgv4465n54 CNV loss 21841781
dgv4466n54 CNV loss 21841781
dgv4467n54 CNV loss 21841781
dgv4468n54 CNV loss 21841781
dgv4469n54 CNV loss 21841781
dgv4470n54 CNV loss 21841781
dgv4471n54 CNV loss 21841781
dgv4472n54 CNV loss 21841781
dgv4473n54 CNV gain+loss 21841781
dgv4474n54 CNV loss 21841781
dgv4475n54 CNV gain 21841781
dgv4476n54 CNV loss 21841781
dgv4477n54 CNV loss 21841781
esv2760024 CNV gain+loss 17122850
esv27955 CNV gain+loss 19812545
esv33337 CNV gain+loss 17666407
esv3569431 CNV gain 25503493
esv3581626 CNV loss 25503493
esv3636115 CNV loss 21293372
esv3636116 CNV gain 21293372
esv3892663 CNV gain+loss 25118596
esv3892664 CNV gain+loss 25118596
esv3892665 CNV loss 25118596
esv3892666 CNV loss 25118596
esv3892668 CNV loss 25118596
esv992827 CNV gain 20482838
nsv1039201 CNV gain 25217958
nsv1048642 CNV loss 25217958
nsv1052620 CNV gain 25217958
nsv110 CNV deletion 15895083
nsv1143778 CNV deletion 24896259
nsv1160279 CNV duplication 26073780
nsv1160280 CNV deletion 26073780
nsv1160284 CNV duplication 26073780
nsv1485 CNV deletion 18451855
nsv428303 CNV gain 18775914
nsv438269 CNV loss 16468122
nsv442698 CNV gain+loss 18776908
nsv469547 CNV loss 16826518
nsv471236 CNV loss 18288195
nsv471237 CNV gain 18288195
nsv471682 CNV gain+loss 15918152
nsv482177 CNV gain 20164927
nsv509567 CNV insertion 20534489
nsv517751 CNV gain+loss 19592680
nsv568925 CNV gain 21841781
nsv568926 CNV gain 21841781
nsv568937 CNV loss 21841781
nsv568972 CNV loss 21841781
nsv568990 CNV loss 21841781
nsv569004 CNV gain+loss 21841781
nsv569024 CNV loss 21841781
nsv819187 CNV gain 19587683
nsv820603 CNV deletion 20802225
nsv820992 CNV deletion 20802225
nsv821682 CNV loss 15273396
nsv827290 CNV loss 20364138
nsv827291 CNV gain 20364138
nsv827292 CNV loss 20364138
nsv9241 CNV gain+loss 18304495
nsv94645 CNV deletion 16902084
nsv952607 CNV deletion 24416366
nsv976918 CNV duplication 23825009
nsv984049 CNV duplication 23825009
nsv984050 CNV duplication 23825009
nsv984215 OTHER complex 23825009

Variation tolerance for GOLGA8A Gene

Gene Damage Index Score: 8.34; 85.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GOLGA8A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOLGA8A Gene

Disorders for GOLGA8A Gene

MalaCards: The human disease database

(2) MalaCards diseases for GOLGA8A Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GOLGA8A

genes like me logo Genes that share disorders with GOLGA8A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GOLGA8A Gene

Publications for GOLGA8A Gene

  1. Human autoantibodies to a novel Golgi protein golgin-67: high similarity with golgin-95/gm 130 autoantigen. (PMID: 10677249) Eystathioy T … Chan EK (Journal of autoimmunity 2000) 2 3 54
  2. Identification and characterization of a novel Golgi protein, golgin-67. (PMID: 10660574) Jakymiw A … Fujita DJ (The Journal of biological chemistry 2000) 2 3 54
  3. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 3 4 54
  4. Identification of Plasma Biomarkers of Human Intracerebral Hemorrhage Subtypes through Microarray Technology. (PMID: 26738811) Merino-Zamorano C … Hernández-Guillamon M (Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2016) 3 54
  5. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M … Rocchi P (Molecular & cellular proteomics : MCP 2014) 3 54

Products for GOLGA8A Gene

Sources for GOLGA8A Gene