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Aliases for GOLGA8A Gene

Aliases for GOLGA8A Gene

  • Golgin A8 Family Member A 2 3 5
  • Golgi Autoantigen, Golgin Subfamily A, 8A 2 3
  • 88 KDa Golgi Matrix Protein 3 4
  • GM88 Autoantigen 3 4
  • GM88 3 4
  • Golgin Subfamily A Member 8A 3
  • Golgin A8 Family, Member A 2
  • 88-KDa Golgi Protein 3
  • Golgin-67 3
  • KIAA0855 4

External Ids for GOLGA8A Gene

Previous GeneCards Identifiers for GOLGA8A Gene

  • GC15M032461
  • GC15M034671
  • GC15M011684

Summaries for GOLGA8A Gene

Entrez Gene Summary for GOLGA8A Gene

  • The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked, flattened membrane sacs referred to as cisternae. Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. The golgins constitute a family of proteins which are localized to the Golgi. This gene encodes a golgin which structurally resembles its family member GOLGA2, suggesting that they may share a similar function. There are many similar copies of this gene on chromosome 15. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]

GeneCards Summary for GOLGA8A Gene

GOLGA8A (Golgin A8 Family Member A) is a Protein Coding gene. An important paralog of this gene is GOLGA8B.

UniProtKB/Swiss-Prot for GOLGA8A Gene

  • May be involved in maintaining Golgi structure.

Additional gene information for GOLGA8A Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOLGA8A Gene

Genomics for GOLGA8A Gene

GeneHancer (GH) Regulatory Elements for GOLGA8A Gene

Promoters and enhancers for GOLGA8A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J034582 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 654.6 -146.0 -146017 2.4 ZFP64 ARID4B SIN3A ZNF48 YY1 ZNF121 GLIS2 ZNF143 ATF7 RUNX3 GOLGA8B GOLGA8A HNRNPLP2 FSCN1P1 LOC100422492
GH15J034588 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 650.1 -150.8 -150835 0.6 PKNOX1 ATF1 ARID4B BRCA1 YY1 POLR2B ZNF766 ZNF143 ZFP91 ATF7 GOLGA8B GOLGA8A AQR HNRNPLP2 LOC100422492
GH15J034435 Promoter/Enhancer 1.4 Ensembl ENCODE 675.2 +0.3 335 2.4 ATF1 ARNT ARID4B DMAP1 ZNF48 SLC30A9 GLIS2 RUNX3 NCOA1 MXD4 GOLGA8A ACTG1P15 FSCN1P1 EMC4 ENSG00000279092
GH15J034389 Promoter 0.5 EPDnew 650.2 +47.7 47654 0.1 GOLGA8A ENSG00000260639 PIR47450
GH15J034533 Promoter 0.5 EPDnew 650.2 -95.6 -95618 0.1 PIR51600 GOLGA8B GOLGA8A PIR59229
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GOLGA8A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GOLGA8A gene promoter:
  • S8
  • AML1a
  • Max1
  • c-Myc
  • Nkx6-1
  • POU3F2
  • Evi-1
  • MyoD
  • STAT5A
  • Pax-3

Genomic Locations for GOLGA8A Gene

Genomic Locations for GOLGA8A Gene
chr15:34,379,068-34,437,466
(GRCh38/hg38)
Size:
58,399 bases
Orientation:
Minus strand
chr15:34,671,269-34,880,704
(GRCh37/hg19)
Size:
209,436 bases
Orientation:
Minus strand

Genomic View for GOLGA8A Gene

Genes around GOLGA8A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GOLGA8A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GOLGA8A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOLGA8A Gene

Proteins for GOLGA8A Gene

  • Protein details for GOLGA8A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A7E2F4-GOG8A_HUMAN
    Recommended name:
    Golgin subfamily A member 8A
    Protein Accession:
    A7E2F4
    Secondary Accessions:
    • A7MCY9
    • B7ZMK5
    • O94937
    • Q52M46
    • Q68DK6
    • Q9NZG8
    • Q9NZW0
    • Q9NZW3

    Protein attributes for GOLGA8A Gene

    Size:
    631 amino acids
    Molecular mass:
    70117 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI44610.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI50330.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAI52411.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA74878.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAH18214.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Alternative splice isoforms for GOLGA8A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GOLGA8A Gene

Post-translational modifications for GOLGA8A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GOLGA8A Gene

No data available for DME Specific Peptides for GOLGA8A Gene

Domains & Families for GOLGA8A Gene

Gene Families for GOLGA8A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GOLGA8A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GOLGA8A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A7E2F4

UniProtKB/Swiss-Prot:

GOG8A_HUMAN :
  • Belongs to the GOLGA8 family.
Family:
  • Belongs to the GOLGA8 family.
genes like me logo Genes that share domains with GOLGA8A: view

Function for GOLGA8A Gene

Molecular function for GOLGA8A Gene

UniProtKB/Swiss-Prot Function:
May be involved in maintaining Golgi structure.

Phenotypes From GWAS Catalog for GOLGA8A Gene

Phenotypes for GOLGA8A Gene

genes like me logo Genes that share phenotypes with GOLGA8A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GOLGA8A

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GOLGA8A Gene

Localization for GOLGA8A Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOLGA8A Gene

Golgi apparatus, Golgi stack membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GOLGA8A gene
Compartment Confidence
cytosol 5
golgi apparatus 5
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GOLGA8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000137 Golgi cis cisterna IBA --
GO:0005794 Golgi apparatus IDA --
GO:0005801 cis-Golgi network IBA --
GO:0005829 cytosol IDA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with GOLGA8A: view

Pathways & Interactions for GOLGA8A Gene

SuperPathways for GOLGA8A Gene

No Data Available

Interacting Proteins for GOLGA8A Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000352111%0d%0a9606.ENSP00000347244%0d%0a9606.ENSP00000440586%0d%0a
Selected Interacting proteins: ENSP00000352111 A7E2F4-GOG8A_HUMAN for GOLGA8A Gene via STRING IID

Gene Ontology (GO) - Biological Process for GOLGA8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007030 Golgi organization IBA --
GO:0051225 NOT spindle assembly IBA --
genes like me logo Genes that share ontologies with GOLGA8A: view

No data available for Pathways by source and SIGNOR curated interactions for GOLGA8A Gene

Drugs & Compounds for GOLGA8A Gene

No Compound Related Data Available

Transcripts for GOLGA8A Gene

mRNA/cDNA for GOLGA8A Gene

(3) REFSEQ mRNAs :
(16) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GOLGA8A Gene

Golgin A8 family, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GOLGA8A

Alternative Splicing Database (ASD) splice patterns (SP) for GOLGA8A Gene

No ASD Table

Relevant External Links for GOLGA8A Gene

GeneLoc Exon Structure for
GOLGA8A
ECgene alternative splicing isoforms for
GOLGA8A

Expression for GOLGA8A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GOLGA8A Gene

Protein differential expression in normal tissues from HIPED for GOLGA8A Gene

This gene is overexpressed in Platelet (42.4) and Adipocyte (26.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GOLGA8A Gene



Protein tissue co-expression partners for GOLGA8A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GOLGA8A Gene:

GOLGA8A

SOURCE GeneReport for Unigene cluster for GOLGA8A Gene:

Hs.182982

Evidence on tissue expression from TISSUES for GOLGA8A Gene

  • Nervous system(4.8)
  • Liver(4.4)
  • Lung(2.9)
  • Pancreas(2.2)
genes like me logo Genes that share expression patterns with GOLGA8A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GOLGA8A Gene

Orthologs for GOLGA8A Gene

This gene was present in the common ancestor of chordates.

Orthologs for GOLGA8A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 96 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 30 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 26 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Golga2 34
  • 25 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 24 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 23 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 21 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 21 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii golga2 34
  • 17 (a)
OneToMany
Species where no ortholog for GOLGA8A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GOLGA8A Gene

ENSEMBL:
Gene Tree for GOLGA8A (if available)
TreeFam:
Gene Tree for GOLGA8A (if available)

Paralogs for GOLGA8A Gene

genes like me logo Genes that share paralogs with GOLGA8A: view

Variants for GOLGA8A Gene

Sequence variations from dbSNP and Humsavar for GOLGA8A Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000009750 -- 34,406,713(-) A/G 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant
rs1000121742 -- 34,423,463(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000374186 -- 34,430,541(-) G/C genic_upstream_transcript_variant, intron_variant
rs1000464811 -- 34,408,398(-) ACACA/ACA genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000712305 -- 34,434,658(-) C/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GOLGA8A Gene

Variant ID Type Subtype PubMed ID
dgv107n111 CNV duplication 26073780
dgv21e213 CNV loss 24956385
dgv21n64 CNV gain+loss 17921354
dgv22e213 CNV gain 24956385
dgv2550n100 CNV gain 25217958
dgv2551n100 CNV gain 25217958
dgv2552n100 CNV gain 25217958
dgv2553n100 CNV loss 25217958
dgv2554n100 CNV loss 25217958
dgv2555n100 CNV loss 25217958
dgv2556n100 CNV loss 25217958
dgv2557n100 CNV loss 25217958
dgv2558n100 CNV gain+loss 25217958
dgv2559n100 CNV gain+loss 25217958
dgv2560n100 CNV loss 25217958
dgv2561n100 CNV gain+loss 25217958
dgv2562n100 CNV gain+loss 25217958
dgv2563n100 CNV loss 25217958
dgv2564n100 CNV loss 25217958
dgv2565n100 CNV loss 25217958
dgv2566n100 CNV gain 25217958
dgv302e201 CNV deletion 23290073
dgv311n27 CNV gain 19166990
dgv312n27 CNV loss 19166990
dgv313n27 CNV loss 19166990
dgv314n27 CNV gain 19166990
dgv43e203 CNV gain+loss 21179565
dgv4456n54 CNV gain 21841781
dgv4458n54 CNV loss 21841781
dgv4459n54 CNV loss 21841781
dgv4460n54 CNV loss 21841781
dgv4461n54 CNV gain 21841781
dgv4462n54 CNV loss 21841781
dgv4463n54 CNV loss 21841781
dgv4464n54 CNV loss 21841781
dgv4465n54 CNV loss 21841781
dgv4466n54 CNV loss 21841781
dgv4467n54 CNV loss 21841781
dgv4468n54 CNV loss 21841781
dgv4469n54 CNV loss 21841781
dgv4470n54 CNV loss 21841781
dgv4471n54 CNV loss 21841781
dgv4472n54 CNV loss 21841781
dgv4473n54 CNV gain+loss 21841781
dgv4474n54 CNV loss 21841781
dgv4475n54 CNV gain 21841781
dgv4476n54 CNV loss 21841781
dgv4477n54 CNV loss 21841781
esv2760024 CNV gain+loss 17122850
esv27955 CNV gain+loss 19812545
esv33337 CNV gain+loss 17666407
esv3569431 CNV gain 25503493
esv3581626 CNV loss 25503493
esv3636115 CNV loss 21293372
esv3636116 CNV gain 21293372
esv3892663 CNV gain+loss 25118596
esv3892664 CNV gain+loss 25118596
esv3892665 CNV loss 25118596
esv3892666 CNV loss 25118596
esv3892668 CNV loss 25118596
esv992827 CNV gain 20482838
nsv1039201 CNV gain 25217958
nsv1048642 CNV loss 25217958
nsv1052620 CNV gain 25217958
nsv110 CNV deletion 15895083
nsv1143778 CNV deletion 24896259
nsv1160279 CNV duplication 26073780
nsv1160280 CNV deletion 26073780
nsv1160284 CNV duplication 26073780
nsv1485 CNV deletion 18451855
nsv428303 CNV gain 18775914
nsv438269 CNV loss 16468122
nsv442698 CNV gain+loss 18776908
nsv469547 CNV loss 16826518
nsv471236 CNV loss 18288195
nsv471237 CNV gain 18288195
nsv471682 CNV gain+loss 15918152
nsv482177 CNV gain 20164927
nsv509567 CNV insertion 20534489
nsv517751 CNV gain+loss 19592680
nsv568925 CNV gain 21841781
nsv568926 CNV gain 21841781
nsv568937 CNV loss 21841781
nsv568972 CNV loss 21841781
nsv568990 CNV loss 21841781
nsv569004 CNV gain+loss 21841781
nsv569024 CNV loss 21841781
nsv819187 CNV gain 19587683
nsv820603 CNV deletion 20802225
nsv820992 CNV deletion 20802225
nsv821682 CNV loss 15273396
nsv827290 CNV loss 20364138
nsv827291 CNV gain 20364138
nsv827292 CNV loss 20364138
nsv9241 CNV gain+loss 18304495
nsv94645 CNV deletion 16902084
nsv952607 CNV deletion 24416366
nsv976918 CNV duplication 23825009
nsv984049 CNV duplication 23825009
nsv984050 CNV duplication 23825009
nsv984215 OTHER complex 23825009

Variation tolerance for GOLGA8A Gene

Gene Damage Index Score: 8.34; 85.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GOLGA8A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GOLGA8A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOLGA8A Gene

Disorders for GOLGA8A Gene

Additional Disease Information for GOLGA8A

No disorders were found for GOLGA8A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GOLGA8A Gene

Publications for GOLGA8A Gene

  1. Identification and characterization of a novel Golgi protein, golgin-67. (PMID: 10660574) Jakymiw A … Fujita DJ (The Journal of biological chemistry 2000) 2 3 58
  2. Human autoantibodies to a novel Golgi protein golgin-67: high similarity with golgin-95/gm 130 autoantigen. (PMID: 10677249) Eystathioy T … Chan EK (Journal of autoimmunity 2000) 2 3 58
  3. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 3 4 58
  4. Identification of Plasma Biomarkers of Human Intracerebral Hemorrhage Subtypes through Microarray Technology. (PMID: 26738811) Merino-Zamorano C … Hernández-Guillamon M (Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2016) 3 58
  5. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M … Rocchi P (Molecular & cellular proteomics : MCP 2014) 3 58

Products for GOLGA8A Gene

Sources for GOLGA8A Gene

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