Aliases for GOLGA7B Gene

Aliases for GOLGA7B Gene

  • Golgin A7 Family Member B 2 3 5
  • Golgi Autoantigen, Golgin Subfamily A, 7B 2 3
  • Golgin Subfamily A Member 7B 3 4
  • C10orf132 3 4
  • C10orf133 3 4
  • Chromosome 10 Open Reading Frame 133 2
  • Chromosome 10 Open Reading Frame 132 2
  • Golgin A7 Family, Member B 2
  • BA451M19.3 3
  • BA459F3.4 3

External Ids for GOLGA7B Gene

Previous HGNC Symbols for GOLGA7B Gene

  • C10orf133
  • C10orf132

Previous GeneCards Identifiers for GOLGA7B Gene

  • GC10P099599
  • GC10P093235
  • GC10P099609

Summaries for GOLGA7B Gene

GeneCards Summary for GOLGA7B Gene

GOLGA7B (Golgin A7 Family Member B) is a Protein Coding gene. Diseases associated with GOLGA7B include Alzheimer Disease 18. An important paralog of this gene is GOLGA7.

UniProtKB/Swiss-Prot Summary for GOLGA7B Gene

Additional gene information for GOLGA7B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GOLGA7B Gene

Genomics for GOLGA7B Gene

GeneHancer (GH) Regulatory Elements for GOLGA7B Gene

Promoters and enhancers for GOLGA7B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J097848 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 506.6 +1.2 1161 4.4 ZNF217 REST ZBTB26 ZBTB25 GATAD2B CTBP1 ZNF341 EZH2 HCFC1 SP2 GOLGA7B LINC00866 lnc-CRTAC1-2 lnc-GOLGA7B-1
GH10J097869 Enhancer 1.2 Ensembl ENCODE dbSUPER 18.9 +19.7 19657 2.2 ZNF217 CTCF NRF1 ZIC2 GABPA REST MYC TGIF2 RAD21 SKI GOLGA7B SFRP5 lnc-GOLGA7B-1 MIR3085-001 CRTAC1
GH10J097819 Enhancer 0.7 Ensembl dbSUPER 21.7 -28.5 -28542 3 ZIC2 MAFF FOS MAFK ZFHX2 CTCF EGR2 STAT3 lnc-GOLGA7B-2 GOLGA7B ZFYVE27 lnc-GOLGA7B-3
GH10J097827 Enhancer 0.6 Ensembl dbSUPER 20.4 -20.8 -20842 3.2 ZIC2 CTCF KLF1 EGR2 GATA2 GOLGA7B SFRP5 CRTAC1 ZFYVE27 lnc-GOLGA7B-2 piR-40459 lnc-GOLGA7B-3 LINC00866
GH10J097837 Enhancer 1.3 Ensembl ENCODE dbSUPER 6.6 -10.9 -10942 6.2 CTCF TCF12 RBAK JUND FOS ZBTB11 AFF1 REST TOE1 MYC piR-40459 SFRP5 CRTAC1 GOLGA7B piR-39488-046 piR-55281-062 piR-56022-052 piR-56088-003 LINC00866 lnc-GOLGA7B-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GOLGA7B on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GOLGA7B

Top Transcription factor binding sites by QIAGEN in the GOLGA7B gene promoter:
  • c-Myc
  • Max1
  • Meis-1
  • Meis-1a
  • NRSF form 1
  • NRSF form 2

Genomic Locations for GOLGA7B Gene

Genomic Locations for GOLGA7B Gene
chr10:97,849,843-97,871,580
(GRCh38/hg38)
Size:
21,738 bases
Orientation:
Plus strand
chr10:99,609,996-99,631,337
(GRCh37/hg19)
Size:
21,342 bases
Orientation:
Plus strand

Genomic View for GOLGA7B Gene

Genes around GOLGA7B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GOLGA7B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GOLGA7B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOLGA7B Gene

Proteins for GOLGA7B Gene

  • Protein details for GOLGA7B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2TAP0-GOG7B_HUMAN
    Recommended name:
    Golgin subfamily A member 7B
    Protein Accession:
    Q2TAP0
    Secondary Accessions:
    • Q5T4F5

    Protein attributes for GOLGA7B Gene

    Size:
    167 amino acids
    Molecular mass:
    18335 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Shares an exon with the neighboring tail-to-tail oriented gene CRTAC1.

neXtProt entry for GOLGA7B Gene

Post-translational modifications for GOLGA7B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GOLGA7B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GOLGA7B Gene

Domains & Families for GOLGA7B Gene

Gene Families for GOLGA7B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GOLGA7B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GOLGA7B Gene

GenScript: Design optimal peptide antigens:
  • Golgin subfamily A member 7B (GOG7B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q2TAP0

UniProtKB/Swiss-Prot:

GOG7B_HUMAN :
  • Belongs to the ERF4 family.
Family:
  • Belongs to the ERF4 family.
genes like me logo Genes that share domains with GOLGA7B: view

Function for GOLGA7B Gene

Molecular function for GOLGA7B Gene

UniProtKB/Swiss-Prot Function:
May be involved in protein transport from Golgi to cell surface.

Phenotypes From GWAS Catalog for GOLGA7B Gene

Gene Ontology (GO) - Molecular Function for GOLGA7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019706 contributes_to protein-cysteine S-palmitoyltransferase activity IBA 21873635
genes like me logo Genes that share ontologies with GOLGA7B: view
genes like me logo Genes that share phenotypes with GOLGA7B: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GOLGA7B Gene

Localization for GOLGA7B Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOLGA7B Gene

Golgi apparatus membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GOLGA7B gene
Compartment Confidence
golgi apparatus 3
cytosol 2
plasma membrane 1
extracellular 1
nucleus 1
endoplasmic reticulum 0
lysosome 0

Gene Ontology (GO) - Cellular Components for GOLGA7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0002178 palmitoyltransferase complex IBA 21873635
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with GOLGA7B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GOLGA7B Gene

Pathways & Interactions for GOLGA7B Gene

PathCards logo

SuperPathways for GOLGA7B Gene

No Data Available

Gene Ontology (GO) - Biological Process for GOLGA7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006612 protein targeting to membrane IBA 21873635
GO:0018230 peptidyl-L-cysteine S-palmitoylation IBA 21873635
genes like me logo Genes that share ontologies with GOLGA7B: view

No data available for Pathways by source and SIGNOR curated interactions for GOLGA7B Gene

Drugs & Compounds for GOLGA7B Gene

No Compound Related Data Available

Transcripts for GOLGA7B Gene

mRNA/cDNA for GOLGA7B Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GOLGA7B Gene

No ASD Table

Relevant External Links for GOLGA7B Gene

GeneLoc Exon Structure for
GOLGA7B

Expression for GOLGA7B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GOLGA7B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GOLGA7B Gene

This gene is overexpressed in Brain - Cerebellum (x7.8), Brain - Cerebellar Hemisphere (x6.9), and Brain - Cortex (x4.5).

Protein differential expression in normal tissues from HIPED for GOLGA7B Gene

This gene is overexpressed in Pancreatic juice (25.4), Tlymphocyte (19.8), Frontal cortex (10.0), and Lung (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GOLGA7B Gene



Protein tissue co-expression partners for GOLGA7B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GOLGA7B

SOURCE GeneReport for Unigene cluster for GOLGA7B Gene:

Hs.567524

mRNA Expression by UniProt/SwissProt for GOLGA7B Gene:

Q2TAP0-GOG7B_HUMAN
Tissue specificity: Expressed in brain, but not in lung, nor chondrocytes.

Evidence on tissue expression from TISSUES for GOLGA7B Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with GOLGA7B: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for GOLGA7B Gene

Orthologs for GOLGA7B Gene

This gene was present in the common ancestor of animals.

Orthologs for GOLGA7B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GOLGA7B 31 30
  • 99.4 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GOLGA7B 31
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GOLGA7B 31 30
  • 94.56 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GOLGA7B 31 30
  • 94.41 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Golga7b 17 31 30
  • 91.22 (n)
rat
(Rattus norvegicus)
Mammalia Golga7b 30
  • 91.22 (n)
chicken
(Gallus gallus)
Aves GOLGA7B 31
  • 89 (a)
OneToOne
LOC423837 30
  • 84.63 (n)
lizard
(Anolis carolinensis)
Reptilia GOLGA7B 31
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia golga7b 30
  • 79.67 (n)
zebrafish
(Danio rerio)
Actinopterygii golga7bb 31 30
  • 79.38 (n)
OneToMany
golga7ba 31
  • 72 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004120 30
  • 64.96 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5447 31 30
  • 60.56 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y57G11C.33 31
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5432 31
  • 32 (a)
OneToMany
Species where no ortholog for GOLGA7B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GOLGA7B Gene

ENSEMBL:
Gene Tree for GOLGA7B (if available)
TreeFam:
Gene Tree for GOLGA7B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GOLGA7B: view image

Paralogs for GOLGA7B Gene

Paralogs for GOLGA7B Gene

(1) SIMAP similar genes for GOLGA7B Gene using alignment to 2 proteins:

  • GOG7B_HUMAN
  • Q6ZUQ1_HUMAN
genes like me logo Genes that share paralogs with GOLGA7B: view

Variants for GOLGA7B Gene

Additional dbSNP identifiers (rs#s) for GOLGA7B Gene

Structural Variations from Database of Genomic Variants (DGV) for GOLGA7B Gene

Variant ID Type Subtype PubMed ID
nsv1045435 CNV gain 25217958
nsv1047572 CNV gain 25217958
nsv1069508 CNV deletion 25765185
nsv1112594 CNV deletion 24896259
nsv819567 CNV gain 19587683
nsv951000 CNV deletion 24416366

Variation tolerance for GOLGA7B Gene

Residual Variation Intolerance Score: 36.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.73; 78.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GOLGA7B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GOLGA7B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GOLGA7B Gene

Disorders for GOLGA7B Gene

MalaCards: The human disease database

(1) MalaCards diseases for GOLGA7B Gene - From: DISEASES

Disorder Aliases PubMed IDs
alzheimer disease 18
  • ad18
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GOLGA7B

genes like me logo Genes that share disorders with GOLGA7B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GOLGA7B Gene

Publications for GOLGA7B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 54
  3. A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway. (PMID: 30561431) Van Quickelberghe E … Gevaert K (Scientific data 2018) 3 54
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 54

Products for GOLGA7B Gene

Sources for GOLGA7B Gene