Aliases for GOLGA7 Gene

Aliases for GOLGA7 Gene

  • Golgin A7 2 3 5
  • GCP16 2 3 4
  • Golgi Complex-Associated Protein Of 16 KDa 3 4
  • Golgi Autoantigen, Golgin Subfamily A, 7 2 3
  • Golgin Subfamily A Member 7 3 4
  • GOLGA3AP1 2 3
  • GOLGA7A 2 3
  • HSPC041 2 3
  • Golgi Complex-Associated Protein Of 16kDa 3
  • GOLGA7 5

External Ids for GOLGA7 Gene

Previous GeneCards Identifiers for GOLGA7 Gene

  • GC08P041365
  • GC08P039875
  • GC08P041347

Summaries for GOLGA7 Gene

GeneCards Summary for GOLGA7 Gene

GOLGA7 (Golgin A7) is a Protein Coding gene. Diseases associated with GOLGA7 include Thymic Dysplasia. Among its related pathways are Innate Immune System. An important paralog of this gene is GOLGA7B.

UniProtKB/Swiss-Prot Summary for GOLGA7 Gene

  • May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GOLGA7 Gene

Genomics for GOLGA7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GOLGA7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J041489 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 258.1 +0.5 461 3.5 BCLAF1 SP1 ZNF207 ZNF592 ZNF223 NFIC ZIC2 ZBTB10 YY1 MXD4 GOLGA7 NONHSAG050069.2 IKBKB GPAT4 piR-32932 GINS4
GH08J041577 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 5.3 +88.2 88205 2.8 ZNF207 MYC ZNF600 IKZF1 JUND ZNF592 POLR2A ZNF10 NONO CTCF GPAT4 ENSG00000253133 GPAT4-AS1 lnc-GPAT4-2 IKBKB KAT6A ENSG00000254165 NKX6-3 GOLGA7 piR-50399-029
GH08J041510 Enhancer 0.6 dbSUPER 15.4 +21.3 21327 1.9 NFIC REST CTCF RXRA JUND HNF4A RAD21 NFIA HNRNPL XRCC5 KRT18P37 lnc-GOLGA7-1 GOLGA7 piR-57133-578 GINS4 ENSG00000253133
GH08J041505 Enhancer 1 Ensembl ENCODE dbSUPER 9 +15.1 15102 2.2 BCL11A IRF4 EBF1 CBFB BATF NFATC1 TCF7 ATF2 JUNB ZBED1 piR-39858-613 GINS4 GOLGA7 KRT18P37 NONHSAG050069.2
GH08J041514 Enhancer 0.5 Ensembl ENCODE 16.5 +25.6 25604 4.4 RNF2 YY1 GOLGA7 ENSG00000253174 lnc-GOLGA7-1 piR-57133-578 GINS4 ENSG00000253133
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GOLGA7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GOLGA7

Top Transcription factor binding sites by QIAGEN in the GOLGA7 gene promoter:
  • COUP
  • COUP-TF
  • COUP-TF1
  • HNF-4alpha1
  • HNF-4alpha2

Genomic Locations for GOLGA7 Gene

Latest Assembly
chr8:41,490,396-41,510,980
(GRCh38/hg38)
Size:
20,585 bases
Orientation:
Plus strand

Previous Assembly
chr8:41,347,915-41,368,499
(GRCh37/hg19 by Entrez Gene)
Size:
20,585 bases
Orientation:
Plus strand

chr8:41,347,915-41,368,499
(GRCh37/hg19 by Ensembl)
Size:
20,585 bases
Orientation:
Plus strand

Genomic View for GOLGA7 Gene

Genes around GOLGA7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GOLGA7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GOLGA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOLGA7 Gene

Proteins for GOLGA7 Gene

  • Protein details for GOLGA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z5G4-GOGA7_HUMAN
    Recommended name:
    Golgin subfamily A member 7
    Protein Accession:
    Q7Z5G4
    Secondary Accessions:
    • D3DSX9
    • J3KQ24
    • Q96EQ4
    • Q9P1S0
    • Q9Y5U7

    Protein attributes for GOLGA7 Gene

    Size:
    137 amino acids
    Molecular mass:
    15824 Da
    Quaternary structure:
    • Interacts with GOLGA3. Interacts with ZDHHC9.
    SequenceCaution:
    • Sequence=AAD39919.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAF65180.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for GOLGA7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GOLGA7 Gene

Post-translational modifications for GOLGA7 Gene

  • Palmitoylated on Cys-69 and Cys-72; which is required for Golgi localization and interaction with GOLGA3.
  • Ubiquitination at Lys29, Lys95, and Lys103
  • Modification sites at PhosphoSitePlus

Antibodies for research

  • Boster Bio Antibodies for GOLGA7
  • Santa Cruz Biotechnology (SCBT) Antibodies for GOLGA7

No data available for DME Specific Peptides for GOLGA7 Gene

Domains & Families for GOLGA7 Gene

Gene Families for GOLGA7 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for GOLGA7 Gene

InterPro:

Suggested Antigen Peptide Sequences for GOLGA7 Gene

GenScript: Design optimal peptide antigens:
  • Golgi complex-associated protein of 16 kDa (GOGA7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7Z5G4

UniProtKB/Swiss-Prot:

GOGA7_HUMAN :
  • Belongs to the ERF4 family.
Family:
  • Belongs to the ERF4 family.
genes like me logo Genes that share domains with GOLGA7: view

Function for GOLGA7 Gene

Molecular function for GOLGA7 Gene

UniProtKB/Swiss-Prot Function:
May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS.

Phenotypes From GWAS Catalog for GOLGA7 Gene

Gene Ontology (GO) - Molecular Function for GOLGA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14522980
GO:0019706 contributes_to protein-cysteine S-palmitoyltransferase activity IBA 21873635
genes like me logo Genes that share ontologies with GOLGA7: view
genes like me logo Genes that share phenotypes with GOLGA7: view

Animal Models for GOLGA7 Gene

MGI Knock Outs for GOLGA7:
  • Golga7 Golga7<tm1b(KOMP)Wtsi>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GOLGA7

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GOLGA7 Gene

Localization for GOLGA7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOLGA7 Gene

Golgi apparatus membrane. Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GOLGA7 gene
Compartment Confidence
golgi apparatus 5
extracellular 4
cytosol 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for GOLGA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IDA 14522980
GO:0002178 palmitoyltransferase complex IDA 16000296
GO:0005576 extracellular region TAS --
GO:0005794 Golgi apparatus IEA --
GO:0005795 Golgi stack IBA,IDA 14522980
genes like me logo Genes that share ontologies with GOLGA7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for GOLGA7 Gene

Pathways & Interactions for GOLGA7 Gene

PathCards logo

SuperPathways for GOLGA7 Gene

genes like me logo Genes that share pathways with GOLGA7: view

Pathways by source for GOLGA7 Gene

3 Reactome pathways for GOLGA7 Gene

SIGNOR curated interactions for GOLGA7 Gene

Activates:

Gene Ontology (GO) - Biological Process for GOLGA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006612 protein targeting to membrane IBA 21873635
GO:0006893 Golgi to plasma membrane transport IDA 14522980
GO:0018215 protein phosphopantetheinylation IEA --
GO:0018230 peptidyl-L-cysteine S-palmitoylation IDA 16000296
GO:0043001 Golgi to plasma membrane protein transport IDA 14522980
genes like me logo Genes that share ontologies with GOLGA7: view

Drugs & Compounds for GOLGA7 Gene

No Compound Related Data Available

Transcripts for GOLGA7 Gene

mRNA/cDNA for GOLGA7 Gene

5 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GOLGA7

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for GOLGA7 Gene

No ASD Table

Relevant External Links for GOLGA7 Gene

GeneLoc Exon Structure for
GOLGA7

Expression for GOLGA7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GOLGA7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GOLGA7 Gene

This gene is overexpressed in Bone (28.2) and Breast (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GOLGA7 Gene



Protein tissue co-expression partners for GOLGA7 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GOLGA7

SOURCE GeneReport for Unigene cluster for GOLGA7 Gene:

Hs.654773

mRNA Expression by UniProt/SwissProt for GOLGA7 Gene:

Q7Z5G4-GOGA7_HUMAN
Tissue specificity: Expressed in all tissues except colon and thymus.

Evidence on tissue expression from TISSUES for GOLGA7 Gene

  • Nervous system(4.9)
  • Blood(4.4)
  • Kidney(2.4)
  • Lung(2.1)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with GOLGA7: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GOLGA7 Gene

Orthologs for GOLGA7 Gene

This gene was present in the common ancestor of animals.

Orthologs for GOLGA7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia GOLGA7 29 30
  • 100 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia GOLGA7 30
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia GOLGA7 29 30
  • 94.89 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Golga7 29 16 30
  • 92.7 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia GOLGA7 29 30
  • 92.7 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Golga7 29
  • 91.73 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia GOLGA7 30
  • 90 (a)
OneToOne
Chicken
(Gallus gallus)
Aves GOLGA7 29 30
  • 86.62 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia GOLGA7 30
  • 90 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia golga7 29
  • 78.86 (n)
Str.6086 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.8761 29
Zebrafish
(Danio rerio)
Actinopterygii golga7 29 30
  • 73.74 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG5447 30
  • 48 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea CELE_Y57G11C.33 29
  • 46.13 (n)
Y57G11C.33 30
  • 25 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.5432 30
  • 34 (a)
OneToMany
Species where no ortholog for GOLGA7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for GOLGA7 Gene

ENSEMBL:
Gene Tree for GOLGA7 (if available)
TreeFam:
Gene Tree for GOLGA7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GOLGA7: view image
Alliance of Genome Resources:
Additional Orthologs for GOLGA7

Paralogs for GOLGA7 Gene

Paralogs for GOLGA7 Gene

(1) SIMAP similar genes for GOLGA7 Gene using alignment to 1 proteins:

  • GOGA7_HUMAN

Pseudogenes.org Pseudogenes for GOLGA7 Gene

genes like me logo Genes that share paralogs with GOLGA7: view

Variants for GOLGA7 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for GOLGA7 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for GOLGA7 Gene

Variant ID Type Subtype PubMed ID
esv3576565 CNV gain 25503493
nsv831299 CNV loss 17160897
nsv981931 CNV duplication 23825009

Variation tolerance for GOLGA7 Gene

Residual Variation Intolerance Score: 58.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.22; 5.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GOLGA7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GOLGA7
Leiden Open Variation Database (LOVD)
GOLGA7

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GOLGA7 Gene

Disorders for GOLGA7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GOLGA7 Gene - From: COP

Disorder Aliases PubMed IDs
thymic dysplasia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GOLGA7

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with GOLGA7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GOLGA7 Gene

Publications for GOLGA7 Gene

  1. DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras. (PMID: 16000296) Swarthout JT … Linder ME (The Journal of biological chemistry 2005) 2 3 4 22
  2. Identification and characterization of GCP16, a novel acylated Golgi protein that interacts with GCP170. (PMID: 14522980) Ohta E … Ikehara Y (The Journal of biological chemistry 2003) 2 3 4
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 40
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 3 4

Products for GOLGA7 Gene

Sources for GOLGA7 Gene