Aliases for GOLGA6L4 Gene

Aliases for GOLGA6L4 Gene

  • Golgin A6 Family Like 4 2 3 5
  • Golgi Autoantigen, Golgin Subfamily A, 6-Like 4 2 3
  • Golgin Subfamily A Member 6-Like Protein 4 3 4
  • Putative Golgin Subfamily A Member 6-Like Protein 4 3
  • GOLGA6L4 5

External Ids for GOLGA6L4 Gene

Previous GeneCards Identifiers for GOLGA6L4 Gene

  • GC15P082697
  • GC15U901116
  • GC15P084906
  • GC15P084912

Summaries for GOLGA6L4 Gene

GeneCards Summary for GOLGA6L4 Gene

GOLGA6L4 (Golgin A6 Family Like 4) is a Protein Coding gene. An important paralog of this gene is GOLGA6L10.

Additional gene information for GOLGA6L4 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GOLGA6L4 Gene

Genomics for GOLGA6L4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GOLGA6L4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GOLGA6L4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GOLGA6L4

Genomic Locations for GOLGA6L4 Gene

Genomic Locations for GOLGA6L4 Gene
chr15:84,235,773-84,245,368
(GRCh38/hg38)
Size:
9,596 bases
Orientation:
Plus strand
chr15:84,904,523-84,915,072
(GRCh37/hg19)
Size:
10,550 bases
Orientation:
Plus strand

Genomic View for GOLGA6L4 Gene

Genes around GOLGA6L4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GOLGA6L4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GOLGA6L4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOLGA6L4 Gene

Proteins for GOLGA6L4 Gene

  • Protein details for GOLGA6L4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NEF3-GG6L4_HUMAN
    Recommended name:
    Golgin subfamily A member 6-like protein 4
    Protein Accession:
    A6NEF3
    Secondary Accessions:
    • D6REZ9

    Protein attributes for GOLGA6L4 Gene

    Size:
    574 amino acids
    Molecular mass:
    67563 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GOLGA6L4 Gene

Post-translational modifications for GOLGA6L4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GOLGA6L4 Gene

No data available for DME Specific Peptides for GOLGA6L4 Gene

Domains & Families for GOLGA6L4 Gene

Gene Families for GOLGA6L4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GOLGA6L4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GOLGA6L4 Gene

GenScript: Design optimal peptide antigens:
  • Putative golgin subfamily A member 6-like protein 4 (GG6L4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NEF3

UniProtKB/Swiss-Prot:

GG6L4_HUMAN :
  • Belongs to the GOLGA6 family.
Family:
  • Belongs to the GOLGA6 family.
genes like me logo Genes that share domains with GOLGA6L4: view

Function for GOLGA6L4 Gene

Phenotypes From GWAS Catalog for GOLGA6L4 Gene

Phenotypes for GOLGA6L4 Gene

genes like me logo Genes that share phenotypes with GOLGA6L4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GOLGA6L4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GOLGA6L4 Gene

Localization for GOLGA6L4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GOLGA6L4 gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for GOLGA6L4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with GOLGA6L4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for GOLGA6L4 Gene

Pathways & Interactions for GOLGA6L4 Gene

PathCards logo

SuperPathways for GOLGA6L4 Gene

No Data Available

Interacting Proteins for GOLGA6L4 Gene

Gene Ontology (GO) - Biological Process for GOLGA6L4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GOLGA6L4 Gene

Drugs & Compounds for GOLGA6L4 Gene

No Compound Related Data Available

Transcripts for GOLGA6L4 Gene

mRNA/cDNA for GOLGA6L4 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GOLGA6L4

Alternative Splicing Database (ASD) splice patterns (SP) for GOLGA6L4 Gene

No ASD Table

Relevant External Links for GOLGA6L4 Gene

GeneLoc Exon Structure for
GOLGA6L4

Expression for GOLGA6L4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GOLGA6L4 Gene

Protein differential expression in normal tissues from HIPED for GOLGA6L4 Gene

This gene is overexpressed in Fetal gut (36.3) and Islet of Langerhans (32.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GOLGA6L4 Gene



Protein tissue co-expression partners for GOLGA6L4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GOLGA6L4

SOURCE GeneReport for Unigene cluster for GOLGA6L4 Gene:

Hs.534573
genes like me logo Genes that share expression patterns with GOLGA6L4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GOLGA6L4 Gene

Orthologs for GOLGA6L4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GOLGA6L4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC744787 30
  • 97.68 (n)
GOLGA6L4 31
  • 95 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 31
  • 16 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 15 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Golga2 31
  • 15 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 14 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 8 (a)
OneToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 12 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 12 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii golga2 31
  • 10 (a)
OneToMany
Species where no ortholog for GOLGA6L4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GOLGA6L4 Gene

ENSEMBL:
Gene Tree for GOLGA6L4 (if available)
TreeFam:
Gene Tree for GOLGA6L4 (if available)

Paralogs for GOLGA6L4 Gene

(21) SIMAP similar genes for GOLGA6L4 Gene using alignment to 4 proteins:

  • GG6L4_HUMAN
  • H0Y618_HUMAN
  • H0YA86_HUMAN
  • J3KQ80_HUMAN
genes like me logo Genes that share paralogs with GOLGA6L4: view

Variants for GOLGA6L4 Gene

Additional dbSNP identifiers (rs#s) for GOLGA6L4 Gene

Structural Variations from Database of Genomic Variants (DGV) for GOLGA6L4 Gene

Variant ID Type Subtype PubMed ID
dgv1456e59 CNV duplication 20981092
dgv2638n100 CNV gain 25217958
dgv2639n100 CNV loss 25217958
dgv2640n100 CNV gain 25217958
dgv2641n100 CNV loss 25217958
dgv2642n100 CNV gain+loss 25217958
dgv752e212 CNV loss 25503493
esv22023 CNV gain 19812545
esv2672879 CNV deletion 23128226
esv2677191 CNV deletion 23128226
esv2760048 CNV gain+loss 17122850
esv2761880 CNV gain 21179565
esv29092 CNV gain+loss 19812545
esv29772 CNV gain+loss 19812545
esv3442061 CNV duplication 20981092
esv3569809 CNV gain 25503493
esv3637089 CNV loss 21293372
nsv1037229 CNV gain+loss 25217958
nsv1038297 CNV gain+loss 25217958
nsv1071229 CNV deletion 25765185
nsv1129329 OTHER inversion 24896259
nsv1139636 CNV duplication 24896259
nsv1144742 CNV deletion 24896259
nsv1149221 CNV duplication 26484159
nsv117 OTHER inversion 15895083
nsv428310 CNV gain+loss 18775914
nsv518289 CNV loss 19592680
nsv570253 CNV loss 21841781
nsv833076 CNV loss 17160897
nsv833077 CNV gain+loss 17160897
nsv9290 CNV gain+loss 18304495
nsv974659 CNV duplication 23825009
nsv976960 CNV duplication 23825009
nsv977000 CNV duplication 23825009
nsv977798 CNV duplication 23825009
nsv984104 CNV duplication 23825009

Variation tolerance for GOLGA6L4 Gene

Gene Damage Index Score: 0.45; 9.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GOLGA6L4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GOLGA6L4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GOLGA6L4 Gene

Disorders for GOLGA6L4 Gene

Additional Disease Information for GOLGA6L4

No disorders were found for GOLGA6L4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GOLGA6L4 Gene

Publications for GOLGA6L4 Gene

  1. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody MC … Nusbaum C (Nature 2006) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  3. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) Schizophrenia Working Group of the Psychiatric Genomics Consortium (Nature 2014) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3

Products for GOLGA6L4 Gene

Sources for GOLGA6L4 Gene