Aliases for GOLGA6L2 Gene

Aliases for GOLGA6L2 Gene

  • Golgin A6 Family Like 2 2 3 5
  • Golgi Autoantigen, Golgin Subfamily A, 6-Like 2 2 3
  • Golgin Subfamily A Member 6-Like Protein 2 3 4
  • Cancer/Testis Antigen 105 2 3
  • CT105 3

External Ids for GOLGA6L2 Gene

Previous GeneCards Identifiers for GOLGA6L2 Gene

  • GC15M021239
  • GC15M023685

Summaries for GOLGA6L2 Gene

GeneCards Summary for GOLGA6L2 Gene

GOLGA6L2 (Golgin A6 Family Like 2) is a Protein Coding gene. Diseases associated with GOLGA6L2 include Mixed Fibrolamellar Hepatocellular Carcinoma and Lymphogranuloma Venereum. An important paralog of this gene is GOLGA6L7.

Additional gene information for GOLGA6L2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GOLGA6L2 Gene

Genomics for GOLGA6L2 Gene

GeneHancer (GH) Regulatory Elements for GOLGA6L2 Gene

Promoters and enhancers for GOLGA6L2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J023435 Enhancer 0.2 dbSUPER 19.8 +10.6 10615 1.6 piR-32214-193 piR-58239 GOLGA6L2 piR-58387-001
GH15J023411 Enhancer 0.2 Ensembl 4.6 +35.9 35942 0.2 lnc-GOLGA8S-2 GOLGA6L2 LOC105370728
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GOLGA6L2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GOLGA6L2

Genomic Locations for GOLGA6L2 Gene

Genomic Locations for GOLGA6L2 Gene
chr15:23,439,038-23,447,243
(GRCh38/hg38)
Size:
8,206 bases
Orientation:
Minus strand
chr15:23,684,645-23,692,381
(GRCh37/hg19)
Size:
7,737 bases
Orientation:
Minus strand

Genomic View for GOLGA6L2 Gene

Genes around GOLGA6L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GOLGA6L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GOLGA6L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOLGA6L2 Gene

Proteins for GOLGA6L2 Gene

  • Protein details for GOLGA6L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9W4-GG6L2_HUMAN
    Recommended name:
    Golgin subfamily A member 6-like protein 2
    Protein Accession:
    Q8N9W4
    Secondary Accessions:
    • A1L301
    • H3BMJ4

    Protein attributes for GOLGA6L2 Gene

    Size:
    909 amino acids
    Molecular mass:
    100610 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI29821.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for GOLGA6L2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GOLGA6L2 Gene

Post-translational modifications for GOLGA6L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GOLGA6L2 Gene

No data available for DME Specific Peptides for GOLGA6L2 Gene

Domains & Families for GOLGA6L2 Gene

Gene Families for GOLGA6L2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GOLGA6L2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GOLGA6L2 Gene

GenScript: Design optimal peptide antigens:
  • LOC283685 protein (A1L302_HUMAN)
  • Golgin subfamily A member 6-like protein 2 (GG6L2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N9W4

UniProtKB/Swiss-Prot:

GG6L2_HUMAN :
  • Belongs to the GOLGA6 family.
Family:
  • Belongs to the GOLGA6 family.
genes like me logo Genes that share domains with GOLGA6L2: view

Function for GOLGA6L2 Gene

Phenotypes for GOLGA6L2 Gene

genes like me logo Genes that share phenotypes with GOLGA6L2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GOLGA6L2 Gene

Localization for GOLGA6L2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GOLGA6L2 gene
Compartment Confidence
nucleus 3
cytosol 2
plasma membrane 1
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for GOLGA6L2 Gene

Pathways & Interactions for GOLGA6L2 Gene

PathCards logo

SuperPathways for GOLGA6L2 Gene

No Data Available

Interacting Proteins for GOLGA6L2 Gene

;

Gene Ontology (GO) - Biological Process for GOLGA6L2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GOLGA6L2 Gene

Drugs & Compounds for GOLGA6L2 Gene

No Compound Related Data Available

Transcripts for GOLGA6L2 Gene

mRNA/cDNA for GOLGA6L2 Gene

2 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for GOLGA6L2 Gene

No ASD Table

Relevant External Links for GOLGA6L2 Gene

GeneLoc Exon Structure for
GOLGA6L2

Expression for GOLGA6L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GOLGA6L2 Gene

mRNA differential expression in normal tissues according to GTEx for GOLGA6L2 Gene

This gene is overexpressed in Testis (x52.5).

Protein differential expression in normal tissues from HIPED for GOLGA6L2 Gene

This gene is overexpressed in Platelet (44.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GOLGA6L2 Gene



Protein tissue co-expression partners for GOLGA6L2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GOLGA6L2

genes like me logo Genes that share expression patterns with GOLGA6L2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GOLGA6L2 Gene

Orthologs for GOLGA6L2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GOLGA6L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GOLGA6L2 31
  • 61 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Golga2 31
  • 17 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 31
  • 17 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 31
  • 16 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 14 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 14 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 31
  • 14 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 13 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii golga2 31
  • 12 (a)
OneToMany
Species where no ortholog for GOLGA6L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GOLGA6L2 Gene

ENSEMBL:
Gene Tree for GOLGA6L2 (if available)
TreeFam:
Gene Tree for GOLGA6L2 (if available)

Paralogs for GOLGA6L2 Gene

(13) SIMAP similar genes for GOLGA6L2 Gene using alignment to 4 proteins:

  • GG6L2_HUMAN
  • F8WBV9_HUMAN
  • H3BMJ4_HUMAN
  • H3BS38_HUMAN
genes like me logo Genes that share paralogs with GOLGA6L2: view

Variants for GOLGA6L2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GOLGA6L2 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
rs12594944 - p.Arg235Pro
rs2344899 - p.Glu64Gly
rs2344900 - p.Arg43Gly
rs3866720 - p.Asn54His
rs4778531 - p.Trp191Arg

Additional dbSNP identifiers (rs#s) for GOLGA6L2 Gene

Variation tolerance for GOLGA6L2 Gene

Gene Damage Index Score: 25.35; 99.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GOLGA6L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GOLGA6L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GOLGA6L2 Gene

Disorders for GOLGA6L2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for GOLGA6L2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
mixed fibrolamellar hepatocellular carcinoma
lymphogranuloma venereum
  • climatic or tropical bubo
granuloma inguinale
  • donovanosis
fibrolamellar carcinoma
  • fibrolamellar hepatocellular carcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GOLGA6L2

genes like me logo Genes that share disorders with GOLGA6L2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GOLGA6L2 Gene

Publications for GOLGA6L2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  2. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 54
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 54
  4. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody MC … Nusbaum C (Nature 2006) 4 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 54

Products for GOLGA6L2 Gene

Sources for GOLGA6L2 Gene