Aliases for GOLGA6C Gene

Aliases for GOLGA6C Gene

  • Golgin A6 Family Member C 2 3 5
  • Golgin Subfamily A Member 6C 3 3 4
  • Golgi Autoantigen, Golgin Subfamily A, 6C 2 3
  • Putative Golgin Subfamily A Member 6C 3
  • Golgin A6 Family, Member C 2
  • GOLGA6C 5

External Ids for GOLGA6C Gene

Previous GeneCards Identifiers for GOLGA6C Gene

  • GC15P073339
  • GC15P075550

Summaries for GOLGA6C Gene

GeneCards Summary for GOLGA6C Gene

GOLGA6C (Golgin A6 Family Member C) is a Protein Coding gene. An important paralog of this gene is GOLGA6D.

Additional gene information for GOLGA6C Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GOLGA6C Gene

Genomics for GOLGA6C Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GOLGA6C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J075259 Enhancer 0.2 Ensembl 600.7 +1.3 1297 1.8 GOLGA6C piR-51363-019 GOLGA6D
GH15J075256 Enhancer 0.2 Ensembl 600.7 -1.4 -1403 0.4 GOLGA6C piR-45301-004 piR-40058-003 NIFKP4 LOC105376731
GH15J075249 Enhancer 0.3 Ensembl ENCODE 0.4 -9.7 -9703 1.4 ENSG00000260104 MIR631 GOLGA6C LOC105376731
GH15J075253 Enhancer 0.2 Ensembl 0.7 -4.3 -4303 2.2 NIFKP4 MAN2C1 SNUPN GOLGA6C piR-40058-003 LOC105376731
GH15J075260 Enhancer 0.2 Ensembl 0.4 +9.6 9617 0.5 NONHSAG017458.2-001 RF00017-1844 RN7SL489P lnc-BBS4-2-003 piR-33199-003 piR-32183-010 piR-30145-005 piR-43245-003 piR-53934-004 piR-44795-004
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GOLGA6C on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GOLGA6C

Top Transcription factor binding sites by QIAGEN in the GOLGA6C gene promoter:
  • AREB6
  • E47
  • HFH-1
  • HSF1 (long)
  • HSF1short
  • IRF-7A
  • MyoD
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2

Genomic Locations for GOLGA6C Gene

Genomic Locations for GOLGA6C Gene
chr15:75,258,404-75,273,455
(GRCh38/hg38)
Size:
15,052 bases
Orientation:
Plus strand
chr15:75,550,899-75,565,796
(GRCh37/hg19)
Size:
14,898 bases
Orientation:
Plus strand

Genomic View for GOLGA6C Gene

Genes around GOLGA6C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GOLGA6C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GOLGA6C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOLGA6C Gene

Proteins for GOLGA6C Gene

  • Protein details for GOLGA6C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NDK9-GOG6C_HUMAN
    Recommended name:
    Golgin subfamily A member 6C
    Protein Accession:
    A6NDK9

    Protein attributes for GOLGA6C Gene

    Size:
    693 amino acids
    Molecular mass:
    79884 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GOLGA6C Gene

Post-translational modifications for GOLGA6C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GOLGA6C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GOLGA6C Gene

Domains & Families for GOLGA6C Gene

Gene Families for GOLGA6C Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GOLGA6C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GOLGA6C Gene

GenScript: Design optimal peptide antigens:
  • Putative golgin subfamily A member 6C (GOG6C_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NDK9

UniProtKB/Swiss-Prot:

GOG6C_HUMAN :
  • Belongs to the GOLGA6 family.
Family:
  • Belongs to the GOLGA6 family.
genes like me logo Genes that share domains with GOLGA6C: view

Function for GOLGA6C Gene

Phenotypes From GWAS Catalog for GOLGA6C Gene

Animal Model Products

CRISPR Products

miRNA for GOLGA6C Gene

miRTarBase miRNAs that target GOLGA6C

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GOLGA6C

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GOLGA6C Gene

Localization for GOLGA6C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GOLGA6C gene
Compartment Confidence
golgi apparatus 3
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for GOLGA6C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000137 Golgi cis cisterna IBA 21873635
GO:0005794 Golgi apparatus IBA 21873635
GO:0005801 cis-Golgi network IBA 21873635
GO:0032580 Golgi cisterna membrane IBA 21873635
genes like me logo Genes that share ontologies with GOLGA6C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for GOLGA6C Gene

Pathways & Interactions for GOLGA6C Gene

PathCards logo

SuperPathways for GOLGA6C Gene

No Data Available

Interacting Proteins for GOLGA6C Gene

Gene Ontology (GO) - Biological Process for GOLGA6C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007030 Golgi organization IBA 21873635
GO:0051225 NOT spindle assembly IBA 21873635
genes like me logo Genes that share ontologies with GOLGA6C: view

No data available for Pathways by source and SIGNOR curated interactions for GOLGA6C Gene

Drugs & Compounds for GOLGA6C Gene

No Compound Related Data Available

Transcripts for GOLGA6C Gene

mRNA/cDNA for GOLGA6C Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GOLGA6C

Alternative Splicing Database (ASD) splice patterns (SP) for GOLGA6C Gene

No ASD Table

Relevant External Links for GOLGA6C Gene

GeneLoc Exon Structure for
GOLGA6C

Expression for GOLGA6C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GOLGA6C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for GOLGA6C Gene

This gene is overexpressed in Testis (x45.2).

Protein differential expression in normal tissues from HIPED for GOLGA6C Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GOLGA6C Gene



Protein tissue co-expression partners for GOLGA6C Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GOLGA6C

SOURCE GeneReport for Unigene cluster for GOLGA6C Gene:

Hs.540230
genes like me logo Genes that share expression patterns with GOLGA6C: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GOLGA6C Gene

Orthologs for GOLGA6C Gene

This gene was present in the common ancestor of chordates.

Orthologs for GOLGA6C Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 94 (a)
ManyToMany
-- 31
  • 93 (a)
ManyToMany
-- 31
  • 92 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 34 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 34 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Golga2 31
  • 33 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 31 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 30 (a)
OneToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 27 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 26 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii golga2 31
  • 22 (a)
OneToMany
Species where no ortholog for GOLGA6C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for GOLGA6C Gene

ENSEMBL:
Gene Tree for GOLGA6C (if available)
TreeFam:
Gene Tree for GOLGA6C (if available)

Paralogs for GOLGA6C Gene

Variants for GOLGA6C Gene

Additional dbSNP identifiers (rs#s) for GOLGA6C Gene

Structural Variations from Database of Genomic Variants (DGV) for GOLGA6C Gene

Variant ID Type Subtype PubMed ID
dgv1242n106 CNV duplication 24896259
dgv2621n100 CNV gain 25217958
esv22004 CNV gain 19812545
esv2749893 CNV deletion 23290073
esv3364343 CNV duplication 20981092
esv3389813 CNV duplication 20981092
esv3399045 CNV duplication 20981092
esv3411961 CNV duplication 20981092
esv996044 CNV gain 20482838
nsv1121512 CNV deletion 24896259
nsv115 CNV insertion 15895083
nsv1151179 CNV duplication 26484159
nsv1613 CNV deletion 18451855
nsv1614 CNV insertion 18451855
nsv436728 CNV insertion 17901297
nsv498851 CNV loss 21111241
nsv821359 CNV duplication 20802225
nsv833056 CNV gain 17160897
nsv9277 CNV loss 18304495
nsv977736 CNV duplication 23825009

Variation tolerance for GOLGA6C Gene

Gene Damage Index Score: 1.66; 31.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GOLGA6C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GOLGA6C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GOLGA6C Gene

Disorders for GOLGA6C Gene

Additional Disease Information for GOLGA6C

No disorders were found for GOLGA6C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GOLGA6C Gene

Publications for GOLGA6C Gene

  1. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody MC … Nusbaum C (Nature 2006) 3 4
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for GOLGA6C Gene

Sources for GOLGA6C Gene