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Aliases for GOLGA6A Gene

Aliases for GOLGA6A Gene

  • Golgin A6 Family Member A 2 3 5
  • Golgi Autoantigen, Golgin Subfamily A, Member 6 2 3
  • Golgi Autoantigen, Golgin Subfamily A, 6A 2 3
  • Golgi Autoantigen, Golgin Subfamily A, 6 2 3
  • Golgin Linked To PML 3 4
  • Golgin-Like Protein 3 4
  • GOLGA6 3 4
  • GLP 3 4
  • Golgin Subfamily A Member 6A 3
  • Golgin A6 Family, Member A 2

External Ids for GOLGA6A Gene

Previous HGNC Symbols for GOLGA6A Gene

  • GOLGA6

Previous GeneCards Identifiers for GOLGA6A Gene

  • GC15M072154
  • GC15M074363

Summaries for GOLGA6A Gene

Entrez Gene Summary for GOLGA6A Gene

  • The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. The protein encoded by this gene is a member of the golgin family of proteins, whose members localize to the Golgi. This gene is found in a large, low copy repeat sequence or duplicon that is found in multiple copies, that are greather than 90% similar, on chromosome 15. Duplicons are associated with deletions, inversions and other chromosome rearrangements that underlie genomic disease. The protein encoded by this gene is thought to be a functional golgin protein while the majority of the related copies of this gene are thought to be transcribed pseudogenes. [provided by RefSeq, Jul 2008]

GeneCards Summary for GOLGA6A Gene

GOLGA6A (Golgin A6 Family Member A) is a Protein Coding gene. An important paralog of this gene is GOLGA6C.

Additional gene information for GOLGA6A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOLGA6A Gene

Genomics for GOLGA6A Gene

GeneHancer (GH) Regulatory Elements for GOLGA6A Gene

Promoters and enhancers for GOLGA6A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I074082 Promoter 0.5 EPDnew 550.8 +0.2 177 0.1 GOLGA6A GC15M074076 GC15P074076 GC15P074079 GC15P074081 GC15P074082 PIR39156 GC15P074088 GC15P074086 GC15P074085
GH15I073682 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.7 +396.7 396685 8 SMAD1 ARID4B SIN3A FEZF1 ZBTB7B FOS SP3 SMARCB1 SMARCA4 GLIS1 CD276 NPTN C15orf59 GOLGA6A GC15P073700
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GOLGA6A on UCSC Golden Path with GeneCards custom track

Genomic Locations for GOLGA6A Gene

Genomic Locations for GOLGA6A Gene
chr15:74,067,654-74,082,747
(GRCh38/hg38)
Size:
15,094 bases
Orientation:
Minus strand
chr15:74,362,198-74,374,891
(GRCh37/hg19)

Genomic View for GOLGA6A Gene

Genes around GOLGA6A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GOLGA6A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GOLGA6A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOLGA6A Gene

Proteins for GOLGA6A Gene

  • Protein details for GOLGA6A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYA3-GOG6A_HUMAN
    Recommended name:
    Golgin subfamily A member 6A
    Protein Accession:
    Q9NYA3
    Secondary Accessions:
    • A8K959
    • Q9NYA7

    Protein attributes for GOLGA6A Gene

    Size:
    693 amino acids
    Molecular mass:
    79946 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GOLGA6A Gene

Post-translational modifications for GOLGA6A Gene

No Post-translational modifications

Other Protein References for GOLGA6A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GOLGA6A Gene

Domains & Families for GOLGA6A Gene

Gene Families for GOLGA6A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GOLGA6A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GOLGA6A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYA3

UniProtKB/Swiss-Prot:

GOG6A_HUMAN :
  • Belongs to the GOLGA6 family.
Family:
  • Belongs to the GOLGA6 family.
genes like me logo Genes that share domains with GOLGA6A: view

Function for GOLGA6A Gene

Phenotypes From GWAS Catalog for GOLGA6A Gene

Phenotypes for GOLGA6A Gene

GenomeRNAi human phenotypes for GOLGA6A:
genes like me logo Genes that share phenotypes with GOLGA6A: view

Animal Model Products

miRNA for GOLGA6A Gene

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GOLGA6A Gene

Localization for GOLGA6A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GOLGA6A gene
Compartment Confidence
nucleus 3
golgi apparatus 3
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GOLGA6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with GOLGA6A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for GOLGA6A Gene

Pathways & Interactions for GOLGA6A Gene

SuperPathways for GOLGA6A Gene

No Data Available

Interacting Proteins for GOLGA6A Gene

Gene Ontology (GO) - Biological Process for GOLGA6A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GOLGA6A Gene

Drugs & Compounds for GOLGA6A Gene

No Compound Related Data Available

Transcripts for GOLGA6A Gene

mRNA/cDNA for GOLGA6A Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GOLGA6A Gene

Golgin A6 family, member A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GOLGA6A Gene

No ASD Table

Relevant External Links for GOLGA6A Gene

GeneLoc Exon Structure for
GOLGA6A
ECgene alternative splicing isoforms for
GOLGA6A

Expression for GOLGA6A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GOLGA6A Gene

mRNA differential expression in normal tissues according to GTEx for GOLGA6A Gene

This gene is overexpressed in Testis (x32.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GOLGA6A Gene



NURSA nuclear receptor signaling pathways regulating expression of GOLGA6A Gene:

GOLGA6A

SOURCE GeneReport for Unigene cluster for GOLGA6A Gene:

Hs.546408

mRNA Expression by UniProt/SwissProt for GOLGA6A Gene:

Q9NYA3-GOG6A_HUMAN
Tissue specificity: Highly expressed in seminiferous tubes in testis. Highly expressed in spermatids, barely detectable in late pachytene spermatocytes, and not detectable in spermatogonia. Detected at intermediate levels in pancreas and lymph nodes, and at much lower levels in spleen, peripheral blood leukocytes, skeletal muscle, liver, lung, placenta, brain and heart.
genes like me logo Genes that share expression patterns with GOLGA6A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GOLGA6A Gene

Orthologs for GOLGA6A Gene

This gene was present in the common ancestor of chordates.

Orthologs for GOLGA6A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 94 (a)
ManyToMany
-- 34
  • 93 (a)
ManyToMany
-- 34
  • 93 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 34 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 34 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Golga2 34
  • 32 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 31 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 30 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 27 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 26 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii golga2 34
  • 21 (a)
OneToMany
Species where no ortholog for GOLGA6A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GOLGA6A Gene

ENSEMBL:
Gene Tree for GOLGA6A (if available)
TreeFam:
Gene Tree for GOLGA6A (if available)

Paralogs for GOLGA6A Gene

Variants for GOLGA6A Gene

Sequence variations from dbSNP and Humsavar for GOLGA6A Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1011419714 -- 74,079,295(-) A/C/T intron_variant
rs1022729226 -- 74,073,240(-) C/T intron_variant
rs1022760295 -- 74,080,088(-) A/G intron_variant
rs1030756753 -- 74,071,479(-) G/A intron_variant
rs1031620802 -- 74,072,867(-) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for GOLGA6A Gene

Variant ID Type Subtype PubMed ID
nsv974597 CNV duplication 23825009
nsv9276 CNV loss 18304495
nsv833053 CNV loss 17160897
nsv833052 CNV gain+loss 17160897
nsv821535 CNV duplication 20802225
nsv510666 CNV deletion 20534489
nsv509575 CNV insertion 20534489
nsv482178 CNV gain 20164927
nsv471380 CNV gain 19718026
nsv469619 CNV loss 16826518
nsv428308 CNV gain+loss 18775914
nsv1606 CNV insertion 18451855
nsv1605 CNV insertion 18451855
nsv1146818 CNV duplication 26484159
nsv1124714 CNV duplication 24896259
nsv1121512 CNV deletion 24896259
nsv1118559 CNV duplication 24896259
nsv1110259 CNV duplication 24896259
esv3377476 CNV duplication 20981092
esv3343612 CNV duplication 20981092
esv2760040 CNV gain+loss 17122850
esv24319 CNV gain 19812545
esv1002288 CNV gain 20482838

Variation tolerance for GOLGA6A Gene

Gene Damage Index Score: 4.68; 65.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GOLGA6A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GOLGA6A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOLGA6A Gene

Disorders for GOLGA6A Gene

Additional Disease Information for GOLGA6A

No disorders were found for GOLGA6A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GOLGA6A Gene

Publications for GOLGA6A Gene

  1. Cloning and characterization of a Golgin-related gene from the large-scale polymorphism linked to the PML gene. (PMID: 11161787) Gilles F … Zelenetz AD (Genomics 2000) 2 3 4 22 58
  2. Human chromosome 15q11-q14 regions of rearrangements contain clusters of LCR15 duplicons. (PMID: 11896453) Pujana MA … Estivill X (European journal of human genetics : EJHG 2002) 3 22 58
  3. Additional complexity on human chromosome 15q: identification of a set of newly recognized duplicons (LCR15) on 15q11-q13, 15q24, and 15q26. (PMID: 11156619) Pujana MA … Estivill X (Genome research 2001) 3 22 58
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for GOLGA6A Gene

Sources for GOLGA6A Gene

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