The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a fami... See more...

Aliases for GOLGA4 Gene

Aliases for GOLGA4 Gene

  • Golgin A4 2 3 5
  • Golgi Autoantigen, Golgin Subfamily A, 4 2 3
  • Golgin Subfamily A Member 4 3 4
  • Trans-Golgi P230 3 4
  • 256 KDa Golgin 3 4
  • Protein 72.1 3 4
  • Golgin-245 3 4
  • Centrosome-Related Protein F46 3
  • 72.1 Protein 3
  • MU-RMS-40.18 3
  • Golgin-240 3
  • Golgin 245 2
  • CRPF46 3
  • GCP2 3
  • GOLG 3
  • P230 3

External Ids for GOLGA4 Gene

Previous GeneCards Identifiers for GOLGA4 Gene

  • GC03P036667
  • GC03P036556
  • GC03P037097
  • GC03P037245
  • GC03P037259
  • GC03P037225
  • GC03P037284

Summaries for GOLGA4 Gene

Entrez Gene Summary for GOLGA4 Gene

  • The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This protein has been postulated to play a role in Rab6-regulated membrane-tethering events in the Golgi apparatus. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]

GeneCards Summary for GOLGA4 Gene

GOLGA4 (Golgin A4) is a Protein Coding gene. Diseases associated with GOLGA4 include Chronic Neutrophilic Leukemia and Alzheimer Disease 14. Among its related pathways are Vesicle-mediated transport and Golgi-to-ER retrograde transport. Gene Ontology (GO) annotations related to this gene include nucleotide binding and GTPase binding.

UniProtKB/Swiss-Prot Summary for GOLGA4 Gene

  • Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking (PubMed:29084197).

Gene Wiki entry for GOLGA4 Gene

Additional gene information for GOLGA4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GOLGA4 Gene

Genomics for GOLGA4 Gene

GeneHancer (GH) Regulatory Elements for GOLGA4 Gene

Promoters and enhancers for GOLGA4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GOLGA4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GOLGA4

Top Transcription factor binding sites by QIAGEN in the GOLGA4 gene promoter:
  • AP-4
  • c-Myc
  • Egr-4
  • FOXI1
  • FOXO4
  • HFH-3
  • LyF-1
  • Max
  • RORalpha1
  • TGIF

Genomic Locations for GOLGA4 Gene

Genomic Locations for GOLGA4 Gene
chr3:37,243,177-37,366,879
(GRCh38/hg38)
Size:
123,703 bases
Orientation:
Plus strand
chr3:37,284,668-37,408,370
(GRCh37/hg19)
Size:
123,703 bases
Orientation:
Plus strand

Genomic View for GOLGA4 Gene

Genes around GOLGA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GOLGA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GOLGA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOLGA4 Gene

Proteins for GOLGA4 Gene

  • Protein details for GOLGA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13439-GOGA4_HUMAN
    Recommended name:
    Golgin subfamily A member 4
    Protein Accession:
    Q13439
    Secondary Accessions:
    • F8W8Q7
    • Q13270
    • Q13654
    • Q14436
    • Q59EW8

    Protein attributes for GOLGA4 Gene

    Size:
    2230 amino acids
    Molecular mass:
    261140 Da
    Quaternary structure:
    • Homodimer (PubMed:14718928). Interacts with RAB6A (PubMed:10209123). Interacts with GTP-bound ARL1 and ARL3 (PubMed:11303027, PubMed:14580338, PubMed:14718928). Interacts with MACF1 (PubMed:15265687). Directly interacts with TBC1D23 (PubMed:29084197). Interacts with FAM91A1; this interaction may be mediated by TBC1D23 (PubMed:29084197).
    Miscellaneous:
    • Antibodies against GOLGA4 are present in sera from patients with Sjoegren syndrome. Sera from patients with Sjoegren syndrome often contain antibodies that react with normal components of the Golgi complex.
    SequenceCaution:
    • Sequence=BAD92930.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=CAA58041.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for GOLGA4 Gene

    Alternative splice isoforms for GOLGA4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GOLGA4 Gene

Post-translational modifications for GOLGA4 Gene

  • Glycosylation at Asn585 and Asn1612
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • GOGA4_HUMAN (690)

No data available for DME Specific Peptides for GOLGA4 Gene

Domains & Families for GOLGA4 Gene

Gene Families for GOLGA4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for GOLGA4 Gene

Blocks:
  • GRIP domain
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GOLGA4 Gene

GenScript: Design optimal peptide antigens:
  • Trans-Golgi p230 (GOGA4_HUMAN)
  • GOLGA4 protein (Q49A56_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13439

UniProtKB/Swiss-Prot:

GOGA4_HUMAN :
  • Extended rod-like protein with coiled-coil domains.
Domain:
  • Extended rod-like protein with coiled-coil domains.
genes like me logo Genes that share domains with GOLGA4: view

Function for GOLGA4 Gene

Molecular function for GOLGA4 Gene

UniProtKB/Swiss-Prot Function:
Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking (PubMed:29084197).

Phenotypes From GWAS Catalog for GOLGA4 Gene

Gene Ontology (GO) - Molecular Function for GOLGA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15265687
GO:0051020 GTPase binding IPI 14580338
genes like me logo Genes that share ontologies with GOLGA4: view
genes like me logo Genes that share phenotypes with GOLGA4: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GOLGA4 Gene

Localization for GOLGA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOLGA4 Gene

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GOLGA4 gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 5
plasma membrane 2
cytoskeleton 2
endoplasmic reticulum 2
endosome 2
lysosome 2
extracellular 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GOLGA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA,IEA 15265687
GO:0005794 Golgi apparatus IDA 15265687
GO:0005802 trans-Golgi network TAS 1400343
genes like me logo Genes that share ontologies with GOLGA4: view

Pathways & Interactions for GOLGA4 Gene

genes like me logo Genes that share pathways with GOLGA4: view

Gene Ontology (GO) - Biological Process for GOLGA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016192 vesicle-mediated transport TAS 8626529
GO:0043001 Golgi to plasma membrane protein transport IMP 22705394
GO:0045773 positive regulation of axon extension IDA 22705394
genes like me logo Genes that share ontologies with GOLGA4: view

No data available for SIGNOR curated interactions for GOLGA4 Gene

Drugs & Compounds for GOLGA4 Gene

No Compound Related Data Available

Transcripts for GOLGA4 Gene

mRNA/cDNA for GOLGA4 Gene

2 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GOLGA4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^
SP1: - - - - - - -
SP2: - - - - - - - -
SP3:
SP4: - - - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - - - - - -
SP6: - - - -
SP7: - - - - - - - - -
SP8:
SP9:
SP10: - -
SP11:
SP12: - -
SP13:

ExUns: 20a · 20b ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33a · 33b
SP1: - - - - -
SP2:
SP3: - - -
SP4: - - - - - - - - - - - - - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for GOLGA4 Gene

GeneLoc Exon Structure for
GOLGA4

Expression for GOLGA4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GOLGA4 Gene

mRNA differential expression in normal tissues according to GTEx for GOLGA4 Gene

This gene is overexpressed in Muscle - Skeletal (x4.7).

Protein differential expression in normal tissues from HIPED for GOLGA4 Gene

This gene is overexpressed in Heart (25.6), Salivary gland (7.6), and Stomach (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GOLGA4 Gene



Protein tissue co-expression partners for GOLGA4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GOLGA4

SOURCE GeneReport for Unigene cluster for GOLGA4 Gene:

Hs.344151

Evidence on tissue expression from TISSUES for GOLGA4 Gene

  • Liver(4.5)
  • Stomach(4.4)
  • Nervous system(4.4)
  • Lung(3)
  • Heart(2.3)
  • Pancreas(2.3)
  • Intestine(2.2)
  • Kidney(2.1)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with GOLGA4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GOLGA4 Gene

Orthologs for GOLGA4 Gene

This gene was present in the common ancestor of animals.

Orthologs for GOLGA4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GOLGA4 31 30
  • 99.38 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GOLGA4 31 30
  • 88.33 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GOLGA4 31 30
  • 87.51 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Golga4 17 31 30
  • 75.95 (n)
rat
(Rattus norvegicus)
Mammalia Golga4 30
  • 75.27 (n)
oppossum
(Monodelphis domestica)
Mammalia GOLGA4 31
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 58 (a)
OneToMany
-- 31
  • 46 (a)
OneToMany
chicken
(Gallus gallus)
Aves GOLGA4 31 30
  • 67.15 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GOLGA4 31
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia golga4 30
  • 59.46 (n)
zebrafish
(Danio rerio)
Actinopterygii golga4 31 30
  • 52.99 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3493 31 32
  • 24 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C02F12.7 32
  • 21 (a)
hcp-1 32
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 29 (a)
OneToMany
-- 31
  • 23 (a)
OneToMany
Species where no ortholog for GOLGA4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GOLGA4 Gene

ENSEMBL:
Gene Tree for GOLGA4 (if available)
TreeFam:
Gene Tree for GOLGA4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GOLGA4: view image

Paralogs for GOLGA4 Gene

Pseudogenes.org Pseudogenes for GOLGA4 Gene

genes like me logo Genes that share paralogs with GOLGA4: view

No data available for Paralogs for GOLGA4 Gene

Variants for GOLGA4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GOLGA4 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
710917 Benign: not provided 37,281,968(+) C/T MISSENSE_VARIANT
710918 Benign: not provided 37,326,541(+) A/G MISSENSE_VARIANT
719408 Benign: not provided 37,323,682(+) A/T MISSENSE_VARIANT
778066 Benign: not provided 37,337,743(+) C/T INTRON_VARIANT
787012 Benign: not provided 37,327,668(+) C/G MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for GOLGA4 Gene

Structural Variations from Database of Genomic Variants (DGV) for GOLGA4 Gene

Variant ID Type Subtype PubMed ID
esv3360632 CNV insertion 20981092
esv3595885 CNV gain 21293372
esv3595886 CNV gain 21293372
esv3595887 CNV gain 21293372
nsv1003117 CNV gain 25217958
nsv834664 CNV loss 17160897
nsv834665 CNV loss 17160897

Variation tolerance for GOLGA4 Gene

Residual Variation Intolerance Score: 49.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.25; 88.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GOLGA4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GOLGA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOLGA4 Gene

Disorders for GOLGA4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for GOLGA4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chronic neutrophilic leukemia
  • cnl
alzheimer disease 14
  • ad14
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for GOLGA4

genes like me logo Genes that share disorders with GOLGA4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GOLGA4 Gene

Publications for GOLGA4 Gene

  1. Molecular characterization of trans-Golgi p230. A human peripheral membrane protein encoded by a gene on chromosome 6p12-22 contains extensive coiled-coil alpha-helical domains and a granin motif. (PMID: 8626529) Erlich R … Toh BH (The Journal of biological chemistry 1996) 2 3 4 23 54
  2. Structural basis for recruitment of GRIP domain golgin-245 by small GTPase Arl1. (PMID: 14718928) Wu M … Song H (Nature structural & molecular biology 2004) 3 4 23 54
  3. Interaction between p230 and MACF1 is associated with transport of a glycosyl phosphatidyl inositol-anchored protein from the Golgi to the cell periphery. (PMID: 15265687) Kakinuma T … Toh BH (Experimental cell research 2004) 3 4 23 54
  4. Structural basis for Arl1-dependent targeting of homodimeric GRIP domains to the Golgi apparatus. (PMID: 14580338) Panic B … Munro S (Molecular cell 2003) 3 4 23 54
  5. ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins. (PMID: 11303027) Van Valkenburgh H … Kahn RA (The Journal of biological chemistry 2001) 3 4 23 54

Products for GOLGA4 Gene

Sources for GOLGA4 Gene