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The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This protein has been postulated to play a role in Rab6-regulated membrane-tethering events in the Golgi apparatus. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]
GOLGA4 (Golgin A4) is a Protein Coding gene. Diseases associated with GOLGA4 include Chronic Neutrophilic Leukemia. Among its related pathways are Retrograde transport at the Trans-Golgi-Network and Golgi-to-ER retrograde transport. Gene Ontology (GO) annotations related to this gene include nucleotide binding and GTPase binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 15265687 |
GO:0051020 | GTPase binding | IPI | 14580338 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000139 | Golgi membrane | IEA | -- |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | IEA,IDA | 15265687 |
GO:0005794 | Golgi apparatus | IDA | 15265687 |
GO:0005802 | trans-Golgi network | TAS | 1400343 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Vesicle-mediated transport | ||
2 | Golgi-to-ER retrograde transport | ||
3 | Retrograde transport at the Trans-Golgi-Network |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0016192 | vesicle-mediated transport | TAS | 8626529 |
GO:0043001 | Golgi to plasma membrane protein transport | IMP | 22705394 |
GO:0045773 | positive regulation of axon extension | IDA | 22705394 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP13: |
ExUns: | 20a | · | 20b | ^ | 21a | · | 21b | ^ | 22 | ^ | 23a | · | 23b | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32 | ^ | 33a | · | 33b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||
SP5: | |||||||||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||||||||||||
SP8: | |||||||||||||||||||||||||||||||||||
SP9: | |||||||||||||||||||||||||||||||||||
SP10: | |||||||||||||||||||||||||||||||||||
SP11: | |||||||||||||||||||||||||||||||||||
SP12: | |||||||||||||||||||||||||||||||||||
SP13: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | GOLGA4 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | GOLGA4 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | GOLGA4 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Golga4 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Golga4 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | GOLGA4 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Chicken (Gallus gallus) |
Aves | GOLGA4 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | GOLGA4 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | golga4 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | golga4 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG3493 31 32 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | C02F12.7 32 |
|
|
|
hcp-1 32 |
|
|
|||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 03 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
710917 | Benign: not provided | 37,281,968(+) | C/T | MISSENSE_VARIANT | |
710918 | Benign: not provided | 37,326,541(+) | A/G | MISSENSE_VARIANT | |
719408 | Benign: not provided | 37,323,682(+) | A/T | MISSENSE_VARIANT | |
778066 | Benign: not provided | 37,337,743(+) | C/T | INTRON_VARIANT | |
787012 | Benign: not provided | 37,327,668(+) | C/G | MISSENSE_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3360632 | CNV | insertion | 20981092 |
esv3595885 | CNV | gain | 21293372 |
esv3595886 | CNV | gain | 21293372 |
esv3595887 | CNV | gain | 21293372 |
nsv1003117 | CNV | gain | 25217958 |
nsv834664 | CNV | loss | 17160897 |
nsv834665 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
chronic neutrophilic leukemia |
|
|