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The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a fami... See more...
Aliases for GOLGA4 Gene
Aliases for GOLGA4 Gene
External Ids for GOLGA4 Gene
- HGNC: 4427
- Entrez Gene: 2803
- Ensembl: ENSG00000144674
- OMIM: 602509
- UniProtKB: Q13439
Previous GeneCards Identifiers for GOLGA4 Gene
- GC03P036667
- GC03P036556
- GC03P037097
- GC03P037245
- GC03P037259
- GC03P037225
- GC03P037284
Summaries for GOLGA4 Gene
-
The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This protein has been postulated to play a role in Rab6-regulated membrane-tethering events in the Golgi apparatus. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]
GeneCards Summary for GOLGA4 Gene
GOLGA4 (Golgin A4) is a Protein Coding gene. Diseases associated with GOLGA4 include Chronic Neutrophilic Leukemia. Among its related pathways are Retrograde transport at the Trans-Golgi-Network and Golgi-to-ER retrograde transport. Gene Ontology (GO) annotations related to this gene include nucleotide binding and GTPase binding.
UniProtKB/Swiss-Prot Summary for GOLGA4 Gene
-
Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking (PubMed:29084197).
Additional gene information for GOLGA4 Gene
- HGNC(4427)
- Entrez Gene(2803)
- Ensembl(ENSG00000144674)
- OMIM(602509)
- UniProtKB(Q13439)
- Open Targets Platform(ENSG00000144674)
- Monarch Initiative
- Search for GOLGA4 at DataMed
- Search for GOLGA4 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GOLGA4 Gene
Genomics for GOLGA4 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for GOLGA4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around GOLGA4 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GOLGA4
- Top Transcription factor binding sites by QIAGEN in the GOLGA4 gene promoter:
-
- AP-4
- c-Myc
- Egr-4
- FOXI1
- FOXO4
- HFH-3
- LyF-1
- Max
- RORalpha1
- TGIF
Genomic Locations for GOLGA4 Gene
Genomic Locations for GOLGA4 Gene
- chr3:37,243,177-37,366,879
- (GRCh38/hg38)
- Size:
- 123,703 bases
- Orientation:
- Plus strand
- chr3:37,284,668-37,408,370
- (GRCh37/hg19)
- Size:
- 123,703 bases
- Orientation:
- Plus strand
Genomic View for GOLGA4 Gene
Genes around GOLGA4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3p22.2 by HGNC
- 3p22.2 by Entrez Gene
- 3p22.2 by Ensembl
GOLGA4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GOLGA4 Gene
Proteins for GOLGA4 Gene
-
Protein details for GOLGA4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13439-GOGA4_HUMAN
- Recommended name:
- Golgin subfamily A member 4
- Protein Accession:
- Q13439
- F8W8Q7
- Q13270
- Q13654
- Q14436
- Q59EW8
Protein attributes for GOLGA4 Gene
- Size:
- 2230 amino acids
- Molecular mass:
- 261140 Da
- Quaternary structure:
-
- Homodimer (PubMed:14718928). Interacts with RAB6A (PubMed:10209123). Interacts with GTP-bound ARL1 and ARL3 (PubMed:11303027, PubMed:14580338, PubMed:14718928). Interacts with MACF1 (PubMed:15265687). Directly interacts with TBC1D23 (PubMed:29084197). Interacts with FAM91A1; this interaction may be mediated by TBC1D23 (PubMed:29084197).
- SequenceCaution:
-
- Sequence=BAD92930.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=CAA58041.1; Type=Frameshift; Evidence={ECO:0000305};
- Miscellaneous:
-
- Antibodies against GOLGA4 are present in sera from patients with Sjoegren syndrome. Sera from patients with Sjoegren syndrome often contain antibodies that react with normal components of the Golgi complex.
Protein Expression for GOLGA4 Gene
Post-translational modifications for GOLGA4 Gene
Other Protein References for GOLGA4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-GOLGA4 (aa 1482-1584) polyclonal antibody
- Novus Biologicals Antibodies for GOLGA4
- Invitrogen Antibodies for GOLGA4 (AFLGC-GOLGA4)
- antibodies-online: Show 31 available GOLGA4 Antibodies ranked by validation data
-
Boster Bio Antibodies for GOLGA4
-
Santa Cruz Biotechnology (SCBT) Antibodies for GOLGA4
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for GOLGA4
- Origene Custom Protein Services for GOLGA4
- Novus Biologicals proteins for GOLGA4
No data available for DME Specific Peptides for GOLGA4 Gene
Domains & Families for GOLGA4 Gene
Gene Families for GOLGA4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for GOLGA4 Gene
- GenScript: Design optimal peptide antigens:
-
- Trans-Golgi p230 (GOGA4_HUMAN)
- GOLGA4 protein (Q49A56_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q13439- Domain:
-
- Extended rod-like protein with coiled-coil domains.
Function for GOLGA4 Gene
Molecular function for GOLGA4 Gene
- UniProtKB/Swiss-Prot Function:
- Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking (PubMed:29084197).
Phenotypes From GWAS Catalog for GOLGA4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 15265687 |
| GO:0051020 | GTPase binding | IPI | 14580338 |
Phenotypes for GOLGA4 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GOLGA4 - Select products 50% OFF >
- * GOLGA4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GOLGA4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GOLGA4
-
Santa Cruz Biotechnology (SCBT) CRISPR for GOLGA4
miRNA for GOLGA4 Gene
- miRTarBase miRNAs that target GOLGA4
-
- mmu-miR-7b-5p (MIRT009170)
- hsa-miR-375 (MIRT019845)
- hsa-miR-21-5p (MIRT030849)
- hsa-miR-186-5p (MIRT045054)
- hsa-miR-450a-1-3p (MIRT091792)
- hsa-miR-769-3p (MIRT091794)
- hsa-miR-450b-3p (MIRT091795)
- hsa-miR-887-5p (MIRT091797)
- hsa-miR-1290 (MIRT091798)
- hsa-miR-3122 (MIRT091799)
- hsa-miR-3913-5p (MIRT091801)
- hsa-miR-4666a-5p (MIRT091804)
- hsa-miR-4769-3p (MIRT091805)
- hsa-miR-5089-5p (MIRT091806)
- hsa-miR-6513-5p (MIRT091808)
- hsa-miR-6728-5p (MIRT091809)
- hsa-miR-6817-5p (MIRT091810)
- hsa-miR-32-5p (MIRT162437)
- hsa-miR-92a-3p (MIRT162439)
- hsa-miR-92b-3p (MIRT162448)
- hsa-miR-2681-5p (MIRT574743)
- hsa-miR-202-3p (MIRT574744)
- hsa-let-7g-5p (MIRT574745)
- hsa-let-7a-5p (MIRT574746)
- hsa-let-7b-5p (MIRT574747)
- hsa-let-7c-5p (MIRT574748)
- hsa-let-7d-5p (MIRT574749)
- hsa-let-7e-5p (MIRT574750)
- hsa-let-7f-5p (MIRT574751)
- hsa-let-7i-5p (MIRT574752)
- hsa-miR-4458 (MIRT574753)
- hsa-miR-4500 (MIRT574754)
- hsa-miR-98-5p (MIRT574755)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GOLGA4
- Browse OriGene Inhibitory RNA Products For GOLGA4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GOLGA4
Clone Products
- Applied Biological Materials (abm): Clones for GOLGA4 - Select products 50% OFF >
- * GOLGA4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for GOLGA4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GOLGA4
Cell Line Products
-
Horizon Cell Lines for GOLGA4
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GOLGA4 Gene
Localization for GOLGA4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GOLGA4 Gene
- Cytoplasm. Golgi apparatus membrane. Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| golgi apparatus | 5 |
| extracellular | 4 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
- Golgi apparatus (3)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 15265687 |
| GO:0005794 | Golgi apparatus | IDA | 15265687 |
| GO:0005802 | trans-Golgi network | TAS | 1400343 |
Pathways & Interactions for GOLGA4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Vesicle-mediated transport | ||
| 2 | Golgi-to-ER retrograde transport | ||
| 3 | Retrograde transport at the Trans-Golgi-Network | ||
Pathways by source for GOLGA4 Gene
4 Reactome pathways for GOLGA4 Gene
Interacting Proteins for GOLGA4 Gene
Selected Interacting proteins:
Q13439-GOGA4_HUMAN
ENSP00000349305
for GOLGA4 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for GOLGA4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016192 | vesicle-mediated transport | TAS | 8626529 |
| GO:0043001 | Golgi to plasma membrane protein transport | IMP | 22705394 |
| GO:0045773 | positive regulation of axon extension | IDA | 22705394 |
No data available for SIGNOR curated interactions for GOLGA4 Gene
Transcripts for GOLGA4 Gene
mRNA/cDNA for GOLGA4 Gene
- 2 REFSEQ mRNAs :
- 18 NCBI additional mRNA sequence :
- 12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000356847 7673 nts (view in UCSC)
- ENST00000361924 7772 nts (view in UCSC)
- ENST00000419177 760 nts (view in UCSC)
- ENST00000429018 2036 nts (view in UCSC)
- ENST00000431105 568 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for GOLGA4 - Select products 50% OFF >
- * GOLGA4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for GOLGA4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GOLGA4
-
Santa Cruz Biotechnology (SCBT) CRISPR for GOLGA4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GOLGA4
- Browse OriGene Inhibitory RNA Products For GOLGA4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GOLGA4
Clone Products
- Applied Biological Materials (abm): Clones for GOLGA4 - Select products 50% OFF >
- * GOLGA4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for GOLGA4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GOLGA4
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: |
| ExUns: | 20a | · | 20b | ^ | 21a | · | 21b | ^ | 22 | ^ | 23a | · | 23b | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32 | ^ | 33a | · | 33b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||||||||||||
| SP13: |
Relevant External Links for GOLGA4 Gene
- GeneLoc Exon Structure for
- GOLGA4
Expression for GOLGA4 Gene
mRNA differential expression in normal tissues according to GTEx for GOLGA4 Gene
This gene is overexpressed in Muscle - Skeletal (x4.7).
This gene is overexpressed in Heart (25.6), Salivary gland (7.6), and Stomach (6.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GOLGA4 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GOLGA4
SOURCE GeneReport for Unigene cluster for GOLGA4 Gene:
Hs.344151Evidence on tissue expression from TISSUES for GOLGA4 Gene
- Liver(4.6)
- Nervous system(4.6)
- Stomach(4.5)
- Lung(3.3)
- Kidney(3)
- Heart(2.8)
- Skin(2.8)
- Intestine(2.7)
- Muscle(2.7)
- Spleen(2.5)
- Pancreas(2.3)
- Bone marrow(2.2)
- Eye(2.2)
- Blood(2)
Primer Products
-
OriGene qPCR primer pairs for GOLGA4
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GOLGA4 Gene
Orthologs for GOLGA4 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | GOLGA4 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | GOLGA4 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | GOLGA4 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Golga4 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Golga4 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | GOLGA4 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Chicken (Gallus gallus) |
Aves | GOLGA4 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | GOLGA4 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | golga4 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | golga4 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG3493 31 32 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | C02F12.7 32 |
|
|
|
| hcp-1 32 |
|
|
|||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany |
- Species where no ortholog for GOLGA4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for GOLGA4 Gene
- ENSEMBL:
- Gene Tree for GOLGA4 (if available)
- TreeFam:
- Gene Tree for GOLGA4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GOLGA4: view image
Paralogs for GOLGA4 Gene
Pseudogenes.org Pseudogenes for GOLGA4 Gene
No data available for Paralogs for GOLGA4 Gene
Variants for GOLGA4 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GOLGA4 Gene
| SNP ID | Clinical significance and condition | Chr 03 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 710917 | Benign: not provided | 37,281,968(+) | C/T | MISSENSE_VARIANT | |
| 710918 | Benign: not provided | 37,326,541(+) | A/G | MISSENSE_VARIANT | |
| 719408 | Benign: not provided | 37,323,682(+) | A/T | MISSENSE_VARIANT | |
| 778066 | Benign: not provided | 37,337,743(+) | C/T | INTRON_VARIANT | |
| 787012 | Benign: not provided | 37,327,668(+) | C/G | MISSENSE_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3360632 | CNV | insertion | 20981092 |
| esv3595885 | CNV | gain | 21293372 |
| esv3595886 | CNV | gain | 21293372 |
| esv3595887 | CNV | gain | 21293372 |
| nsv1003117 | CNV | gain | 25217958 |
| nsv834664 | CNV | loss | 17160897 |
| nsv834665 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
49.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
9.25;
88.12% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GOLGA4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- GOLGA4
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOLGA4 Gene
Disorders for GOLGA4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| chronic neutrophilic leukemia |
|
|
Search GOLGA4 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GOLGA4
No data available for UniProtKB/Swiss-Prot and Genatlas for GOLGA4 Gene
Publications for GOLGA4 Gene
- Molecular characterization of trans-Golgi p230. A human peripheral membrane protein encoded by a gene on chromosome 6p12-22 contains extensive coiled-coil alpha-helical domains and a granin motif. (PMID: 8626529) Erlich R … Toh BH (The Journal of biological chemistry 1996) 2 3 4 23
- Interaction between p230 and MACF1 is associated with transport of a glycosyl phosphatidyl inositol-anchored protein from the Golgi to the cell periphery. (PMID: 15265687) Kakinuma T … Toh BH (Experimental cell research 2004) 3 4 23
- Structural basis for recruitment of GRIP domain golgin-245 by small GTPase Arl1. (PMID: 14718928) Wu M … Song H (Nature structural & molecular biology 2004) 3 4 23
- Structural basis for Arl1-dependent targeting of homodimeric GRIP domains to the Golgi apparatus. (PMID: 14580338) Panic B … Munro S (Molecular cell 2003) 3 4 23
- ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins. (PMID: 11303027) Van Valkenburgh H … Kahn RA (The Journal of biological chemistry 2001) 3 4 23
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Products for GOLGA4 Gene
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- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for GOLGA4
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- Invitrogen Antibodies for GOLGA4 (AFLGC-GOLGA4)
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- antibodies-online: Show 31 available GOLGA4 Antibodies ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for GOLGA4
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- Boster Bio Antibodies for GOLGA4
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Sources for GOLGA4 Gene
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