The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes a member of the golgin fam... See more...

Aliases for GOLGA3 Gene

Aliases for GOLGA3 Gene

  • Golgin A3 2 3 5
  • Golgi Complex-Associated Protein Of 170 KDa 3 4
  • Golgi Autoantigen, Golgin Subfamily A, 3 2 3
  • Golgin Subfamily A Member 3 3 4
  • SY2/SY10 Protein 2 3
  • Golgin-160 3 4
  • GCP170 3 4
  • Golgi Complex-Associated Protein Of 170 KD 2
  • Golgi Membrane Associated Protein 3
  • Golgi Peripheral Membrane Protein 3
  • Male Enhanced Antigen-2 3
  • Golgin-165 3
  • MEA-2 3

External Ids for GOLGA3 Gene

Previous GeneCards Identifiers for GOLGA3 Gene

  • GC12M130854
  • GC12M132899
  • GC12M132973
  • GC12M131584
  • GC12M131955
  • GC12M131855
  • GC12M133345
  • GC12M130123

Summaries for GOLGA3 Gene

Entrez Gene Summary for GOLGA3 Gene

  • The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes a member of the golgin family of proteins which are localized to the Golgi. Its encoded protein has been postulated to play a role in nuclear transport and Golgi apparatus localization. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Feb 2010]

GeneCards Summary for GOLGA3 Gene

GOLGA3 (Golgin A3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transporter activity. An important paralog of this gene is NUMA1.

UniProtKB/Swiss-Prot Summary for GOLGA3 Gene

  • Golgi auto-antigen; probably involved in maintaining Golgi structure.

Gene Wiki entry for GOLGA3 Gene

Additional gene information for GOLGA3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GOLGA3 Gene

Genomics for GOLGA3 Gene

GeneHancer (GH) Regulatory Elements for GOLGA3 Gene

Promoters and enhancers for GOLGA3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J132827 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 510.4 +0.6 627 2.6 ZBTB40 ZNF217 EP300 SIN3A NRF1 TCF12 POLR2G SP1 GTF2E2 PHF8 GOLGA3 ANKLE2 ZNF26 ZNF140 CHFR EP400 ZNF891 ZNF268 NOC4L RPS11P5
GH12J132826 Promoter/Enhancer 0.6 EPDnew dbSUPER 500.7 +2.9 2868 0.1 RBFOX2 GOLGA3 RPS11P5 lnc-CHFR-3 CHFR
GH12J132836 Promoter/Enhancer 0.6 EPDnew dbSUPER 500.4 -7.8 -7848 0.1 ZNF394 RNU6-327P RF00026-274 lnc-GOLGA3-4 GOLGA3 lnc-CHFR-3 CHFR
GH12J132593 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 90.7 +232.3 232317 6.4 NRF1 ZNF300 RBAK TEAD4 ZNF639 ZIC2 ZBTB10 ZNF423 ZBTB26 RFX1 LOC105370094 lnc-FBRSL1-5 ZNF140 EP400 ZNF84 ZNF268 ZNF26 ZNF891 GOLGA3 ZNF605
GH12J131927 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 40 +899.7 899725 3.6 HNRNPK SIN3A TCF12 NRF1 MYC POLR2G USF1 SP1 PHF8 ZFX PUS1 ENSG00000255992 EP400P1 EP400 GOLGA3 NOC4L ANKLE2 SFSWAP ENSG00000255933 RPS11P5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GOLGA3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GOLGA3

Top Transcription factor binding sites by QIAGEN in the GOLGA3 gene promoter:
  • AML1a
  • AREB6
  • c-Myb
  • HSF2
  • POU2F1
  • POU2F1a
  • SRF
  • SRF (504 AA)
  • USF-1
  • USF1

Genomic Locations for GOLGA3 Gene

Genomic Locations for GOLGA3 Gene
chr12:132,768,909-132,829,118
(GRCh38/hg38)
Size:
60,210 bases
Orientation:
Minus strand
chr12:133,345,495-133,405,444
(GRCh37/hg19)
Size:
59,950 bases
Orientation:
Minus strand

Genomic View for GOLGA3 Gene

Genes around GOLGA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GOLGA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GOLGA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GOLGA3 Gene

Proteins for GOLGA3 Gene

  • Protein details for GOLGA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08378-GOGA3_HUMAN
    Recommended name:
    Golgin subfamily A member 3
    Protein Accession:
    Q08378
    Secondary Accessions:
    • A5PKX6
    • O43241
    • Q6P9C7
    • Q86XW3
    • Q8TDA9
    • Q8WZA3

    Protein attributes for GOLGA3 Gene

    Size:
    1498 amino acids
    Molecular mass:
    167355 Da
    Quaternary structure:
    • Homodimer. Interacts with GOLGA7. Isoform 1 interacts with GOPC while isoform 3 does not.
    Miscellaneous:
    • [Isoform 2]: May be due to an intron retention.
    SequenceCaution:
    • Sequence=AAA35921.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH60826.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA23661.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for GOLGA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GOLGA3 Gene

Post-translational modifications for GOLGA3 Gene

No data available for DME Specific Peptides for GOLGA3 Gene

Domains & Families for GOLGA3 Gene

Gene Families for GOLGA3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GOLGA3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GOLGA3 Gene

GenScript: Design optimal peptide antigens:
  • Golgin-160 (GOGA3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q08378

UniProtKB/Swiss-Prot:

GOGA3_HUMAN :
  • Extended rod-like protein with coiled-coil domains.
Domain:
  • Extended rod-like protein with coiled-coil domains.
genes like me logo Genes that share domains with GOLGA3: view

Function for GOLGA3 Gene

Molecular function for GOLGA3 Gene

UniProtKB/Swiss-Prot Function:
Golgi auto-antigen; probably involved in maintaining Golgi structure.

Phenotypes From GWAS Catalog for GOLGA3 Gene

Gene Ontology (GO) - Molecular Function for GOLGA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14522980
GO:0045296 cadherin binding HDA 25468996
genes like me logo Genes that share ontologies with GOLGA3: view
genes like me logo Genes that share phenotypes with GOLGA3: view

Animal Models for GOLGA3 Gene

MGI Knock Outs for GOLGA3:
  • Golga3 Golga3<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

miRNA for GOLGA3 Gene

miRTarBase miRNAs that target GOLGA3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GOLGA3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GOLGA3 Gene

Localization for GOLGA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GOLGA3 Gene

Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GOLGA3 gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 5
cytoskeleton 2
endoplasmic reticulum 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (4)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GOLGA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS 9295333
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA,IBA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with GOLGA3: view

Pathways & Interactions for GOLGA3 Gene

PathCards logo

SuperPathways for GOLGA3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for GOLGA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006891 intra-Golgi vesicle-mediated transport NAS 8315394
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with GOLGA3: view

No data available for Pathways by source and SIGNOR curated interactions for GOLGA3 Gene

Drugs & Compounds for GOLGA3 Gene

No Compound Related Data Available

Transcripts for GOLGA3 Gene

mRNA/cDNA for GOLGA3 Gene

2 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GOLGA3

Alternative Splicing Database (ASD) splice patterns (SP) for GOLGA3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: -
SP2:
SP3: - - -
SP4:
SP5: -
SP6: - - - -
SP7:
SP8:

ExUns: 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b · 25c ^ 26 ^ 27a · 27b · 27c ^ 28 ^ 29
SP1: - -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for GOLGA3 Gene

GeneLoc Exon Structure for
GOLGA3

Expression for GOLGA3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GOLGA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for GOLGA3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.3), Lymph node (11.4), and Salivary gland (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GOLGA3 Gene



Protein tissue co-expression partners for GOLGA3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GOLGA3

SOURCE GeneReport for Unigene cluster for GOLGA3 Gene:

Hs.507333

mRNA Expression by UniProt/SwissProt for GOLGA3 Gene:

Q08378-GOGA3_HUMAN
Tissue specificity: Expressed in all tissues tested. Expressed in liver, testis, lung, heart, salivary gland and kidney.

Evidence on tissue expression from TISSUES for GOLGA3 Gene

  • Liver(4.3)
genes like me logo Genes that share expression patterns with GOLGA3: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for GOLGA3 Gene

Orthologs for GOLGA3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GOLGA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GOLGA3 31 30
  • 99.31 (n)
OneToOne
cow
(Bos Taurus)
Mammalia GOLGA3 31 30
  • 84.33 (n)
OneToOne
dog
(Canis familiaris)
Mammalia GOLGA3 31 30
  • 82.87 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Golga3 17 31 30
  • 79.63 (n)
rat
(Rattus norvegicus)
Mammalia Golga3 30
  • 79.38 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GOLGA3 31
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GOLGA3 31
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves GOLGA3 31 30
  • 71.1 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GOLGA3 31
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia golga3 30
  • 66.62 (n)
zebrafish
(Danio rerio)
Actinopterygii golga3 31 30
  • 65.84 (n)
OneToOne
Species where no ortholog for GOLGA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GOLGA3 Gene

ENSEMBL:
Gene Tree for GOLGA3 (if available)
TreeFam:
Gene Tree for GOLGA3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for GOLGA3: view image

Paralogs for GOLGA3 Gene

Paralogs for GOLGA3 Gene

genes like me logo Genes that share paralogs with GOLGA3: view

Variants for GOLGA3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GOLGA3 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
708572 Benign: not provided 132,789,169(-) A/G MISSENSE_VARIANT
711100 Benign: not provided 132,808,223(-) G/A SYNONYMOUS_VARIANT
715428 Benign: not provided 132,804,984(-) G/A SYNONYMOUS_VARIANT
778691 Benign: not provided 132,801,879(-) G/A MISSENSE_VARIANT
791635 Likely Benign: not provided 132,786,531(-) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for GOLGA3 Gene

Structural Variations from Database of Genomic Variants (DGV) for GOLGA3 Gene

Variant ID Type Subtype PubMed ID
dgv318e214 CNV loss 21293372
esv1041062 CNV deletion 17803354
esv1099700 CNV deletion 17803354
esv1379006 CNV deletion 17803354
esv1610869 CNV insertion 17803354
esv22525 CNV loss 19812545
esv25686 CNV loss 19812545
esv2661448 CNV deletion 23128226
esv2667719 CNV deletion 23128226
esv2673163 CNV deletion 23128226
esv2674717 CNV deletion 23128226
esv2747040 CNV deletion 23290073
esv3326208 CNV duplication 20981092
esv3550097 CNV deletion 23714750
esv3550098 CNV deletion 23714750
esv3550100 CNV deletion 23714750
esv3580555 CNV loss 25503493
esv3631312 CNV loss 21293372
esv3631315 CNV loss 21293372
esv3631316 CNV loss 21293372
esv3631317 CNV gain 21293372
esv3631320 CNV gain 21293372
esv994357 CNV deletion 20482838
nsv1037074 CNV gain 25217958
nsv1071080 CNV deletion 25765185
nsv1120273 CNV tandem duplication 24896259
nsv1124853 CNV deletion 24896259
nsv1130673 CNV deletion 24896259
nsv1138190 CNV deletion 24896259
nsv1139775 CNV deletion 24896259
nsv1143584 CNV deletion 24896259
nsv1147106 CNV deletion 26484159
nsv455811 CNV loss 19166990
nsv455812 CNV loss 19166990
nsv52999 CNV insertion 16902084
nsv53567 CNV deletion 16902084
nsv561129 CNV loss 21841781
nsv561130 CNV loss 21841781
nsv561131 CNV gain 21841781
nsv561132 CNV loss 21841781
nsv561133 CNV loss 21841781
nsv561134 CNV loss 21841781
nsv952513 CNV deletion 24416366
nsv958702 CNV deletion 24416366
nsv975543 CNV duplication 23825009

Variation tolerance for GOLGA3 Gene

Residual Variation Intolerance Score: 29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.23; 95.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GOLGA3 Gene

Human Gene Mutation Database (HGMD)
GOLGA3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GOLGA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOLGA3 Gene

Disorders for GOLGA3 Gene

Additional Disease Information for GOLGA3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for GOLGA3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GOLGA3 Gene

Publications for GOLGA3 Gene

  1. Molecular characterization of two human autoantigens: unique cDNAs encoding 95- and 160-kD proteins of a putative family in the Golgi complex. (PMID: 8315394) Fritzler MJ … Chan EK (The Journal of experimental medicine 1993) 2 3 4 23 54
  2. Caspase-resistant Golgin-160 disrupts apoptosis induced by secretory pathway stress and ligation of death receptors. (PMID: 15829563) Maag RS … Machamer CE (Molecular biology of the cell 2005) 2 3 23 54
  3. The NH2-terminal domain of Golgin-160 contains both Golgi and nuclear targeting information. (PMID: 12130652) Hicks SW … Machamer CE (The Journal of biological chemistry 2002) 3 4 23 54
  4. Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis. (PMID: 10791974) Mancini M … Rosen A (The Journal of cell biology 2000) 3 4 23 54
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54

Products for GOLGA3 Gene

Sources for GOLGA3 Gene