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The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a fami... See more...
Aliases for GOLGA2 Gene
Aliases for GOLGA2 Gene
External Ids for GOLGA2 Gene
- HGNC: 4425
- NCBI Entrez Gene: 2801
- Ensembl: ENSG00000167110
- OMIM®: 602580
- UniProtKB/Swiss-Prot: Q08379
Previous GeneCards Identifiers for GOLGA2 Gene
- GC09M122134
- GC09M122665
- GC09M124471
- GC09M126394
- GC09M128097
- GC09M130057
- GC09M131018
- GC09M100631
Summaries for GOLGA2 Gene
-
The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This encoded protein has been postulated to play roles in the stacking of Golgi cisternae and in vesicular transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Feb 2010]
GeneCards Summary for GOLGA2 Gene
GOLGA2 (Golgin A2) is a Protein Coding gene. Diseases associated with GOLGA2 include Smith-Mccort Dysplasia 1 and Mucolipidosis Iii Gamma. Among its related pathways are Vesicle-mediated transport and Neurodegenerative Diseases. Gene Ontology (GO) annotations related to this gene include protein kinase binding and syntaxin binding. An important paralog of this gene is GOLGA6B.
UniProtKB/Swiss-Prot Summary for GOLGA2 Gene
-
Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane (Probable) (PubMed:16489344). Required for normal protein transport from the endoplasmic reticulum to the Golgi apparatus and the cell membrane (By similarity). Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly: phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing tethering of COPI vesicles and thereby inhibiting transport through the Golgi apparatus during mitosis (By similarity). Also plays a key role in spindle pole assembly and centrosome organization (PubMed:26165940). Promotes the mitotic spindle pole assembly by activating the spindle assembly factor TPX2 to nucleate microtubules around the Golgi and capture them to couple mitotic membranes to the spindle: upon phosphorylation at the onset of mitosis, GOLGA2 interacts with importin-alpha via the nuclear localization signal region, leading to recruit importin-alpha to the Golgi membranes and liberate the spindle assembly factor TPX2 from importin-alpha. TPX2 then activates AURKA kinase and stimulates local microtubule nucleation. Upon filament assembly, nascent microtubules are further captured by GOLGA2, thus linking Golgi membranes to the spindle (PubMed:19242490, PubMed:26165940). Regulates the meiotic spindle pole assembly, probably via the same mechanism (By similarity). Also regulates the centrosome organization (PubMed:18045989, PubMed:19109421). Also required for the Golgi ribbon formation and glycosylation of membrane and secretory proteins (PubMed:16489344, PubMed:17314401).
Additional gene information for GOLGA2 Gene
- HGNC (4425)
- NCBI Entrez Gene (2801)
- Ensembl (ENSG00000167110)
- OMIM® (602580)
- UniProtKB/Swiss-Prot (Q08379)
- Open Targets Platform(ENSG00000167110)
- Search for GOLGA2 at DataMed
- Search for GOLGA2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GOLGA2 Gene
Genomics for GOLGA2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for GOLGA2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around GOLGA2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for GOLGA2
- Top Transcription factor binding sites by QIAGEN in the GOLGA2 gene promoter:
-
- ATF6
- Bach1
- C/EBPalpha
- Chx10
- Egr-1
- FOXD3
- HFH-1
- ITF-2
- MyoD
- Tal-1beta
Genomic Locations for GOLGA2 Gene
Latest Assembly
- chr9:128,255,829-128,276,000
- (GRCh38/hg38)
- Size:
- 20,172 bases
- Orientation:
- Minus strand
Previous Assembly
- chr9:131,018,108-131,038,231
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 20,124 bases
- Orientation:
- Minus strand
- chr9:131,018,108-131,038,274
- (GRCh37/hg19 by Ensembl)
- Size:
- 20,167 bases
- Orientation:
- Minus strand
Genomic View for GOLGA2 Gene
Genes around GOLGA2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q34.11 by HGNC
- 9q34.11 by Entrez Gene
- 9q34.11 by Ensembl
GOLGA2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GOLGA2 Gene
Proteins for GOLGA2 Gene
-
Protein details for GOLGA2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q08379-GOGA2_HUMAN
- Recommended name:
- Golgin subfamily A member 2
- Protein Accession:
- Q08379
- A0A0C4DGS5
- Q6GRM9
- Q9BRB0
- Q9NYF9
Protein attributes for GOLGA2 Gene
- Size:
- 1002 amino acids
- Molecular mass:
- 113086 Da
- Quaternary structure:
-
- Homodimer, may assemble into homohexamers (PubMed:26363069). Homotetramer; forms a parallel homotetramer with a flexible rod-like structure that can give rise to I- and Y-shaped conformations (By similarity). Interacts with GORASP1/GRASP65 (PubMed:16489344, PubMed:18045989, PubMed:26363069). The homooligomer forms a complex with GORASP1 with a 1:1 stoichiometry (By similarity). Interacts with RAB1B that has been activated by GTP-binding (PubMed:11306556). Interacts with p115/USO1; interaction with p115/USO1 inhibits interaction with STX5 and/or RAB1B. Interacts with STX5 (By similarity). Interacts with ZFPL1 (PubMed:18323775). Interacts with AKAP450/AKAP9; leading to recruit AKAP450/AKAP9 to the cis-Golgi (PubMed:19242490).
- SequenceCaution:
-
- Sequence=AAH69268.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAP35912.1; Type=Miscellaneous discrepancy; Note=Sequence differs from that shown after position 826 due to an internal deletion.; Evidence={ECO:0000305}; Sequence=EAW87762.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for GOLGA2 Gene
Protein Expression for GOLGA2 Gene
Post-translational modifications for GOLGA2 Gene
- Cleaved by caspases at the onset of apoptosis.
- Methylation by PRMT5 is required for Golgi ribbon formation. While dimethylation at Arg-30 and Arg-35 are confirmed in vivo, it is unclear whether Arg-18 is methylated in vivo.
- Phosphorylated at Ser-37 by CDK1 at the onset of mitosis, inhibiting the interaction with p115/USO1 and triggering Golgi disassembly (PubMed:20421892, PubMed:26165940). Phosphorylated at Ser-37 in prophase as the Golgi complex starts to break down, and remains phosphorylated during further breakdown and partitioning of the Golgi fragments in metaphase and anaphase. In telophase, GM130 is dephosphorylated by PP2A as the Golgi fragments start to reassemble (By similarity).
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for GOLGA2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences GOLGA2 / GM130 Antibody (LS-B14891) and GOLGA2 / GM130 Antibody (LS-B15297)
- G Biosciences Immunotagā¢ GOLGA2 Antibody and Immunotagā¢ GM130 Antibody
- GeneTex Anti-GM130 antibody [EP818Y] and Anti-GM130 antibody
- NSJ Bioreagents GM130 Antibody
- Novus Biologicals Antibodies for GOLGA2
-
Abcam antibodies for GOLGA2
- Invitrogen Antibodies for GOLGA2 (AFLGC-Golga2)
-
Custom Antibody ServicesProSci Antibodies for GOLGA2
-
Santa Cruz Biotechnology (SCBT) Antibodies for GOLGA2
- Sino Biological Antibodies for GOLGA2
Protein products for research
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for GOLGA2
- Origene Custom Protein Services for GOLGA2
- antibodies-online: Show 4 available GOLGA2 Proteins ranked by validation data
- Compare Top GOLGA2 Proteins
-
Quality Products:
-
Abcam proteins for GOLGA2
Assay products for research
No data available for DME Specific Peptides for GOLGA2 Gene
Domains & Families for GOLGA2 Gene
Gene Families for GOLGA2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for GOLGA2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for GOLGA2 Gene
- GenScript: Design optimal peptide antigens:
-
- Golgi autoantigen, golgin subfamily a, 2 (B7ZC05_HUMAN)
- Golgin-95 (GOGA2_HUMAN)
- Golgi matrix protein GM130 (Q5PXD5_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q08379UniProtKB/Swiss-Prot:
GOGA2_HUMAN :- Extended rod-like protein with long coiled-coil domains.
- Belongs to the GOLGA2 family.
- Domain:
-
- Extended rod-like protein with long coiled-coil domains.
- The nuclear localization signal (cNLS) mediates interaction with importin-alpha, recruiting importin-alpha to the Golgi membrane and liberating TPX2.
- Family:
-
- Belongs to the GOLGA2 family.
Function for GOLGA2 Gene
Molecular function for GOLGA2 Gene
- UniProtKB/Swiss-Prot Function:
- Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane (Probable) (PubMed:16489344). Required for normal protein transport from the endoplasmic reticulum to the Golgi apparatus and the cell membrane (By similarity). Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly: phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing tethering of COPI vesicles and thereby inhibiting transport through the Golgi apparatus during mitosis (By similarity). Also plays a key role in spindle pole assembly and centrosome organization (PubMed:26165940). Promotes the mitotic spindle pole assembly by activating the spindle assembly factor TPX2 to nucleate microtubules around the Golgi and capture them to couple mitotic membranes to the spindle: upon phosphorylation at the onset of mitosis, GOLGA2 interacts with importin-alpha via the nuclear localization signal region, leading to recruit importin-alpha to the Golgi membranes and liberate the spindle assembly factor TPX2 from importin-alpha. TPX2 then activates AURKA kinase and stimulates local microtubule nucleation. Upon filament assembly, nascent microtubules are further captured by GOLGA2, thus linking Golgi membranes to the spindle (PubMed:19242490, PubMed:26165940). Regulates the meiotic spindle pole assembly, probably via the same mechanism (By similarity). Also regulates the centrosome organization (PubMed:18045989, PubMed:19109421). Also required for the Golgi ribbon formation and glycosylation of membrane and secretory proteins (PubMed:16489344, PubMed:17314401).
Phenotypes From GWAS Catalog for GOLGA2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 15037601 |
| GO:0008017 | microtubule binding | IDA | 26165940 |
| GO:0019901 | protein kinase binding | IPI | 20332113 |
| GO:0019905 | syntaxin binding | IPI | 18167358 |
| GO:0042802 | identical protein binding | IPI | 27107012 |
Phenotypes for GOLGA2 Gene
- MGI mutant phenotypes for GOLGA2:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for GOLGA2:
Animal Models for GOLGA2 Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for GOLGA2 - Starting at $85 >
- * GOLGA2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for GOLGA2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GOLGA2
-
Santa Cruz Biotechnology (SCBT) CRISPR for GOLGA2
miRNA for GOLGA2 Gene
- miRTarBase miRNAs that target GOLGA2
-
- mmu-miR-15a-5p (MIRT011929)
- hsa-miR-615-3p (MIRT040359)
- rno-miR-17-5p (MIRT438008)
- hsa-miR-412-3p (MIRT440542)
- mmu-miR-761 (MIRT603967)
- mmu-miR-214-3p (MIRT603968)
- mmu-miR-3076-3p (MIRT603969)
- mmu-miR-3971 (MIRT603970)
- mmu-miR-3070b-5p (MIRT603971)
- mmu-miR-331-3p (MIRT603972)
- mmu-miR-3475-3p (MIRT603973)
- hsa-miR-5089-5p (MIRT679767)
- hsa-miR-4715-3p (MIRT679768)
- hsa-miR-7151-3p (MIRT679769)
- hsa-miR-5095 (MIRT679770)
- hsa-miR-1227-3p (MIRT679771)
- hsa-miR-6778-3p (MIRT679772)
- hsa-miR-6506-5p (MIRT679773)
- hsa-miR-619-5p (MIRT679774)
- hsa-miR-6747-3p (MIRT679775)
- hsa-miR-6727-3p (MIRT679776)
- hsa-miR-4722-3p (MIRT679777)
- hsa-miR-4740-3p (MIRT679778)
- hsa-miR-6715b-5p (MIRT679779)
- hsa-miR-4269 (MIRT679780)
- hsa-miR-6767-3p (MIRT679781)
- hsa-miR-6504-3p (MIRT679782)
- hsa-miR-3622a-5p (MIRT679783)
- hsa-miR-4438 (MIRT679784)
- hsa-miR-5589-5p (MIRT716539)
- hsa-miR-4731-5p (MIRT716540)
- hsa-miR-150-5p (MIRT716541)
- hsa-miR-186-3p (MIRT716542)
- hsa-miR-512-3p (MIRT716543)
- hsa-miR-520e (MIRT716544)
- hsa-miR-520d-3p (MIRT716545)
- hsa-miR-520c-3p (MIRT716546)
- hsa-miR-520b (MIRT716547)
- hsa-miR-520a-3p (MIRT716548)
- hsa-miR-373-3p (MIRT716549)
- hsa-miR-372-3p (MIRT716550)
- hsa-miR-302e (MIRT716551)
- hsa-miR-302d-3p (MIRT716552)
- hsa-miR-302c-3p (MIRT716553)
- hsa-miR-302b-3p (MIRT716554)
- hsa-miR-302a-3p (MIRT716555)
- hsa-miR-93-5p (MIRT716556)
- hsa-miR-526b-3p (MIRT716557)
- hsa-miR-519d-3p (MIRT716558)
- hsa-miR-20b-5p (MIRT716559)
- hsa-miR-20a-5p (MIRT716560)
- hsa-miR-17-5p (MIRT716561)
- hsa-miR-106b-5p (MIRT716562)
- hsa-miR-106a-5p (MIRT716563)
- hsa-miR-548t-5p (MIRT716564)
- hsa-miR-548az-5p (MIRT716565)
- hsa-miR-1306-5p (MIRT762455)
- hsa-miR-1915-3p (MIRT763417)
- hsa-miR-1976 (MIRT763561)
- hsa-miR-3653-5p (MIRT766357)
- hsa-miR-4279 (MIRT768307)
- hsa-miR-4726-3p (MIRT771650)
- hsa-miR-4772-3p (MIRT772204)
- hsa-miR-498 (MIRT772829)
- hsa-miR-6764-5p (MIRT778506)
- hsa-miR-6840-3p (MIRT780129)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GOLGA2
- Browse OriGene Inhibitory RNA Products For GOLGA2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GOLGA2
Clone products for research
- Applied Biological Materials (abm): Clones for GOLGA2 - Starting at $45 >
- * GOLGA2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG209451
- MG223835
- MG224240
- MR209451
- MR209451L3
- MR209451L4
- MR223835
- MR223835L3
- MR223835L4
- MR224240
- MR224240L3
- MR224240L4
- RC209641
- RC209641L1
- RC209641L2
- RC209641L3
- RC209641L4
- RG209641
- RR209440
- RR209440L3
- RR209440L4
- MR209451L3V
- MR209451L4V
- MR223835L3V
- MR223835L4V
- MR224240L3V
- MR224240L4V
- RC209641L1V
- RC209641L2V
- RC209641L3V
- RC209641L4V
- RR209440L3V
- RR209440L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GOLGA2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GOLGA2
Cell Lines for research
-
Horizon Cell Lines for GOLGA2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GOLGA2 Gene
Localization for GOLGA2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GOLGA2 Gene
- Golgi apparatus, cis-Golgi network membrane. Peripheral membrane protein. Cytoplasmic side. Endoplasmic reticulum-Golgi intermediate compartment membrane. Peripheral membrane protein. Cytoplasmic side. Cytoplasm, cytoskeleton, spindle pole. Note=Associates with the mitotic spindle during mitosis (PubMed:26165940). {ECO:0000250 UniProtKB:Q62839, ECO:0000269 PubMed:26165940}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| golgi apparatus | 5 |
| nucleus | 4 |
| endoplasmic reticulum | 3 |
| endosome | 3 |
| cytosol | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| mitochondrion | 2 |
| lysosome | 2 |
| peroxisome | 1 |
- Golgi apparatus (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000137 | Golgi cis cisterna | IDA | 17488291 |
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0000922 | spindle pole | ISS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005794 | Golgi apparatus | IEA,IDA | 15229288 |
Pathways & Interactions for GOLGA2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transport to the Golgi and subsequent modification | ||
| 2 | Cell Cycle, Mitotic |
.83
|
.60
|
| 3 | Neurodegenerative Diseases | ||
| 4 | Mitotic Prophase |
.57
|
|
| 5 | Vesicle-mediated transport | ||
Pathways by source for GOLGA2 Gene
1 BioSystems pathway for GOLGA2 Gene
17 Reactome pathways for GOLGA2 Gene
1 Cell Signaling Technology pathway for GOLGA2 Gene
Interacting Proteins for GOLGA2 Gene
Selected Interacting proteins:
Q08379-GOGA2_HUMAN
ENSP00000416097
for GOLGA2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for GOLGA2
SIGNOR curated interactions for GOLGA2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006486 | protein glycosylation | IMP | 16489344 |
| GO:0006888 | ER to Golgi vesicle-mediated transport | TAS | -- |
| GO:0007020 | microtubule nucleation | IMP | 19242490 |
| GO:0007030 | Golgi organization | IBA | 21873635 |
| GO:0007049 | cell cycle | IEA | -- |
Drugs & Compounds for GOLGA2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Guanosine triphosphate | Experimental | Pharma | 0 |
Transcripts for GOLGA2 Gene
mRNA/cDNA for GOLGA2 Gene
- 14 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000421699 4260 nts (view in UCSC)
- ENST00000450617 1439 nts (view in UCSC)
- ENST00000458730 704 nts (view in UCSC)
- ENST00000461031 475 nts (view in UCSC)
- ENST00000462089 766 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for GOLGA2 - Starting at $85 >
- * GOLGA2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for GOLGA2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GOLGA2
-
Santa Cruz Biotechnology (SCBT) CRISPR for GOLGA2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for GOLGA2
- Browse OriGene Inhibitory RNA Products For GOLGA2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GOLGA2
Clone products for research
- Applied Biological Materials (abm): Clones for GOLGA2 - Starting at $45 >
- * GOLGA2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG209451
- MG223835
- MG224240
- MR209451
- MR209451L3
- MR209451L4
- MR223835
- MR223835L3
- MR223835L4
- MR224240
- MR224240L3
- MR224240L4
- RC209641
- RC209641L1
- RC209641L2
- RC209641L3
- RC209641L4
- RG209641
- RR209440
- RR209440L3
- RR209440L4
- MR209451L3V
- MR209451L4V
- MR223835L3V
- MR223835L4V
- MR224240L3V
- MR224240L4V
- RC209641L1V
- RC209641L2V
- RC209641L3V
- RC209641L4V
- RR209440L3V
- RR209440L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for GOLGA2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GOLGA2
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19a | · | 19b | · | 19c | ^ | 20 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
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| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: |
| ExUns: | 21a | · | 21b | ^ | 22 | ^ | 23a | · | 23b | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||
| SP2: | |||||||||||||||||||
| SP3: | |||||||||||||||||||
| SP4: | |||||||||||||||||||
| SP5: | |||||||||||||||||||
| SP6: | |||||||||||||||||||
| SP7: | |||||||||||||||||||
| SP8: |
Relevant External Links for GOLGA2 Gene
- GeneLoc Exon Structure for
- GOLGA2
Expression for GOLGA2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Peripheral blood mononuclear cells (12.1), Nasal epithelium (8.8), and Pancreas (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GOLGA2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GOLGA2
SOURCE GeneReport for Unigene cluster for GOLGA2 Gene:
Hs.155827Evidence on tissue expression from TISSUES for GOLGA2 Gene
- Nervous system(4.7)
- Liver(4.6)
- Lung(3.7)
- Skin(3)
- Kidney(2.9)
- Heart(2.6)
- Muscle(2.6)
- Intestine(2.5)
- Pancreas(2.3)
- Thyroid gland(2.3)
- Blood(2.3)
- Adrenal gland(2.2)
- Stomach(2.2)
- Spleen(2.1)
- Eye(2.1)
Primer products for research
-
OriGene qPCR primer pairs for GOLGA2
-
OriGene qPCR primer pairs and template standards for GOLGA2
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GOLGA2 Gene
Orthologs for GOLGA2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | GOLGA2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | GOLGA2 30 |
|
||
| -- 31 |
|
OneToMany | |||
| Cow (Bos Taurus) |
Mammalia | GOLGA2 30 |
|
||
| -- 31 |
|
OneToMany | |||
| Rat (Rattus norvegicus) |
Mammalia | Golga2 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Golga2 30 17 31 |
|
OneToMany | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| Chicken (Gallus gallus) |
Aves | GOLGA2 30 |
|
||
| -- 31 |
|
OneToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100492442 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.28684 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | golga2 30 31 |
|
OneToMany | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP011337 30 |
|
- Species where no ortholog for GOLGA2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for GOLGA2 Gene
- ENSEMBL:
- Gene Tree for GOLGA2 (if available)
- TreeFam:
- Gene Tree for GOLGA2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for GOLGA2: view image
Paralogs for GOLGA2 Gene
Paralogs for GOLGA2 Gene
(22) SIMAP similar genes for GOLGA2 Gene using alignment to 5 proteins:
- GOGA2_HUMAN
- B7ZC06_HUMAN
- H0Y7B8_HUMAN
- Q5PXD5_HUMAN
- R4GND7_HUMAN
Pseudogenes.org Pseudogenes for GOLGA2 Gene
- PGOHUM00000291445
- PGOHUM00000292833
- PGOHUM00000292835
- PGOHUM00000292840
- PGOHUM00000292863
- PGOHUM00000292872
- PGOHUM00000292879
- PGOHUM00000292890
- PGOHUM00000292893
- PGOHUM00000292974
- PGOHUM00000292977
- PGOHUM00000292980
- PGOHUM00000293012
- PGOHUM00000293040
- PGOHUM00000293047
- PGOHUM00000293052
- PGOHUM00000293056
- PGOHUM00000293062
- PGOHUM00000293076
- PGOHUM00000293092
- PGOHUM00000293094
- PGOHUM00000293104
- PGOHUM00000293107
- PGOHUM00000293133
- PGOHUM00000293136
- PGOHUM00000293142
- PGOHUM00000293150
- PGOHUM00000293165
- PGOHUM00000293167
- PGOHUM00000293176
- PGOHUM00000293179
- PGOHUM00000293182
- PGOHUM00000293184
- PGOHUM00000293196
- PGOHUM00000293286
- PGOHUM00000293290
- PGOHUM00000293296
- PGOHUM00000293297
- PGOHUM00000293321
- PGOHUM00000293331
- PGOHUM00000293333
- PGOHUM00000293334
- PGOHUM00000293335
- PGOHUM00000293342
- PGOHUM00000293378
- PGOHUM00000293611
- PGOHUM00000293612
- PGOHUM00000294953
- PGOHUM00000295296
- PGOHUM00000295297
- PGOHUM00000297773
- PGOHUM00000300484
- PGOHUM00000306603
- PGOHUM00000303293
- PGOHUM00000306701
- PGOHUM00000306702
- PGOHUM00000287953
- PGOHUM00000287958
- PGOHUM00000306705
- PGOHUM00000306710
- PGOHUM00000306718
- PGOHUM00000287999
- PGOHUM00000288022
- PGOHUM00000307460
- PGOHUM00000288047
- PGOHUM00000288049
- PGOHUM00000306719
- PGOHUM00000288060
- PGOHUM00000288062
- PGOHUM00000306724
- PGOHUM00000306730
- PGOHUM00000306736
- PGOHUM00000307471
- PGOHUM00000307480
- PGOHUM00000307482
- PGOHUM00000307484
- PGOHUM00000305569
- PGOHUM00000305571
- PGOHUM00000305586
- PGOHUM00000305748
- PGOHUM00000305764
- PGOHUM00000305766
- PGOHUM00000289778
Variants for GOLGA2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for GOLGA2 Gene
| SNP ID | Clinical significance and condition | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs146408180 | Benign: not provided | 128,258,143(-) |
C/T NM_004486.5(GOLGA2):c.2228G>A (p.Arg743His) |
MISSENSE | |
| rs200462679 | Likely Benign: not provided | 128,260,612(-) |
C/T NM_004486.5(GOLGA2):c.1494G>A (p.Ala498=) |
SYNONYMOUS | |
| rs201662917 | Uncertain Significance: not provided | 128,257,383(-) |
G/A NM_004486.5(GOLGA2):c.2744C>T (p.Ala915Val) |
MISSENSE | |
| rs74686374 | Benign: not provided | 128,260,497(-) |
G/C NM_004486.5(GOLGA2):c.1609C>G (p.Leu537Val) |
MISSENSE | |
| rs2240961 | - |
p.Arg902Gly |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
70.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
12.48;
94.34% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GOLGA2 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOLGA2 Gene
Disorders for GOLGA2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| smith-mccort dysplasia 1 |
|
|
| mucolipidosis iii gamma |
|
|
| vohwinkel syndrome |
|
|
| dyggve-melchior-clausen disease |
|
|
| encephalopathy, familial, with neuroserpin inclusion bodies |
|
|
Search GOLGA2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GOLGA2
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for GOLGA2 Gene
Publications for GOLGA2 Gene
- Molecular characterization of two human autoantigens: unique cDNAs encoding 95- and 160-kD proteins of a putative family in the Golgi complex. (PMID: 8315394) Fritzler MJ ā¦ Chan EK (The Journal of experimental medicine 1993) 2 3 4 23
- Microtubule nucleation at the cis-side of the Golgi apparatus requires AKAP450 and GM130. (PMID: 19242490) Rivero S ā¦ Rios RM (The EMBO journal 2009) 3 4 23
- The Golgi protein GM130 regulates centrosome morphology and function. (PMID: 18045989) Kodani A ā¦ Sütterlin C (Molecular biology of the cell 2008) 3 4 23
- The biogenesis of the Golgi ribbon: the roles of membrane input from the ER and of GM130. (PMID: 17314401) Marra P ā¦ De Matteis MA (Molecular biology of the cell 2007) 3 4 23
- The GM130 and GRASP65 Golgi proteins cycle through and define a subdomain of the intermediate compartment. (PMID: 11781572) Marra P ā¦ De Matteis MA (Nature cell biology 2001) 3 4 23
ExternalLinks
Products for GOLGA2 Gene
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- OriGene CRISPR knockouts for GOLGA2
- MG209451
- MG223835
- MG224240
- MR209451
- MR209451L3
- MR209451L4
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- RC209641
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- RC209641L3
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- RR209440
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- RC209641L1V
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals proteins and lysates for GOLGA2
- Browse Antibodies
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- Abcam antibodies for GOLGA2
- Abcam proteins for GOLGA2
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- Browse Primary Antibodies
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- Invitrogen Antibodies for GOLGA2 (AFLGC-Golga2)
- VectorBuilder Custom and pre-made DNA vectors for GOLGA2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for GOLGA2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for GOLGA2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for GOLGA2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for GOLGA2
- antibodies-online: Show 9 available GOLGA2 Antibodies ranked by validation data
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- antibodies-online: Show 4 available GOLGA2 Proteins ranked by validation data
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- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for GOLGA2
- Search Santa Cruz Biotechnology (SCBT) for GOLGA2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for GOLGA2
- Custom Antibody ServicesProSci Antibodies for GOLGA2
- Search for GOLGA2 Proteins at ProSci
- Horizon Cell Lines for GOLGA2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for GOLGA2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for GOLGA2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for GOLGA2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GOLGA2
Sources for GOLGA2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO