Aliases for GOLGA2 Gene
Aliases for GOLGA2 Gene
External Ids for GOLGA2 Gene
- HGNC: 4425
- Entrez Gene: 2801
- Ensembl: ENSG00000167110
- OMIM: 602580
- UniProtKB: Q08379
Previous GeneCards Identifiers for GOLGA2 Gene
- GC09M122134
- GC09M122665
- GC09M124471
- GC09M126394
- GC09M128097
- GC09M130057
- GC09M131018
- GC09M100631
Summaries for GOLGA2 Gene
-
The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This encoded protein has been postulated to play roles in the stacking of Golgi cisternae and in vesicular transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Feb 2010]
GeneCards Summary for GOLGA2 Gene
GOLGA2 (Golgin A2) is a Protein Coding gene. Diseases associated with GOLGA2 include Deafness, Autosomal Recessive 9 and Mucopolysaccharidosis Iii. Among its related pathways are Mitotic Prophase and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include protein kinase binding and syntaxin binding. An important paralog of this gene is GOLGA6D.
UniProtKB/Swiss-Prot for GOLGA2 Gene
-
Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane. Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly: phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing tethering of COPI vesicles and thereby inhibiting transport through the Golgi apparatus during mitosis (By similarity). Also plays a key role in spindle pole assembly and centrosome organization (PubMed:26165940). Promotes the mitotic spindle pole assembly by activating the spindle assembly factor TPX2 to nucleate microtubules around the Golgi and capture them to couple mitotic membranes to the spindle: upon phosphorylation at the onset of mitosis, GOLGA2 interacts with importin-alpha via the nuclear localization signal region, leading to recruit importin-alpha to the Golgi membranes and liberate the spindle assembly factor TPX2 from importin-alpha. TPX2 then activates AURKA kinase and stimulates local microtubule nucleation. Upon filament assembly, nascent microtubules are further captured by GOLGA2, thus linking Golgi membranes to the spindle (PubMed:19242490, PubMed:26165940). Regulates the meiotic spindle pole assembly, probably via the same mechanism (By similarity). Also regulates the centrosome organization (PubMed:18045989, PubMed:19109421). Also required for the Golgi ribbon formation and glycosylation of membrane and secretory proteins (PubMed:16489344, PubMed:17314401).
Additional gene information for GOLGA2 Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GOLGA2 Gene
Genomics for GOLGA2 Gene
GeneHancer (GH) Regulatory Elements for GOLGA2 Gene
Promoters and enhancers for GOLGA2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around GOLGA2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for GOLGA2 Gene
Genomic Locations for GOLGA2 Gene
- chr9:128,255,829-128,276,007
- (GRCh38/hg38)
- Size:
- 20,179 bases
- Orientation:
- Minus strand
- chr9:131,018,108-131,038,274
- (GRCh37/hg19)
Genomic View for GOLGA2 Gene
Genes around GOLGA2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q34.11 by Ensembl
- 9q34.11 by Entrez Gene
- 9q34.11 by HGNC
GOLGA2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for GOLGA2 Gene
Proteins for GOLGA2 Gene
-
Protein details for GOLGA2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q08379-GOGA2_HUMAN
- Recommended name:
- Golgin subfamily A member 2
- Protein Accession:
- Q08379
- A0A0C4DGS5
- Q6GRM9
- Q9BRB0
- Q9NYF9
Protein attributes for GOLGA2 Gene
- Size:
- 1002 amino acids
- Molecular mass:
- 113086 Da
- Quaternary structure:
-
- Part of a larger oligomeric complex (By similarity). Interacts with p115/USO1 (By similarity). Interacts with RAB1B that has been activated by GTP-binding (PubMed:11306556). Interacts with GORASP1/GRASP65 (PubMed:16489344, PubMed:18045989). Interacts with ZFPL1 (PubMed:18323775). Interacts with AKAP450/AKAP9; leading to recruit AKAP450/AKAP9 to the cis-Golgi (PubMed:19242490).
- SequenceCaution:
-
- Sequence=AAH69268.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAP35912.1; Type=Miscellaneous discrepancy; Note=Sequence differs from that shown after position 826 due to an internal deletion.; Evidence={ECO:0000305}; Sequence=EAW87762.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for GOLGA2 Gene
Post-translational modifications for GOLGA2 Gene
- Cleaved by caspases at the onset of apoptosis.
- Methylation by PRMT5 is required for Golgi ribbon formation. While dimethylation at Arg-30 and Arg-35 are confirmed in vivo, it is unclear whether Arg-18 is methylated in vivo.
- Phosphorylated at Ser-37 by CDK1 at the onset of mitosis, inhibiting the interaction with p115/USO1 and triggering Golgi disassembly (PubMed:20421892, PubMed:26165940). Phosphorylated at Ser-37 in prophase as the Golgi complex starts to break down, and remains phosphorylated during further breakdown and partitioning of the Golgi fragments in metaphase and anaphase. In telophase, GM130 is dephosphorylated by PP2A as the Golgi fragments start to reassemble (By similarity).
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for GOLGA2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for GOLGA2 (GM130/GOLGA2)
- Novus Biologicals Antibodies for GOLGA2
-
Abcam antibodies for GOLGA2
- Invitrogen Antibodies for GOLGA2
- GeneTex GOLGA2 antibody for GOLGA2
-
Santa Cruz Biotechnology (SCBT) Antibodies for GOLGA2
- Sino Biological Antibodies for GOLGA2
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for GOLGA2
- Origene Custom Protein Services for GOLGA2
- antibodies-online: Search results for 5 available GOLGA2 Proteins ranked by validation data
- Compare Top GOLGA2 Proteins
-
Quality Products:
- Search GeneTex for Proteins for GOLGA2
-
Abcam proteins for GOLGA2
Assay Products
No data available for DME Specific Peptides for GOLGA2 Gene
Domains & Families for GOLGA2 Gene
Gene Families for GOLGA2 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for GOLGA2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q08379UniProtKB/Swiss-Prot:
GOGA2_HUMAN :- The nuclear localization signal (cNLS) mediates interaction with importin-alpha, recruiting importin-alpha to the Golgi membrane and liberating TPX2.
- Belongs to the GOLGA2 family.
- Domain:
-
- The nuclear localization signal (cNLS) mediates interaction with importin-alpha, recruiting importin-alpha to the Golgi membrane and liberating TPX2.
- Family:
-
- Belongs to the GOLGA2 family.
Function for GOLGA2 Gene
Molecular function for GOLGA2 Gene
- UniProtKB/Swiss-Prot Function:
- Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane. Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly: phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing tethering of COPI vesicles and thereby inhibiting transport through the Golgi apparatus during mitosis (By similarity). Also plays a key role in spindle pole assembly and centrosome organization (PubMed:26165940). Promotes the mitotic spindle pole assembly by activating the spindle assembly factor TPX2 to nucleate microtubules around the Golgi and capture them to couple mitotic membranes to the spindle: upon phosphorylation at the onset of mitosis, GOLGA2 interacts with importin-alpha via the nuclear localization signal region, leading to recruit importin-alpha to the Golgi membranes and liberate the spindle assembly factor TPX2 from importin-alpha. TPX2 then activates AURKA kinase and stimulates local microtubule nucleation. Upon filament assembly, nascent microtubules are further captured by GOLGA2, thus linking Golgi membranes to the spindle (PubMed:19242490, PubMed:26165940). Regulates the meiotic spindle pole assembly, probably via the same mechanism (By similarity). Also regulates the centrosome organization (PubMed:18045989, PubMed:19109421). Also required for the Golgi ribbon formation and glycosylation of membrane and secretory proteins (PubMed:16489344, PubMed:17314401).
Phenotypes From GWAS Catalog for GOLGA2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 15037601 |
| GO:0008017 | microtubule binding | IDA | 26165940 |
| GO:0019901 | protein kinase binding | IPI | 20332113 |
| GO:0019905 | syntaxin binding | IPI | 18167358 |
| GO:0045296 | cadherin binding | IDA | 25468996 |
Phenotypes for GOLGA2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for GOLGA2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for GOLGA2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GOLGA2 gene
- Search ViGene Biosciences for GOLGA2
CRISPR Products
-
OriGene CRISPR knockouts for GOLGA2
- genomics-online: gRNA clones - Search results for available GOLGA2 gene related products
- Applied Biological Materials CRISPR for GOLGA2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GOLGA2
- GenScript: Design CRISPR guide RNA sequences for GOLGA2
miRNA for GOLGA2 Gene
- miRTarBase miRNAs that target GOLGA2
-
- hsa-mir-615-3p (MIRT040359)
- hsa-mir-412-3p (MIRT440542)
- hsa-mir-5089-5p (MIRT679767)
- hsa-mir-4715-3p (MIRT679768)
- hsa-mir-7151-3p (MIRT679769)
- hsa-mir-5095 (MIRT679770)
- hsa-mir-1227-3p (MIRT679771)
- hsa-mir-6778-3p (MIRT679772)
- hsa-mir-6506-5p (MIRT679773)
- hsa-mir-619-5p (MIRT679774)
- hsa-mir-6747-3p (MIRT679775)
- hsa-mir-6727-3p (MIRT679776)
- hsa-mir-4722-3p (MIRT679777)
- hsa-mir-4740-3p (MIRT679778)
- hsa-mir-6715b-5p (MIRT679779)
- hsa-mir-4269 (MIRT679780)
- hsa-mir-6767-3p (MIRT679781)
- hsa-mir-6504-3p (MIRT679782)
- hsa-mir-3622a-5p (MIRT679783)
- hsa-mir-4438 (MIRT679784)
- hsa-mir-5589-5p (MIRT716539)
- hsa-mir-4731-5p (MIRT716540)
- hsa-mir-150-5p (MIRT716541)
- hsa-mir-186-3p (MIRT716542)
- hsa-mir-512-3p (MIRT716543)
- hsa-mir-520e (MIRT716544)
- hsa-mir-520d-3p (MIRT716545)
- hsa-mir-520c-3p (MIRT716546)
- hsa-mir-520b (MIRT716547)
- hsa-mir-520a-3p (MIRT716548)
- hsa-mir-373-3p (MIRT716549)
- hsa-mir-372-3p (MIRT716550)
- hsa-mir-302e (MIRT716551)
- hsa-mir-302d-3p (MIRT716552)
- hsa-mir-302c-3p (MIRT716553)
- hsa-mir-302b-3p (MIRT716554)
- hsa-mir-302a-3p (MIRT716555)
- hsa-mir-93-5p (MIRT716556)
- hsa-mir-526b-3p (MIRT716557)
- hsa-mir-519d-3p (MIRT716558)
- hsa-mir-20b-5p (MIRT716559)
- hsa-mir-20a-5p (MIRT716560)
- hsa-mir-17-5p (MIRT716561)
- hsa-mir-106b-5p (MIRT716562)
- hsa-mir-106a-5p (MIRT716563)
- hsa-mir-548t-5p (MIRT716564)
- hsa-mir-548az-5p (MIRT716565)
- hsa-mir-1306-5p (MIRT762455)
- hsa-mir-1915-3p (MIRT763417)
- hsa-mir-1976 (MIRT763561)
- hsa-mir-3653-5p (MIRT766357)
- hsa-mir-4279 (MIRT768307)
- hsa-mir-4726-3p (MIRT771650)
- hsa-mir-4772-3p (MIRT772204)
- hsa-mir-498 (MIRT772829)
- hsa-mir-6764-5p (MIRT778506)
- hsa-mir-6840-3p (MIRT780129)
miRNA Products
- Search ViGene Biosciences for GOLGA2
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for GOLGA2
- Browse OriGene Inhibitory RNA Products For GOLGA2
- genomics-online: shRNA clones - Search results for available GOLGA2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for GOLGA2 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for GOLGA2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GOLGA2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available GOLGA2 gene related products
- orf clones - Search results for available GOLGA2 gene related products
- Applied Biological Materials Clones for GOLGA2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for GOLGA2
-
ViGene Biosciences adenoviral particle packaged cDNA for GOLGA2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for GOLGA2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for GOLGA2 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GOLGA2 Gene
Localization for GOLGA2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GOLGA2 Gene
- Golgi apparatus, cis-Golgi network membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, spindle pole. Note=Peripheral membrane protein associated with cis-Golgi stacks (By similarity). Associates with the mitotic spindle during mitosis (PubMed:26165940). {ECO:0000250 UniProtKB:Q62839, ECO:0000269 PubMed:26165940}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| golgi apparatus | 5 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| endosome | 2 |
| plasma membrane | 1 |
| lysosome | 1 |
- Golgi apparatus (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000137 | Golgi cis cisterna | IDA | 17488291 |
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0000922 | spindle pole | ISS | -- |
| GO:0005634 | nucleus | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for GOLGA2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transport to the Golgi and subsequent modification | ||
| 2 | Cell Cycle, Mitotic |
.83
|
.60
|
| 3 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimers disease models | ||
| 4 | Mitotic Prophase |
.57
|
|
| 5 | Vesicle-mediated transport | ||
Pathways by source for GOLGA2 Gene
1 BioSystems pathway for GOLGA2 Gene
17 Reactome pathways for GOLGA2 Gene
1 Cell Signaling Technology pathway for GOLGA2 Gene
Interacting Proteins for GOLGA2 Gene
Selected Interacting proteins:
Q08379-GOGA2_HUMAN
ENSP00000416097
for GOLGA2 Gene via
UniProtKB
IID
STRING
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006486 | protein glycosylation | IMP | 16489344 |
| GO:0006888 | ER to Golgi vesicle-mediated transport | TAS | -- |
| GO:0007020 | microtubule nucleation | IMP | 19242490 |
| GO:0007049 | cell cycle | IEA | -- |
| GO:0007098 | centrosome cycle | IMP | 18045989 |
Drugs & Compounds for GOLGA2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Guanosine triphosphate | Experimental | Pharma | 0 |
Transcripts for GOLGA2 Gene
mRNA/cDNA for GOLGA2 Gene
- (4) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (255) Selected AceView cDNA sequences:
- (15) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for GOLGA2
- genomics-online: gRNA clones - Search results for available GOLGA2 gene related products
- Applied Biological Materials CRISPR for GOLGA2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for GOLGA2
- GenScript: Design CRISPR guide RNA sequences for GOLGA2
miRNA Products
- Search ViGene Biosciences for GOLGA2
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for GOLGA2
- Browse OriGene Inhibitory RNA Products For GOLGA2
- genomics-online: shRNA clones - Search results for available GOLGA2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for GOLGA2 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for GOLGA2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for GOLGA2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available GOLGA2 gene related products
- orf clones - Search results for available GOLGA2 gene related products
- Applied Biological Materials Clones for GOLGA2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19a | · | 19b | · | 19c | ^ | 20 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: |
| ExUns: | 21a | · | 21b | ^ | 22 | ^ | 23a | · | 23b | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||
| SP2: | |||||||||||||||||||
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| SP4: | |||||||||||||||||||
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| SP7: | |||||||||||||||||||
| SP8: |
Expression for GOLGA2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Peripheral blood mononuclear cells (12.1), Nasal epithelium (8.8), and Pancreas (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GOLGA2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of GOLGA2 Gene:
GOLGA2SOURCE GeneReport for Unigene cluster for GOLGA2 Gene:
Hs.155827Evidence on tissue expression from TISSUES for GOLGA2 Gene
- Liver(4.6)
- Nervous system(4.6)
- Lung(3.1)
- Kidney(2.1)
- Muscle(2)
Primer Products
-
OriGene qPCR primer pairs for GOLGA2
-
OriGene qPCR primer pairs and template standards for GOLGA2
- genomics-online: primer clones - Search results for available GOLGA2 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GOLGA2 Gene
Orthologs for GOLGA2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | GOLGA2 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | GOLGA2 33 |
|
||
| -- 34 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | GOLGA2 33 |
|
||
| -- 34 |
|
OneToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Golga2 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Golga2 33 16 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | GOLGA2 33 |
|
||
| -- 34 |
|
OneToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100492442 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.28684 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | golga2 33 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP011337 33 |
|
- Species where no ortholog for GOLGA2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for GOLGA2 Gene
Paralogs for GOLGA2 Gene
(22) SIMAP similar genes for GOLGA2 Gene using alignment to 5 proteins:
Pseudogenes.org Pseudogenes for GOLGA2 Gene
- PGOHUM00000291445
- PGOHUM00000292833
- PGOHUM00000292835
- PGOHUM00000292840
- PGOHUM00000292863
- PGOHUM00000292872
- PGOHUM00000292879
- PGOHUM00000292890
- PGOHUM00000292893
- PGOHUM00000292974
- PGOHUM00000292977
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- PGOHUM00000293056
- PGOHUM00000293062
- PGOHUM00000293076
- PGOHUM00000293092
- PGOHUM00000293094
- PGOHUM00000293104
- PGOHUM00000293107
- PGOHUM00000293133
- PGOHUM00000293136
- PGOHUM00000293142
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- PGOHUM00000293165
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- PGOHUM00000293286
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- PGOHUM00000294953
- PGOHUM00000295296
- PGOHUM00000295297
- PGOHUM00000297773
- PGOHUM00000300484
- PGOHUM00000306603
- PGOHUM00000303293
- PGOHUM00000306701
- PGOHUM00000306702
- PGOHUM00000287953
- PGOHUM00000287958
- PGOHUM00000306705
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- PGOHUM00000306718
- PGOHUM00000287999
- PGOHUM00000288022
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- PGOHUM00000306719
- PGOHUM00000288060
- PGOHUM00000288062
- PGOHUM00000306724
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- PGOHUM00000306736
- PGOHUM00000307471
- PGOHUM00000307480
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- PGOHUM00000305586
- PGOHUM00000305748
- PGOHUM00000305764
- PGOHUM00000305766
- PGOHUM00000289778
Variants for GOLGA2 Gene
| SNP ID | Clin | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000329079 | -- | 128,274,335(-) | G/A | intron_variant | |
| rs1000425640 | -- | 128,274,686(-) | G/A | intron_variant | |
| rs1000532506 | -- | 128,270,649(-) | G/A | intron_variant | |
| rs1000599684 | -- | 128,270,892(-) | A/G/T | intron_variant | |
| rs1000666890 | -- | 128,275,729(-) | T/C | intron_variant |
Residual Variation Intolerance Score:
70.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
12.48;
94.34% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for GOLGA2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GOLGA2 Gene
Disorders for GOLGA2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| deafness, autosomal recessive 9 |
|
|
| mucopolysaccharidosis iii |
|
|
Search GOLGA2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for GOLGA2
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for GOLGA2 Gene
Publications for GOLGA2 Gene
- Molecular characterization of two human autoantigens: unique cDNAs encoding 95- and 160-kD proteins of a putative family in the Golgi complex. (PMID: 8315394) Fritzler MJ … Chan EK (The Journal of experimental medicine 1993) 2 3 4 22 58
- Microtubule nucleation at the cis-side of the Golgi apparatus requires AKAP450 and GM130. (PMID: 19242490) Rivero S … Rios RM (The EMBO journal 2009) 3 4 22 58
- The Golgi protein GM130 regulates centrosome morphology and function. (PMID: 18045989) Kodani A … Sütterlin C (Molecular biology of the cell 2008) 3 4 22 58
- The biogenesis of the Golgi ribbon: the roles of membrane input from the ER and of GM130. (PMID: 17314401) Marra P … De Matteis MA (Molecular biology of the cell 2007) 3 4 22 58
- The Golgi matrix protein GM130: a specific interacting partner of the small GTPase rab1b. (PMID: 11306556) Weide T … Barnekow A (EMBO reports 2001) 3 4 22 58
Products for GOLGA2 Gene
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- Cyagen custom Knockout/knockin (KOKI) mouse models for GOLGA2
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 112 available GOLGA2 Antibodies ranked by validation data
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Sources for GOLGA2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
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- (11) GO
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- (24) DrugBank
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- (27) AceView
- (28) ASD
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- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
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- (42) GenAtlas
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- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
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- (60) TGDB
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- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
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- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
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- (91) Illumina
- (92) COMPARTMENTS
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- (96) Addgene
- (97) antibodies-online
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- (103) GeneReviews
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- (105) Taconic Biosciences
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- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems