In non-hominoid primates and non-mammalian vertebrates, the gonadotropin releasing hormone 2 receptor gene (GnRHR2) encodes a seven-transmembrane G-protein coupled receptor. However, in human, the corresponding reading frame contains a premature stop codon, which has been suggested to encode a selenocysteine residue, but there is no solid evidence for selenocysteine incorporati... See more...

Aliases for GNRHR2 Gene

Aliases for GNRHR2 Gene

  • Gonadotropin Releasing Hormone Receptor 2 (Pseudogene) 2 3 5
  • Type II GnRH Receptor 3 4
  • GnRH-II-R 3 4
  • Gonadotropin-Releasing Hormone (Type 2) Receptor 2, Pseudogene 3
  • Putative Gonadotropin-Releasing Hormone II Receptor 4
  • Gonadotropin-Releasing Hormone (Type 2) Receptor 2 2
  • GnRH Receptor II 5TM 3
  • GnRH II Receptor 4
  • GNRHR2 5

External Ids for GNRHR2 Gene

Previous GeneCards Identifiers for GNRHR2 Gene

  • GC01M144030
  • GC01M142096
  • GC01M143236
  • GC01M143258
  • GC01M142998
  • GC01M144221
  • GC01M145509
  • GC01M119475

Summaries for GNRHR2 Gene

Entrez Gene Summary for GNRHR2 Gene

  • In non-hominoid primates and non-mammalian vertebrates, the gonadotropin releasing hormone 2 receptor gene (GnRHR2) encodes a seven-transmembrane G-protein coupled receptor. However, in human, the corresponding reading frame contains a premature stop codon, which has been suggested to encode a selenocysteine residue, but there is no solid evidence for selenocysteine incorporation (PMID: 12538601). It appears that the human GnRHR2 transcription occurs but the gene does not likely produce a functional multi-transmembrane protein. A non-transcribed pseudogene of GnRHR2 is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2013]

GeneCards Summary for GNRHR2 Gene

GNRHR2 (Gonadotropin Releasing Hormone Receptor 2 (Pseudogene)) is a Pseudogene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include peptide binding and gonadotropin-releasing hormone receptor activity.

UniProtKB/Swiss-Prot Summary for GNRHR2 Gene

  • Putative receptor for gonadotropin releasing hormone II (GnRH II) which is most probably non-functional.

Tocris Summary for GNRHR2 Gene

  • Gonadotropin-releasing hormone (GnRH) receptors are a group of Gq/11-protein-coupled receptors that are divided into two subtypes; GnRH and GnRH2. GnRH receptors are predominantly expressed by pituitary gonadotrophs. GnRH2 is silenced in humans.

Gene Wiki entry for GNRHR2 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for GNRHR2 Gene

Genomics for GNRHR2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for GNRHR2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GNRHR2 on the GeneHancer Hub at the UCSC Golden Path

Top Transcription factor binding sites by QIAGEN in the GNRHR2 gene promoter:
  • AML1a
  • Cart-1
  • Egr-2
  • GATA-1
  • HTF
  • NRF-2
  • POU3F1
  • RP58
  • Sox9

Genomic Locations for GNRHR2 Gene

Latest Assembly
chr1:145,919,013-145,925,341
(GRCh38/hg38)
Size:
6,329 bases
Orientation:
Plus strand

Previous Assembly
chr1:145,509,752-145,516,076
(GRCh37/hg19 by Entrez Gene)
Size:
6,325 bases
Orientation:
Minus strand

chr1:145,509,752-145,516,076
(GRCh37/hg19 by Ensembl)
Size:
6,325 bases
Orientation:
Minus strand

Genomic View for GNRHR2 Gene

Genes around GNRHR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GNRHR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GNRHR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNRHR2 Gene

Proteins for GNRHR2 Gene

  • Protein details for GNRHR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96P88-GNRR2_HUMAN
    Recommended name:
    Putative gonadotropin-releasing hormone II receptor
    Protein Accession:
    Q96P88
    Secondary Accessions:
    • E7EN27
    • Q8TCX8

    Protein attributes for GNRHR2 Gene

    Size:
    292 amino acids
    Molecular mass:
    32537 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAL27000.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for GNRHR2 Gene

Post-translational modifications for GNRHR2 Gene

No data available for DME Specific Peptides for GNRHR2 Gene

Domains & Families for GNRHR2 Gene

Protein Domains for GNRHR2 Gene

InterPro:
Blocks:
  • Gonadotrophin releasing hormone receptor signature

Suggested Antigen Peptide Sequences for GNRHR2 Gene

GenScript: Design optimal peptide antigens:
  • Type II GnRH receptor (GNRR2_HUMAN)
  • Type II gonadotropin-releasing hormone receptor splice variant (Q2MZ38_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96P88

UniProtKB/Swiss-Prot:

GNRR2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with GNRHR2: view

Function for GNRHR2 Gene

Molecular function for GNRHR2 Gene

UniProtKB/Swiss-Prot Function:
Putative receptor for gonadotropin releasing hormone II (GnRH II) which is most probably non-functional.

Phenotypes From GWAS Catalog for GNRHR2 Gene

Gene Ontology (GO) - Molecular Function for GNRHR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IBA 21873635
GO:0004968 gonadotropin-releasing hormone receptor activity IBA 21873635
GO:0042277 peptide binding IBA 21873635
genes like me logo Genes that share ontologies with GNRHR2: view
genes like me logo Genes that share phenotypes with GNRHR2: view

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GNRHR2 Gene

Localization for GNRHR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNRHR2 Gene

Cell membrane. Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for GNRHR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
genes like me logo Genes that share ontologies with GNRHR2: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for GNRHR2 Gene

Pathways & Interactions for GNRHR2 Gene

genes like me logo Genes that share pathways with GNRHR2: view

Gene Ontology (GO) - Biological Process for GNRHR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G protein-coupled receptor signaling pathway IBA, TAS --
GO:0097211 cellular response to gonadotropin-releasing hormone IEA --
genes like me logo Genes that share ontologies with GNRHR2: view

No data available for Interacting Proteins and SIGNOR curated interactions for GNRHR2 Gene

Drugs & Compounds for GNRHR2 Gene

(16) Drugs for GNRHR2 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nafarelin Approved Pharma Target, agonist GnRH receptor agonist 5
Danazol Approved Pharma Target, negative modulator, antagonist 32
Gonadorelin Approved, Investigational, Vet_approved Pharma Target, agonist 0
Degarelix Approved Pharma 0
histrelin Approved Pharma 0

(4) Additional Compounds for GNRHR2 Gene - From: IUPHAR, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I]GnRH II (human)
Agonist, Full agonist
trptorelix-1
Antagonist
Goserelin acetate
1233494-97-7

(5) Tocris Compounds for GNRHR2 Gene

Compound Action Cas Number
AG 045572 Selective GnRH receptor antagonist 263847-55-8
Goserelin acetate GnRH receptor agonist 1233494-97-7
Leuprolide GnRH receptor agonist 53714-56-0
Nafarelin GnRH receptor agonist 76932-56-4
T 98475 GnRH receptor antagonist 199119-18-1

(4) ApexBio Compounds for GNRHR2 Gene

Compound Action Cas Number
AG 045572 Selective GnRH receptor antagonist 263847-55-8
GnRH Associated Peptide (GAP) (1-13), human Asp-Ala-Glu-Asn-Leu-Ile-Asp-Ser-Phe-Gln-Glu-Ile-Val 100111-07-7
T 98475 199119-18-1
WAY 207024 dihydrochloride GnRH-R antagonist, potent 872002-73-8
genes like me logo Genes that share compounds with GNRHR2: view

Drug products for research

Transcripts for GNRHR2 Gene

mRNA/cDNA for GNRHR2 Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for GNRHR2 Gene

No ASD Table

Relevant External Links for GNRHR2 Gene

GeneLoc Exon Structure for
GNRHR2

Expression for GNRHR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for GNRHR2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GNRHR2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for GNRHR2

SOURCE GeneReport for Unigene cluster for GNRHR2 Gene:

Hs.356873

mRNA Expression by UniProt/SwissProt for GNRHR2 Gene:

Q96P88-GNRR2_HUMAN
Tissue specificity: Expressed in many tissues.
genes like me logo Genes that share expression patterns with GNRHR2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for GNRHR2 Gene

Orthologs for GNRHR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for GNRHR2 Gene

Organism Taxonomy Gene Similarity Type Details
African clawed frog
(Xenopus laevis)
Amphibia gnrhr2-A 29
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.11761 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8048 29
Fruit Fly
(Drosophila melanogaster)
Insecta GRHR 31
  • 30 (a)
Species where no ortholog for GNRHR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for GNRHR2 Gene

ENSEMBL:
Gene Tree for GNRHR2 (if available)
TreeFam:
Gene Tree for GNRHR2 (if available)
Alliance of Genome Resources:
Additional Orthologs for GNRHR2

Paralogs for GNRHR2 Gene

(6) SIMAP similar genes for GNRHR2 Gene using alignment to 2 proteins:

  • GNRR2_HUMAN
  • Q2MZ38_HUMAN
genes like me logo Genes that share paralogs with GNRHR2: view

No data available for Paralogs for GNRHR2 Gene

Variants for GNRHR2 Gene

Structural Variations from Database of Genomic Variants (DGV) for GNRHR2 Gene

Variant ID Type Subtype PubMed ID
esv3587419 CNV gain 21293372
nsv1005055 CNV loss 25217958
nsv2710 CNV insertion 18451855
nsv831381 CNV gain 17160897
nsv946264 CNV duplication 23825009

Additional Variant Information for GNRHR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
GNRHR2
Leiden Open Variation Database (LOVD)
GNRHR2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , dbSNP identifiers (rs#s) for variants without ClinVar clinical significance and Variation tolerance for GNRHR2 Gene

Disorders for GNRHR2 Gene

Additional Disease Information for GNRHR2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for GNRHR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GNRHR2 Gene

Publications for GNRHR2 Gene

  1. The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci. (PMID: 11707068) Faurholm B … Katz AA (Genomics 2001) 2 3 4 22
  2. Retention and silencing of prepro-GnRH-II and type II GnRH receptor genes in mammals. (PMID: 19657181) Stewart AJ … Morgan K (Neuroendocrinology 2009) 3 4 22
  3. A transcriptionally active human type II gonadotropin-releasing hormone receptor gene homolog overlaps two genes in the antisense orientation on chromosome 1q.12. (PMID: 12538601) Morgan K … Millar RP (Endocrinology 2003) 3 4 22
  4. Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. (PMID: 20398908) Saus E … Estivill X (Journal of psychiatric research 2010) 3 40
  5. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) Gratacòs M … Psychiatric Genetics Network Group (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009) 3 40

Products for GNRHR2 Gene

Sources for GNRHR2 Gene