Aliases for GNRH1 Gene
External Ids for GNRH1 Gene
Previous HGNC Symbols for GNRH1 Gene
Previous GeneCards Identifiers for GNRH1 Gene
This gene encodes a preproprotein that is proteolytically processed to generate a peptide that is a member of the gonadotropin-releasing hormone (GnRH) family of peptides. Alternative splicing results in multiple transcript variants, at least one of which is secreted and then cleaved to generate gonadoliberin-1 and GnRH-associated peptide 1. Gonadoliberin-1 stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutations in this gene are associated with hypogonadotropic hypogonadism. [provided by RefSeq, Nov 2015]
GeneCards Summary for GNRH1 Gene
GNRH1 (Gonadotropin Releasing Hormone 1) is a Protein Coding gene. Diseases associated with GNRH1 include Hypogonadotropic Hypogonadism 12 With Or Without Anosmia and Normosmic Congenital Hypogonadotropic Hypogonadism. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and PAK Pathway. Gene Ontology (GO) annotations related to this gene include hormone activity and gonadotropin hormone-releasing hormone activity.
UniProtKB/Swiss-Prot for GNRH1 Gene
Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.